KR101933251B1 - 시탁센탄 유도체 - Google Patents

시탁센탄 유도체 Download PDF

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Publication number
KR101933251B1
KR101933251B1 KR1020147021115A KR20147021115A KR101933251B1 KR 101933251 B1 KR101933251 B1 KR 101933251B1 KR 1020147021115 A KR1020147021115 A KR 1020147021115A KR 20147021115 A KR20147021115 A KR 20147021115A KR 101933251 B1 KR101933251 B1 KR 101933251B1
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South Korea
Prior art keywords
compound
group
reaction
solvent
methyl
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KR1020147021115A
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English (en)
Korean (ko)
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KR20140117455A (ko
Inventor
케이고 타나카
토모키 니시오카
Original Assignee
에자이 알앤드디 매니지먼트 가부시키가이샤
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Publication of KR20140117455A publication Critical patent/KR20140117455A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
KR1020147021115A 2012-01-31 2013-01-29 시탁센탄 유도체 Active KR101933251B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261592923P 2012-01-31 2012-01-31
US61/592,923 2012-01-31
PCT/JP2013/051857 WO2013115162A1 (ja) 2012-01-31 2013-01-29 シタキセンタン誘導体

Publications (2)

Publication Number Publication Date
KR20140117455A KR20140117455A (ko) 2014-10-07
KR101933251B1 true KR101933251B1 (ko) 2018-12-27

Family

ID=48870751

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147021115A Active KR101933251B1 (ko) 2012-01-31 2013-01-29 시탁센탄 유도체

Country Status (16)

Country Link
US (1) US8592470B2 (https=)
EP (1) EP2810943B1 (https=)
JP (1) JP6144631B2 (https=)
KR (1) KR101933251B1 (https=)
CN (1) CN104039781B (https=)
AR (1) AR089838A1 (https=)
AU (1) AU2013216122B9 (https=)
BR (1) BR112014016204B1 (https=)
CA (1) CA2861477C (https=)
ES (1) ES2651293T3 (https=)
IL (1) IL233171A (https=)
IN (1) IN2014CN04945A (https=)
MX (1) MX358151B (https=)
RU (1) RU2622386C2 (https=)
TW (1) TW201336496A (https=)
WO (1) WO2013115162A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3217189A1 (en) * 2021-06-22 2022-12-29 Alchemedicine, Inc. Compound, endothelin a receptor antagonist and pharmaceutical composition
JP2025183466A (ja) * 2022-11-11 2025-12-17 株式会社アークメディスン 化合物、エンドセリンａ受容体拮抗剤、アンジオテンシンｉｉタイプ１受容体拮抗剤及び医薬組成物
WO2024242594A1 (ru) * 2023-05-23 2024-11-28 Общество С Ограниченной Ответственностью "Ифар" Средство для лечения легочных гипертензий

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996031492A1 (en) 1995-04-04 1996-10-10 Texas Biotechnology Corporation Thienyl-, furyl-, pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
WO2008124803A1 (en) 2007-04-10 2008-10-16 Auspex Pharmaceuticals, Inc. Substituted deuterium enriched thiophenes for the treatment of hypertension

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4861366A (en) 1984-08-27 1989-08-29 E. I. Du Pont De Nemours And Company Herbicidal acetals and ketals
US4659369A (en) 1984-08-27 1987-04-21 E. I. Du Pont De Nemours And Company Herbicidal acetals and ketals
US4753672A (en) 1985-07-16 1988-06-28 E. I. Du Pont De Nemours And Company Herbicidal acetals and ketals
TW224462B (https=) * 1992-02-24 1994-06-01 Squibb & Sons Inc
MXPA02006461A (es) * 1999-12-31 2003-09-05 Texas Biotechnology Corp Sulfonamidas y derivados de las mismas que modulan la actividad de endotelina.
US20060205733A1 (en) * 2004-08-26 2006-09-14 Encysive Pharmaceuticals Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof
JP2009184924A (ja) 2006-05-31 2009-08-20 Eisai R & D Management Co Ltd 生物学的試薬用化合物

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996031492A1 (en) 1995-04-04 1996-10-10 Texas Biotechnology Corporation Thienyl-, furyl-, pyrrolyl- and biphenylsulfonamides and derivatives thereof that modulate the activity of endothelin
WO2008124803A1 (en) 2007-04-10 2008-10-16 Auspex Pharmaceuticals, Inc. Substituted deuterium enriched thiophenes for the treatment of hypertension

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Curr Drug Metab., 2005.06., Vol.6, No.3, pp 161-225

Also Published As

Publication number Publication date
CN104039781A (zh) 2014-09-10
RU2014126427A (ru) 2016-03-20
AR089838A1 (es) 2014-09-17
CN104039781B (zh) 2016-08-17
US20130197045A1 (en) 2013-08-01
ES2651293T3 (es) 2018-01-25
MX2014007619A (es) 2014-09-15
AU2013216122B2 (en) 2016-12-08
AU2013216122B9 (en) 2017-02-02
US8592470B2 (en) 2013-11-26
AU2013216122A1 (en) 2014-07-24
TW201336496A (zh) 2013-09-16
BR112014016204A8 (pt) 2017-07-04
BR112014016204A2 (pt) 2017-06-13
JP6144631B2 (ja) 2017-06-07
IL233171A (en) 2017-07-31
EP2810943A1 (en) 2014-12-10
CA2861477C (en) 2018-01-02
EP2810943A4 (en) 2015-09-02
CA2861477A1 (en) 2013-08-08
KR20140117455A (ko) 2014-10-07
WO2013115162A1 (ja) 2013-08-08
IN2014CN04945A (https=) 2015-09-18
JPWO2013115162A1 (ja) 2015-05-11
MX358151B (es) 2018-08-07
EP2810943B1 (en) 2017-09-27
IL233171A0 (en) 2014-07-31
BR112014016204B1 (pt) 2020-09-24
RU2622386C2 (ru) 2017-06-15

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