CN106458974A - 作为smo抑制剂的喹啉衍生物 - Google Patents

作为smo抑制剂的喹啉衍生物 Download PDF

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CN106458974A
CN106458974A CN201580015666.7A CN201580015666A CN106458974A CN 106458974 A CN106458974 A CN 106458974A CN 201580015666 A CN201580015666 A CN 201580015666A CN 106458974 A CN106458974 A CN 106458974A
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CN106458974B (zh
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吴颢
龙超峰
林军
陈小新
李云辉
刘卓伟
韦昌青
陈俐娟
陈曙辉
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Medshine Discovery Inc
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  • Chemical & Material Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

本发明公开了一类喹啉衍生物，作为hedgehog通路的抑制剂、特别是作为SMO抑制剂，本发明的化合物可用于治疗包括癌症在内的hedgehog通路有关病症。

Description

PCT国内申请，说明书已公开。

Claims (17)

  1. PCT国内申请，权利要求书已公开。
CN201580015666.7A 2014-03-24 2015-03-16 作为smo抑制剂的喹啉衍生物 Active CN106458974B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201410110890.1A CN104945377A (zh) 2014-03-24 2014-03-24 作为smo抑制剂的喹啉衍生物
CN2014101108901 2014-03-24
CN2015101049081 2015-03-10
CN201510104908 2015-03-10
PCT/CN2015/074268 WO2015144001A1 (zh) 2014-03-24 2015-03-16 作为smo抑制剂的喹啉衍生物

Publications (2)

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CN106458974A true CN106458974A (zh) 2017-02-22
CN106458974B CN106458974B (zh) 2019-07-16

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US (1) US9938292B2 (zh)
EP (1) EP3124482B1 (zh)
JP (1) JP6377245B2 (zh)
KR (1) KR101910724B1 (zh)
CN (1) CN106458974B (zh)
AU (1) AU2015237050B2 (zh)
BR (1) BR112016021730B1 (zh)
CA (1) CA2943100C (zh)
CL (1) CL2016002394A1 (zh)
EC (1) ECSP16083602A (zh)
IL (1) IL247970A (zh)
MX (1) MX370438B (zh)
NZ (1) NZ724691A (zh)
PE (1) PE20170331A1 (zh)
RU (1) RU2695815C9 (zh)
SG (1) SG11201607973XA (zh)
TW (1) TW201623242A (zh)
WO (1) WO2015144001A1 (zh)

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