TNSN08507A1 - Process for making n-hydroxy -3- [4-[[[2-(2-metyl -1h- indol -3- yl) ethyl] amino] methyl]phenyl] -2e -2- propenamide and starting materials therefor - Google Patents

Process for making n-hydroxy -3- [4-[[[2-(2-metyl -1h- indol -3- yl) ethyl] amino] methyl]phenyl] -2e -2- propenamide and starting materials therefor

Info

Publication number
TNSN08507A1
TNSN08507A1 TNP2008000507A TNSN08507A TNSN08507A1 TN SN08507 A1 TNSN08507 A1 TN SN08507A1 TN P2008000507 A TNP2008000507 A TN P2008000507A TN SN08507 A TNSN08507 A TN SN08507A TN SN08507 A1 TNSN08507 A1 TN SN08507A1
Authority
TN
Tunisia
Prior art keywords
methyl
propenamide
indol
hydroxy
phenyl
Prior art date
Application number
TNP2008000507A
Other languages
English (en)
Inventor
Joginder S Bajwa
Murat Acemoglu
David John Parker
Joel Slade
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38832681&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TNSN08507(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of TNSN08507A1 publication Critical patent/TNSN08507A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TNP2008000507A 2006-06-12 2008-12-05 Process for making n-hydroxy -3- [4-[[[2-(2-metyl -1h- indol -3- yl) ethyl] amino] methyl]phenyl] -2e -2- propenamide and starting materials therefor TNSN08507A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80452706P 2006-06-12 2006-06-12
US86787806P 2006-11-30 2006-11-30
PCT/US2007/070564 WO2007146718A2 (en) 2006-06-12 2007-06-07 Process for making n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino] methyl]phenyl]-2e-2-propenamide and starting materials therefor

Publications (1)

Publication Number Publication Date
TNSN08507A1 true TNSN08507A1 (en) 2010-04-14

Family

ID=38832681

Family Applications (1)

Application Number Title Priority Date Filing Date
TNP2008000507A TNSN08507A1 (en) 2006-06-12 2008-12-05 Process for making n-hydroxy -3- [4-[[[2-(2-metyl -1h- indol -3- yl) ethyl] amino] methyl]phenyl] -2e -2- propenamide and starting materials therefor

Country Status (31)

Country Link
US (2) US20090306405A1 (OSRAM)
EP (2) EP2394991B1 (OSRAM)
JP (2) JP5431926B2 (OSRAM)
KR (2) KR101493530B1 (OSRAM)
CN (4) CN101466674A (OSRAM)
AR (1) AR061296A1 (OSRAM)
AU (1) AU2007257883B2 (OSRAM)
BR (1) BRPI0712847A2 (OSRAM)
CA (1) CA2653657C (OSRAM)
CL (2) CL2007001691A1 (OSRAM)
DK (1) DK2032533T3 (OSRAM)
EC (1) ECSP088978A (OSRAM)
ES (2) ES2553255T3 (OSRAM)
GT (1) GT200800282A (OSRAM)
HR (1) HRP20130798T1 (OSRAM)
IL (2) IL195211A (OSRAM)
IN (1) IN2015DN00910A (OSRAM)
JO (1) JO2900B1 (OSRAM)
MA (1) MA30513B1 (OSRAM)
MX (2) MX2008015898A (OSRAM)
MY (1) MY147576A (OSRAM)
NO (1) NO341870B1 (OSRAM)
NZ (1) NZ572707A (OSRAM)
PE (2) PE20120221A1 (OSRAM)
PL (1) PL2032533T3 (OSRAM)
PT (1) PT2032533E (OSRAM)
RU (1) RU2448090C2 (OSRAM)
TN (1) TNSN08507A1 (OSRAM)
TW (1) TWI395734B (OSRAM)
WO (1) WO2007146718A2 (OSRAM)
ZA (1) ZA200809490B (OSRAM)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202000004075A1 (it) 2020-02-27 2021-08-27 Flamma Spa Processo per la preparazione di panobinostat

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB146260A (en) 1918-07-11 1921-08-11 Elektro Osmose Ag A process for preparing proteids charged with immune substances
GB8531612D0 (en) * 1985-12-23 1986-02-05 Beecham Wuelfing Gmbh & Co Kg Compounds
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
JP2004517334A (ja) 2001-01-09 2004-06-10 ノバルティス アクチエンゲゼルシャフト 化合物のインビボ活性をスクリーニングする迅速な方法
AU2002351844B2 (en) 2001-11-06 2006-12-21 Novartis Ag Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination
MY147013A (en) * 2006-06-12 2012-10-15 Novartis Ag Process for making salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide

Also Published As

Publication number Publication date
EP2032533B1 (en) 2013-04-03
JP5431926B2 (ja) 2014-03-05
NO20090137L (no) 2009-03-03
IL195211A (en) 2014-08-31
JP5809223B2 (ja) 2015-11-10
KR20090015969A (ko) 2009-02-12
CL2010000973A1 (es) 2011-07-01
JO2900B1 (en) 2015-09-15
EP2394991A1 (en) 2011-12-14
AU2007257883B2 (en) 2011-09-29
IL233836A (en) 2017-05-29
MY147576A (en) 2012-12-31
BRPI0712847A2 (pt) 2012-08-07
NO341870B1 (no) 2018-02-12
JP2009540008A (ja) 2009-11-19
JP2014058532A (ja) 2014-04-03
CN101466674A (zh) 2009-06-24
EP2032533A2 (en) 2009-03-11
US8536346B2 (en) 2013-09-17
US20090306405A1 (en) 2009-12-10
NZ572707A (en) 2011-12-22
CA2653657C (en) 2015-10-27
PE20120221A1 (es) 2012-03-21
ECSP088978A (es) 2009-01-30
KR101493530B1 (ko) 2015-02-13
IL233836A0 (en) 2014-09-30
PL2032533T3 (pl) 2013-08-30
MX366213B (es) 2019-07-01
CN103086944A (zh) 2013-05-08
CA2653657A1 (en) 2007-12-21
AU2007257883A1 (en) 2007-12-21
PT2032533E (pt) 2013-06-28
EP2032533B8 (en) 2013-12-11
RU2448090C2 (ru) 2012-04-20
MA30513B1 (fr) 2009-06-01
EP2394991B1 (en) 2015-09-23
IN2015DN00910A (OSRAM) 2015-07-10
TWI395734B (zh) 2013-05-11
ZA200809490B (en) 2009-10-28
CL2007001691A1 (es) 2008-05-16
CN102174008A (zh) 2011-09-07
GT200800282A (es) 2009-03-09
HRP20130798T1 (en) 2013-09-30
US20120010418A1 (en) 2012-01-12
AR061296A1 (es) 2008-08-20
MX2008015898A (es) 2009-01-12
WO2007146718A2 (en) 2007-12-21
KR20140117703A (ko) 2014-10-07
WO2007146718A3 (en) 2008-06-19
KR101540194B1 (ko) 2015-07-28
CN102167678B (zh) 2013-08-28
ES2553255T3 (es) 2015-12-07
TW200815345A (en) 2008-04-01
HK1162029A1 (en) 2012-08-17
HK1126759A1 (en) 2009-09-11
RU2008151726A (ru) 2010-07-20
CN102167678A (zh) 2011-08-31
PE20080851A1 (es) 2008-08-18
DK2032533T3 (da) 2013-07-01
ES2416286T3 (es) 2013-07-31
IL195211A0 (en) 2009-08-03

Similar Documents

Publication Publication Date Title
TNSN08501A1 (en) Salts of n-hydroxy-3-[4-[[[2-(2- methyl-ih-indol-3-yl) ethyl ]amino]methyl ]phenyl ]-2e-2-propenamide
TNSN08508A1 (en) PROCESS FOR MAKING SALTS OF N-HYDROXY -3- [4-[[[2- (2- METHYL -lH¬INDOL -3- YL) ETHYL] AMINO] METHYL] PHENYL] -2E -2 -PROPENAMIDE
MY149337A (en) Polymorphs of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
UA95289C2 (en) Salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
TNSN08507A1 (en) Process for making n-hydroxy -3- [4-[[[2-(2-metyl -1h- indol -3- yl) ethyl] amino] methyl]phenyl] -2e -2- propenamide and starting materials therefor
UA97243C2 (en) Crystalline anhydrous form of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
CY1114470T1 (el) Διαδικασια για την παρασκευη ν- υδροξυ-3-ý4-ýýý2-(2-μεθυλο-1η-ινδολ-3- υλ) αιθυλο ¨αμινο¨ μεθυλο ¨φαινυλο¨-2ε-2- προπεναμιδιου και τα υλικα εναρξης αυτων
HK1132509A (en) Polymorphs of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide
CY1117493T1 (el) Αλατα του ν-υδροξυ-3-[4-[[[2-(2-μεθυλ-1η-ινδολ-3-υλ)αιθυλ]αμινο]μεθυλο]φαινυλο]-2ε-2-προπεναμιδιου
DOP2008000069A (es) Sales de n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]amino]metil]]fenil]-2e-2-propenamida.