KR101851774B1 - 2-피페라진-1-일-4h-1,3-벤조티아진-4-온 유도체 및 포유동물 감염을 치료하기 위한 이의 용도 - Google Patents

2-피페라진-1-일-4h-1,3-벤조티아진-4-온 유도체 및 포유동물 감염을 치료하기 위한 이의 용도 Download PDF

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KR101851774B1
KR101851774B1 KR1020177034344A KR20177034344A KR101851774B1 KR 101851774 B1 KR101851774 B1 KR 101851774B1 KR 1020177034344 A KR1020177034344 A KR 1020177034344A KR 20177034344 A KR20177034344 A KR 20177034344A KR 101851774 B1 KR101851774 B1 KR 101851774B1
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compound
benzothiazin
broad
piperazin
nitro
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KR20170137211A (ko
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바딤 마카로브
스튜어트 콜
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에꼴 뽈리떼끄닉 뻬데랄 드 로잔느 (으뻬에프엘)
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/08—Antibacterial agents for leprosy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
    • C07D279/08—1,3-Thiazines; Hydrogenated 1,3-thiazines condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020177034344A 2010-11-19 2011-11-21 2-피페라진-1-일-4h-1,3-벤조티아진-4-온 유도체 및 포유동물 감염을 치료하기 위한 이의 용도 Expired - Fee Related KR101851774B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
RUPCT/RU2010/000688 2010-11-19
RU2010000688 2010-11-19
PCT/IB2011/055209 WO2012066518A1 (en) 2010-11-19 2011-11-21 2-piperazin-1-yl-4h-1,3-benzothiazin-4-one derivatives and their use for the treatment of mammalian infections

Related Parent Applications (1)

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KR1020137015671A Division KR101871970B1 (ko) 2010-11-19 2011-11-21 2-피페라진-1-일-4h-1,3-벤조티아진-4-온 유도체 및 포유동물 감염을 치료하기 위한 이의 용도

Publications (2)

Publication Number Publication Date
KR20170137211A KR20170137211A (ko) 2017-12-12
KR101851774B1 true KR101851774B1 (ko) 2018-04-25

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KR1020137015671A Expired - Fee Related KR101871970B1 (ko) 2010-11-19 2011-11-21 2-피페라진-1-일-4h-1,3-벤조티아진-4-온 유도체 및 포유동물 감염을 치료하기 위한 이의 용도
KR1020177034344A Expired - Fee Related KR101851774B1 (ko) 2010-11-19 2011-11-21 2-피페라진-1-일-4h-1,3-벤조티아진-4-온 유도체 및 포유동물 감염을 치료하기 위한 이의 용도

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KR1020137015671A Expired - Fee Related KR101871970B1 (ko) 2010-11-19 2011-11-21 2-피페라진-1-일-4h-1,3-벤조티아진-4-온 유도체 및 포유동물 감염을 치료하기 위한 이의 용도

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Country Link
US (1) US8796264B2 (enExample)
EP (1) EP2640712B1 (enExample)
JP (1) JP6061346B2 (enExample)
KR (2) KR101871970B1 (enExample)
CN (2) CN107011287A (enExample)
AU (1) AU2011330742B2 (enExample)
BR (1) BR112013012280B1 (enExample)
CA (1) CA2817931C (enExample)
EA (1) EA023879B1 (enExample)
ES (1) ES2690728T3 (enExample)
GE (1) GEP201606545B (enExample)
HU (1) HUE040152T2 (enExample)
IL (1) IL226289A (enExample)
LT (1) LT2640712T (enExample)
PL (1) PL2640712T3 (enExample)
TR (1) TR201815010T4 (enExample)
UA (1) UA109557C2 (enExample)
WO (1) WO2012066518A1 (enExample)
ZA (1) ZA201303829B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103508980B (zh) * 2012-06-14 2016-07-06 四川大学 苯并噻嗪-4-酮衍生物及其制备方法和用途
CN104211708B (zh) * 2013-05-29 2018-08-24 中国医学科学院药物研究所 苯并噁嗪酮衍生物及其作为抗菌剂的应用
BR112016017112A2 (pt) 2014-01-24 2017-08-08 Ai Therapeutics Inc Composições de apilimod e métodos de uso das mesmas
DE102014012546A1 (de) * 2014-09-26 2016-03-31 Martin-Luther-Universität Halle-Wittenberg Antimykobakteriell wirksame Substanzen, Verfahren zu ihrer Herstellung und deren Verwendung
JP6705828B2 (ja) 2014-11-07 2020-06-03 エイアイ・セラピューティクス・インコーポレーテッド 腎癌の処置に使用するためのアピリモド
EP3072889A1 (en) * 2015-03-23 2016-09-28 Ecole Polytechnique Federale De Lausanne (Epfl) 2-Homopiperazine-1-yl-4H-1,3-benzothiazine-4-one derivatives and process for the preparation of 2-(homo)piperazine 1,3-benzothiazine-4-one hydrochlorides
CN110312725B (zh) * 2016-09-22 2022-03-11 莱比尼兹自然研究和感染生物学研究所协会汉斯诺尔研究所(Hki) 新型抗菌化合物，其在哺乳动物感染治疗中的应用及新的代谢机制
CN108929329B (zh) * 2017-05-24 2020-12-11 中国医学科学院药物研究所 2-氮杂环-5-三氟甲基-8-硝基苯并(硫代)吡喃-4-酮类化合物
RU2751163C9 (ru) * 2020-04-06 2021-10-20 Общество С Ограниченной Ответственностью "Ниармедик Плюс" Фармацевтическая композиция на основе макозинона для лечения туберкулеза, включая его формы с множественной и широкой лекарственной устойчивостью.
CN111303075A (zh) * 2020-04-08 2020-06-19 苏州大学 苯并噻嗪酮衍生物及其制备方法与作为抗结核药物的应用
KR102409518B1 (ko) 2020-06-22 2022-06-17 조은바이오주식회사 대량의 하천수를 저장하여 인공양어장을 조성함과 동시에 미세먼지 발생량을 줄여주도록 유도시켜서 대기중의 오염된 공기를 개선시킴과 동시에 비중이 무거운 깨끗한 물 분자를 우선적으로 배출하여 오염된 하천수를 깨끗한 하천수로 정화시키도록 구성되는 자연친화적인 친환경 저수시스템을 이용하여 대량의 전기를 생산하면서 저수지, 호수,댐, 석호,하천,강의 수질을 자연정화시키는 자연친화적인 수질정화 친환경공법

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007134625A1 (en) 2006-05-24 2007-11-29 Leibniz Institute For Natural Product Research And Infection Biology E.V. Hans-Knöll-Institut (Hki) New benzothiazinone derivatives and their use as antibacterial agents
WO2009010163A1 (en) 2007-07-16 2009-01-22 Leibniz-Institut Für Naturstoff-Forschung Und Infektionsbiologie E.V. Hans-Knöll-Institut New antimicrobial compounds, their synthesis and their use for treatment of mammalian infections

Family Cites Families (4)

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Publication number Priority date Publication date Assignee Title
US3470168A (en) * 1967-03-31 1969-09-30 American Home Prod 2-substituted-4h-1,3-benzothiazin-4-one derivatives
US3522247A (en) 1967-11-07 1970-07-28 Pfizer & Co C 2-amino-6,7-disubstituted-4h-1,3-benzothiazine-4-ones as bronchodilators
EP2380886A1 (en) * 2010-04-23 2011-10-26 Vadim A. Makarov Process for the preparation of 2-aminosubstituted 1,3-benzothiazine-4-ones
CN102367239B (zh) * 2011-07-20 2015-10-28 沈阳药科大学 2-芳基-2,3-二氢-4h-1,3-苯并噻嗪-4-酮衍生物及其用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007134625A1 (en) 2006-05-24 2007-11-29 Leibniz Institute For Natural Product Research And Infection Biology E.V. Hans-Knöll-Institut (Hki) New benzothiazinone derivatives and their use as antibacterial agents
WO2009010163A1 (en) 2007-07-16 2009-01-22 Leibniz-Institut Für Naturstoff-Forschung Und Infektionsbiologie E.V. Hans-Knöll-Institut New antimicrobial compounds, their synthesis and their use for treatment of mammalian infections

Also Published As

Publication number Publication date
KR20140012956A (ko) 2014-02-04
US20130245007A1 (en) 2013-09-19
CN107011287A (zh) 2017-08-04
UA109557C2 (uk) 2015-09-10
CA2817931C (en) 2017-10-31
IL226289A (en) 2016-07-31
ZA201303829B (en) 2014-01-29
KR101871970B1 (ko) 2018-08-02
BR112013012280A2 (pt) 2020-09-01
BR112013012280B1 (pt) 2022-01-04
JP6061346B2 (ja) 2017-01-18
LT2640712T (lt) 2018-11-12
WO2012066518A1 (en) 2012-05-24
EA201390639A1 (ru) 2013-09-30
EA023879B1 (ru) 2016-07-29
JP2013542980A (ja) 2013-11-28
US8796264B2 (en) 2014-08-05
AU2011330742A1 (en) 2013-06-27
GEP201606545B (en) 2016-09-26
ES2690728T3 (es) 2018-11-22
EP2640712B1 (en) 2018-07-11
CA2817931A1 (en) 2012-05-24
AU2011330742B2 (en) 2016-10-13
HUE040152T2 (hu) 2019-02-28
TR201815010T4 (tr) 2018-11-21
CN103221399A (zh) 2013-07-24
EP2640712A1 (en) 2013-09-25
KR20170137211A (ko) 2017-12-12
PL2640712T3 (pl) 2019-03-29
IL226289A0 (en) 2013-07-31

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