KR101861025B1 - 영상화 제제로서의 ｎ-알콕시아미드 접합체 - Google Patents
영상화 제제로서의 ｎ-알콕시아미드 접합체 Download PDFInfo
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- KR101861025B1 KR101861025B1 KR1020167003565A KR20167003565A KR101861025B1 KR 101861025 B1 KR101861025 B1 KR 101861025B1 KR 1020167003565 A KR1020167003565 A KR 1020167003565A KR 20167003565 A KR20167003565 A KR 20167003565A KR 101861025 B1 KR101861025 B1 KR 101861025B1
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- South Korea
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- amino
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- substituted
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- 0 *CC(NO*)=O Chemical compound *CC(NO*)=O 0.000 description 6
- AJXIALOTHAXHCD-HXUWFJFHSA-N CC(C)C[C@H](C(NOCCCCCCNC(CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O)=O)=O)N Chemical compound CC(C)C[C@H](C(NOCCCCCCNC(CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O)=O)=O)N AJXIALOTHAXHCD-HXUWFJFHSA-N 0.000 description 1
- KYHAVQNZEKRLJP-HSZRJFAPSA-N CC(C)C[C@H](C(NOCCc1ccc(CNC(CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O)=O)cc1)=O)N Chemical compound CC(C)C[C@H](C(NOCCc1ccc(CNC(CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O)=O)cc1)=O)N KYHAVQNZEKRLJP-HSZRJFAPSA-N 0.000 description 1
- XLSLYFBGVSVDLG-RUZDIDTESA-N CC(C)C[C@H](C(NOCc1ccc(CNC(CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)=O)cc1)=O)N Chemical compound CC(C)C[C@H](C(NOCc1ccc(CNC(CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)=O)cc1)=O)N XLSLYFBGVSVDLG-RUZDIDTESA-N 0.000 description 1
- CEVGJZLSMBFPQU-SSEXGKCCSA-N CONC([C@@H](CCc1ccccc1)NCc1ccc(CNC(CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)=O)cc1)=O Chemical compound CONC([C@@H](CCc1ccccc1)NCc1ccc(CNC(CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)=O)cc1)=O CEVGJZLSMBFPQU-SSEXGKCCSA-N 0.000 description 1
- LMRMEPOQUGSMAE-SANMLTNESA-N N[C@@H](CCc1ccccc1)C(NOCc1ccc(CNC(CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O)=O)cc1)=O Chemical compound N[C@@H](CCc1ccccc1)C(NOCc1ccc(CNC(CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O)=O)cc1)=O LMRMEPOQUGSMAE-SANMLTNESA-N 0.000 description 1
- XAXZMAHWKRPIKF-MRXNPFEDSA-N N[C@H](CCc1ccccc1)C(NOCc1ccccc1)=O Chemical compound N[C@H](CCc1ccccc1)C(NOCc1ccccc1)=O XAXZMAHWKRPIKF-MRXNPFEDSA-N 0.000 description 1
- VSQDUXWLPVJNHT-MUUNZHRXSA-N N[C@H](Cc1c[nH]c2c1cccc2)C(NOCCCc1ccc(CNC(CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O)=O)cc1)=O Chemical compound N[C@H](Cc1c[nH]c2c1cccc2)C(NOCCCc1ccc(CNC(CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O)=O)cc1)=O VSQDUXWLPVJNHT-MUUNZHRXSA-N 0.000 description 1
- KLKCQNGXDNPSAF-GDLZYMKVSA-N N[C@H](Cc1cc(cccc2)c2[nH]1)C(NOCc1ccc(CNC(CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)=O)cc1)=O Chemical compound N[C@H](Cc1cc(cccc2)c2[nH]1)C(NOCc1ccc(CNC(CN2CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC2)=O)cc1)=O KLKCQNGXDNPSAF-GDLZYMKVSA-N 0.000 description 1
- ZMFUIUPIEJTHHJ-MUUNZHRXSA-N N[C@H](Cc1cc2ccccc2cc1)C(NOc1ccc(CNC(CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O)=O)cc1)=O Chemical compound N[C@H](Cc1cc2ccccc2cc1)C(NOc1ccc(CNC(CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O)=O)cc1)=O ZMFUIUPIEJTHHJ-MUUNZHRXSA-N 0.000 description 1
- FUEVAWCBLPGYPU-XMMPIXPASA-N N[C@H](Cc1cccnc1)C(NOCc1ccc(CNC(CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O)=O)cc1)=O Chemical compound N[C@H](Cc1cccnc1)C(NOCc1ccc(CNC(CN(CCN(CC(O)=O)CC(O)=O)CCN(CC(O)=O)CC(O)=O)=O)cc1)=O FUEVAWCBLPGYPU-XMMPIXPASA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/103—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being acyclic, e.g. DTPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
- A61K49/108—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA the metal complex being Gd-DOTA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
- C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C53/00—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen
- C07C53/15—Saturated compounds having only one carboxyl group bound to an acyclic carbon atom or hydrogen containing halogen
- C07C53/16—Halogenated acetic acids
- C07C53/18—Halogenated acetic acids containing fluorine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/56—Amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1962708P | 2008-01-08 | 2008-01-08 | |
| US61/019,627 | 2008-01-08 | ||
| PCT/US2009/000096 WO2009089022A1 (en) | 2008-01-08 | 2009-01-08 | N-alkoxyamide conjugates as imaging agents |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107017602A Division KR101595324B1 (ko) | 2008-01-08 | 2009-01-08 | 영상화 제제로서의 ｎ-알콕시아미드 접합체 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20160022394A KR20160022394A (ko) | 2016-02-29 |
| KR101861025B1 true KR101861025B1 (ko) | 2018-05-24 |
Family
ID=40456854
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167003565A Expired - Fee Related KR101861025B1 (ko) | 2008-01-08 | 2009-01-08 | 영상화 제제로서의 ｎ-알콕시아미드 접합체 |
| KR1020107017602A Expired - Fee Related KR101595324B1 (ko) | 2008-01-08 | 2009-01-08 | 영상화 제제로서의 ｎ-알콕시아미드 접합체 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107017602A Expired - Fee Related KR101595324B1 (ko) | 2008-01-08 | 2009-01-08 | 영상화 제제로서의 ｎ-알콕시아미드 접합체 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US8361438B2 (enExample) |
| EP (1) | EP2240206B1 (enExample) |
| JP (2) | JP5730581B2 (enExample) |
| KR (2) | KR101861025B1 (enExample) |
| CN (2) | CN103965128B (enExample) |
| AU (2) | AU2009204427B2 (enExample) |
| BR (1) | BRPI0907612A2 (enExample) |
| CA (1) | CA2711426C (enExample) |
| ES (1) | ES2629340T3 (enExample) |
| IL (1) | IL206846A (enExample) |
| MX (1) | MX2010007501A (enExample) |
| TW (1) | TWI465251B (enExample) |
| WO (1) | WO2009089022A1 (enExample) |
| ZA (1) | ZA201005130B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3209821B2 (ja) | 1993-03-31 | 2001-09-17 | 日立ビアメカニクス株式会社 | 消耗電極式ガスシールドアーク溶接の出力制御方法およびその溶接装置 |
| KR101861025B1 (ko) | 2008-01-08 | 2018-05-24 | 랜티우스 메디컬 이메징, 인크. | 영상화 제제로서의 ｎ-알콕시아미드 접합체 |
| US8877157B2 (en) | 2009-07-08 | 2014-11-04 | Lantheus Medical Imaging, Inc. | N-alkoxyamide conjugates as imaging agents |
| DK3929196T3 (da) | 2013-09-24 | 2023-09-25 | Fujifilm Corp | Farmaceutisk sammensætning af en nitrogenholdig forbindelse eller salt deraf, eller metalkompleks deraf |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070014721A1 (en) * | 2005-06-30 | 2007-01-18 | Harris Thomas D | Hydrazide conjugates as imaging agents |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPS5122885A (en) * | 1974-08-13 | 1976-02-23 | Sagami Chem Res | Ashiru ll aminosan oo chikanhidorokisamidono seizohoho |
| JPS5910322B2 (ja) | 1975-07-30 | 1984-03-08 | 三井東圧化学株式会社 | 殺草剤 |
| HU175152B (hu) * | 1976-12-30 | 1980-05-28 | Richter Gedeon Vegyeszet | Sposob poluchenija peptidov s gastrin-aktivnost'ju, soderzhahhikh amino-oksi-kisloty |
| US4859777A (en) | 1981-07-01 | 1989-08-22 | Eastman Kodak Company | Terpyridine chelating agents |
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| AU6621586A (en) | 1985-11-18 | 1987-06-02 | University Of Texas System, The | Polychelating agents for image and spectral enhancement (and spectral shift) |
| DE3768523D1 (de) | 1986-02-18 | 1991-04-18 | Squibb & Sons Inc | ((2,2,2-trichloroethoxy)methoxy)amin. |
| US5064956A (en) | 1987-06-24 | 1991-11-12 | The Dow Chemical Company | Process for preparing mono-n-alkylated polyazamacrocycles |
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| IT1224627B (it) | 1988-04-12 | 1990-10-04 | Guidotti & C Spa Labor | Ammidi di acidi ciclometilen_1,2_dicarbossilici adattivita' terapeutica, procedimenti per la loro preparazione e composizioni farmaceutiche che le contengono. |
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| JPH0491070A (ja) * | 1990-08-06 | 1992-03-24 | Kanebo Ltd | カリックスアレーン誘導体 |
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| US20070014721A1 (en) * | 2005-06-30 | 2007-01-18 | Harris Thomas D | Hydrazide conjugates as imaging agents |
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