KR101992925B1 - 유전자 발현 조절을 위한 올리고뉴클레오타이드 및 그 용도 - Google Patents

유전자 발현 조절을 위한 올리고뉴클레오타이드 및 그 용도 Download PDF

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KR101992925B1
KR101992925B1 KR1020147026837A KR20147026837A KR101992925B1 KR 101992925 B1 KR101992925 B1 KR 101992925B1 KR 1020147026837 A KR1020147026837 A KR 1020147026837A KR 20147026837 A KR20147026837 A KR 20147026837A KR 101992925 B1 KR101992925 B1 KR 101992925B1
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oligonucleotide
seq
oligonucleotides
gene
pna
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KR20140130514A (ko
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로베르토 토넬리
레오나르도 벤투렐리
안드레아 토르토리
루카 몬테무로
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바이오제네라 에스.피.에이.
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
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KR1020147026837A 2012-02-24 2013-02-21 유전자 발현 조절을 위한 올리고뉴클레오타이드 및 그 용도 Active KR101992925B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITMI2012A000275 2012-02-24
IT000275A ITMI20120275A1 (it) 2012-02-24 2012-02-24 Oligonucleotidi per la modulazione dell'espressione genica e loro usi
PCT/IB2013/051410 WO2013124807A2 (en) 2012-02-24 2013-02-21 Oligonucleotides for modulating gene expression and uses thereof

Publications (2)

Publication Number Publication Date
KR20140130514A KR20140130514A (ko) 2014-11-10
KR101992925B1 true KR101992925B1 (ko) 2019-06-25

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KR1020147026837A Active KR101992925B1 (ko) 2012-02-24 2013-02-21 유전자 발현 조절을 위한 올리고뉴클레오타이드 및 그 용도

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US (2) US10023867B2 (enExample)
EP (1) EP2817407B1 (enExample)
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KR (1) KR101992925B1 (enExample)
CN (2) CN115216475A (enExample)
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ITMI20120275A1 (it) * 2012-02-24 2013-08-25 Biogenera Societa A Responsabilita Limitata Oligonucleotidi per la modulazione dell'espressione genica e loro usi
JP2015518712A (ja) 2012-05-16 2015-07-06 ラナ セラピューティクス インコーポレイテッド Ｍｅｃｐ２発現を調節するための組成物及び方法
JP2015518713A (ja) 2012-05-16 2015-07-06 ラナ セラピューティクス インコーポレイテッド Ｕｔｒｎ発現を調節するための組成物及び方法
US10837014B2 (en) 2012-05-16 2020-11-17 Translate Bio Ma, Inc. Compositions and methods for modulating SMN gene family expression
CN104583401A (zh) 2012-05-16 2015-04-29 Rana医疗有限公司 用于调节atp2a2表达的组合物和方法
EP2850188A4 (en) 2012-05-16 2016-01-20 Rana Therapeutics Inc COMPOSITIONS AND METHOD FOR MODULATING THE EXPRESSION OF THE HEMOGLOBIN GENE FAMILIES
WO2013173638A1 (en) 2012-05-16 2013-11-21 Rana Therapeutics, Inc. Compositions and methods for modulating smn gene family expression
CA3047076A1 (en) * 2016-12-13 2018-06-21 Am Sciences Inc Pharmaceutical composition for preventing or treating hepatitis b
US20250205341A1 (en) * 2022-03-22 2025-06-26 Bion Inc. Protein delivery composition containing bile salt and cationic peptide and use thereof

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ITMI20120275A1 (it) * 2012-02-24 2013-08-25 Biogenera Societa A Responsabilita Limitata Oligonucleotidi per la modulazione dell'espressione genica e loro usi

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CA2864060C (en) 2020-03-10
CY1120084T1 (el) 2018-12-12
NO2817407T3 (enExample) 2018-02-03
US10752900B2 (en) 2020-08-25
EP2817407A2 (en) 2014-12-31
KR20140130514A (ko) 2014-11-10
SMT201800042T1 (it) 2018-03-08
EP2817407B1 (en) 2017-09-06
JP2018078893A (ja) 2018-05-24
AU2013223694B2 (en) 2019-01-03
AU2013223694A1 (en) 2014-09-25
TN2014000327A1 (en) 2015-12-21
CA2864060A1 (en) 2013-08-29
CN104169421A (zh) 2014-11-26
PL2817407T3 (pl) 2018-03-30
IN2014MN01493A (enExample) 2015-04-17
AR090129A1 (es) 2014-10-22
CN115216475A (zh) 2022-10-21
AU2018278972A1 (en) 2019-01-17
JP6333739B2 (ja) 2018-05-30
SI2817407T1 (en) 2018-01-31
BR112014020885A2 (pt) 2018-01-09
SG10201606946YA (en) 2016-10-28
DK2817407T3 (en) 2017-12-18
RS56631B1 (sr) 2018-03-30
WO2013124807A3 (en) 2013-12-27
HUE034846T2 (en) 2018-03-28
JP2015513398A (ja) 2015-05-14
RU2014138198A (ru) 2016-04-10
HK1201878A1 (en) 2015-09-11
US10023867B2 (en) 2018-07-17
WO2013124807A2 (en) 2013-08-29
ITMI20120275A1 (it) 2013-08-25
ES2651147T3 (es) 2018-01-24
LT2817407T (lt) 2018-01-25
US20180282731A1 (en) 2018-10-04
RU2648140C2 (ru) 2018-03-22
MA35935B1 (fr) 2014-12-01
BR112014020885B1 (pt) 2020-10-27
US20160040166A1 (en) 2016-02-11
PT2817407T (pt) 2017-12-07

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