KR101493530B1 - Ｎ-히드록시-3-［4-［［［2-(2-메틸-1ｈ-인돌-3-일)에틸］아미노］메틸］페닐］-2ｅ-2-프로펜아미드 및 이의 출발 물질의 제조 방법 - Google Patents

Ｎ-히드록시-3-［4-［［［2-(2-메틸-1ｈ-인돌-3-일)에틸］아미노］메틸］페닐］-2ｅ-2-프로펜아미드 및 이의 출발 물질의 제조 방법 Download PDF

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Publication number
KR101493530B1
KR101493530B1 KR20087030232A KR20087030232A KR101493530B1 KR 101493530 B1 KR101493530 B1 KR 101493530B1 KR 20087030232 A KR20087030232 A KR 20087030232A KR 20087030232 A KR20087030232 A KR 20087030232A KR 101493530 B1 KR101493530 B1 KR 101493530B1
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KR
South Korea
Prior art keywords
delete delete
methyl
sub
phenyl
mixture
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Expired - Fee Related
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KR20087030232A
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Korean (ko)
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KR20090015969A (ko
Inventor
무라트 아세모글루
조긴더 에스. 바즈와
데이비드 존 파커
조엘 슬레이드
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노파르티스 아게
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Application filed by 노파르티스 아게 filed Critical 노파르티스 아게
Publication of KR20090015969A publication Critical patent/KR20090015969A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR20087030232A 2006-06-12 2007-06-07 Ｎ-히드록시-3-［4-［［［2-(2-메틸-1ｈ-인돌-3-일)에틸］아미노］메틸］페닐］-2ｅ-2-프로펜아미드 및 이의 출발 물질의 제조 방법 Expired - Fee Related KR101493530B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US80452706P 2006-06-12 2006-06-12
US60/804,527 2006-06-12
US86787806P 2006-11-30 2006-11-30
US60/867,878 2006-11-30
PCT/US2007/070564 WO2007146718A2 (en) 2006-06-12 2007-06-07 Process for making n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino] methyl]phenyl]-2e-2-propenamide and starting materials therefor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020147026120A Division KR101540194B1 (ko) 2006-06-12 2007-06-07 Ｎ-히드록시-3-［4-［［［2-(2-메틸-1ｈ-인돌-3-일)에틸］아미노］메틸］페닐］-2ｅ-2-프로펜아미드 및 이의 출발 물질의 제조 방법

Publications (2)

Publication Number Publication Date
KR20090015969A KR20090015969A (ko) 2009-02-12
KR101493530B1 true KR101493530B1 (ko) 2015-02-13

Family

ID=38832681

Family Applications (2)

Application Number Title Priority Date Filing Date
KR20087030232A Expired - Fee Related KR101493530B1 (ko) 2006-06-12 2007-06-07 Ｎ-히드록시-3-［4-［［［2-(2-메틸-1ｈ-인돌-3-일)에틸］아미노］메틸］페닐］-2ｅ-2-프로펜아미드 및 이의 출발 물질의 제조 방법
KR1020147026120A Expired - Fee Related KR101540194B1 (ko) 2006-06-12 2007-06-07 Ｎ-히드록시-3-［4-［［［2-(2-메틸-1ｈ-인돌-3-일)에틸］아미노］메틸］페닐］-2ｅ-2-프로펜아미드 및 이의 출발 물질의 제조 방법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020147026120A Expired - Fee Related KR101540194B1 (ko) 2006-06-12 2007-06-07 Ｎ-히드록시-3-［4-［［［2-(2-메틸-1ｈ-인돌-3-일)에틸］아미노］메틸］페닐］-2ｅ-2-프로펜아미드 및 이의 출발 물질의 제조 방법

Country Status (31)

Country Link
US (2) US20090306405A1 (OSRAM)
EP (2) EP2394991B1 (OSRAM)
JP (2) JP5431926B2 (OSRAM)
KR (2) KR101493530B1 (OSRAM)
CN (4) CN101466674A (OSRAM)
AR (1) AR061296A1 (OSRAM)
AU (1) AU2007257883B2 (OSRAM)
BR (1) BRPI0712847A2 (OSRAM)
CA (1) CA2653657C (OSRAM)
CL (2) CL2007001691A1 (OSRAM)
DK (1) DK2032533T3 (OSRAM)
EC (1) ECSP088978A (OSRAM)
ES (2) ES2553255T3 (OSRAM)
GT (1) GT200800282A (OSRAM)
HR (1) HRP20130798T1 (OSRAM)
IL (2) IL195211A (OSRAM)
IN (1) IN2015DN00910A (OSRAM)
JO (1) JO2900B1 (OSRAM)
MA (1) MA30513B1 (OSRAM)
MX (2) MX2008015898A (OSRAM)
MY (1) MY147576A (OSRAM)
NO (1) NO341870B1 (OSRAM)
NZ (1) NZ572707A (OSRAM)
PE (2) PE20120221A1 (OSRAM)
PL (1) PL2032533T3 (OSRAM)
PT (1) PT2032533E (OSRAM)
RU (1) RU2448090C2 (OSRAM)
TN (1) TNSN08507A1 (OSRAM)
TW (1) TWI395734B (OSRAM)
WO (1) WO2007146718A2 (OSRAM)
ZA (1) ZA200809490B (OSRAM)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202000004075A1 (it) 2020-02-27 2021-08-27 Flamma Spa Processo per la preparazione di panobinostat

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002022577A2 (en) * 2000-09-01 2002-03-21 Novartis Ag Hydroxamate derivatives useful as deacetylase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB146260A (en) 1918-07-11 1921-08-11 Elektro Osmose Ag A process for preparing proteids charged with immune substances
GB8531612D0 (en) * 1985-12-23 1986-02-05 Beecham Wuelfing Gmbh & Co Kg Compounds
JP2004517334A (ja) 2001-01-09 2004-06-10 ノバルティス アクチエンゲゼルシャフト 化合物のインビボ活性をスクリーニングする迅速な方法
AU2002351844B2 (en) 2001-11-06 2006-12-21 Novartis Ag Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination
MY147013A (en) * 2006-06-12 2012-10-15 Novartis Ag Process for making salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002022577A2 (en) * 2000-09-01 2002-03-21 Novartis Ag Hydroxamate derivatives useful as deacetylase inhibitors

Also Published As

Publication number Publication date
EP2032533B1 (en) 2013-04-03
JP5431926B2 (ja) 2014-03-05
NO20090137L (no) 2009-03-03
IL195211A (en) 2014-08-31
JP5809223B2 (ja) 2015-11-10
KR20090015969A (ko) 2009-02-12
CL2010000973A1 (es) 2011-07-01
JO2900B1 (en) 2015-09-15
EP2394991A1 (en) 2011-12-14
AU2007257883B2 (en) 2011-09-29
TNSN08507A1 (en) 2010-04-14
IL233836A (en) 2017-05-29
MY147576A (en) 2012-12-31
BRPI0712847A2 (pt) 2012-08-07
NO341870B1 (no) 2018-02-12
JP2009540008A (ja) 2009-11-19
JP2014058532A (ja) 2014-04-03
CN101466674A (zh) 2009-06-24
EP2032533A2 (en) 2009-03-11
US8536346B2 (en) 2013-09-17
US20090306405A1 (en) 2009-12-10
NZ572707A (en) 2011-12-22
CA2653657C (en) 2015-10-27
PE20120221A1 (es) 2012-03-21
ECSP088978A (es) 2009-01-30
IL233836A0 (en) 2014-09-30
PL2032533T3 (pl) 2013-08-30
MX366213B (es) 2019-07-01
CN103086944A (zh) 2013-05-08
CA2653657A1 (en) 2007-12-21
AU2007257883A1 (en) 2007-12-21
PT2032533E (pt) 2013-06-28
EP2032533B8 (en) 2013-12-11
RU2448090C2 (ru) 2012-04-20
MA30513B1 (fr) 2009-06-01
EP2394991B1 (en) 2015-09-23
IN2015DN00910A (OSRAM) 2015-07-10
TWI395734B (zh) 2013-05-11
ZA200809490B (en) 2009-10-28
CL2007001691A1 (es) 2008-05-16
CN102174008A (zh) 2011-09-07
GT200800282A (es) 2009-03-09
HRP20130798T1 (en) 2013-09-30
US20120010418A1 (en) 2012-01-12
AR061296A1 (es) 2008-08-20
MX2008015898A (es) 2009-01-12
WO2007146718A2 (en) 2007-12-21
KR20140117703A (ko) 2014-10-07
WO2007146718A3 (en) 2008-06-19
KR101540194B1 (ko) 2015-07-28
CN102167678B (zh) 2013-08-28
ES2553255T3 (es) 2015-12-07
TW200815345A (en) 2008-04-01
HK1162029A1 (en) 2012-08-17
HK1126759A1 (en) 2009-09-11
RU2008151726A (ru) 2010-07-20
CN102167678A (zh) 2011-08-31
PE20080851A1 (es) 2008-08-18
DK2032533T3 (da) 2013-07-01
ES2416286T3 (es) 2013-07-31
IL195211A0 (en) 2009-08-03

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