KR102020018B1 - 종양 선택적 ｅ１ａ 및 ｅ１ｂ 돌연변이 - Google Patents

종양 선택적 ｅ１ａ 및 ｅ１ｂ 돌연변이 Download PDF

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KR102020018B1
KR102020018B1 KR1020187012031A KR20187012031A KR102020018B1 KR 102020018 B1 KR102020018 B1 KR 102020018B1 KR 1020187012031 A KR1020187012031 A KR 1020187012031A KR 20187012031 A KR20187012031 A KR 20187012031A KR 102020018 B1 KR102020018 B1 KR 102020018B1
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pea3
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KR20180049188A (ko
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토니 레이드
파라 헤드란
샨타누 쿠말
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더 리젠츠 오브 더 유니버시티 오브 캘리포니아
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KR1020187012031A 2009-03-02 2010-03-02 종양 선택적 ｅ１ａ 및 ｅ１ｂ 돌연변이 Active KR102020018B1 (ko)

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US15682209P 2009-03-02 2009-03-02
US61/156,822 2009-03-02
PCT/US2010/025926 WO2010101921A2 (en) 2009-03-02 2010-03-02 Tumor-selective e1a and e1b mutants

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KR102020018B1 true KR102020018B1 (ko) 2019-09-09

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KR1020117022884A Active KR101752910B1 (ko) 2009-03-02 2010-03-02 종양 선택적 ｅ１ａ 및 ｅ１ｂ 돌연변이
KR1020197025813A Active KR102150027B1 (ko) 2009-03-02 2010-03-02 종양 선택적 ｅ１ａ 및 ｅ１ｂ 돌연변이
KR1020177017391A Active KR101922539B1 (ko) 2009-03-02 2010-03-02 종양 선택적 ｅ１ａ 및 ｅ１ｂ 돌연변이

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KR1020197025813A Active KR102150027B1 (ko) 2009-03-02 2010-03-02 종양 선택적 ｅ１ａ 및 ｅ１ｂ 돌연변이
KR1020177017391A Active KR101922539B1 (ko) 2009-03-02 2010-03-02 종양 선택적 ｅ１ａ 및 ｅ１ｂ 돌연변이

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JP (5) JP6072414B2 (cg-RX-API-DMAC7.html)
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CY (1) CY1122385T1 (cg-RX-API-DMAC7.html)
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Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK2403951T3 (en) 2009-03-02 2016-01-11 Univ California Tumor-selective E1a and E1b adenoviral mutants
SG11201507393TA (en) 2013-03-14 2015-10-29 Salk Inst For Biological Studi Oncolytic adenovirus compositions
EP3022320B2 (en) 2013-07-19 2024-09-25 Ludwig Institute for Cancer Research Ltd Whole-genome and targeted haplotype reconstruction
ES2899913T3 (es) 2014-09-24 2022-03-15 Salk Inst For Biological Studi Virus tumorales oncolíticos y métodos de uso
WO2017147265A1 (en) 2016-02-23 2017-08-31 Salk Institute For Biological Studies High throughput assay for measuring adenovirus replication kinetics
EP3390645B1 (en) 2016-02-23 2022-09-14 Salk Institute for Biological Studies Exogenous gene expression in therapeutic adenovirus for minimal impact on viral kinetics
US10906957B2 (en) 2016-09-27 2021-02-02 Epicentrx, Inc. Immunomodulatory fusion proteins
AU2017375633C1 (en) 2016-12-12 2023-04-27 Salk Institute For Biological Studies Tumor-targeting synthetic adenoviruses and uses thereof
US10232053B2 (en) * 2016-12-30 2019-03-19 Trieza Therapeutics, Inc. Immunomodulatory oncolytic adenoviral vectors, and methods of production and use thereof for treatment of cancer
CN110741081B (zh) * 2017-01-30 2024-07-23 埃皮辛特瑞柯斯公司 肿瘤选择性tata盒和caat盒突变体
CA3052090A1 (en) * 2017-01-30 2018-08-02 Epicentrx, Inc. Multiple transgene recombinant adenovirus
AU2018253088B2 (en) * 2017-04-10 2024-09-19 Epicentrx, Inc. Method for producing recombinant virus
EA201990822A1 (ru) * 2017-04-12 2020-01-09 Эписентарикс, Инк. Иммуномодулирующие слитые белки
MX2019014059A (es) * 2017-05-24 2020-07-28 Epicentrx Inc Adenovirus antiangiogenico.
KR102702230B1 (ko) 2017-05-26 2024-09-03 에피센트알엑스, 인코포레이티드 트랜스진을 보유하는 재조합 아데노바이러스
KR102757384B1 (ko) 2017-09-27 2025-01-20 에피센트알엑스, 인코포레이티드 면역조절 융합 단백질
WO2019164593A2 (en) 2018-01-08 2019-08-29 Epicentrx, Inc. Methods and compositions utilizing rrx-001 combination therapy for radioprotection
CA3094329A1 (en) 2018-03-19 2020-02-20 Multivir Inc. Methods and compositions comprising tumor suppressor gene therapy and cd122/cd132 agonists for the treatment of cancer
EP3773649A4 (en) 2018-03-28 2022-02-23 EpicentRx, Inc. PERSONALIZED CANCER VACCINE
BR112020019942A2 (pt) 2018-04-09 2021-01-26 Salk Institute For Biological Studies composições de adenovírus oncolítico com propriedades de replicação aprimoradas
EP3844286A1 (en) * 2018-08-31 2021-07-07 Orca Therapeutics B.V. Recombinant replication competent viruses comprising a coding region for glycogen synthase kinase-3 (gsk3) and methods of killing aberrant cells
US12680122B2 (en) 2019-10-08 2026-07-14 Trustees Of Boston College Proteins containing multiple, different unnatural amino acids and methods of making and using such proteins
WO2021113644A1 (en) 2019-12-05 2021-06-10 Multivir Inc. Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer
JP2023517011A (ja) 2020-03-05 2023-04-21 ネオティーエックス セラピューティクス リミテッド 免疫細胞を用いて癌を治療するための方法および組成物
CN114262691A (zh) * 2020-09-16 2022-04-01 杭州康万达医药科技有限公司 分离的能够用于表达外源基因的溶瘤腺病毒、载体、治疗剂及其用途
WO2024015876A1 (en) 2022-07-13 2024-01-18 Epicentrx, Inc. Adenoviral vectors encapsulated in cationic liposomes, and preparation and use thereof
CN118931897B (zh) * 2024-06-27 2026-01-16 中山大学 一种识别肿瘤细胞并诱导其焦亡的基因、重组载体和重组病毒及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643567A (en) 1990-12-04 1997-07-01 Board Of Regents, The University Of Texas System Methods for the suppression of neu mediated tumors by adenoviral E1A and SV40 large T antigen
US20050287120A1 (en) 1997-03-21 2005-12-29 Fisher Paul B Cancer - targeted viral vectors
US20060270016A1 (en) 2003-11-14 2006-11-30 Holm Per S Novel adenoviruses, nucleic acids that code for the same and the use of said viruses

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5352775A (en) 1991-01-16 1994-10-04 The Johns Hopkins Univ. APC gene and nucleic acid probes derived therefrom
CA2113990A1 (en) 1991-07-26 1993-02-18 Frederick L. Moolten Cancer therapy utilizing malignant cells
US5631236A (en) 1993-08-26 1997-05-20 Baylor College Of Medicine Gene therapy for solid tumors, using a DNA sequence encoding HSV-Tk or VZV-Tk
WO1995007994A2 (en) * 1993-09-15 1995-03-23 Viagene, Inc. Recombinant alphavirus vectors
AUPN477695A0 (en) 1995-08-14 1995-09-07 Commonwealth Scientific And Industrial Research Organisation Gene therapy
US5902925A (en) 1996-07-01 1999-05-11 Integrated Sensor Solutions System and method for high accuracy calibration of a sensor for offset and sensitivity variation with temperature
GB9626029D0 (en) 1996-12-14 1997-01-29 Univ Leeds EVH-1 vectors
PT1135514E (pt) * 1999-01-28 2009-07-20 Onyx Pharma Inc Vectores de vaivém adenovirais com deleção em e1b
US6764674B1 (en) * 1999-01-28 2004-07-20 Onyx Pharmaceuticals Inc. Adenovirus E1B shuttle vectors
AU2001257611A1 (en) * 2000-04-28 2001-11-12 Avigen, Inc. Polynucleotides for use in recombinant adeno-associated virus virion production
US6884613B2 (en) * 2000-08-25 2005-04-26 The General Hospital Corporation Selective precipitation of viruses
CN1183250C (zh) 2000-12-01 2005-01-05 卫健生物科技有限公司 高效表达肿瘤血管生成抑制因子的肿瘤细胞内特异性增殖的病毒及其构建方法
GB0117198D0 (en) * 2001-07-13 2001-09-05 Btg Int Ltd Anti-neoplastic viral agents
US20040219516A1 (en) * 2002-07-18 2004-11-04 Invitrogen Corporation Viral vectors containing recombination sites
US20040106184A1 (en) * 2002-08-28 2004-06-03 Introgen Therapeutics Inc. Chromatographic methods for adenovirus purification
US20090232800A1 (en) * 2004-12-31 2009-09-17 Per Sonne Holm E1-minus adenoviruses and use thereof
JP5484897B2 (ja) * 2007-04-20 2014-05-07 タカラバイオ株式会社 遺伝子治療のためのベクター
DK2403951T3 (en) 2009-03-02 2016-01-11 Univ California Tumor-selective E1a and E1b adenoviral mutants

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643567A (en) 1990-12-04 1997-07-01 Board Of Regents, The University Of Texas System Methods for the suppression of neu mediated tumors by adenoviral E1A and SV40 large T antigen
US20050287120A1 (en) 1997-03-21 2005-12-29 Fisher Paul B Cancer - targeted viral vectors
US20060270016A1 (en) 2003-11-14 2006-11-30 Holm Per S Novel adenoviruses, nucleic acids that code for the same and the use of said viruses

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CANCER CELL. 2002, vol. 1, no. 4, pp. 325-337.

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