KR101910724B1 - Smo 억제제로서의 퀴놀린 유도체 - Google Patents

Smo 억제제로서의 퀴놀린 유도체 Download PDF

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KR101910724B1
KR101910724B1 KR1020167029472A KR20167029472A KR101910724B1 KR 101910724 B1 KR101910724 B1 KR 101910724B1 KR 1020167029472 A KR1020167029472 A KR 1020167029472A KR 20167029472 A KR20167029472 A KR 20167029472A KR 101910724 B1 KR101910724 B1 KR 101910724B1
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mmol
found
reaction mixture
alkyl
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KR20160127159A (ko
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하오 우
준 린
윤후이 리
창칭 웨이
슈후이 첸
차오펑 롱
샤오신 첸
쭈오웨이 리우
리주안 첸
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광동 쫑성 파마세티컬 컴패니, 리미티드
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    • C07—ORGANIC CHEMISTRY
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    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
KR1020167029472A 2014-03-24 2015-03-16 Smo 억제제로서의 퀴놀린 유도체 Active KR101910724B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201410110890.1 2014-03-24
CN201410110890.1A CN104945377A (zh) 2014-03-24 2014-03-24 作为smo抑制剂的喹啉衍生物
CN201510104908 2015-03-10
CN201510104908.1 2015-03-10
PCT/CN2015/074268 WO2015144001A1 (zh) 2014-03-24 2015-03-16 作为smo抑制剂的喹啉衍生物

Publications (2)

Publication Number Publication Date
KR20160127159A KR20160127159A (ko) 2016-11-02
KR101910724B1 true KR101910724B1 (ko) 2018-10-22

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KR1020167029472A Active KR101910724B1 (ko) 2014-03-24 2015-03-16 Smo 억제제로서의 퀴놀린 유도체

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US (1) US9938292B2 (enExample)
EP (1) EP3124482B1 (enExample)
JP (1) JP6377245B2 (enExample)
KR (1) KR101910724B1 (enExample)
CN (1) CN106458974B (enExample)
AU (1) AU2015237050B2 (enExample)
BR (1) BR112016021730B1 (enExample)
CA (1) CA2943100C (enExample)
CL (1) CL2016002394A1 (enExample)
EC (1) ECSP16083602A (enExample)
IL (1) IL247970A (enExample)
MX (1) MX370438B (enExample)
NZ (1) NZ724691A (enExample)
PE (1) PE20170331A1 (enExample)
RU (1) RU2695815C9 (enExample)
SG (1) SG11201607973XA (enExample)
TW (1) TW201623242A (enExample)
WO (1) WO2015144001A1 (enExample)

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