KR101944163B1 - 생체모방 콜라겐-히드록시아파타이트 복합재 재료 - Google Patents

생체모방 콜라겐-히드록시아파타이트 복합재 재료 Download PDF

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Publication number
KR101944163B1
KR101944163B1 KR1020167001407A KR20167001407A KR101944163B1 KR 101944163 B1 KR101944163 B1 KR 101944163B1 KR 1020167001407 A KR1020167001407 A KR 1020167001407A KR 20167001407 A KR20167001407 A KR 20167001407A KR 101944163 B1 KR101944163 B1 KR 101944163B1
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South Korea
Prior art keywords
collagen
hydroxyapatite
composite material
bone
biomimetic
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Expired - Fee Related
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KR1020167001407A
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English (en)
Korean (ko)
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KR20160032116A (ko
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미하엘 부플러
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가이스틀리히 파마 아게
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28—Materials for coating prostheses
    • A61L27/30—Inorganic materials
    • A61L27/32—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
    • B82B1/00—Nanostructures formed by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
    • G01N29/34—Generating the ultrasonic, sonic or infrasonic waves, e.g. electronic circuits specially adapted therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/112—Phosphorus-containing compounds, e.g. phosphates, phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2420/00—Materials or methods for coatings medical devices
    • A61L2420/02—Methods for coating medical devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/06—Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Materials Engineering (AREA)
  • Nanotechnology (AREA)
  • Composite Materials (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
KR1020167001407A 2013-07-19 2014-07-18 생체모방 콜라겐-히드록시아파타이트 복합재 재료 Expired - Fee Related KR101944163B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13003647.8A EP2826495A1 (en) 2013-07-19 2013-07-19 Biomimetic collagen-hydroxyapatite composite material
EP13003647.8 2013-07-19
PCT/EP2014/001966 WO2015007393A1 (en) 2013-07-19 2014-07-18 Biomimetic collagen-hydroxyapatite composite material

Publications (2)

Publication Number Publication Date
KR20160032116A KR20160032116A (ko) 2016-03-23
KR101944163B1 true KR101944163B1 (ko) 2019-01-30

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KR1020167001407A Expired - Fee Related KR101944163B1 (ko) 2013-07-19 2014-07-18 생체모방 콜라겐-히드록시아파타이트 복합재 재료

Country Status (16)

Country Link
US (1) US10029028B2 (enExample)
EP (2) EP2826495A1 (enExample)
JP (1) JP6478993B2 (enExample)
KR (1) KR101944163B1 (enExample)
CN (1) CN105358189B (enExample)
AU (1) AU2014292503B2 (enExample)
BR (1) BR112016001093B1 (enExample)
CA (1) CA2917997C (enExample)
DK (1) DK3021883T3 (enExample)
ES (1) ES2611202T3 (enExample)
HU (1) HUE031178T2 (enExample)
PL (1) PL3021883T3 (enExample)
PT (1) PT3021883T (enExample)
RU (1) RU2662326C2 (enExample)
SG (1) SG11201600364VA (enExample)
WO (1) WO2015007393A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10238507B2 (en) 2015-01-12 2019-03-26 Surgentec, Llc Bone graft delivery system and method for using same
WO2016179089A1 (en) 2015-05-01 2016-11-10 Rensselaer Polytechnic Institute Biomimetic nano-composite scaffold for enhanced bone healing and fracture repair
DE202016103296U1 (de) 2016-06-09 2017-09-18 Michael Gahlert Knochenersatzmaterial aus Zirkondioxidkeramik
DE102016110622A1 (de) 2016-06-09 2017-12-14 Michael Gahlert Knochenersatzmaterial aus Zirkondioxidkeramik
TWI783093B (zh) * 2017-12-14 2022-11-11 瑞士商蓋茲特利製藥公司 骨替代材料及其製備及應用
CN111511415B (zh) * 2017-12-14 2021-04-20 盖斯特里希医药公司 干式植入物组合物和可注射的水性植入物制剂
PT3544643T (pt) 2017-12-14 2020-07-27 Geistlich Pharma Ag Material de substituição óssea
US11116647B2 (en) 2018-04-13 2021-09-14 Surgentec, Llc Bone graft delivery system and method for using same
US10687828B2 (en) 2018-04-13 2020-06-23 Surgentec, Llc Bone graft delivery system and method for using same
EP3695856A1 (en) * 2019-02-13 2020-08-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Biomaterials comprising a scaffold containing a mineral compound, and uses thereof as bone substitutes
WO2020249714A1 (en) * 2019-06-14 2020-12-17 Geistlich Pharma Ag Collagen matrix or granulate blend of bone substitute material
KR102636183B1 (ko) * 2019-06-14 2024-02-13 가이스틀리히 파마 아게 골 대체 물질의 콜라겐 기질 또는 그래뉼레이트 블렌드
FR3101773B1 (fr) 2019-10-10 2023-04-21 Regeska Procede de mineralisation d’une membrane de biopolymere
CN114209880B (zh) * 2021-11-25 2022-11-08 浙江大学 一种有序矿化多肽的生物复合材料的制备方法及其产品和应用
CN114732957B (zh) * 2022-03-16 2022-12-23 武汉理工大学 一种具有预应力的矿化肌腱复合材料及其制备方法与应用
CN114890400B (zh) * 2022-06-15 2023-12-01 杭州彗搏科技有限公司 纳米晶体羟基磷灰石骨修复颗粒、制备方法及应用
CN116271232B (zh) * 2022-09-06 2025-11-07 浙江大学 一种基于原位矿化类骨羟基磷灰石的复合凝胶的合成方法及其产品和应用
CN119857939B (zh) * 2025-03-05 2025-10-03 中南大学 一种种植体表面处理技术

Citations (3)

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Publication number Priority date Publication date Assignee Title
US6201039B1 (en) 1993-09-21 2001-03-13 The Penn State Research Foundation Bone substitute composition comprising hydroxyapatite and a method of production therefor
US20090216336A1 (en) 2004-11-23 2009-08-27 Marco Springer Bioresorbable, mineralised material for filling osseous defects
US20100021520A1 (en) 2006-04-13 2010-01-28 Jonathan Baskin Biomaterial implants

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US5231169A (en) 1990-10-17 1993-07-27 Norian Corporation Mineralized collagen
US5532217A (en) 1992-04-24 1996-07-02 Silver; Frederick H. Process for the mineralization of collagen fibers, product produced thereby and use thereof to repair bone
GB9400163D0 (en) 1994-01-06 1994-03-02 Geistlich Soehne Ag Membrane
JP2754348B2 (ja) * 1994-10-20 1998-05-20 バイオマップ有限会社 アパタイト被覆基材とその製造法
GB9503492D0 (en) 1995-02-22 1995-04-12 Ed Geistlich S Hne A G F R Che Chemical product
US6395036B1 (en) 1998-04-06 2002-05-28 Isis Innovation Limited Composite material and methods of making the same
US7514249B2 (en) 2002-04-18 2009-04-07 The University Of Florida Research Foundation, Inc. Biomimetic organic/inorganic composites
ITMI20050343A1 (it) * 2005-03-04 2006-09-05 Fin Ceramica Faenza S R L Sostituto cartilagineo e osteocindrale comprendente una struttura multistrato e relativo impiego
US8691273B2 (en) * 2005-07-21 2014-04-08 Lisopharm Ag Method for producing hydroxyapatite particles
FR2933303B1 (fr) * 2008-06-30 2010-12-03 Univ Paris Curie Substitut osseux,et procede pour sa preparation.
ES2402961T3 (es) 2009-06-23 2013-05-10 Geistlich Pharma Ag Material sustitutivo del hueso
EP2600911B1 (de) * 2010-08-04 2017-10-11 Technische Universität Dresden Wachstumsinhibierter hydroxylapatit, verfahren zu dessen herstellung und verwendung
EP2654816B1 (en) * 2010-12-22 2015-02-11 Geistlich Pharma AG Bone substitute material

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6201039B1 (en) 1993-09-21 2001-03-13 The Penn State Research Foundation Bone substitute composition comprising hydroxyapatite and a method of production therefor
US20090216336A1 (en) 2004-11-23 2009-08-27 Marco Springer Bioresorbable, mineralised material for filling osseous defects
US20100021520A1 (en) 2006-04-13 2010-01-28 Jonathan Baskin Biomaterial implants

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Publication number Publication date
EP3021883B1 (en) 2016-11-09
RU2016105556A (ru) 2017-08-24
ES2611202T3 (es) 2017-05-05
CA2917997A1 (en) 2015-01-22
US20160144071A1 (en) 2016-05-26
HK1218083A1 (en) 2017-02-03
CN105358189A (zh) 2016-02-24
CN105358189B (zh) 2018-03-16
EP3021883A1 (en) 2016-05-25
DK3021883T3 (en) 2017-01-16
AU2014292503B2 (en) 2017-06-15
PT3021883T (pt) 2016-12-23
SG11201600364VA (en) 2016-02-26
KR20160032116A (ko) 2016-03-23
JP2016524964A (ja) 2016-08-22
RU2662326C2 (ru) 2018-07-25
PL3021883T3 (pl) 2017-03-31
WO2015007393A1 (en) 2015-01-22
AU2014292503A1 (en) 2016-02-11
CA2917997C (en) 2019-08-20
HUE031178T2 (en) 2017-06-28
JP6478993B2 (ja) 2019-03-06
US10029028B2 (en) 2018-07-24
BR112016001093B1 (pt) 2020-07-28
EP2826495A1 (en) 2015-01-21

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