KR101671874B1 - 5번 위치에서 치환된 (아자)인돌 화합물, 이를 포함하는 약학적 조성물, 중간 화합물들 및 이의 제조 방법 - Google Patents

5번 위치에서 치환된 (아자)인돌 화합물, 이를 포함하는 약학적 조성물, 중간 화합물들 및 이의 제조 방법 Download PDF

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KR101671874B1
KR101671874B1 KR1020107015290A KR20107015290A KR101671874B1 KR 101671874 B1 KR101671874 B1 KR 101671874B1 KR 1020107015290 A KR1020107015290 A KR 1020107015290A KR 20107015290 A KR20107015290 A KR 20107015290A KR 101671874 B1 KR101671874 B1 KR 101671874B1
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KR20100103569A (ko
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마리아 알레산드라 알리시
구이도 푸로티
니콜라 카졸라
카테리나 마우게리
파트리치아 드라고네
바바라 가로팔로
이사벨라 콜레타
죠르지나 만가노
베아트리체 가로네
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아지엔드 키미쉐 리유나이트 안젤리니 프란체스코 에이.씨.알.에이.에프. 에스.피.에이
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020107015290A 2007-12-28 2008-12-16 5번 위치에서 치환된 (아자)인돌 화합물, 이를 포함하는 약학적 조성물, 중간 화합물들 및 이의 제조 방법 Expired - Fee Related KR101671874B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07425830A EP2078711A1 (en) 2007-12-28 2007-12-28 (Aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor
EP07425830.2 2007-12-28
PCT/EP2008/067622 WO2009083436A1 (en) 2007-12-28 2008-12-16 (aza)indole derivative substituted in position 5, pharmaceutical composition comprising it, intermediate compounds and preparation process therefor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020167004925A Division KR20160029861A (ko) 2007-12-28 2008-12-16 5번 위치에서 치환된 (아자)인돌 화합물, 이를 포함하는 약학적 조성물, 중간 화합물들 및 이의 제조 방법

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Publication Number Publication Date
KR20100103569A KR20100103569A (ko) 2010-09-27
KR101671874B1 true KR101671874B1 (ko) 2016-11-03

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KR1020167004925A Ceased KR20160029861A (ko) 2007-12-28 2008-12-16 5번 위치에서 치환된 (아자)인돌 화합물, 이를 포함하는 약학적 조성물, 중간 화합물들 및 이의 제조 방법
KR1020107015290A Expired - Fee Related KR101671874B1 (ko) 2007-12-28 2008-12-16 5번 위치에서 치환된 (아자)인돌 화합물, 이를 포함하는 약학적 조성물, 중간 화합물들 및 이의 제조 방법

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KR1020167004925A Ceased KR20160029861A (ko) 2007-12-28 2008-12-16 5번 위치에서 치환된 (아자)인돌 화합물, 이를 포함하는 약학적 조성물, 중간 화합물들 및 이의 제조 방법

Country Status (20)

Country Link
US (2) US8399477B2 (OSRAM)
EP (3) EP2078711A1 (OSRAM)
JP (1) JP5698985B2 (OSRAM)
KR (2) KR20160029861A (OSRAM)
CN (1) CN101910127B (OSRAM)
AR (1) AR069961A1 (OSRAM)
AU (1) AU2008342705B2 (OSRAM)
BR (1) BRPI0821450A2 (OSRAM)
CA (1) CA2707339C (OSRAM)
DK (2) DK2234968T3 (OSRAM)
EA (1) EA020373B1 (OSRAM)
ES (2) ES2408955T3 (OSRAM)
GE (1) GEP20125547B (OSRAM)
IL (1) IL206062A (OSRAM)
PL (2) PL2234968T3 (OSRAM)
PT (2) PT2444392E (OSRAM)
SG (1) SG187400A1 (OSRAM)
SI (2) SI2444392T1 (OSRAM)
UA (1) UA100867C2 (OSRAM)
WO (1) WO2009083436A1 (OSRAM)

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KR101365824B1 (ko) 2010-10-22 2014-02-20 엘지디스플레이 주식회사 유기전계발광소자
EA031804B1 (ru) 2014-02-03 2019-02-28 Вайтаи Фармасьютиклз, Инк. Дигидропирролопиридиновые ингибиторы ror-гамма
ES2838625T3 (es) * 2014-04-14 2021-07-02 Shanghai hengrui pharmaceutical co ltd Derivados de amida y sales farmacéuticamente aceptables de los mismos, su método de preparación y aplicación médica de los mismos
US9663515B2 (en) 2014-11-05 2017-05-30 Vitae Pharmaceuticals, Inc. Dihydropyrrolopyridine inhibitors of ROR-gamma
WO2017024018A1 (en) * 2015-08-05 2017-02-09 Vitae Pharmaceuticals, Inc. Modulators of ror-gamma
CN108463458B (zh) 2015-11-20 2022-02-01 生命医药有限责任公司 ROR-γ的调节剂
TW202220968A (zh) 2016-01-29 2022-06-01 美商維它藥物有限責任公司 ＲＯＲ－γ調節劑
CN107033026A (zh) * 2017-06-07 2017-08-11 李博强 一种对硝基苯肼盐酸盐的制备方法
WO2019018975A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. INHIBITORS OF ROR GAMMA
WO2019023207A1 (en) 2017-07-24 2019-01-31 Vitae Pharmaceuticals, Inc. Inhibitors of rorϒ
JP7337260B2 (ja) * 2019-08-26 2023-09-01 クッジェ ファーマ カンパニー，リミテッド インドールカルボキサミド誘導体及びそれを含む薬剤学的組成物
CN114605303A (zh) * 2022-03-14 2022-06-10 武汉工程大学 一种地拉韦啶及其中间体的合成方法
CN119019389A (zh) * 2024-06-05 2024-11-26 四川大学 7-氮杂吲哚类化合物及其合成方法和用途
CN119101040B (zh) * 2024-11-08 2025-03-21 杭州澳赛诺医药技术有限公司 一种通过去对称化合成芳基取代的手性四氢吡喃环的方法

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US20030225036A1 (en) 2000-03-20 2003-12-04 Aleksandr Kolesnikov Non-amidine containing protease inhibitors
US20070244159A1 (en) 2006-04-07 2007-10-18 Hadida Ruah Sara S Modulators of ATP-binding cassette transporters

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SE0300908D0 (sv) * 2003-03-31 2003-03-31 Astrazeneca Ab Azaindole derivatives, preparations thereof, uses thereof and compositions containing them
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Publication number Priority date Publication date Assignee Title
US20030225036A1 (en) 2000-03-20 2003-12-04 Aleksandr Kolesnikov Non-amidine containing protease inhibitors
US20070244159A1 (en) 2006-04-07 2007-10-18 Hadida Ruah Sara S Modulators of ATP-binding cassette transporters

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AU2008342705B2 (en) 2013-11-14
SG187400A1 (en) 2013-02-28
ES2523167T3 (es) 2014-11-21
DK2444392T3 (en) 2014-12-08
PT2444392E (pt) 2014-11-19
BRPI0821450A2 (pt) 2015-06-16
IL206062A (en) 2015-08-31
DK2234968T3 (da) 2013-06-17
PL2444392T3 (pl) 2015-03-31
GEP20125547B (en) 2012-05-25
JP5698985B2 (ja) 2015-04-08
AU2008342705A1 (en) 2009-07-09
PT2234968E (pt) 2013-06-03
US20100286189A1 (en) 2010-11-11
HK1165410A1 (en) 2012-10-05
US8399477B2 (en) 2013-03-19
IL206062A0 (en) 2010-11-30
CA2707339A1 (en) 2009-07-09
US8871948B2 (en) 2014-10-28
UA100867C2 (uk) 2013-02-11
CN101910127A (zh) 2010-12-08
SI2444392T1 (sl) 2014-12-31
CN101910127B (zh) 2013-01-23
EP2078711A1 (en) 2009-07-15
US20130158269A1 (en) 2013-06-20
WO2009083436A1 (en) 2009-07-09
JP2011507929A (ja) 2011-03-10
EA201070804A1 (ru) 2010-12-30
EP2234968B1 (en) 2013-03-27
EP2444392A1 (en) 2012-04-25
EA020373B1 (ru) 2014-10-30
ES2408955T3 (es) 2013-06-24
KR20160029861A (ko) 2016-03-15
AR069961A1 (es) 2010-03-03
EP2234968A1 (en) 2010-10-06
KR20100103569A (ko) 2010-09-27
EP2444392B1 (en) 2014-09-24
CA2707339C (en) 2018-05-01
HK1145172A1 (en) 2011-04-08
SI2234968T1 (sl) 2013-06-28
PL2234968T3 (pl) 2013-08-30

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