KR101687686B1 - Pth를 정제하는 방법 - Google Patents

Pth를 정제하는 방법 Download PDF

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Publication number
KR101687686B1
KR101687686B1 KR1020167003963A KR20167003963A KR101687686B1 KR 101687686 B1 KR101687686 B1 KR 101687686B1 KR 1020167003963 A KR1020167003963 A KR 1020167003963A KR 20167003963 A KR20167003963 A KR 20167003963A KR 101687686 B1 KR101687686 B1 KR 101687686B1
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KR
South Korea
Prior art keywords
exchange chromatography
fraction
pth
parathyroid hormone
weak
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Expired - Fee Related
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KR1020167003963A
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English (en)
Korean (ko)
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KR20160027204A (ko
Inventor
산제에브 쿠마르 멘디라타
산자이 반디오파디아이
아바니쉬 쿠마르 싱
Original Assignee
카딜라 핼쓰캐어 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
KR1020167003963A 2013-08-21 2014-08-21 Pth를 정제하는 방법 Expired - Fee Related KR101687686B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2726/MUM/2013 2013-08-21
IN2726MU2013 IN2013MU02726A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2013-08-21 2014-08-21
PCT/IN2014/000539 WO2015025335A1 (en) 2013-08-21 2014-08-21 Purification process for pth

Publications (2)

Publication Number Publication Date
KR20160027204A KR20160027204A (ko) 2016-03-09
KR101687686B1 true KR101687686B1 (ko) 2016-12-19

Family

ID=51862491

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167003963A Expired - Fee Related KR101687686B1 (ko) 2013-08-21 2014-08-21 Pth를 정제하는 방법

Country Status (16)

Country Link
US (1) US20160200792A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EP (1) EP3036252A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
JP (1) JP6046862B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
KR (1) KR101687686B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CN (1) CN105473610A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
AU (1) AU2014310255B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CA (1) CA2919604A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
EA (1) EA201690264A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
HK (1) HK1223378A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IL (1) IL243642A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
IN (1) IN2013MU02726A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MX (1) MX2016002274A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
NZ (1) NZ716205A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SG (1) SG11201600511QA (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
WO (1) WO2015025335A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
ZA (1) ZA201600424B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR3012952B1 (fr) * 2013-11-08 2015-11-06 Essilor Int Methode de determination d'au moins un parametre de conception optique d'une lentille ophtalmique progressive
WO2019077432A1 (en) * 2017-10-16 2019-04-25 Intas Pharmaceuticals Ltd. IMPROVED PURIFICATION METHOD OF RECOMBINANT PTH (1-34)
CN107941983B (zh) * 2018-01-05 2020-05-15 北京博康健基因科技有限公司 一种rhPTH蛋白或rhPTH蛋白制剂的检测方法和纯度的分析方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009019715A1 (en) 2007-08-09 2009-02-12 Usv Limited Novel orthogonal process for purification of recombinant human parathyroid hormone (rhpth) (1-34)
WO2011151714A1 (en) 2010-06-04 2011-12-08 Lupin Limited Modified sak gene for the production of recombinant proteins

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988000596A1 (en) * 1986-07-18 1988-01-28 The University Of Melbourne A PROTEIN ACTIVE IN HUMORAL HYPERCALCEMIA OF MALIGNANCY-PTHrP
US5171670A (en) * 1989-05-12 1992-12-15 The General Hospital Corporation Recombinant dna method for production of parathyroid hormone
DE3935738A1 (de) * 1989-10-27 1991-05-08 Forssmann Wolf Georg Arzneimittel, enthaltend das humane parathormon-fragment (1-37) als aktiven wirkstoff
EP0812856B1 (en) * 1996-06-14 1999-09-29 Takeda Chemical Industries, Ltd. Method for removing N-terminal methionine
AU7701398A (en) * 1997-05-30 1998-12-30 Bion, Inc. Large-scale isolation and purification of hif
WO2003102132A2 (en) 2002-04-26 2003-12-11 Genetech, Inc. Non-affinity purification of proteins
EP1598075A1 (en) * 2004-05-21 2005-11-23 LEK Pharmaceuticals d.d. Process for the isolation and / or purification of proteins
CN1706947A (zh) * 2004-06-04 2005-12-14 南京大学生物制药工程研究中心 重组人甲状旁腺激素在大肠杆菌中的构建、表达与纯化方法
DE602006014126D1 (de) * 2005-04-20 2010-06-17 Viromed Co Ltd Zusammensetzungen und verfahren zur trennung von fusionsproteinen
CN1861790A (zh) * 2006-04-25 2006-11-15 华东理工大学 重组人甲状旁腺激素1－84的制备方法
SG10201508401TA (en) * 2010-10-11 2015-11-27 Abbvie Bahamas Ltd Processes for purification of proteins

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009019715A1 (en) 2007-08-09 2009-02-12 Usv Limited Novel orthogonal process for purification of recombinant human parathyroid hormone (rhpth) (1-34)
WO2011151714A1 (en) 2010-06-04 2011-12-08 Lupin Limited Modified sak gene for the production of recombinant proteins

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Chemical Abstract CN1311256 (2002. 05. 13.)

Also Published As

Publication number Publication date
CA2919604A1 (en) 2015-02-26
AU2014310255A1 (en) 2016-02-25
IN2013MU02726A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 2015-06-26
WO2015025335A8 (en) 2016-02-04
JP2016528173A (ja) 2016-09-15
KR20160027204A (ko) 2016-03-09
IL243642A0 (en) 2016-03-31
HK1223378A1 (zh) 2017-07-28
EP3036252A1 (en) 2016-06-29
AU2014310255B2 (en) 2017-02-16
MX2016002274A (es) 2016-05-31
WO2015025335A1 (en) 2015-02-26
EA201690264A1 (ru) 2016-06-30
ZA201600424B (en) 2017-03-29
US20160200792A1 (en) 2016-07-14
CN105473610A (zh) 2016-04-06
IL243642A (en) 2017-05-29
SG11201600511QA (en) 2016-02-26
NZ716205A (en) 2017-05-26
JP6046862B2 (ja) 2016-12-21

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