KR101714107B1 - 단백질 키나제 억제제로서의 화합물 및 조성물 - Google Patents

단백질 키나제 억제제로서의 화합물 및 조성물 Download PDF

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Publication number
KR101714107B1
KR101714107B1 KR1020127007838A KR20127007838A KR101714107B1 KR 101714107 B1 KR101714107 B1 KR 101714107B1 KR 1020127007838 A KR1020127007838 A KR 1020127007838A KR 20127007838 A KR20127007838 A KR 20127007838A KR 101714107 B1 KR101714107 B1 KR 101714107B1
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South Korea
Prior art keywords
methyl
ylcarbamate
propan
ylamino
imidazol
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Expired - Fee Related
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KR1020127007838A
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English (en)
Korean (ko)
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KR20120092577A (ko
Inventor
아브란 큐. 코스탈스
쉔린 후앙
제프 진 (시안밍)
주오셩 리우
사비나 페키
다니엘 푼
존 텔류
충 장
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노파르티스 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020127007838A 2009-08-28 2010-08-26 단백질 키나제 억제제로서의 화합물 및 조성물 Expired - Fee Related KR101714107B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US23808309P 2009-08-28 2009-08-28
US61/238,083 2009-08-28
US31306110P 2010-03-11 2010-03-11
US61/313,061 2010-03-11
PCT/EP2010/062495 WO2011023773A1 (en) 2009-08-28 2010-08-26 Compounds and compositions as protein kinase inhibitors

Publications (2)

Publication Number Publication Date
KR20120092577A KR20120092577A (ko) 2012-08-21
KR101714107B1 true KR101714107B1 (ko) 2017-03-08

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KR1020127007838A Expired - Fee Related KR101714107B1 (ko) 2009-08-28 2010-08-26 단백질 키나제 억제제로서의 화합물 및 조성물

Country Status (19)

Country Link
US (3) US8242260B2 (enExample)
EP (1) EP2470528B1 (enExample)
JP (1) JP5726190B2 (enExample)
KR (1) KR101714107B1 (enExample)
CN (1) CN102596937B (enExample)
AR (1) AR077977A1 (enExample)
AU (1) AU2010288455B2 (enExample)
BR (1) BR112012004448A2 (enExample)
CA (1) CA2771673C (enExample)
EA (1) EA020479B1 (enExample)
ES (1) ES2527176T3 (enExample)
IN (1) IN2012DN00869A (enExample)
JO (1) JO3007B1 (enExample)
MX (1) MX2012002542A (enExample)
PL (1) PL2470528T3 (enExample)
PT (1) PT2470528E (enExample)
TW (1) TWI487701B (enExample)
UY (1) UY32859A (enExample)
WO (1) WO2011023773A1 (enExample)

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CA2912568A1 (en) 2013-05-30 2014-12-04 Plexxikon Inc. Compounds for kinase modulation, and indications therefor
UY35625A (es) 2013-06-25 2014-12-31 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Compuestos de tetrahidrocarbazol y carbazol carboxamida sustituidos como inhibidores de quinasa
CN105473573B (zh) 2013-06-25 2018-03-16 百时美施贵宝公司 用作激酶抑制剂的咔唑甲酰胺化合物
CN106029072A (zh) * 2013-08-28 2016-10-12 麦迪韦逊技术股份有限公司 杂环化合物和使用方法
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UY36294A (es) 2014-09-12 2016-04-29 Novartis Ag Compuestos y composiciones como inhibidores de quinasa
EP3206749B1 (en) 2014-10-14 2021-09-08 The Regents of the University of California The cdk9 and brd4 inhibitors flavopiridol and jq1 to inhibit cartilage inflammation
CN104402920B (zh) * 2014-11-27 2018-04-03 河南科技学院 一种合成2‑卤代‑3‑频那醇硼酸酯‑5‑氯苯胺的方法
KR102341660B1 (ko) 2016-09-19 2021-12-23 노파르티스 아게 Raf 억제제 및 erk 억제제를 포함하는 치료적 조합
EP3579872A1 (en) 2017-02-10 2019-12-18 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cancers associated with activation of the mapk pathway
ES2952265T3 (es) 2017-05-02 2023-10-30 Novartis Ag Terapia combinada que comprende un inhibidor de Raf y trametinib
CA3086765A1 (en) 2017-12-28 2019-07-04 Tract Pharmaceuticals, Inc. Stem cell culture systems for columnar epithelial stem cells, and uses related thereto
WO2020124397A1 (en) * 2018-12-19 2020-06-25 Inventisbio Shanghai Ltd. C-terminal src kinase inhibitors
EP3969449B1 (en) 2019-05-13 2025-02-12 Novartis AG New crystalline forms of n-(3-(2-(2-hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methvlphenyl)-2(trifluoromethyl)isonicotinamide as raf inhibitors for the treatment of cancer
WO2022036176A1 (en) * 2020-08-13 2022-02-17 Albert Einstein College Of Medicine N-cyclyl-sulfonamides useful for inhibiting raf
US12331026B2 (en) 2022-03-28 2025-06-17 Nikang Therapeutics, Inc. Sulfonamido derivatives as cyclin-dependent kinase 2 inhibitors
CN119790053A (zh) 2022-06-08 2025-04-08 霖康疗法公司 作为细胞周期蛋白依赖性激酶2抑制剂的磺酰胺衍生物
WO2025072462A1 (en) 2023-09-27 2025-04-03 Nikang Therapeutics, Inc. Sulfonamide derivatives as cyclin-dependent kinase 2 inhibitors

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Also Published As

Publication number Publication date
US20110052578A1 (en) 2011-03-03
US8563553B2 (en) 2013-10-22
AU2010288455A1 (en) 2012-02-23
WO2011023773A1 (en) 2011-03-03
EA201200323A1 (ru) 2012-09-28
EP2470528B1 (en) 2014-10-01
ES2527176T3 (es) 2015-01-21
JP2013503139A (ja) 2013-01-31
AU2010288455B2 (en) 2013-01-31
PL2470528T3 (pl) 2015-03-31
JO3007B1 (ar) 2016-09-05
TW201111365A (en) 2011-04-01
BR112012004448A2 (pt) 2017-05-30
CA2771673C (en) 2016-07-12
US20120225899A1 (en) 2012-09-06
MX2012002542A (es) 2012-04-02
KR20120092577A (ko) 2012-08-21
US8242260B2 (en) 2012-08-14
EA020479B1 (ru) 2014-11-28
AR077977A1 (es) 2011-10-05
CN102596937A (zh) 2012-07-18
EP2470528A1 (en) 2012-07-04
IN2012DN00869A (enExample) 2015-07-10
JP5726190B2 (ja) 2015-05-27
CA2771673A1 (en) 2011-03-03
US20140011825A1 (en) 2014-01-09
US8859548B2 (en) 2014-10-14
CN102596937B (zh) 2014-02-12
PT2470528E (pt) 2014-12-29
UY32859A (es) 2011-03-31
TWI487701B (zh) 2015-06-11

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