KR101939538B1 - Cosmetic compositon for prevention and improvement of atopic dermatitis - Google Patents

Abstract

The present invention relates to a cosmetic composition for prevention and treatment of atopic dermatitis, and more particularly, to a cosmetic composition which can stably contain ceramides to prevent and alleviate atopic dermatitis. To this end, the cosmetic composition for prevention and alleviation of atopic dermatitis contains ceramide-containing multilamellar liposomes comprising glycerin, dimethicone, polyglyceryl-10 stearate, 1,2-hexanediol, hydrogenated lecithin, ceramide, and water.

Description

TECHNICAL FIELD [0001] The present invention relates to a cosmetic composition for prevention and improvement of atopic skin diseases,

The present invention relates to a cosmetic composition for prevention and treatment of atopic skin disease, and more particularly, to a cosmetic composition which can stably contain ceramide and prevent and improve atopic skin disease.

Atopy is the name given to the inherent irritability of humans for certain kinds of substances that are specific to A. coca in the United States in 1925. Atopy is characterized by asthma and inflammation in the family or by allergens (egg white, dandruff, pollen, dust (Atopic allergen) in the serum or an abnormal reaction to various stresses (temperature, humidity, trauma, mental strain, infection, etc.) many.

Atopic dermatitis has been known to occur mainly in early childhood and is known as fever, and it is known that it occurs mainly as the content of ceramide in the stratum corneum is decreased. Particularly, atopic dermatitis has a problem in that it does not have the ability to maintain the moisture content of the stratum corneum, and the skin is dried and the skin is easily dried, and the function as a protective barrier of the skin is lowered. Therefore, the stimulant- It is common for skin allergies to occur easily due to invasion of difficult antigen proteins and symptoms of pruritus which is difficult to tolerate.

Such atopic skin is severely scratched, accompanied by eczema, keloid, and severe keratinization. These atopic skin are largely attributed to four factors (genetic factors, immunological factors, skin barrier factors, and environmental factors).

Atopic dermatitis is a chronic, recurrent inflammatory skin disease that starts in infancy or childhood and is accompanied by pruritus (itching), dry skin, and characteristic eczema.

In infancy, it begins with eczema on the unfolded side of the face and limbs, but it appears as a form of eczema on the part where the arm is bent and on the bending part behind the knee in growth, and in many cases it tends to improve naturally .

In adults, lichenification appears in which the skin folds up, and eczema is more common on the face than in childhood. Atopic dermatitis is a worldwide increasing trend and its prevalence is reported to be 20% of the population.

In the case of severe atopic dermatitis patients, these diseases cause a great social impact, and in actual healed atopic patients, the quality of life is improved. . Therefore, it is imperative to develop a method to relieve symptoms.

Although the use of existing therapeutic agents has achieved some improvement in the prevention and treatment of atopic skin, it has some problems in terms of effective side and skin safety. For example, it has been reported that the use of a steroid preparation such as hydrocortisone may cause side effects such as inhibition of growth of the epidermis or side effects, and urea peroxide may cause skin irritation and other contact dermatitis . Antibiotics such as antihistamines are known to be tolerant to antibiotics, and known antioxidants, phlegmatics, sorghum, malt, mugwort, etc. have some effect, but in some cases, sensitized atopic skin, There is a problem that the range of use can be limited.

Accordingly, development of a cosmetic composition which can effectively prevent and ameliorate atopic skin diseases is desired.

Korean Patent Publication No. 10-0452757

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made keeping in mind the above problems occurring in the prior art, and an object of the present invention is to provide a cosmetic composition capable of preventing and improving atopic skin diseases.

These and other objects and advantages of the present invention will become apparent from the following description of a preferred embodiment.

It is an object of the present invention to provide a cosmetic composition for prevention and improvement of atopic skin diseases which comprises glycerin, dimethicone, polyglyceryl-10stearate, 1,2-hexanediol (1 , 2-hexanediol, hydrogenated lecithin, ceramide, and water. ≪ Desc / Clms Page number 2 >

Specifically, the ceramide-containing multi-lamellar liposome comprises 30 to 40% by weight of glycerin, 20 to 30% by weight of dimethicone, 1 to 5% by weight of polyglyceryl-10stearate, 1 to 3% by weight of 1,2-hexanediol, 0.1 to 1% by weight of hydrogenated lecithin, 0.1 to 3% by weight of ceramide and a balance of water desirable.

Preferably, the ceramide-containing multicamera liposome may further contain various additives, alone or in combination. That is, it may further contain 1 to 2% by weight of a cinnamon extract, 1 to 4% by weight of a ginseng extract, 2 to 5% by weight of a citrus juice solution, and 1 to 3% .

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to prevent and improve atopic skin disease.

Specifically, a multi-lamella liposome structure can be formed to stably contain ceramides, and an effective ingredient such as a cinnamon extract can be effectively contained to prevent or ameliorate atopic skin diseases.

However, the effects of the present invention are not limited to the above-mentioned effects, and other effects not mentioned can be clearly understood by those skilled in the art from the following description.

BRIEF DESCRIPTION OF THE DRAWINGS Figure 1 is a graph showing the temperature stability test of ceramide-containing multi-lamellar liposomes.

Hereinafter, the present invention will be described in detail with reference to embodiments and drawings of the present invention. It will be apparent to those skilled in the art that these embodiments are provided by way of illustration only for the purpose of more particularly illustrating the present invention and that the scope of the present invention is not limited by these embodiments .

Also, unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains and, where contradictory, Will be given priority.

In order to clearly illustrate the claimed invention, parts not related to the description are omitted, and like reference numerals are used for like parts throughout the specification. And, when a section is referred to as "including " an element, it does not exclude other elements unless specifically stated to the contrary. In addition, "part" described in the specification means one unit or block performing a specific function.

In each step, the identification code (first, second, etc.) is used for convenience of explanation, the identification code does not describe the order of each step, and each step does not explicitly list a specific order in the context May be performed differently from the above-described sequence. That is, each of the steps may be performed in the same order as described, or may be performed substantially concurrently or in the reverse order.

The cosmetic composition according to one embodiment of the present invention is a cosmetic composition for prevention and improvement of atopic skin diseases, which comprises glycerin, dimethicone, polyglyceryl-10stearate, Containing multicamera liposomes comprising ceramide-containing ceramides, including 1,2-hexanediol, hydrogenated lecithin, ceramide, and water. That is, after mixing the components, the ceramide-containing multi-lamellar liposome can be prepared using a high-pressure micro emulsifier (pressure of about 1200 to 1500 bar). The present invention provides a multilamellar liposome structure by using hydrogenated lecithin and stabilizes the skin with ceramides, thereby enhancing skin moisturizing power and improving the itching effect, thereby preventing and preventing atopic skin diseases. It is possible to have an effect that can be improved.

Glycerin suppresses the growth of anaerobic bacteria and improves skin conditioning, which promotes skin vitality.

Dimethicone functions as an oil that dissolves ceramides.

Polyglyceryl-10 stearate is a glycerin and fatty acid of 100% natural plant system. It can be obtained by making glycerin derived from vegetable oil into polyglycerin by dehydration condensation and then ester-bonding fatty acids derived from plant oil. It functions as a surfactant.

1,2-hexanediol has a surfactant structure with both hydrophobic and hydrophilic groups and functions as a moisturizer and preservative. 1,2-Hexanediol can replace preservatives such as conventional parabens. Mixing with caprylic glycols at a weight ratio of 1: 1 can exert more excellent effects.

Hydrogenated lecithin can enhance the moisture retention. Lecithin is a component of the cell membrane, which helps to form a healthy cell membrane. In other words, it accepts active ingredients such as nutrients and enzymes well, and exhausts wastes and so on to enhance moisture. In the case of hydrogenated lecithin, the EWG grade given by the Environmental Working Group (EWG), a US environmental NGO, has been recognized as safe and has better moisture retention than lecithin.

Ceramide is a type of sphingolipid having a structure in which fatty acids are linked to sphingosine or phytosphingosine. Ceramides occupy more than 40% of the intercellular lipids constituting the stratum corneum of the skin, and are essential components to show the structure and function of the stratum corneum. Ceramides present in the human body are classified into six types depending on the degree of polarity. Ceramide is known to be one of the most important components of the stratum corneum, which is called the skin barrier, which protects the skin. It inhibits the evaporation of water and combines with water to make it contain the moisture of the skin. It provides an optimal environment for performing metabolic functions. Newly growing skin cells have a low content of ceramide and are present in the form of a sugar sphingolipid, mainly sugar-linked. However, when new skin cells migrate to the outer stratum and reach the stratum corneum, the neutrophil barrier of the stratum corneum is formed due to the increase of the neutral ceramide in the sacrum. The keratinocyte lipid is secreted by lamellar bodies called lamella bodies in the differentiation process of the stratum corneum. The lamellar bodies are mainly rich in phospholipids, glycosphingolipids, lipids such as cholesterol, In addition, it has various enzymes (lipid hydrolase, glycosidase, protease, acid phosphatase, etc.).

Water functions as a solvent.

It is important that each component is mixed in an appropriate amount to effectively contain the ceramide and to form the multi-lamellar liposome form. That is, the ceramide-containing multi-lamellar liposome comprises 30 to 40% by weight of glycerin, 20 to 30% by weight of dimethicone, 1 to 5% by weight of polyglyceryl-10stearate, 1 to 3% by weight of 2-hexanediol, 0.1 to 1% by weight of hydrogenated lecithin, 0.1 to 3% by weight of ceramide, and the balance of water desirable. When the content of the above components is exceeded, it may be a problem to form a multi-lamellar liposome form.

On the other hand, various additives for exhibiting additional effects on the ceramide-containing multi-lamellar liposome may be further included singly or in combination.

In one embodiment, the composition may further comprise a cinnamon extract in the mixing step. The cinnamon extract is obtained by extracting the dried cinnamon with a solvent. Cinnamon is a cinnamon bark of camphor tree and is divided into True-cinnamon in Sri Lanka and Cassia-cinnamon in China, Japan and Korea. The cinnamon shell is removed or dried as it is usually called cinnamon or broiler. Cinnamon has been used as herbal medicine, medicines and food. The extract of cinnamon is called cinnamic oil and it contains cinnamic aldehyde, camphene, cineol, cinnamic acid, linalool, eugenol, , Iron, vitamin A, vitamin B1 and vitamin B2. Cinnamon is proved to be effective not only in traditional oriental medicine but also in modern medicine. The ingredients of cinnamon are antimicrobial activity function which suppresses decay of food, inhibitory effect of propagation of chewing gum, strong anti-inflammation and hair loss prevention effect on scalp by using in hair, itching, light wound treatment, local redness control, harmful Escherichia coli inhibitory effect, Formation inhibitory effect, antibacterial activity effect, and the like.

Cinnamon extracts can be extracted by conventional plant extract preparation methods such as ethanol extraction, hot water extraction, autoclave pressure extraction, and simple extraction. As an example, the dried cinnamon is placed in distilled water 10 times the weight of cinnamon, boiled at 100 ° C, cooled to 70 ° C and immersed for 3 hours. After that, it can be extracted by vacuum concentration.

The cinnamon extract is preferably contained in an amount of 1 to 2% by weight based on the total composition in which the components are mixed. When the content of the cinnamon extract is less than 1% by weight, effects such as anti-inflammation by the cinnamon extract and prevention of itching are not exhibited, and when it exceeds 2% by weight, the mixing property with other components may be inhibited.

In one embodiment, the composition may further comprise a chewing gum extract in the mixing step. Charm is mainly used in oriental medicine, but it can improve elasticity when used on skin. Cheongma is a relatively strong herb, and it is important to control its concentration, and it is preferable that 1 to 4% by weight of each constituent component is included in the mixed composition. When the extract of Chionmae is less than 1% by weight, the effect of improving the elasticity by the Chionmae extract is not exhibited. If it is more than 4% by weight, the skin may be rash.

In one embodiment, it may further comprise a solution of citric acid in the mixing step of each component. It is preferable that the vegetable oil solution is a mixture of vegetable oil and salt in water, and the mass ratio of water: vegetable oil: salt is 90-110: 70-80: 0.5-1.5. When mixed with citron juice, it helps prevent skin aging, prevents spots and freckles, and improves moisturizing power. The citron liquid is preferably contained in an amount of 2 to 5% by weight with respect to the total composition in which each constituent is mixed. When the content of the vegetable oil is less than 2% by weight, the effect of preventing skin aging by the vegetable oil is not exhibited, and when it exceeds 5% by weight, the formation of the multi-lamellar liposome structure may be inhibited.

In one embodiment, the crocodile oil may be further included in the mixing step of each component.

Crocodile oil is extracted and purified from fatty tissue of crocodile. Crocodile oil has been known to treat many intractable and chronic skin diseases for centuries. In modern clinical trials Crocodile oil has been proven to have skin permeability, antibacterial activity and blood circulation enhancement. , Burns, eczema, abrasions, cuts, ulcers, pressure ulcers, contusions, and acne. Crocodile oil has little scent and very little skin irritation. It is suitable for all ages. It can be applied immediately to the skin, and is especially effective in improving eczema, wrinkles and atopic dermatitis. Specifically, crocodile oils include saturated fatty acids, monounsaturated fatty acids and polyunsaturated fatty acids. Saturated fatty acids include at least one of palmitic acid, stearic acid and myristic acid. Monounsaturated fatty acids include at least one of oleic acid and palmitoleic acid. The polyunsaturated fatty acids are selected from the group consisting of linoleic acid, gamma-linolenic acid, alpha-linolenic acid, docosahexaenoic acid, and eicosatrienoic acid. At least one of them.

The crocodile oil is preferably contained in an amount of 1 to 3% by weight based on the total composition in which the components are mixed. When the amount of the crocodile oil is less than 1% by weight, effects such as eczema and wrinkle prevention due to crocodile oil are not exhibited. If the amount exceeds 3% by weight, the stability of the multi-lamellar liposome may deteriorate.

Hereinafter, the structure and effects of the present invention will be described in more detail with reference to specific examples and comparative examples. However, this embodiment is intended to explain the present invention more specifically, and the scope of the present invention is not limited to these embodiments.

[Example]

After mixing the components shown in Table 1 below, the mixture was passed through a high-pressure microemulsifier machine having a high pressure of 1200 bar three times in succession, followed by cooling and defoaming to prepare a cosmetic composition comprising a multi-lamellar liposome.

[Table 1]

[Experimental Example 1: Skin elasticity measurement test]

Sixty healthy women (mean age 29.5 years) 20 years old or older under the conditions of temperature 22 to 24 ° C and relative humidity 55% were applied to Examples 1 to 3 for 12 weeks (twice / day) The skin elasticity was measured using a skin elasticity tester (Cutometer SEM 575, C + K Electronic Co., Germany). The experimental results are shown in the following Table 2 as the average value of R5 (R5 (12 weeks) -R5 (0 weeks)), which is the average value of the cutometer SEM 575. R5 value is a value representing the real elastic modulus. Indicates excellentness. The degree of improvement was calculated by the following equation (1).

[Equation 1]

Improvement degree (%) = (? R5 / before application) X 100

[Table 2]

According to Table 2, it was found that the skin elasticity-enhancing effect of Examples 1 to 3 was obtained.

[Experimental Example 2: Experimental measurement of skin moisture]

(Average age: 29.5 years) in a room with no air flow at 22 to 24 ° C, 55% relative humidity. Examples 1 to 3 were applied to the whole face twice a day for 6 weeks . The moisture content of the ball area was measured before and after coating using Skicon-200 (IBS Co. Japan), and the persistence of the moisturizing effect was measured. The results are shown in Table 3 as average values. The degree of improvement was calculated according to the following equation (2).

&Quot; (2) "

(%) = [(6 weeks after application - before the test) / before the test] X 100

[Table 3]

According to the above Table 3, in the case of Example 3 among Examples 1 to 3, it is found that the skin moisturizing effect is most persistent.

[Experimental Example 3: Temperature Stability Test]

The stability test was carried out at 4 ° C, 25 ° C and 45 ° C for 4 weeks for Example 3 showing the best effect through Experimental Examples 1 and 2, and the results are shown in FIG.

As can be seen from FIG. 1, in Example 3, it was found that there was almost no statistical separation and specification change at all temperatures, and it was very stable.

It is to be understood that the present invention is not limited to the above embodiments and various changes and modifications may be made by those skilled in the art without departing from the spirit and scope of the invention.

Claims (3)

A cosmetic composition for prevention and improvement of atopic skin disease,
Glycerin, dimethicone, polyglyceryl-10stearate, 1,2-hexanediol, hydrogenated lecithin, ceramide, and the like. ceramide-containing multicamera liposomes comprising ceramide, cinnamon extract, chondroma extract, citrus juice, crocodile oil and water,
A mixture of 30 to 40% by weight of glycerin, 20 to 30% by weight of dimethicone, 1 to 5% by weight of polyglyceryl-10stearate, 1,2-hexanediol (1, 1 to 2% by weight of cinnamon extract, 1 to 4% by weight of Chimmae extract, 1 to 3% by weight of hydrogenated lecithin, 0.1 to 3% by weight of ceramide, 1 to 3% 2 to 5% by weight of liquid, 1 to 3% by weight of crocodile oil and the balance water,
Wherein the citrus juice solution is prepared by mixing 90 to 110 parts by weight of water, 70 to 80 parts by weight of citron juice, and 0.5 to 1.5 parts by weight of salt. delete delete

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