KR101892330B1 - 항응혈 역전 물질들 - Google Patents

항응혈 역전 물질들 Download PDF

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KR101892330B1
KR101892330B1 KR1020147016304A KR20147016304A KR101892330B1 KR 101892330 B1 KR101892330 B1 KR 101892330B1 KR 1020147016304 A KR1020147016304 A KR 1020147016304A KR 20147016304 A KR20147016304 A KR 20147016304A KR 101892330 B1 KR101892330 B1 KR 101892330B1
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compound
pharmaceutically acceptable
acceptable salt
dap
anticoagulant
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KR20140107259A (ko
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솔로몬 에스 스테이너
브라이언 이 라울리츠트
사샤 에이치 바크루
에디트 마티오비츠
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페로스피어 파마슈티컬스 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020147016304A 2011-11-29 2012-11-29 항응혈 역전 물질들 Active KR101892330B1 (ko)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161564559P 2011-11-29 2011-11-29
US61/564,559 2011-11-29
US201261614292P 2012-03-22 2012-03-22
US61/614,292 2012-03-22
US201261641698P 2012-05-02 2012-05-02
US61/641,698 2012-05-02
US201261666291P 2012-06-29 2012-06-29
US61/666,291 2012-06-29
PCT/US2012/066938 WO2013082210A1 (en) 2011-11-29 2012-11-29 Anticoagulant reversal agents

Publications (2)

Publication Number Publication Date
KR20140107259A KR20140107259A (ko) 2014-09-04
KR101892330B1 true KR101892330B1 (ko) 2018-08-27

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KR1020147016304A Active KR101892330B1 (ko) 2011-11-29 2012-11-29 항응혈 역전 물질들

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US (5) US9522892B2 (enExample)
EP (1) EP2785700B1 (enExample)
JP (1) JP6134731B2 (enExample)
KR (1) KR101892330B1 (enExample)
CN (1) CN104080772B (enExample)
AP (1) AP2014007662A0 (enExample)
AR (1) AR089020A1 (enExample)
AU (1) AU2012345975B2 (enExample)
BR (1) BR112014012892B1 (enExample)
CA (1) CA2856540C (enExample)
CL (1) CL2014001399A1 (enExample)
CO (1) CO6990738A2 (enExample)
CR (1) CR20140310A (enExample)
CY (1) CY1117414T1 (enExample)
DK (1) DK2785700T3 (enExample)
EA (1) EA027603B1 (enExample)
EC (1) ECSP14006696A (enExample)
ES (1) ES2569674T3 (enExample)
HR (1) HRP20160513T1 (enExample)
HU (1) HUE027452T2 (enExample)
IL (1) IL232788B (enExample)
ME (1) ME02424B (enExample)
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PE (1) PE20141295A1 (enExample)
PH (1) PH12014501176B1 (enExample)
PL (1) PL2785700T3 (enExample)
PT (1) PT2785700E (enExample)
RS (1) RS54738B1 (enExample)
SG (1) SG11201402713WA (enExample)
SI (1) SI2785700T1 (enExample)
SM (1) SMT201600161B (enExample)
UA (1) UA116336C2 (enExample)
WO (1) WO2013082210A1 (enExample)
ZA (1) ZA201404793B (enExample)

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CA3077308A1 (en) 2017-09-27 2019-04-04 Incyte Corporation Salts of pyrrolotriazine derivatives useful as tam inhibitors
BR112019027735A8 (pt) * 2017-11-13 2020-10-13 Maximum Fidelity Surgical Simulations Llc reconstituição de circulação pós-morte, métodos e procedimentos especializados
EA202190153A1 (ru) 2018-06-29 2021-04-09 Инсайт Корпорейшн Составы ингибитора axl/mer
US11716989B2 (en) 2019-04-16 2023-08-08 Maximum Fidelity Surgical Simulations, LLC Cadaver preservation systems and methods
US11915610B2 (en) 2019-05-15 2024-02-27 Maximum Fidelity Surgical Simulations, LLC Cadaverous heart model
CN112010930B (zh) * 2019-05-28 2022-08-02 首都医科大学 Rgd修饰的五环哌嗪二酮及其制备和应用
AU2021230385A1 (en) 2020-03-06 2022-09-22 Incyte Corporation Combination therapy comprising AXL/MER and PD-1/PD-L1 inhibitors
WO2024199096A1 (zh) * 2023-03-24 2024-10-03 陕西麦科奥特科技有限公司 一种抗凝逆转剂及其制备方法和应用
CN117624137A (zh) * 2023-12-04 2024-03-01 中国药科大学 三嗪骨架小分子肝素逆转剂及其制备方法与用途
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Also Published As

Publication number Publication date
US9522892B2 (en) 2016-12-20
ME02424B (me) 2016-09-20
CO6990738A2 (es) 2014-07-10
US20130137702A1 (en) 2013-05-30
SI2785700T1 (sl) 2016-09-30
JP6134731B2 (ja) 2017-05-24
PL2785700T3 (pl) 2016-09-30
MX349514B (es) 2017-08-02
US20210169874A1 (en) 2021-06-10
CA2856540A1 (en) 2013-06-06
EP2785700A1 (en) 2014-10-08
ES2569674T3 (es) 2016-05-12
US20170056396A1 (en) 2017-03-02
CY1117414T1 (el) 2017-04-26
BR112014012892A8 (pt) 2021-06-08
DK2785700T3 (en) 2016-06-13
CA2856540C (en) 2018-04-03
AP2014007662A0 (en) 2014-05-31
SMT201600161B (it) 2016-07-01
BR112014012892A2 (pt) 2017-06-13
HUE027452T2 (en) 2016-09-28
JP2014534270A (ja) 2014-12-18
SG11201402713WA (en) 2014-06-27
EP2785700B1 (en) 2016-03-09
ECSP14006696A (es) 2015-06-30
BR112014012892B1 (pt) 2022-12-20
PT2785700E (pt) 2016-06-02
IL232788B (en) 2018-05-31
NZ625337A (en) 2016-11-25
CL2014001399A1 (es) 2014-11-03
MX2014006349A (es) 2014-09-04
AU2012345975B2 (en) 2016-12-15
CN104080772B (zh) 2016-10-05
US20240366592A1 (en) 2024-11-07
HK1202858A1 (en) 2015-10-09
US9877961B2 (en) 2018-01-30
AR089020A1 (es) 2014-07-23
HRP20160513T1 (hr) 2016-07-15
IL232788A0 (en) 2014-08-03
ZA201404793B (en) 2015-04-29
CR20140310A (es) 2014-08-20
AU2012345975A1 (en) 2014-05-29
CN104080772A (zh) 2014-10-01
KR20140107259A (ko) 2014-09-04
WO2013082210A1 (en) 2013-06-06
UA116336C2 (uk) 2018-03-12
US20180207152A1 (en) 2018-07-26
PH12014501176A1 (en) 2014-09-01
PE20141295A1 (es) 2014-10-01
EA201490823A1 (ru) 2015-01-30
RS54738B1 (sr) 2016-10-31
EA027603B1 (ru) 2017-08-31
PH12014501176B1 (en) 2014-09-01

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