KR101941308B1 - 장, 혈액-뇌 장벽 투과성 검출 방법 및 테스트 물질 - Google Patents

장, 혈액-뇌 장벽 투과성 검출 방법 및 테스트 물질 Download PDF

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KR101941308B1
KR101941308B1 KR1020137022644A KR20137022644A KR101941308B1 KR 101941308 B1 KR101941308 B1 KR 101941308B1 KR 1020137022644 A KR1020137022644 A KR 1020137022644A KR 20137022644 A KR20137022644 A KR 20137022644A KR 101941308 B1 KR101941308 B1 KR 101941308B1
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KR20140052941A (ko
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아리스토 보즈다니
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이뮤노사이언시스 랩. 인크.
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/195—Assays involving biological materials from specific organisms or of a specific nature from bacteria
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/06—Gastro-intestinal diseases
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/709—Toxin induced

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Rheumatology (AREA)
  • Rehabilitation Therapy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020137022644A 2011-01-28 2012-01-26 장, 혈액-뇌 장벽 투과성 검출 방법 및 테스트 물질 Active KR101941308B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161437244P 2011-01-28 2011-01-28
US61/437,244 2011-01-28
PCT/US2012/022706 WO2012103324A2 (en) 2011-01-28 2012-01-26 Method for detection of intestinal, and blood-brain barrier permeability and testing materials thereto

Publications (2)

Publication Number Publication Date
KR20140052941A KR20140052941A (ko) 2014-05-07
KR101941308B1 true KR101941308B1 (ko) 2019-01-22

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KR1020137022644A Active KR101941308B1 (ko) 2011-01-28 2012-01-26 장, 혈액-뇌 장벽 투과성 검출 방법 및 테스트 물질

Country Status (12)

Country Link
US (2) US8663911B2 (https=)
EP (1) EP2668498B1 (https=)
JP (1) JP6068362B2 (https=)
KR (1) KR101941308B1 (https=)
CN (2) CN103460044B (https=)
AU (3) AU2012211328A1 (https=)
BR (1) BR112013019380A2 (https=)
CA (2) CA2828194A1 (https=)
IL (2) IL227676A (https=)
MX (1) MX2013008746A (https=)
RU (2) RU2016149216A (https=)
WO (1) WO2012103324A2 (https=)

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Publication number Priority date Publication date Assignee Title
EP2628013B1 (en) 2010-10-14 2019-06-12 The Johns Hopkins University Biomarkers of brain injury
US9709573B2 (en) 2012-03-13 2017-07-18 The Johns Hopkins University Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration
US20140147856A1 (en) * 2012-11-29 2014-05-29 Rush University Medical Center Intestinal Permeability Assay for Neurodegenerative Diseases
EP3022322A4 (en) 2013-07-17 2017-05-17 The Johns Hopkins University A multi-protein biomarker assay for brain injury detection and outcome
JP2018510359A (ja) 2015-02-05 2018-04-12 イミューンアレイ ユーエスエイ インコーポレイテッド 脳損傷または神経変性を診断するための方法および組成物
US11131676B2 (en) 2016-02-25 2021-09-28 The Trustees Of Columbia University In The City Of New York Systemic immune activation and biomarkers of nonceliac wheat/gluten sensitivity
CN105974105A (zh) * 2016-05-16 2016-09-28 河北艾驰生物科技有限公司 基质金属蛋白酶-3（mmp3）检测试剂盒
CN110312937B (zh) * 2017-01-19 2023-01-10 和田孝一郎 诊断肠黏膜通透性的诊断药、诊断方法及诊断装置
CN108191977B (zh) * 2017-12-25 2018-12-18 首都医科大学宣武医院 用于检测缺血性脑卒中血脑屏障早期损伤的抗体及其应用
CN108152492B (zh) * 2017-12-25 2019-03-08 首都医科大学宣武医院 用于检测缺血性脑卒中血脑屏障早期损伤的抗体及其应用
WO2019157119A1 (en) 2018-02-07 2019-08-15 University Of Cincinnati System and method for detecting small blood-tissue barrier disruption
KR102341906B1 (ko) * 2018-10-26 2021-12-22 가천대학교 산학협력단 청년기 우울증 동물모델의 제조방법
CN112958172B (zh) * 2021-02-24 2021-12-28 北京航空航天大学 一种模拟体内微生物-肠-脑轴信号传导过程的仿生微流控芯片

Citations (2)

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US20030170747A1 (en) 2001-06-25 2003-09-11 Damir Janigro Peripheral marker of blood brain barrier permeability
US20100190191A1 (en) 2009-01-26 2010-07-29 Dodds W Jean Multi-stage nutrigenomic diagnostic food sensitivity testing in animals

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US20020028215A1 (en) * 1999-08-09 2002-03-07 Jagath L. Kadurugamuwa Novel vaccines and pharmaceutical compositions using membrane vesicles of microorganisms, and methods for preparing same
DE19842609C2 (de) * 1998-09-17 2000-09-21 Diagnostik Gmbh Leipzig Lab Salmonellenantigengemisch und Kit zur Bestimmung von Antikörpern gegen Salmonellen
US6958324B2 (en) * 1998-12-02 2005-10-25 Inotek Pharmaceuticals Corporation Inosine compounds and their use for treating or preventing an inflamation or a reperfusion disease
CN1788017B (zh) * 2003-02-10 2013-04-24 to-BBB控股股份有限公司 炎症状态下在血脑屏障中差异表达的核酸
US20080038843A1 (en) * 2006-08-11 2008-02-14 University Of Maryland - Baltimore Method of diagnosing celiac disease
CN101189518A (zh) * 2005-05-13 2008-05-28 马里兰巴尔的摩大学 评价治疗方案有效性的方法
US7795314B2 (en) * 2005-06-01 2010-09-14 Cytokine Pharmasciences, Inc. Protective role of semapimod in necrotizing enterocolitis
EP1757940A1 (en) * 2005-08-26 2007-02-28 Cézanne S.A.S. In vitro method for diagnosing and monitoring renal cell carcinoma (RCC) using MMP-7 as humoral biomarker for RCC
JP4791866B2 (ja) * 2006-03-24 2011-10-12 国立大学法人秋田大学 下痢原性大腸菌感染症の判別に用いられる固相等

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030170747A1 (en) 2001-06-25 2003-09-11 Damir Janigro Peripheral marker of blood brain barrier permeability
US20100190191A1 (en) 2009-01-26 2010-07-29 Dodds W Jean Multi-stage nutrigenomic diagnostic food sensitivity testing in animals

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Glycoconjugate Journal, 2008, Vol. 25, pp 27-36.
Plus One, 2010, Vol. 5, pp 1-8.

Also Published As

Publication number Publication date
CN103460044A (zh) 2013-12-18
IL227676A (en) 2017-03-30
MX2013008746A (es) 2014-06-23
US8663911B2 (en) 2014-03-04
RU2607479C2 (ru) 2017-01-10
EP2668498B1 (en) 2019-10-02
JP2014503829A (ja) 2014-02-13
RU2016149216A (ru) 2018-11-02
EP2668498A4 (en) 2015-05-20
CN103460044B (zh) 2016-04-20
EP2668498A2 (en) 2013-12-04
AU2012211328A1 (en) 2013-09-19
BR112013019380A2 (pt) 2019-10-01
IL227676A0 (en) 2013-09-30
AU2016262726A1 (en) 2016-12-15
HK1189938A1 (zh) 2014-06-20
AU2016262726B2 (en) 2018-12-06
NZ614707A (en) 2015-04-24
JP6068362B2 (ja) 2017-01-25
US20140186855A1 (en) 2014-07-03
CN105823887B (zh) 2018-06-12
KR20140052941A (ko) 2014-05-07
IL250871A0 (en) 2017-04-30
AU2016259430B2 (en) 2019-01-03
US20120196299A1 (en) 2012-08-02
AU2016259430A1 (en) 2016-12-08
US9194867B2 (en) 2015-11-24
IL250871B (en) 2021-05-31
WO2012103324A3 (en) 2012-11-01
CN105823887A (zh) 2016-08-03
WO2012103324A2 (en) 2012-08-02
CA2964555C (en) 2024-05-14
CA2964555A1 (en) 2012-08-02
RU2013139476A (ru) 2015-03-10
CA2828194A1 (en) 2012-08-02

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