KR101521306B1 - 치유 부전 상처를 치유하는 조성물로서의 항-커넥신 폴리뉴클레오티드 - Google Patents

치유 부전 상처를 치유하는 조성물로서의 항-커넥신 폴리뉴클레오티드 Download PDF

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KR101521306B1
KR101521306B1 KR1020097014484A KR20097014484A KR101521306B1 KR 101521306 B1 KR101521306 B1 KR 101521306B1 KR 1020097014484 A KR1020097014484 A KR 1020097014484A KR 20097014484 A KR20097014484 A KR 20097014484A KR 101521306 B1 KR101521306 B1 KR 101521306B1
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connexin
composition
wound
polynucleotide
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KR20090118910A (ko
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데이비드 엘. 벡커
콜린 알. 그린
브래드포드 제이. 듀프트
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코다 테라퓨틱스, 인크.
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/35—Special therapeutic applications based on a specific dosage / administration regimen

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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
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  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020097014484A 2006-12-11 2007-12-11 치유 부전 상처를 치유하는 조성물로서의 항-커넥신 폴리뉴클레오티드 Expired - Fee Related KR101521306B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87440406P 2006-12-11 2006-12-11
US60/874,404 2006-12-11
PCT/US2007/025446 WO2008073479A2 (en) 2006-12-11 2007-12-11 Anticonnexin polynucleotides as impaired wound healing compositions

Publications (2)

Publication Number Publication Date
KR20090118910A KR20090118910A (ko) 2009-11-18
KR101521306B1 true KR101521306B1 (ko) 2015-05-18

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US (5) US8063023B2 (https=)
EP (3) EP2543377A1 (https=)
JP (3) JP5431949B2 (https=)
KR (1) KR101521306B1 (https=)
CN (2) CN101835476B (https=)
AU (1) AU2007333535B2 (https=)
BR (1) BRPI0721094A2 (https=)
CA (1) CA2672220A1 (https=)
DK (1) DK2101791T3 (https=)
ES (1) ES2527131T3 (https=)
PL (1) PL2101791T3 (https=)
PT (1) PT2101791E (https=)
RU (1) RU2521329C2 (https=)
SI (1) SI2101791T1 (https=)
WO (1) WO2008073479A2 (https=)

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KR102073629B1 (ko) 2005-02-03 2020-02-05 코다 테라퓨틱스 (엔지) 리미티드 항-코넥신 화합물 및 그의 용도
AU2007319811A1 (en) 2006-11-15 2008-05-22 Coda Therapeutics, Inc. Improved methods and compositions for wound healing
EP2543377A1 (en) 2006-12-11 2013-01-09 Coda Therapeutics, INC. Anticonnexin polynucleotides as impaired wound healing compositions
US20080249044A1 (en) * 2007-04-03 2008-10-09 Masaya Tanaka Nucleic acid external skin formulation
WO2009075881A2 (en) * 2007-12-11 2009-06-18 Coda Therapeutics, Inc. Impaired wound healing compositions and treatments
EP2245158A2 (en) * 2007-12-11 2010-11-03 Coda Therapeutics, Inc. Impaired wound healing compositions and treatments
US20110092449A1 (en) * 2007-12-21 2011-04-21 Bradford James Duft Treatment of fibrotic conditions
US8975237B2 (en) 2007-12-21 2015-03-10 Coda Therapeutics, Inc. Treatment of fibrotic conditions
CA2819810A1 (en) * 2010-12-06 2012-06-14 The University Of British Columbia Granzyme b inhibitor compositions, methods and uses for promoting wound healing
GB201117538D0 (en) * 2011-10-11 2011-11-23 Royal Veterinary College The Methods
DK2819682T3 (en) 2012-03-01 2017-08-21 Firststring Res Inc TOPICAL GELLS CONTAINING ALPHA-CONNEXIN C-TERMINAL (ACT) PEPTIDES
WO2013148736A1 (en) * 2012-03-27 2013-10-03 Coda Therapeutics, Inc. Compositions and treatments based on cadherin modulation
US9156896B2 (en) * 2013-03-15 2015-10-13 Coda Therapeutics, Inc. Wound healing compositions and treatments
EP3116996A4 (en) * 2014-03-14 2018-01-10 Ocunexus Therapeutics, Inc. Treatment of resistant lesions
CN107109410B (zh) 2014-08-22 2021-11-02 奥克兰联合服务有限公司 通道调节剂
US10450569B2 (en) * 2015-08-13 2019-10-22 Somagenics, Inc. Methods and compositions of short small hairpin RNAS and microRNAS for wound healing
EP3518847B1 (en) * 2016-09-27 2023-03-01 Smith & Nephew plc Wound closure devices with dissolvable portions
CA3061738A1 (en) 2017-04-28 2018-11-01 Auckland Uniservices Limited Methods of treatment and novel constructs
CN108588075A (zh) * 2018-05-03 2018-09-28 天德悦（北京）生物科技有限责任公司 人Cx43基因干扰序列、shRNA-Cx43病毒及低表达Cx43蛋白的细胞系
MX2023004631A (es) 2020-10-22 2023-07-20 Xequel Bio Inc Formulaciones peptidicas y usos oftalmicos de las mismas.
RU2754383C1 (ru) * 2020-12-07 2021-09-01 Федеральное Государственное Бюджетное Учреждение "Национальный Медицинский Исследовательский Центр Эндокринологии" Министерства Здравоохранения Российской Федерации (Фгбу "Нмиц Эндокринологии" Минздрава России) Способ лечения неинфицированного послеоперационного раневого дефекта стопы при отсутствии признаков критической ишемии конечности у больных с нейропатической и нейроишемической формой синдрома диабетической стопы

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JP2010512404A (ja) 2010-04-22
JP2015063565A (ja) 2015-04-09
KR20090118910A (ko) 2009-11-18
RU2521329C2 (ru) 2014-06-27
CN103520197B (zh) 2017-11-21
US20170240905A1 (en) 2017-08-24
AU2007333535B2 (en) 2014-04-17
DK2101791T3 (en) 2015-01-05
WO2008073479A2 (en) 2008-06-19
EP2543377A1 (en) 2013-01-09
EP2543378A1 (en) 2013-01-09
US9637745B2 (en) 2017-05-02
EP2101791B1 (en) 2014-09-10
RU2009126594A (ru) 2011-01-20
PL2101791T3 (pl) 2015-04-30
US20080242631A1 (en) 2008-10-02
CN101835476B (zh) 2016-08-17
CN103520197A (zh) 2014-01-22
JP2013173796A (ja) 2013-09-05
EP2101791A2 (en) 2009-09-23
ES2527131T3 (es) 2015-01-20
JP5911454B2 (ja) 2016-04-27
US8063023B2 (en) 2011-11-22
WO2008073479A3 (en) 2008-08-07
CA2672220A1 (en) 2008-06-19
HK1136213A1 (en) 2010-06-25
PT2101791E (pt) 2014-12-18
US20120289579A1 (en) 2012-11-15
JP5431949B2 (ja) 2014-03-05
US20130143952A1 (en) 2013-06-06
SI2101791T1 (sl) 2015-02-27
US8685940B2 (en) 2014-04-01
BRPI0721094A2 (pt) 2014-02-11
AU2007333535A1 (en) 2008-06-19
US9029339B2 (en) 2015-05-12
US20150315598A1 (en) 2015-11-05
CN101835476A (zh) 2010-09-15

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