KR101707246B1 - 고체 형태의 (2ｓ,3ｒ,4ｒ,5ｓ,6ｒ)-2-(4-클로로-3-(4-에톡시벤질)페닐)-6-(메틸티오)테트라히드로-2ｈ-피란-3,4,5-트리올 및 그의 사용 방법 - Google Patents

고체 형태의 (2ｓ,3ｒ,4ｒ,5ｓ,6ｒ)-2-(4-클로로-3-(4-에톡시벤질)페닐)-6-(메틸티오)테트라히드로-2ｈ-피란-3,4,5-트리올 및 그의 사용 방법 Download PDF

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KR101707246B1
KR101707246B1 KR1020117001024A KR20117001024A KR101707246B1 KR 101707246 B1 KR101707246 B1 KR 101707246B1 KR 1020117001024 A KR1020117001024 A KR 1020117001024A KR 20117001024 A KR20117001024 A KR 20117001024A KR 101707246 B1 KR101707246 B1 KR 101707246B1
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ethoxybenzyl
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수잔 마거릿 드 폴
아네트 펄베르크
매튜 망주 자오
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렉시컨 파마슈티컬스 인코퍼레이티드
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    • C—CHEMISTRY; METALLURGY
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    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
    • C—CHEMISTRY; METALLURGY
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    • C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
    • C07H5/08—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to sulfur, selenium or tellurium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/04—Carbocyclic radicals

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  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020117001024A 2008-07-17 2009-07-15 고체 형태의 (2ｓ,3ｒ,4ｒ,5ｓ,6ｒ)-2-(4-클로로-3-(4-에톡시벤질)페닐)-6-(메틸티오)테트라히드로-2ｈ-피란-3,4,5-트리올 및 그의 사용 방법 Active KR101707246B1 (ko)

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US8142308P 2008-07-17 2008-07-17
US61/081,423 2008-07-17
PCT/US2009/050636 WO2010009197A1 (en) 2008-07-17 2009-07-15 Solid forms of (2s,3r,4r,5s,6r)-2-(4-chloro-3-(4-ethoxybenzyl)phenyl)-6-(methylthio)tetrahydro-2h-pyran-3,4,5-triol and methods of their use

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KR1020177001061A Division KR20170010069A (ko) 2008-07-17 2009-07-15 고체 형태의 (2ｓ,3ｒ,4ｒ,5ｓ,6ｒ)-2-(4-클로로-3-(4-에톡시벤질)페닐)-6-(메틸티오)테트라히드로-2ｈ-피란-3,4,5-트리올 및 그의 사용 방법

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KR20110031196A KR20110031196A (ko) 2011-03-24
KR101707246B1 true KR101707246B1 (ko) 2017-02-15

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KR1020117001024A Active KR101707246B1 (ko) 2008-07-17 2009-07-15 고체 형태의 (2ｓ,3ｒ,4ｒ,5ｓ,6ｒ)-2-(4-클로로-3-(4-에톡시벤질)페닐)-6-(메틸티오)테트라히드로-2ｈ-피란-3,4,5-트리올 및 그의 사용 방법
KR1020177001061A Ceased KR20170010069A (ko) 2008-07-17 2009-07-15 고체 형태의 (2ｓ,3ｒ,4ｒ,5ｓ,6ｒ)-2-(4-클로로-3-(4-에톡시벤질)페닐)-6-(메틸티오)테트라히드로-2ｈ-피란-3,4,5-트리올 및 그의 사용 방법

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US (2) US8217156B2 (https=)
EP (1) EP2332947B1 (https=)
JP (2) JP2011528366A (https=)
KR (2) KR101707246B1 (https=)
CN (2) CN102112483A (https=)
AR (1) AR072807A1 (https=)
AU (1) AU2009270973B2 (https=)
CA (1) CA2730931A1 (https=)
CL (1) CL2009001595A1 (https=)
CO (1) CO6351797A2 (https=)
DK (1) DK2332947T3 (https=)
ES (1) ES2656357T3 (https=)
HK (1) HK1243713A1 (https=)
HU (1) HUE035400T2 (https=)
IL (1) IL210269A (https=)
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NO (1) NO2332947T3 (https=)
NZ (1) NZ590184A (https=)
PE (1) PE20100260A1 (https=)
PL (1) PL2332947T3 (https=)
PT (1) PT2332947T (https=)
RU (1) RU2505543C2 (https=)
SG (1) SG185317A1 (https=)
TW (1) TWI472521B (https=)
UA (1) UA106048C2 (https=)
UY (1) UY31992A (https=)
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ES2656357T3 (es) 2018-02-26
CA2730931A1 (en) 2010-01-21
HUE035400T2 (en) 2018-05-02
IL210269A0 (en) 2011-03-31
US20100016422A1 (en) 2010-01-21
EP2332947A1 (en) 2011-06-15
BRPI0916191A2 (pt) 2017-08-29
RU2505543C2 (ru) 2014-01-27
CN102112483A (zh) 2011-06-29
CL2009001595A1 (es) 2010-07-19
ZA201100175B (en) 2012-03-28
AR072807A1 (es) 2010-09-22
NZ590184A (en) 2012-09-28
US20130165395A1 (en) 2013-06-27
KR20110031196A (ko) 2011-03-24
JP2011528366A (ja) 2011-11-17
DK2332947T3 (da) 2018-01-29
US8217156B2 (en) 2012-07-10
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UA106048C2 (uk) 2014-07-25
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IL210269A (en) 2015-06-30
PT2332947T (pt) 2018-02-06
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CN107629097A (zh) 2018-01-26
EP2332947B1 (en) 2017-11-01
PL2332947T3 (pl) 2018-04-30
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