KR101720095B1 - Cleansing composition for acne containing natural plant extracts - Google Patents

Abstract

The present invention relates to a cleanser composition for acne containing natural plant extracts and salicylic acid or salts thereof, and more particularly to a cleanser composition comprising at least one of a yellowish white extract, a rhubarb extract and a cauliflower extract and a salicylic acid or a salicylic acid The present invention relates to a cleanser composition which can relieve acne inflammation and inhibit pigmentation that may appear after acne inflammation and minimize inflammation by minimizing excessive sebum secretion.

Huang Baek extract, rhubarb extract, gooseberry extract, salicylic acid, acne, cleanser

Description

[0001] Cleansing composition for acne containing natural plant extracts containing natural plant extract [

The present invention relates to a cleanser composition for acne containing natural plant extracts, salicylic acid and salts thereof, and more particularly to a cleanser composition comprising at least one of a yellowish white extract, a rhubarb extract and a cauliflower extract and salicylic acid, The present invention relates to a cleanser composition which can relieve acne inflammation and inhibit pigmentation that may appear after acne inflammation and minimize inflammation by minimizing excessive sebum secretion.

In general, acne is caused by sebum excess associated with male hormone secretion. Specifically, sebum is generated by the male hormone and hyperkeratinization of the pore is caused, and the pore opening becomes narrow or becomes obstructed in severe cases.

When the pore opening is narrowed or clogged, sebum in the pore can not be discharged to the outside, and fine microfilaments are formed. Propionibacterium acnes, which is an anaerobic bacteria living in the pores, grows and inflammation is induced .

The inflamed reaction may cause erythema, tingling or swelling, and in severe cases hyperpigmentation may occur. In addition, when the acne area is squeezed or pressed, the risk of acne scarring is increased as the cotton bum pops and the inflammation worsens or tissue damage occurs.

Such acne inflammation can be caused by various causes, for example, various additives contained in cosmetics may be left on the skin and cause acne inflammation. Skin inflammation may also be caused by sebum, sweat or ultraviolet rays emitted from the body.

In the meantime, approaches to acne have been done in various fields, among which various approaches using plant extracts have been attempted and a lot of therapeutic methods using plant extracts have been studied. This is because a complex effect of a natural-derived component can be obtained while the burden on the skin is small.

Korean Patent Registration No. 10-0858196 appealed to the antimicrobial effect against acne bacterium by the extract of nutmeg and Korean Patent Registration No. 10-0610951 claimed the antibacterial effect against acne by the extract.

Korean Patent Application No. 2006-0125879 appealed to cosmetic compositions for treating and preventing acne containing extracts of Panchromatopsis extract. Korean Patent Application No. 2005-006052 discloses a cosmetic composition for treating and preventing acne, The present invention provides a composition for relieving sebum and reducing acne, which is excellent in cell activity, antioxidant, anti-inflammation and anti-aging effect while providing safe sebum reduction and acne relieving effect without side effects.

Although various kinds of natural extracts have been widely used to prevent acne, there is a problem that the amount of natural extracts is limited due to problems such as supply and demand of raw materials, base selection problems in products, and excessive use of them.

Accordingly, the present inventors have studied to provide a cleanser that can prevent the inflammation caused by the cleansing agent and the pigmentation that may appear after the acne inflammation, in addition to the effect of alleviating the acne inflammation in using the cleanser. As a result, The present invention can be completed by developing a cleanser containing saliva acid or its salt, which is known to be effective for the prevention of acne, using the extract of Saururus sativa, Rhodobacterium or Rhodiola extract.

Accordingly, it is an object of the present invention to provide a skin cleanser for the human body, which can alleviate skin inflammation caused by various external contaminants, inflammation caused by a surfactant and acne inflammation, inhibits pigmentation that may appear after acne inflammation, And to provide a cleanser composition which can be used comfortably without stimulation by inhibiting the induction of normalization of keratinization and formation of cotton.

In order to accomplish the above object, the present invention provides a plant extract comprising at least one plant extract selected from the group consisting of a yellowish white extract, a rhubarb extract, and a gooseberry extract; And salicylic acid and salts thereof as an active ingredient.

The cleanser composition for acne of the present invention alleviates skin irritation caused by various external contaminants, inflammation caused by surfactants and acne inflammation, inhibits pigmentation that may appear after acne inflammation, and can cause hyperkeratosis Inducing normalization of the hair, and suppressing the formation of cotton, so that it can be easily used without stimulation.

The cleanser composition for acne according to the present invention contains at least one of a yellowish white extract, a rhubarb extract and a caustic extract and salicylic acid or a salt thereof.

The Phellodendri Cortex used in the present invention is also referred to as a medicinal herb which is derived from the bark of an aurantium tree. It is a deciduous broad-leaved arboreous tree of rutaceae, which grows up to 10 meters in height, with a cork developed in its shell and yellowish in its bark. The whites are peeled off from the trunks before and after the legs to remove the rough skin or cut and dried in the sun. It is known that hypoglycemia has a hypoglycemic effect. It inhibits development of pneumococcal, mycobacterial, and staphylococci, and inhibits the growth of tumor cells and sterilization. It is known that when taking the yellow whites, the secretion of gastric juice is accelerated by the increase of the gustatory reflex and the effect of the appetite is enhanced.

The yellowish white extract can be extracted by various conventional methods without any limitations. In one embodiment, the yellowish white extract may be extracted with an organic solvent such as distilled water, C ₁ to C ₅ anhydrous or hydrous lower alcohol. For example, yellowfin is added to purified water and extracted at room temperature for 12 to 36 hours. The extract is filtered at low temperature to precipitate the precipitate, and the filtrate is separated. The process of removing the color and odor of the filtrate using activated carbon can be further roughened.

The term " Rheum undulatum " used in the present invention means the term " perennial seedlings " The rhubarb grows mainly in the wetlands of the valley, and its origin is China. It has thick yellow roots and the height of the main stem which grows straight is 1m. It is the root of the rhubarb that is mainly used as medicine. Remove the husks and root roots of the original roots and use them as is or as a whole. It has been used since BC as an anti-inflammatory lowering agent and has been used in various prescriptions. The main components are anthraquinone derivatives, glycosides and tannins.

The rhubarb extract can be extracted by various conventional methods without any limitation. In one embodiment, the rhubarb extract can be extracted with an organic solvent such as distilled water, C ₁ to C ₅ anhydrous or hydrous lower alcohols. For example, purified water is added to rhubarb and extracted at room temperature for 12 to 36 hours. The extract is filtered at low temperature to precipitate the precipitate, and the filtrate is separated. The process of removing the color and odor of the filtrate using activated carbon can be further roughened.

The Acanthopanax senticosus used in the present invention is a deciduous shrub of Araliaceae, sometimes referred to as Acanthopanax senticosus. Leucocephala is a leaf-bush and its height is 2 ~ 3m. Thick and long thorns grow thickly in the whole tree, and the compound leaf which is formed like palm is diagonally. The name of Acanthopanax Acantho means 'thorn tree' and panax means 'cure all kinds of diseases.' It means 'thorn tree that regulates all kinds of diseases.' Roots, stems, leaves, fruits and flowers can be used for medicinal purposes and have been widely used as neuralgia, arthritis, hypertension, nervous breakdown, diabetes and tonic.

The extract can be extracted by various conventional methods without any limitation. In one embodiment, the extract can be extracted with an organic solvent such as distilled water, C ₁ to C ₅ anhydrous or hydrated lower alcohols. For example, purified water is added to garlic extract and extracted at room temperature for 12 to 36 hours. The extract is filtered at low temperature to precipitate the precipitate, and the filtrate is separated. The process of removing the color and odor of the filtrate using activated carbon can be further roughened.

At least one selected from the group consisting of the yellowish white extract, the rhubarb extract and the gooseberry extract used in the present invention is contained in an amount of 0.01 to 10% by weight based on the total weight of the composition. If it is less than 0.01% by weight, it can not sufficiently attain an inhibitory effect on acne inflammation, sebum secretion and pigment deposition. If it exceeds 10% by weight, irritation to the skin may occur.

The salicylic acid used in the present invention is the main ingredient for treating acne, which is most widely used in cosmetics, and has an effect of preventing clogging of the pores of the skin by accelerating the regeneration speed of the skin without burdening the skin even when used for a long time. Therefore, it has been widely used for preventing pore pressure and alleviating acne symptoms.

In the present invention, a salicylate salt can be used as a component for treating acne. Salicylates which can be used include sodium salicylate, potassium salicylate, magnesium salicylate, and tiei-salicylate.

In the present invention, salicylic acid or a salt thereof is contained in an amount of 0.01 to 10% by weight based on the total weight of the composition. If the content is less than 0.01% by weight, the effect can not be satisfied. If the content is more than 10% by weight, irritation to the skin may be caused, and if the content of salicylic acid is 0.5% or more,

In addition, the inventive product as a cleanser can be mixed with the following raw materials.

As the cleaning component in the present invention, a soap component that causes a saponification reaction of a higher fatty acid with potassium hydroxide may be used as a fatty acid soap component most commonly used in general cleansers. Examples of the higher fatty acid used in the present invention include lauric acid, myristic acid, palmitic acid and stearic acid.

The content of the soap component in the cleanser composition according to the present invention is preferably 5 to 35% by weight based on the total weight of the composition. If the content is less than 5% by weight, the basic cleaning effect of wiping off the dirt and scratching off the skin wastes and makeup residues can not be sufficiently achieved. If the content is more than 35% by weight, the skin may be irritated.

Examples of the cleaning component that can be used in addition to the fatty acid-based soap component include phosphate ester, isothionate, sulfate, sulfonate, and taurate, which are mainly anionic surfactants, and the content thereof is 5 to 30 wt% 10 to 20% by weight can be used. If less than 5% by weight is used, the foaming power and washing power are too low. If the amount exceeds 20% by weight, irritation may occur.

In the present invention, an amphoteric surfactant may be used in order to enhance bubble power and detergency. Examples thereof include betaines, glycinates, alkylamidoalkylamines, etc. These surfactants may be used singly or in combination of two or more. And 0.1 to 10% by weight, preferably 0.5 to 8% by weight, based on the total weight of the composition. If it is less than 0.1% by weight, it can not show bubble power at all, and if it is more than 10% by weight, it may be stimulated.

In addition, several ingredients can be prescribed to give the basic efficacy of a cleanser.

For moisturizing, polyols such as glycerin, dipropylene glycol, propylene glycol, 1,3-butylene glycol, and polyethylene glycol can be used. The polyol contains 0.5 to 10% by weight, preferably 3 to 7% by weight, based on the total weight of the composition. When the content of the polyol is less than 0.5% by weight, the effect of moisturizing is insignificant. When the content of polyol is more than 10% by weight, the feeling of slippery feeling is not so good.

In addition, a chelating agent, a pH adjuster, a preservative, and the like may be included to maintain the basic quality of the cleanser.

Hereinafter, the constitution and effect of the present invention will be described in more detail with reference to the following examples and test examples.

[Reference Example 1] Preparation of yellowish white extract

20 kg of purified water was added to 1 kg of yellowish white and extracted at 25 ° C for 24 hours. The extract was allowed to settle at 0 to 4 ° C for 24 hours and then filtered through a 250 mesh filter. The color and odor of the filtrate were removed by using activated carbon, followed by additional filtration to produce a yellowish white extract.

[Reference Example 2] Preparation of rhubarb extract

20 kg of purified water was added to 1 kg of rhubarb and extracted at 25 캜 for 24 hours. The extract was allowed to settle at 0 to 4 ° C for 24 hours, and then filtered through a 250 mesh filter. After removing the color and odor of the filtrate by using activated carbon, the rhubarb extract was further subjected to repeated filtration.

[Reference Example 3] Preparation of Acanthopanax senticosus extract

20 kg of purified water was added to 1 kg of goose root and extracted at 25 캜 for 24 hours. The extract was allowed to settle at 0 to 4 ° C for 24 hours, and then filtered through a 250 mesh filter. After removing the color and odor of the filtrate by using activated carbon, the extract was further subjected to a repeated filtration process.

[Reference Example 4] Preparation of Examples 1 to 3 and Comparative Examples 1 to 14

Examples 1 to 6 and Comparative Examples 1 to 14 were prepared with the compositions shown in Table 1 below. The extracts used in Examples 1 to 6 mean the same amount of the yellowish white extract, the rhubarb extract, and the rhizome extract.

Comparative Example 1 Control group - Comparative Example 2 Isotretinoin (nM) 100 Comparative Example 3 Yellowish white extract
(ppm) 25 Comparative Example 4 50 Comparative Example 5 250 Comparative Example 6 Rhubarb extract
(ppm) 25 Comparative Example 7 50 Comparative Example 8 250 Comparative Example 9 Acanthopanax senticosus extract
(ppm) 25 Comparative Example 10 50 Comparative Example 11 250 Comparative Example 12 Salicylic acid
(ppm) 5 Comparative Example 13 10 Comparative Example 14 50 Example 1 Mix (extract + salicylic acid)
(ppm) 25 + 5 Example 2 50 + 10 Example 3 250 + 50 Example 4 Mix (extract + salicylate)
(ppm) 25 + 5 Example 5 50 + 10 Example 6 250 + 50

[Reference Example 5] Cell culture conditions

A hamster-derived sebaceous cell (sebocyte) was used for the experiment. The cells were cultured in a culture flask to give 2.35 x 10 ⁴ / cm ² . The culture medium was cultured in DMEM / Ham's F12 medium (DMEM / Ham's F12 medium; 1: 1 (DMEM / F12) (Invitrogen, Carlsbad, Calif.) With fetal bovine serum (JRH Bioscience, %, And was prepared by adding 0.68 mM L-glutamine (Invitrogen) and 10 nM rhEGF (recombinant human epidermal growth factor; Progen Biotechnik GmbH, Heidelberg, Germany).

Penicillin 100 mg / ml and streptomycin 100 mg / ml (GIBCO, Milan, Italy) were used as the antibiotics. Hamster sebaceous cells were attached to the culture flask for 24 hours and cultured at 37 ° C and 5% CO ₂ .

HaCaT, a human keratinocyte cell line, was prepared by adding 10% fetal bovine serum (JRH Bioscience, Tokyo, Japan) to DMEM medium (Invitrogen, Carlsbad, Calif.), Adding penicillin 100 mg / The cells were cultured in a medium supplemented with 100 mg / ml of streptomycin (all of them GIBCO, Milan, Italy) at 37 ° C and 5% CO ₂ .

Melan-a melanocyte melanocyte derived from C57BL / 6J mouse was cultured in RPMI-1640 (Invitrogen, Carlsbad, CA) with fetal bovine serum (JRH Bioscience, Tokyo, , 10% CO ₂ (100 μL), and the medium was supplemented with 200 nM of TPA (tetradecanoyl phorbol acetate), 100 mg / ml of penicillin and 100 mg / ml of streptomycin (all of them GIBCO, Milan, Italy) Lt; / RTI >

[Test Example 1] In vitro test for inhibiting acne inflammation

In order to efficiently evaluate the effect of inhibiting acne inflammation, an in vitro inflammation model of an environment similar to human acne lesion was used by using hamster-derived sebaceous cells and human-derived keratinocytes together. HaCaT keratinocytes and golden hamster sebaceous cells were inoculated in a 24 well culture plate at 3.75x10 ⁴ and 6.0x10 ⁴ , respectively. After inoculation, the cells were allowed to adhere to the bottom of the culture plate for one day. At this time, the medium was incubated with fetal bovine serum (JRH Bioscience, Tokyo, Japan) supplemented with DMEM / Ham's F12 medium (DMEM / Ham's F12 medium; (DMEM / F12) (Invitrogen, Carlsbad, CA) 10% penicillin 100 mg / ml streptomycin 100 mg / ml (all of them GIBCO, Milan, Italy) were added.

Day of linoleic acid with irritants in the last cell for causing acne inflammation (linoleic acid) 50 μM, arachidonic acid (arachidonic acid) 50 μM, dihydrotestosterone (dihydrotestosterone) 10 nM, acne bacteria (P. acnes) treated with 0.5% Respectively. At the same time, Examples 1 to 6 and Comparative Examples 1 to 14 of Reference Example 4 were each treated to observe the inhibitory effect of acupuncture on the production of acne inflammation. DMSO was used as a negative control (Comparative Example 1) and 100 nM of isotretinoin, which is widely used as a positive control (Comparative Example 2), as a drug specializing in the treatment of acne. GM-CSF (granulocyte macrophage colony-stimulating factor), which is a post-inflammatory cytokine dissolved in the culture solution after one day of treatment with each of the stimulation source and Examples 1 to 6 and Comparative Examples 1 to 14, The concentration of IL-8 (interleukin-8) was measured in a 50 μl medium using a multiplex bead-based cytokine assay.

Specifically, the following procedure was performed. The solution in the 96-well filter plate, which had been pre-soaked with the wash buffer, was all sucked off using a vacuum pump. Next, the cell culture was reacted with an antibody-conjugated bead for 30 minutes. When the reaction was completed, a detection antibody was added and the reaction was further continued for 30 minutes. Then streptavidin-phycoerythrin (Streptavidin-PE) was added to each well and waited for 30 minutes. After removing unattached streptavidin-picoerythrin using wash buffer, the amount of beads attached to the cytokine was analyzed using a Bio-plex 200 apparatus. The results are shown in Fig. 1 and Fig.

1 and 2, the results of measurement of GM-CSF and IL-8, which are inflammatory cytokines, show that inflammation is suppressed even when the extracts of Hwangbyeo, Rhodopus, Guanxi, and Salicylic acid are used respectively, but the plant extracts and salicylic acid or salicylic acid It is understood that when the salts are used in combination, the inflammation is suppressed more significantly and the degree of suppression of inflammation is similar to or better than that of the known acne treatment drug isotretinoin.

[Test Example 2] In vitro evaluation of the effect of inhibiting the production of acne-causing sebum

To effectively evaluate the inhibitory effect of acne vulgaris production, an in vitro model of an environment similar to human acne lesions was used, using sebaceous gland cells and keratinocytes together. HaCaT keratinocytes and golden hamster sebaceous cells were inoculated in a 24 well culture plate at 3.75x10 ⁴ and 6.0x10 ⁴ , respectively. After inoculation, the cells were allowed to adhere to the bottom of the culture plate for one day. At this time, the medium was incubated with fetal bovine serum (JRH Bioscience, Tokyo, Japan) supplemented with DMEM / Ham's F12 medium (DMEM / Ham's F12 medium; (DMEM / F12) (Invitrogen, Carlsbad, CA) (Penicillin 100 mg / ml) and streptomycin 100 mg / ml (all from GIBCO, Milan, Italy) were added to each well.

By day irritant for causing the last cell acne-sebum production of linoleic acid (linoleic acid) 50 μM, arachidonic acid (arachidonic acid) 50 μM, dihydrotestosterone (dihydrotestosterone) 10 nM, acne bacteria (P. acnes) 0.5% Respectively. At the same time, Examples 1 to 6 and Comparative Examples 1 to 14 of Reference Example 4 were each treated to observe the effect of inhibiting the production of acne-causing sebum by a stimulation source. As a negative control (Comparative Example 1), DMSO was used. As a positive control (Comparative Example 2), 100 nM of isotretinoin, which is widely used as an acne treatment specialty drug, was used. After one day of treatment with stimulus source and Examples 1-6 and Comparative Examples 1 to 14, the amount of neutral fat produced in the cells was measured using Oil Red O staining.

Specifically, the following procedure was performed. Cells washed with PBS were fixed with 3.7% formaldehyde solution for 30 minutes. The fixed cells were washed 3 times with PBS, once with 70% ethanol, and stained with 0.4% Oil Red O solution for 30 minutes. The stained cells were washed once with 70% ethanol and three times with PBS. Then, isopropanol dyed Oil Red O solution was re-dissolved and absorbance was measured at 520 nm using a spectrophotometer. The results are shown in FIG.

FIG. 3 shows the results of measurement of the amount of triglyceride produced in the cells. However, when the extracts of HwangByong, Rhodobacterium, Rhizopus extract, Salicylic acid and Salicylic acid were used respectively, The inhibition of cell lipid production is more significant and the inhibition of lipogenesis is similar to or better than the known acne treatment drug isotretinoin.

[Test Example 3] In vitro test evaluation for inhibiting acne pigment deposition

In order to efficiently evaluate the effect of inhibiting the acne pigmentation, an in vitro model of an environment similar to pigmentation induced by human acne inflammation was used, using mouse-derived melanin-forming cells. Melan-a melanin-forming cells were inoculated in a 24-well culture plate at 5.0 x 10 ⁴ cells / well. After inoculation, the cells were allowed to adhere to the bottom of the culture plate for one day. At this time, 10% of fetal bovine serum (JRH Bioscience, Tokyo, Japan) was added to RPMI-1640 (Invitrogen, Carlsbad, Calif.) And 200 nM of tetradecanoyl phorbol acetate (TPA), 100 mg of penicillin / ml, streptomycin 100 mg / ml (GIBCO, Milan, Italy).

One day later, 50 μM of linoleic acid, 50 μM of arachidonic acid, 10 nM of dihydrotestosterone, and 0.5% of acne ( P. acnes ) were treated as stimulants to cause acne pigmentation And cultured for 5 days. Then, Examples 1 to 6 and Comparative Examples 1 and 3 to 14 of Reference Example 4 were treated to observe the effect of inhibiting acne pigment deposition by stimulus sources. DMSO was used as a negative control (Comparative Example 1), and hydroquinone (1 μM) and kojic acid (kojic acid; 200 ppm) were used as positive control groups, respectively. Hydroquinone is a specialty medicine used as a melamine inhibitor. In addition, kojic acid is recognized as a whitening effect and may be used as one of raw materials for a cosmetic composition. However, Kojisan may cause a strong irritation to the skin, and recently it has been reported that it may cause various cancers. After 5 days of treatment, the extract was treated with 1 N NaOH to dissolve the melanin, and the absorbance was measured at 405 nm using a spectrophotometer. The results are shown in Fig.

As shown in FIG. 4, when melanin production was measured, melanin production was reduced even when the extracts were used, respectively. However, when melanin production was mixed with salicylic acid or salicylate, And the degree of inhibition of melanin production is similar to that of known whitening substances, hydroquinone and kojic acid.

[Reference Example 6] Preparation of cleaner composition

Formulation Example 1 containing both a mixture of a yellowish white extract, a rhubarb extract and a sea squirt extract and salicylic acid in the composition shown in the following Table 2, and a cleanser composition of Comparative Formulation Example 1 as a general cleanser containing only salicylic acid as an active ingredient were prepared. A mixture of the yellowish white extract, the rhubarb extract and the cauliflower extract used as an effective ingredient is an equal amount of these extracts.

division Raw material name Content (% by weight) Formulation Example 1 Formulation Example 2 Comparative Formulation Example 1 Comparative Formulation Example 2 Cleanser Laurick Acid 3.0 3.0 3.0 3.0 Myristic acid 6.0 6.0 6.0 6.0 Moisturizer glycerin 5 5 5 5 corrector Potassium hydroxide 5.6 5.6 5.6 5.6 Chelating agent Disodium iodide 0.1 0.1 0.1 0.1 Auxiliary cleanser Cocamide Profile Betaine 3.0 3.0 3.0 3.0 Auxiliary cleanser Lauryl glucoside 2.0 2.0 2.0 2.0 Flavoring agent incense Suitable amount Suitable amount Suitable amount Suitable amount Efficacy component Mixture of Huang Baek Extract, Rhubarb Extract and Rhizopus Extract 0.1 0.1 - - Salicylic acid 0.5 0.5 Salicylate 0.5 0.5 antiseptic antiseptic Suitable amount Suitable amount Suitable amount Suitable amount solvent Purified water To 100 To 100 To 100 To 100

[Test Example 4] Measurement and evaluation of each mass and inflammatory lesion

The subjects were allowed to use the cleanser composition of Reference Example 6 in the morning and evening, and the number of masses and inflammation (papillary) lesions were measured before use and after 4 weeks of use.

The skin surface of the skin was sampled using a black tape and the extracted keratin was 700 times magnified using a charmview (Moritex, Japan) apparatus.

The images were analyzed using an image analysis program (BMI). Inflammatory lesions were directly counted. The results are shown in Fig. 5 and Fig.

5 and 6, the results of clinical trials show that when the plant extract and the salicylic acid or the silicate salt are used in combination, the mass reduction rate and the reduction rate of papulosis are remarkably lower than those in the case of only containing salicylic acid.

[Formulation Example 2] Preparation of a cleanser composition

The inventive cleaner compositions can be prepared with the compositions of Table 3 below.

division Raw material name Content (% by weight) Cleanser Laurick Acid 3.0 Myristic acid 6.0 Moisturizer glycerin 5 corrector Potassium hydroxide 5.6 Chelating agent Disodium iodide 0.1 Auxiliary cleanser Cocamide Profile Betaine 3.0 Auxiliary cleanser Lauryl glucoside 2.0 Flavoring agent incense Suitable amount Efficacy component One or more of the extracts of Hwangbyeong, Rhododendron and Rhodiola extract 0.1 Salicylic acid 0.5 antiseptic antiseptic Suitable amount solvent Purified water To 100

FIG. 1 shows the results of GM-CSF measurement after the treatment of Examples 1 to 6 and Comparative Examples 1 to 14.

Fig. 2 shows the results of Il-8 measurement after the treatment of Examples 1 to 6 and Comparative Examples 1 to 14.

FIG. 3 shows the results of measurement of the amount of triglyceride produced in the cells after the treatment of Examples 1 to 6 and Comparative Examples 1 to 14. FIG.

Fig. 4 shows the results of measurement of the amount of melanin produced after the treatment of Examples 1 to 6 and Comparative Examples 1 and 3 to 14.

FIG. 5 shows the results of measurement of mass and inflammation lesion when using the cleanser composition according to the present invention.

Fig. 6 shows the reduction rate of the pale green when using the cleanser composition according to the present invention.

Claims (8)

A plant extract comprising a yellowish white extract, a rhubarb extract, and a rhizome extract; And Salicylic acid and salts thereof; As an active ingredient, The plant extract is prepared by using distilled water or C ₁ to C ₅ alcohol as an extraction solvent, Wherein the plant extract is mixed with at least one of salicylic acid and its salts in a weight ratio of 5: 1, at least one inhibitor for production selected from the group consisting of keratin, pap smear, and acne inflammation, and a pigment inhibitor cleanser Composition. The cleanser composition according to claim 1, wherein the content of the plant extract is 0.01 to 10% by weight based on the total weight of the composition. The cleanser composition according to claim 1, wherein the content of at least one of salicylic acid and salts thereof is 0.01 to 10% by weight based on the total weight of the composition. delete delete delete delete delete

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