KR101548414B1 - 퀴놀론 화합물 및 제약 조성물 - Google Patents

퀴놀론 화합물 및 제약 조성물 Download PDF

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KR101548414B1
KR101548414B1 KR1020127004414A KR20127004414A KR101548414B1 KR 101548414 B1 KR101548414 B1 KR 101548414B1 KR 1020127004414 A KR1020127004414 A KR 1020127004414A KR 20127004414 A KR20127004414 A KR 20127004414A KR 101548414 B1 KR101548414 B1 KR 101548414B1
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KR20120034806A (ko
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겐지 오쯔보
다까히또 야마우찌
유지 오찌
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오츠카 세이야쿠 가부시키가이샤
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
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    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI366565B (en) * 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
TWI492943B (zh) 2008-12-05 2015-07-21 大塚製藥股份有限公司 喹啉酮化合物及藥學組成物（二）
WO2010073078A2 (en) * 2008-12-22 2010-07-01 Orchid Research Laboratories Ltd. Heterocyclic compounds as hdac inhibitors
JP5769504B2 (ja) * 2010-06-04 2015-08-26 大塚製薬株式会社 医薬
RU2617512C1 (ru) * 2015-10-23 2017-04-25 Общество с ограниченной ответственностью "Нормофарм" Средство с антистрессовой, анксиолитической и антидепрессивной активностью и композиция на его основе
JP2019508400A (ja) * 2016-02-09 2019-03-28 ファーマケア，インク． キノリノンリシルオキシダーゼ様２阻害剤とその使用
CN106960913A (zh) * 2017-03-31 2017-07-18 武汉华星光电技术有限公司 量子点发光二极管显示面板及其制备方法
CN114209694A (zh) 2018-05-31 2022-03-22 华领医药技术（上海）有限公司 含有葡萄糖激酶激活剂和ppar受体激活剂的药物组合及其制备方法和用途
JP2023012557A (ja) * 2020-02-10 2023-01-26 大塚製薬株式会社 新規肝性脳症治療剤

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645983B1 (en) 1999-08-13 2003-11-11 Laboratoire L. Lafon Pharmaceutical compositions comprising 4-quinolones for treating cancers
EP1886996A1 (en) 2006-08-10 2008-02-13 Ferrer Internacional, S.A. 1H-Quinolin-4-one compounds, with affinity for the GABA receptor, processes, uses and compositions

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3416695A1 (de) 1984-05-05 1985-11-07 Bayer Ag, 5090 Leverkusen Amidinohydrazone von tetralin-, chromon-, thiochromon- und tretrahydrochinolin-derivaten, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
ATE56327T1 (de) * 1984-12-11 1990-09-15 Siemens Ag Anordnung zum ankoppeln von betaetigungsvorrichtungen an elektronische naeherungsschalter hierfuer.
IL100555A (en) * 1991-02-07 2000-08-31 Hoechst Marion Roussel Inc N-substituted quinoline derivatives their preparation their use for the preparation of medicaments and the pharmaceutical compositions containing them
MX9200299A (es) 1991-02-07 1992-12-01 Roussel Uclaf Nuevos derivados biciclicos nitrogenados, su procedimiento de preparacion los nuevos compuestos intermedios obtenidos su aplicacion como medicamentos y las composiciones farmaceuticas que los contienen.
DE69513689T2 (de) 1994-12-30 2000-05-25 Ligand Pharmaceuticals, Inc. Trizyclische retinoidverbindungen verfahren zu ihrer herstellung und verwendung
GB9621757D0 (en) 1996-10-18 1996-12-11 Ciba Geigy Ag Phenyl-substituted bicyclic heterocyclyl derivatives and their use
AU7165798A (en) 1997-04-28 1998-11-24 Anticancer, Inc. Use of genistein and related compounds to treat certain sex hormone related conditions
IT1296985B1 (it) 1997-12-19 1999-08-03 Zambon Spa Derivati benzazinici inibitori della fosfodiesterasi 4
WO2000042026A1 (en) 1999-01-15 2000-07-20 Novo Nordisk A/S Non-peptide glp-1 agonists
KR20010108509A (ko) 1999-04-16 2001-12-07 다비드 에 질레스 에스트로겐 수용체-β리간드
ATE289593T1 (de) 1999-05-06 2005-03-15 Neurogen Corp Substituierte 4-oxo-chinolin-3-carboxamide als gaba gehirnrezeptorliganden
AUPQ266199A0 (en) 1999-09-06 1999-09-30 Novogen Research Pty Ltd Compositions and therapeutic methods involving isoflavones and analogues thereof
FR2813791B1 (fr) 2000-09-14 2004-03-12 Lafon Labor Utilisation de 2- et 4-quinolones pour inhiber la neo-proliferation intimale
GB0023918D0 (en) 2000-09-29 2000-11-15 King S College London Antiparasitic compounds
WO2002030407A1 (en) 2000-10-13 2002-04-18 Astrazeneca Ab ESTROGEN RECEPTOR-β LIGANDS
WO2002074307A1 (en) 2001-03-16 2002-09-26 Novogen Research Pty Ltd Treatment of restenosis
AUPR846401A0 (en) 2001-10-25 2001-11-15 Novogen Research Pty Ltd 6-Hydroxy isoflavones, derivatives and medicaments involving same
AU2002950217A0 (en) 2002-07-16 2002-09-12 Prana Biotechnology Limited 8- Hydroxy Quinoline Derivatives
US20050080024A1 (en) 2002-08-15 2005-04-14 Joseph Tucker Nitric oxide donating derivatives for the treatment of cardiovascular disorders
US20040033480A1 (en) 2002-08-15 2004-02-19 Wong Norman C.W. Use of resveratrol to regulate expression of apolipoprotein A1
GB0222516D0 (en) 2002-09-27 2002-11-06 Karobio Ab Novel compounds
AU2004226876A1 (en) 2003-04-03 2004-10-14 Prana Biotechnology Ltd Treatment of neurological conditions
US7183413B2 (en) 2003-04-11 2007-02-27 Taigen Biotechnology Aminoquinoline compounds
US20060025337A1 (en) 2003-07-01 2006-02-02 President And Fellows Of Harvard College Sirtuin related therapeutics and diagnostics for neurodegenerative diseases
AU2004279644A1 (en) 2003-10-10 2005-04-21 Resverlogix Corp. Treatment of diseases associated with the egr-1 enhancer element
US20060167037A1 (en) 2003-11-19 2006-07-27 Kelly Graham E Combinational radiotherapy and chemotherapy compositions and methods
KR100636423B1 (ko) 2004-04-30 2006-10-19 한국화학연구원 신규한 퀴놀리논 유도체, 이의 제조방법 및 이를유효성분으로 하는 약학적 조성물
WO2006045096A2 (en) 2004-10-20 2006-04-27 Resverlogix Corp. Flavanoids and isoflavanoids for the prevention and treatment of cardiovascular diseases
TWI366565B (en) * 2007-06-06 2012-06-21 Otsuka Pharma Co Ltd Quinolone compound and pharmaceutical composition
WO2009053799A1 (en) 2007-10-24 2009-04-30 Glenmark Pharmaceuticals, S.A. Novel cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
TWI492943B (zh) 2008-12-05 2015-07-21 大塚製藥股份有限公司 喹啉酮化合物及藥學組成物（二）
CN102238951A (zh) 2008-12-05 2011-11-09 大塚制药株式会社 含有喹诺酮化合物的药剂

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645983B1 (en) 1999-08-13 2003-11-11 Laboratoire L. Lafon Pharmaceutical compositions comprising 4-quinolones for treating cancers
EP1886996A1 (en) 2006-08-10 2008-02-13 Ferrer Internacional, S.A. 1H-Quinolin-4-one compounds, with affinity for the GABA receptor, processes, uses and compositions

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Bioorganic & Medicinal Chemistry Letters. Vol. 18, pp. 4092-4094(2008.06.13. 온라인 공개)*

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