CN104080772B - 抗凝血逆转剂 - Google Patents

抗凝血逆转剂 Download PDF

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Publication number
CN104080772B
CN104080772B CN201280060950.2A CN201280060950A CN104080772B CN 104080772 B CN104080772 B CN 104080772B CN 201280060950 A CN201280060950 A CN 201280060950A CN 104080772 B CN104080772 B CN 104080772B
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China
Prior art keywords
dap
compound
anticoagulant
pharmaceutically acceptable
factor
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CN201280060950.2A
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English (en)
Chinese (zh)
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CN104080772A (zh
Inventor
S·S·斯泰纳尔
B·E·劳利希特
S·H·贝克鲁
E·马希奥维茨
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kewei Medical Holding Co., Ltd.
Sila Patra Holding Limited
Xirapathe Holding Co., Ltd.
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Perosphere Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47430065&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN104080772(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
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Publication of CN104080772A publication Critical patent/CN104080772A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201280060950.2A 2011-11-29 2012-11-29 抗凝血逆转剂 Active CN104080772B (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201161564559P 2011-11-29 2011-11-29
US61/564,559 2011-11-29
US201261614292P 2012-03-22 2012-03-22
US61/614,292 2012-03-22
US201261641698P 2012-05-02 2012-05-02
US61/641,698 2012-05-02
US201261666291P 2012-06-29 2012-06-29
US61/666,291 2012-06-29
PCT/US2012/066938 WO2013082210A1 (en) 2011-11-29 2012-11-29 Anticoagulant reversal agents

Publications (2)

Publication Number Publication Date
CN104080772A CN104080772A (zh) 2014-10-01
CN104080772B true CN104080772B (zh) 2016-10-05

Family

ID=47430065

Family Applications (1)

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CN201280060950.2A Active CN104080772B (zh) 2011-11-29 2012-11-29 抗凝血逆转剂

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US (5) US9522892B2 (enExample)
EP (1) EP2785700B1 (enExample)
JP (1) JP6134731B2 (enExample)
KR (1) KR101892330B1 (enExample)
CN (1) CN104080772B (enExample)
AP (1) AP2014007662A0 (enExample)
AR (1) AR089020A1 (enExample)
AU (1) AU2012345975B2 (enExample)
BR (1) BR112014012892B1 (enExample)
CA (1) CA2856540C (enExample)
CL (1) CL2014001399A1 (enExample)
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SG (1) SG11201402713WA (enExample)
SI (1) SI2785700T1 (enExample)
SM (1) SMT201600161B (enExample)
UA (1) UA116336C2 (enExample)
WO (1) WO2013082210A1 (enExample)
ZA (1) ZA201404793B (enExample)

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US9999690B2 (en) 2013-11-08 2018-06-19 Perosphere Pharmaceuticals Inc. Labeled compounds and methods of imaging, diagnosing cartilage disorders and diseases, and monitoring cartilage health using labeled and unlabeled compounds
JP7034084B2 (ja) 2016-03-28 2022-03-11 インサイト・コーポレイション Ｔａｍ阻害剤としてのピロロトリアジン化合物
CA3077308A1 (en) 2017-09-27 2019-04-04 Incyte Corporation Salts of pyrrolotriazine derivatives useful as tam inhibitors
BR112019027735A8 (pt) * 2017-11-13 2020-10-13 Maximum Fidelity Surgical Simulations Llc reconstituição de circulação pós-morte, métodos e procedimentos especializados
EA202190153A1 (ru) 2018-06-29 2021-04-09 Инсайт Корпорейшн Составы ингибитора axl/mer
US11716989B2 (en) 2019-04-16 2023-08-08 Maximum Fidelity Surgical Simulations, LLC Cadaver preservation systems and methods
US11915610B2 (en) 2019-05-15 2024-02-27 Maximum Fidelity Surgical Simulations, LLC Cadaverous heart model
CN112010930B (zh) * 2019-05-28 2022-08-02 首都医科大学 Rgd修饰的五环哌嗪二酮及其制备和应用
AU2021230385A1 (en) 2020-03-06 2022-09-22 Incyte Corporation Combination therapy comprising AXL/MER and PD-1/PD-L1 inhibitors
WO2024199096A1 (zh) * 2023-03-24 2024-10-03 陕西麦科奥特科技有限公司 一种抗凝逆转剂及其制备方法和应用
CN117624137A (zh) * 2023-12-04 2024-03-01 中国药科大学 三嗪骨架小分子肝素逆转剂及其制备方法与用途
EP4667582A1 (en) * 2024-06-20 2025-12-24 Instrumentation Laboratory Company Factor xa reagent

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WO1996010022A1 (en) * 1994-09-26 1996-04-04 Zeneca Limited Aminoheterocyclic derivatives as antithrombotic or anticoagulant agents
WO1997012904A1 (en) * 1995-10-02 1997-04-10 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
CN1314895A (zh) * 1998-07-17 2001-09-26 L·拉峰试验公司 取代的哌嗪酮及其治疗应用
US20020022614A1 (en) * 2000-06-29 2002-02-21 Pinto Donald J.P. Thrombin or factor Xa inhibitors
US6403583B1 (en) * 1998-12-23 2002-06-11 Patrick Y. S. Lam Thrombin or factor Xa inhibitors
CN1905883A (zh) * 2004-01-08 2007-01-31 阿斯利康(瑞典)有限公司 6－{4－[4－(1h－吲哚－2－磺酰基)－哌嗪－1－羰基－苯基]}哒嗪－3－酮的新衍生物

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WO1997012904A1 (en) * 1995-10-02 1997-04-10 Hoechst Marion Roussel, Inc. Polyfluoroalkyl tryptophan tripeptide thrombin inhibitors
CN1198748A (zh) * 1995-10-02 1998-11-11 赫彻斯特马里恩鲁斯公司 多氟烷基色氨酸三肽凝血酶抑制剂
CN1314895A (zh) * 1998-07-17 2001-09-26 L·拉峰试验公司 取代的哌嗪酮及其治疗应用
US6403583B1 (en) * 1998-12-23 2002-06-11 Patrick Y. S. Lam Thrombin or factor Xa inhibitors
US20020022614A1 (en) * 2000-06-29 2002-02-21 Pinto Donald J.P. Thrombin or factor Xa inhibitors
CN1905883A (zh) * 2004-01-08 2007-01-31 阿斯利康(瑞典)有限公司 6－{4－[4－(1h－吲哚－2－磺酰基)－哌嗪－1－羰基－苯基]}哒嗪－3－酮的新衍生物

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US9522892B2 (en) 2016-12-20
ME02424B (me) 2016-09-20
CO6990738A2 (es) 2014-07-10
US20130137702A1 (en) 2013-05-30
SI2785700T1 (sl) 2016-09-30
JP6134731B2 (ja) 2017-05-24
PL2785700T3 (pl) 2016-09-30
MX349514B (es) 2017-08-02
US20210169874A1 (en) 2021-06-10
CA2856540A1 (en) 2013-06-06
EP2785700A1 (en) 2014-10-08
ES2569674T3 (es) 2016-05-12
US20170056396A1 (en) 2017-03-02
CY1117414T1 (el) 2017-04-26
BR112014012892A8 (pt) 2021-06-08
DK2785700T3 (en) 2016-06-13
CA2856540C (en) 2018-04-03
AP2014007662A0 (en) 2014-05-31
SMT201600161B (it) 2016-07-01
BR112014012892A2 (pt) 2017-06-13
HUE027452T2 (en) 2016-09-28
JP2014534270A (ja) 2014-12-18
SG11201402713WA (en) 2014-06-27
EP2785700B1 (en) 2016-03-09
ECSP14006696A (es) 2015-06-30
BR112014012892B1 (pt) 2022-12-20
PT2785700E (pt) 2016-06-02
IL232788B (en) 2018-05-31
NZ625337A (en) 2016-11-25
CL2014001399A1 (es) 2014-11-03
MX2014006349A (es) 2014-09-04
AU2012345975B2 (en) 2016-12-15
US20240366592A1 (en) 2024-11-07
KR101892330B1 (ko) 2018-08-27
HK1202858A1 (en) 2015-10-09
US9877961B2 (en) 2018-01-30
AR089020A1 (es) 2014-07-23
HRP20160513T1 (hr) 2016-07-15
IL232788A0 (en) 2014-08-03
ZA201404793B (en) 2015-04-29
CR20140310A (es) 2014-08-20
AU2012345975A1 (en) 2014-05-29
CN104080772A (zh) 2014-10-01
KR20140107259A (ko) 2014-09-04
WO2013082210A1 (en) 2013-06-06
UA116336C2 (uk) 2018-03-12
US20180207152A1 (en) 2018-07-26
PH12014501176A1 (en) 2014-09-01
PE20141295A1 (es) 2014-10-01
EA201490823A1 (ru) 2015-01-30
RS54738B1 (sr) 2016-10-31
EA027603B1 (ru) 2017-08-31
PH12014501176B1 (en) 2014-09-01

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