CL2007001691A1 - Metodo para hacer n-hidroxi-3-(4(((2-(2-metil-1h-indol-3-il)etil)amino)metil)fenil)-2e-2-propenamida. - Google Patents
Metodo para hacer n-hidroxi-3-(4(((2-(2-metil-1h-indol-3-il)etil)amino)metil)fenil)-2e-2-propenamida.Info
- Publication number
- CL2007001691A1 CL2007001691A1 CL200701691A CL2007001691A CL2007001691A1 CL 2007001691 A1 CL2007001691 A1 CL 2007001691A1 CL 200701691 A CL200701691 A CL 200701691A CL 2007001691 A CL2007001691 A CL 2007001691A CL 2007001691 A1 CL2007001691 A1 CL 2007001691A1
- Authority
- CL
- Chile
- Prior art keywords
- methyl
- hydroxi
- propenamide
- indol
- phenyl
- Prior art date
Links
- -1 AMINO Chemical class 0.000 title 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 title 1
- 125000001495 ethyl group Chemical class [H]C([H])([H])C([H])([H])* 0.000 title 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/14—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Indole Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80452706P | 2006-06-12 | 2006-06-12 | |
| US86787806P | 2006-11-30 | 2006-11-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2007001691A1 true CL2007001691A1 (es) | 2008-05-16 |
Family
ID=38832681
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL200701691A CL2007001691A1 (es) | 2006-06-12 | 2007-06-11 | Metodo para hacer n-hidroxi-3-(4(((2-(2-metil-1h-indol-3-il)etil)amino)metil)fenil)-2e-2-propenamida. |
| CL2010000973A CL2010000973A1 (es) | 2006-06-12 | 2010-09-13 | Procedimiento de preparacion de la sal de clorhidrato de ester metilico del acido (e)-3-(4-{[2-(2-metil-1h-indol-3-il)etilamino]metil}fenil)-acrilico por combinacion de 2-metiltriptamina y el ester metilico del acido (e)-3-(4-formil-fenil)-acrilico, y posterior reduccion de la imina formada ( divisional de la sol. n° 1691-2007). |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2010000973A CL2010000973A1 (es) | 2006-06-12 | 2010-09-13 | Procedimiento de preparacion de la sal de clorhidrato de ester metilico del acido (e)-3-(4-{[2-(2-metil-1h-indol-3-il)etilamino]metil}fenil)-acrilico por combinacion de 2-metiltriptamina y el ester metilico del acido (e)-3-(4-formil-fenil)-acrilico, y posterior reduccion de la imina formada ( divisional de la sol. n° 1691-2007). |
Country Status (31)
| Country | Link |
|---|---|
| US (2) | US20090306405A1 (OSRAM) |
| EP (2) | EP2394991B1 (OSRAM) |
| JP (2) | JP5431926B2 (OSRAM) |
| KR (2) | KR101493530B1 (OSRAM) |
| CN (4) | CN101466674A (OSRAM) |
| AR (1) | AR061296A1 (OSRAM) |
| AU (1) | AU2007257883B2 (OSRAM) |
| BR (1) | BRPI0712847A2 (OSRAM) |
| CA (1) | CA2653657C (OSRAM) |
| CL (2) | CL2007001691A1 (OSRAM) |
| DK (1) | DK2032533T3 (OSRAM) |
| EC (1) | ECSP088978A (OSRAM) |
| ES (2) | ES2553255T3 (OSRAM) |
| GT (1) | GT200800282A (OSRAM) |
| HR (1) | HRP20130798T1 (OSRAM) |
| IL (2) | IL195211A (OSRAM) |
| IN (1) | IN2015DN00910A (OSRAM) |
| JO (1) | JO2900B1 (OSRAM) |
| MA (1) | MA30513B1 (OSRAM) |
| MX (2) | MX2008015898A (OSRAM) |
| MY (1) | MY147576A (OSRAM) |
| NO (1) | NO341870B1 (OSRAM) |
| NZ (1) | NZ572707A (OSRAM) |
| PE (2) | PE20120221A1 (OSRAM) |
| PL (1) | PL2032533T3 (OSRAM) |
| PT (1) | PT2032533E (OSRAM) |
| RU (1) | RU2448090C2 (OSRAM) |
| TN (1) | TNSN08507A1 (OSRAM) |
| TW (1) | TWI395734B (OSRAM) |
| WO (1) | WO2007146718A2 (OSRAM) |
| ZA (1) | ZA200809490B (OSRAM) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT202000004075A1 (it) | 2020-02-27 | 2021-08-27 | Flamma Spa | Processo per la preparazione di panobinostat |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB146260A (en) | 1918-07-11 | 1921-08-11 | Elektro Osmose Ag | A process for preparing proteids charged with immune substances |
| GB8531612D0 (en) * | 1985-12-23 | 1986-02-05 | Beecham Wuelfing Gmbh & Co Kg | Compounds |
| PE20020354A1 (es) * | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| JP2004517334A (ja) | 2001-01-09 | 2004-06-10 | ノバルティス アクチエンゲゼルシャフト | 化合物のインビボ活性をスクリーニングする迅速な方法 |
| AU2002351844B2 (en) | 2001-11-06 | 2006-12-21 | Novartis Ag | Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination |
| MY147013A (en) * | 2006-06-12 | 2012-10-15 | Novartis Ag | Process for making salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide |
-
2007
- 2007-06-07 IN IN910DEN2015 patent/IN2015DN00910A/en unknown
- 2007-06-07 CA CA2653657A patent/CA2653657C/en active Active
- 2007-06-07 EP EP11179043.2A patent/EP2394991B1/en active Active
- 2007-06-07 ES ES11179043.2T patent/ES2553255T3/es active Active
- 2007-06-07 KR KR20087030232A patent/KR101493530B1/ko not_active Expired - Fee Related
- 2007-06-07 PL PL07784350T patent/PL2032533T3/pl unknown
- 2007-06-07 NZ NZ572707A patent/NZ572707A/en not_active IP Right Cessation
- 2007-06-07 BR BRPI0712847-9A patent/BRPI0712847A2/pt not_active IP Right Cessation
- 2007-06-07 WO PCT/US2007/070564 patent/WO2007146718A2/en not_active Ceased
- 2007-06-07 ES ES07784350T patent/ES2416286T3/es active Active
- 2007-06-07 MX MX2008015898A patent/MX2008015898A/es active IP Right Grant
- 2007-06-07 CN CNA2007800217257A patent/CN101466674A/zh active Pending
- 2007-06-07 EP EP07784350.6A patent/EP2032533B8/en active Active
- 2007-06-07 CN CN2012103501544A patent/CN103086944A/zh active Pending
- 2007-06-07 AU AU2007257883A patent/AU2007257883B2/en not_active Ceased
- 2007-06-07 KR KR1020147026120A patent/KR101540194B1/ko not_active Expired - Fee Related
- 2007-06-07 CN CN2011100630820A patent/CN102174008A/zh active Pending
- 2007-06-07 DK DK07784350.6T patent/DK2032533T3/da active
- 2007-06-07 CN CN2011100629486A patent/CN102167678B/zh active Active
- 2007-06-07 MX MX2012002221A patent/MX366213B/es unknown
- 2007-06-07 US US12/302,572 patent/US20090306405A1/en not_active Abandoned
- 2007-06-07 RU RU2008151726/04A patent/RU2448090C2/ru active
- 2007-06-07 PT PT77843506T patent/PT2032533E/pt unknown
- 2007-06-07 HR HRP20130798TT patent/HRP20130798T1/hr unknown
- 2007-06-07 JP JP2009515575A patent/JP5431926B2/ja active Active
- 2007-06-08 PE PE2011002097A patent/PE20120221A1/es active IP Right Grant
- 2007-06-08 AR ARP070102498A patent/AR061296A1/es unknown
- 2007-06-08 PE PE2007000720A patent/PE20080851A1/es active IP Right Grant
- 2007-06-11 CL CL200701691A patent/CL2007001691A1/es unknown
- 2007-06-11 TW TW096120985A patent/TWI395734B/zh not_active IP Right Cessation
- 2007-06-12 JO JO2007219A patent/JO2900B1/en active
-
2008
- 2008-11-06 ZA ZA200809490A patent/ZA200809490B/xx unknown
- 2008-11-10 IL IL195211A patent/IL195211A/en active IP Right Grant
- 2008-11-28 MY MYPI20084865A patent/MY147576A/en unknown
- 2008-12-05 TN TNP2008000507A patent/TNSN08507A1/en unknown
- 2008-12-10 GT GT200800282A patent/GT200800282A/es unknown
- 2008-12-12 EC EC2008008978A patent/ECSP088978A/es unknown
- 2008-12-12 MA MA31472A patent/MA30513B1/fr unknown
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2009
- 2009-01-09 NO NO20090137A patent/NO341870B1/no not_active IP Right Cessation
-
2010
- 2010-09-13 CL CL2010000973A patent/CL2010000973A1/es unknown
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2011
- 2011-09-23 US US13/243,001 patent/US8536346B2/en active Active
-
2013
- 2013-10-25 JP JP2013222442A patent/JP5809223B2/ja active Active
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2014
- 2014-07-28 IL IL233836A patent/IL233836A/en active IP Right Grant
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