KR101648593B1 - Ａｍｐ-활성화된 단백질 키나아제 (ａｍｐｋ) 활성화제로서의 티에노피리돈 유도체 - Google Patents

Ａｍｐ-활성화된 단백질 키나아제 (ａｍｐｋ) 활성화제로서의 티에노피리돈 유도체 Download PDF

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KR101648593B1
KR101648593B1 KR1020107027208A KR20107027208A KR101648593B1 KR 101648593 B1 KR101648593 B1 KR 101648593B1 KR 1020107027208 A KR1020107027208 A KR 1020107027208A KR 20107027208 A KR20107027208 A KR 20107027208A KR 101648593 B1 KR101648593 B1 KR 101648593B1
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pyridin
thieno
dihydro
phenyl
hydroxy
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KR20110010757A (ko
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다니엘 크라보
프랑크 르피쁘레
소삐 알라꿔-보제끄
크리스띤 샤롱
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메르크 파텐트 게엠베하
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020107027208A 2008-05-05 2009-04-08 Ａｍｐ-활성화된 단백질 키나아제 (ａｍｐｋ) 활성화제로서의 티에노피리돈 유도체 Expired - Fee Related KR101648593B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08290423.6 2008-05-05
EP08290423 2008-05-05

Related Child Applications (1)

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KR1020167007434A Division KR20160038065A (ko) 2008-05-05 2009-04-08 Ａｍｐ-활성화된 단백질 키나아제 (ａｍｐｋ) 활성화제로서의 티에노피리돈 유도체

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KR20110010757A KR20110010757A (ko) 2011-02-07
KR101648593B1 true KR101648593B1 (ko) 2016-08-16

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KR1020107027208A Expired - Fee Related KR101648593B1 (ko) 2008-05-05 2009-04-08 Ａｍｐ-활성화된 단백질 키나아제 (ａｍｐｋ) 활성화제로서의 티에노피리돈 유도체
KR1020167007434A Ceased KR20160038065A (ko) 2008-05-05 2009-04-08 Ａｍｐ-활성화된 단백질 키나아제 (ａｍｐｋ) 활성화제로서의 티에노피리돈 유도체

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KR1020167007434A Ceased KR20160038065A (ko) 2008-05-05 2009-04-08 Ａｍｐ-활성화된 단백질 키나아제 (ａｍｐｋ) 활성화제로서의 티에노피리돈 유도체

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US (1) US8604202B2 (enExample)
EP (1) EP2280952B1 (enExample)
JP (1) JP5536757B2 (enExample)
KR (2) KR101648593B1 (enExample)
CN (1) CN102015676B (enExample)
AR (1) AR071530A1 (enExample)
AU (1) AU2009243811B2 (enExample)
BR (1) BRPI0910832B8 (enExample)
CA (1) CA2723429C (enExample)
CO (1) CO6331304A2 (enExample)
CY (1) CY1113112T1 (enExample)
DK (1) DK2280952T3 (enExample)
EA (1) EA020773B1 (enExample)
EC (1) ECSP10010654A (enExample)
ES (1) ES2388485T3 (enExample)
HR (1) HRP20120549T1 (enExample)
IL (1) IL208988A (enExample)
MX (1) MX2010011916A (enExample)
MY (1) MY160357A (enExample)
NZ (1) NZ589690A (enExample)
PL (1) PL2280952T3 (enExample)
PT (1) PT2280952E (enExample)
SI (1) SI2280952T1 (enExample)
UA (1) UA103617C2 (enExample)
WO (1) WO2009135580A1 (enExample)
ZA (1) ZA201008722B (enExample)

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WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2552435A1 (en) 2010-04-02 2013-02-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions comprising ampk activator (metformin/troglitazone) for the treatment of myotonic dystrophy type 1 (dm1)
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
JP5990170B2 (ja) * 2010-09-01 2016-09-07 バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ 除草活性を有するケトスルタム類及びジケトピリジン類
KR101624020B1 (ko) * 2011-03-07 2016-05-24 글락소스미스클라인 엘엘씨 퀴놀리논 유도체
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
EP2760862B1 (en) 2011-09-27 2015-10-21 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP2679591A1 (en) 2012-06-29 2014-01-01 Poxel Thienopyridone derivatives useful as activators of AMPK
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk
US10143703B2 (en) 2014-01-02 2018-12-04 Massachusetts Eye And Ear Infirmary Treating ocular neovascularization
WO2015114663A1 (en) 2014-01-30 2015-08-06 Council Of Scientific & Industrial Research Novel thieno [2,3-d]pyrimidin-4(3h)-one compounds with antimycobacterial properties
EP3310355B1 (en) 2015-06-16 2020-11-11 University of Virginia Patent Foundation Ptp4a3 inhibitor for the treatment of cancer
PL3322711T3 (pl) 2015-06-25 2021-10-25 University Health Network Inhibitory hpk1 i sposoby ich zastosowania
EP3355876A2 (en) 2015-09-30 2018-08-08 Instituto de Medicina Molecular Methods for attenuating parasite virulence
US11584755B2 (en) 2017-09-26 2023-02-21 Ideaya Biosciences, Inc. Dihydrothieno[3,2-b]pyridine compounds
WO2019106087A1 (en) * 2017-11-29 2019-06-06 Syddansk Universitet Ampk inhibitors
JP2023526625A (ja) 2020-05-19 2023-06-22 キャリーオペ，インク． Ａｍｐｋアクチベーター
CN116390925A (zh) 2020-06-26 2023-07-04 卡尔优普公司 Ampk活化剂
EP4221700A1 (en) 2020-09-30 2023-08-09 Bioverativ Therapeutics Inc. Ampk activators and methods of use thereof
WO2022106892A1 (en) 2020-11-17 2022-05-27 Instituto De Medicina Molecular Anti-malarial compounds
US12404348B2 (en) 2021-11-19 2025-09-02 The Brigham And Women's Hospital, Inc. Bifunctional chimeric molecules for labeling of kinases with target binding moieties and methods of use thereof

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Also Published As

Publication number Publication date
IL208988A (en) 2016-02-29
CN102015676A (zh) 2011-04-13
KR20160038065A (ko) 2016-04-06
CN102015676B (zh) 2014-05-28
CO6331304A2 (es) 2011-10-20
AU2009243811A1 (en) 2009-11-12
NZ589690A (en) 2012-07-27
CY1113112T1 (el) 2016-04-13
EP2280952B1 (en) 2012-06-27
US20110060001A1 (en) 2011-03-10
CA2723429A1 (en) 2009-11-12
ECSP10010654A (es) 2011-01-31
CA2723429C (en) 2016-10-11
PL2280952T3 (pl) 2012-10-31
AU2009243811B2 (en) 2014-04-10
BRPI0910832A8 (pt) 2016-07-12
IL208988A0 (en) 2011-01-31
EP2280952A1 (en) 2011-02-09
MX2010011916A (es) 2010-11-26
EA201001733A1 (ru) 2011-06-30
ES2388485T3 (es) 2012-10-15
WO2009135580A1 (en) 2009-11-12
SI2280952T1 (sl) 2012-09-28
BRPI0910832B8 (pt) 2021-05-25
JP2011519876A (ja) 2011-07-14
MY160357A (en) 2017-02-28
JP5536757B2 (ja) 2014-07-02
EA020773B1 (ru) 2015-01-30
PT2280952E (pt) 2012-09-28
ZA201008722B (en) 2012-01-25
BRPI0910832B1 (pt) 2020-09-15
DK2280952T3 (da) 2012-07-23
BRPI0910832A2 (pt) 2015-08-11
UA103617C2 (ru) 2013-11-11
HK1156313A1 (en) 2012-06-08
HRP20120549T1 (hr) 2012-07-31
US8604202B2 (en) 2013-12-10
KR20110010757A (ko) 2011-02-07
AR071530A1 (es) 2010-06-23

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