KR101837488B1 - 광학적으로 순수한 벤질-4-클로로페닐-c-글루코사이드 유도체 - Google Patents

광학적으로 순수한 벤질-4-클로로페닐-c-글루코사이드 유도체 Download PDF

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KR101837488B1
KR101837488B1 KR1020140037632A KR20140037632A KR101837488B1 KR 101837488 B1 KR101837488 B1 KR 101837488B1 KR 1020140037632 A KR1020140037632 A KR 1020140037632A KR 20140037632 A KR20140037632 A KR 20140037632A KR 101837488 B1 KR101837488 B1 KR 101837488B1
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formula
compound
rti
diabetes
chlorophenyl
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KR20150081220A (ko
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프랭크 우
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수안주 파마 코포레이션 리미티드
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Assigned to 베이징 훼이쯔헝 바이오테크놀로지 리미티드 컴퍼니, 지 린 훼이 셩 바이오-파마수티컬 리미티드 컴퍼니 reassignment 베이징 훼이쯔헝 바이오테크놀로지 리미티드 컴퍼니 권리의 전부이전등록 Assignors: 수안주 파마 코포레이션 리미티드
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020140037632A 2014-01-03 2014-03-31 광학적으로 순수한 벤질-4-클로로페닐-c-글루코사이드 유도체 Active KR101837488B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201410004395.2A CN104761522B (zh) 2014-01-03 2014-01-03 光学纯的苄基‑4‑氯苯基的c‑糖苷衍生物
CN201410004395.2 2014-01-03

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KR20150081220A KR20150081220A (ko) 2015-07-13
KR101837488B1 true KR101837488B1 (ko) 2018-03-12

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JP (1) JP6008892B2 (https=)
KR (1) KR101837488B1 (https=)
CN (2) CN106349201B (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105153137A (zh) * 2015-09-17 2015-12-16 上海应用技术学院 一种艾格列净的制备方法
DK3404033T3 (da) * 2016-01-04 2020-11-02 Jeil Pharmaceutical Co Ltd C-glukosidderivat med kondenseret phenylring eller farmaceutisk acceptabelt salt deraf, fremgangsmåde til fremstilling deraf og farmaceutisk sammensætning indeholdende dette
KR102226465B1 (ko) * 2016-05-28 2021-03-11 하이난 수안주 파마 코포레이션 리미티드 나트륨-글루코스 공수송체 2에 대한 억제제의 결정형
CN108285439B (zh) * 2017-01-09 2023-05-02 江苏天士力帝益药业有限公司 一种碳糖苷类钠葡萄糖转运蛋白体2抑制剂
CN111465598B (zh) * 2018-03-30 2023-04-21 山东丹红制药有限公司 作为SGLTs抑制剂的葡糖苷类衍生物及其应用
CN110551088B (zh) * 2018-06-01 2022-10-21 北京惠之衡生物科技有限公司 氘修饰的苄基-4-氯苯基的c-糖苷衍生物
CN112047915B (zh) * 2019-06-05 2023-02-17 北京惠之衡生物科技有限公司 C-糖苷类衍生物新的制备工艺
CN110683998A (zh) * 2019-11-20 2020-01-14 杭州华东医药集团浙江华义制药有限公司 一种恩格列净中间体的制备方法
CN113248464B (zh) * 2021-05-31 2021-10-26 北京惠之衡生物科技有限公司 一种c-糖苷类衍生物的合成方法
CN113045525B (zh) * 2021-05-31 2021-09-17 北京惠之衡生物科技有限公司 一种c-糖苷类衍生物的制备方法及其制剂
CN113336733B (zh) * 2021-05-31 2022-02-18 北京惠之衡生物科技有限公司 一种sglt-2抑制剂的l-脯氨酸共结晶体的制备方法
CN113248554A (zh) * 2021-06-25 2021-08-13 北京惠之衡生物科技有限公司 一种c-糖苷类衍生物的杂质的合成方法
CN113372315B (zh) * 2021-08-12 2021-10-29 北京惠之衡生物科技有限公司 一种c-糖苷类衍生物的杂质的合成方法
CN115073271A (zh) * 2022-06-08 2022-09-20 苏州敬业医药化工有限公司 一种4’-(5-溴-2-氯苄基)苯酚的制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013000275A1 (zh) * 2011-06-25 2013-01-03 山东轩竹医药科技有限公司 C-糖苷衍生物

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US6515117B2 (en) * 1999-10-12 2003-02-04 Bristol-Myers Squibb Company C-aryl glucoside SGLT2 inhibitors and method
JP2006516257A (ja) * 2003-01-03 2006-06-29 ブリストル−マイヤーズ　スクイブ　カンパニー Ｃ−アリールグルコシドｓｇｌｔ２阻害剤の製造法
CN103030617A (zh) * 2004-03-16 2013-04-10 贝林格尔.英格海姆国际有限公司 吡喃葡萄糖基取代的苯基衍生物、含该化合物的药物、其用途及其制造方法
US7772191B2 (en) * 2005-05-10 2010-08-10 Boehringer Ingelheim International Gmbh Processes for preparing of glucopyranosyl-substituted benzyl-benzene derivatives and intermediates therein
EP2548871B1 (en) * 2010-03-18 2017-07-19 Daiichi Sankyo Company, Limited Cycloalkyl-substituted imidazole derivative
WO2012025857A1 (en) * 2010-08-23 2012-03-01 Hetero Research Foundation Cycloalkyl methoxybenzyl phenyl pyran derivatives as sodium dependent glucose co transporter (sglt2) inhibitors

Patent Citations (1)

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WO2013000275A1 (zh) * 2011-06-25 2013-01-03 山东轩竹医药科技有限公司 C-糖苷衍生物

Also Published As

Publication number Publication date
JP6008892B2 (ja) 2016-10-19
CN104761522B (zh) 2017-02-15
KR20150081220A (ko) 2015-07-13
CN106349201A (zh) 2017-01-25
CN106349201B (zh) 2018-09-18
CN104761522A (zh) 2015-07-08
JP2015129106A (ja) 2015-07-16
HK1207626A1 (zh) 2016-02-05

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