JP5431926B2 - Ｎ−ヒドロキシ−３−［４−［［［２−（２−メチル−１ｈ−インドール−３−イル）エチル］アミノ］メチル］フェニル］−２ｅ−２−プロペンアミドの製造方法およびその出発物質 - Google Patents

Ｎ−ヒドロキシ−３−［４−［［［２−（２−メチル−１ｈ−インドール−３−イル）エチル］アミノ］メチル］フェニル］−２ｅ−２−プロペンアミドの製造方法およびその出発物質 Download PDF

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JP5431926B2
JP5431926B2 JP2009515575A JP2009515575A JP5431926B2 JP 5431926 B2 JP5431926 B2 JP 5431926B2 JP 2009515575 A JP2009515575 A JP 2009515575A JP 2009515575 A JP2009515575 A JP 2009515575A JP 5431926 B2 JP5431926 B2 JP 5431926B2
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methyl
phenyl
indol
hydroxy
temperature
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JP2009540008A (ja
JP2009540008A5 (OSRAM
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ムラト・アシモグル
ジョギンダー・エス・バジワ
デイビッド・ジョン・パーカー
ジョエル・スレイド
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ノバルティス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2009515575A 2006-06-12 2007-06-07 Ｎ−ヒドロキシ−３−［４−［［［２−（２−メチル−１ｈ−インドール−３−イル）エチル］アミノ］メチル］フェニル］−２ｅ−２−プロペンアミドの製造方法およびその出発物質 Active JP5431926B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US80452706P 2006-06-12 2006-06-12
US60/804,527 2006-06-12
US86787806P 2006-11-30 2006-11-30
US60/867,878 2006-11-30
PCT/US2007/070564 WO2007146718A2 (en) 2006-06-12 2007-06-07 Process for making n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino] methyl]phenyl]-2e-2-propenamide and starting materials therefor

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2013222442A Division JP5809223B2 (ja) 2006-06-12 2013-10-25 Ｎ−ヒドロキシ−３−［４−［［［２−（２−メチル−１ｈ−インドール−３−イル）エチル］アミノ］メチル］フェニル］−２ｅ−２−プロペンアミドの製造方法およびその出発物質

Publications (3)

Publication Number Publication Date
JP2009540008A JP2009540008A (ja) 2009-11-19
JP2009540008A5 JP2009540008A5 (OSRAM) 2010-07-15
JP5431926B2 true JP5431926B2 (ja) 2014-03-05

Family

ID=38832681

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009515575A Active JP5431926B2 (ja) 2006-06-12 2007-06-07 Ｎ−ヒドロキシ−３−［４−［［［２−（２−メチル−１ｈ−インドール−３−イル）エチル］アミノ］メチル］フェニル］−２ｅ−２−プロペンアミドの製造方法およびその出発物質
JP2013222442A Active JP5809223B2 (ja) 2006-06-12 2013-10-25 Ｎ−ヒドロキシ−３−［４−［［［２−（２−メチル−１ｈ−インドール−３−イル）エチル］アミノ］メチル］フェニル］−２ｅ−２−プロペンアミドの製造方法およびその出発物質

Family Applications After (1)

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JP2013222442A Active JP5809223B2 (ja) 2006-06-12 2013-10-25 Ｎ−ヒドロキシ−３−［４−［［［２−（２−メチル−１ｈ−インドール−３−イル）エチル］アミノ］メチル］フェニル］−２ｅ−２−プロペンアミドの製造方法およびその出発物質

Country Status (31)

Country Link
US (2) US20090306405A1 (OSRAM)
EP (2) EP2394991B1 (OSRAM)
JP (2) JP5431926B2 (OSRAM)
KR (2) KR101493530B1 (OSRAM)
CN (4) CN101466674A (OSRAM)
AR (1) AR061296A1 (OSRAM)
AU (1) AU2007257883B2 (OSRAM)
BR (1) BRPI0712847A2 (OSRAM)
CA (1) CA2653657C (OSRAM)
CL (2) CL2007001691A1 (OSRAM)
DK (1) DK2032533T3 (OSRAM)
EC (1) ECSP088978A (OSRAM)
ES (2) ES2553255T3 (OSRAM)
GT (1) GT200800282A (OSRAM)
HR (1) HRP20130798T1 (OSRAM)
IL (2) IL195211A (OSRAM)
IN (1) IN2015DN00910A (OSRAM)
JO (1) JO2900B1 (OSRAM)
MA (1) MA30513B1 (OSRAM)
MX (2) MX2008015898A (OSRAM)
MY (1) MY147576A (OSRAM)
NO (1) NO341870B1 (OSRAM)
NZ (1) NZ572707A (OSRAM)
PE (2) PE20120221A1 (OSRAM)
PL (1) PL2032533T3 (OSRAM)
PT (1) PT2032533E (OSRAM)
RU (1) RU2448090C2 (OSRAM)
TN (1) TNSN08507A1 (OSRAM)
TW (1) TWI395734B (OSRAM)
WO (1) WO2007146718A2 (OSRAM)
ZA (1) ZA200809490B (OSRAM)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT202000004075A1 (it) 2020-02-27 2021-08-27 Flamma Spa Processo per la preparazione di panobinostat

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB146260A (en) 1918-07-11 1921-08-11 Elektro Osmose Ag A process for preparing proteids charged with immune substances
GB8531612D0 (en) * 1985-12-23 1986-02-05 Beecham Wuelfing Gmbh & Co Kg Compounds
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
JP2004517334A (ja) 2001-01-09 2004-06-10 ノバルティス アクチエンゲゼルシャフト 化合物のインビボ活性をスクリーニングする迅速な方法
AU2002351844B2 (en) 2001-11-06 2006-12-21 Novartis Ag Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination
MY147013A (en) * 2006-06-12 2012-10-15 Novartis Ag Process for making salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide

Also Published As

Publication number Publication date
EP2032533B1 (en) 2013-04-03
NO20090137L (no) 2009-03-03
IL195211A (en) 2014-08-31
JP5809223B2 (ja) 2015-11-10
KR20090015969A (ko) 2009-02-12
CL2010000973A1 (es) 2011-07-01
JO2900B1 (en) 2015-09-15
EP2394991A1 (en) 2011-12-14
AU2007257883B2 (en) 2011-09-29
TNSN08507A1 (en) 2010-04-14
IL233836A (en) 2017-05-29
MY147576A (en) 2012-12-31
BRPI0712847A2 (pt) 2012-08-07
NO341870B1 (no) 2018-02-12
JP2009540008A (ja) 2009-11-19
JP2014058532A (ja) 2014-04-03
CN101466674A (zh) 2009-06-24
EP2032533A2 (en) 2009-03-11
US8536346B2 (en) 2013-09-17
US20090306405A1 (en) 2009-12-10
NZ572707A (en) 2011-12-22
CA2653657C (en) 2015-10-27
PE20120221A1 (es) 2012-03-21
ECSP088978A (es) 2009-01-30
KR101493530B1 (ko) 2015-02-13
IL233836A0 (en) 2014-09-30
PL2032533T3 (pl) 2013-08-30
MX366213B (es) 2019-07-01
CN103086944A (zh) 2013-05-08
CA2653657A1 (en) 2007-12-21
AU2007257883A1 (en) 2007-12-21
PT2032533E (pt) 2013-06-28
EP2032533B8 (en) 2013-12-11
RU2448090C2 (ru) 2012-04-20
MA30513B1 (fr) 2009-06-01
EP2394991B1 (en) 2015-09-23
IN2015DN00910A (OSRAM) 2015-07-10
TWI395734B (zh) 2013-05-11
ZA200809490B (en) 2009-10-28
CL2007001691A1 (es) 2008-05-16
CN102174008A (zh) 2011-09-07
GT200800282A (es) 2009-03-09
HRP20130798T1 (en) 2013-09-30
US20120010418A1 (en) 2012-01-12
AR061296A1 (es) 2008-08-20
MX2008015898A (es) 2009-01-12
WO2007146718A2 (en) 2007-12-21
KR20140117703A (ko) 2014-10-07
WO2007146718A3 (en) 2008-06-19
KR101540194B1 (ko) 2015-07-28
CN102167678B (zh) 2013-08-28
ES2553255T3 (es) 2015-12-07
TW200815345A (en) 2008-04-01
HK1162029A1 (en) 2012-08-17
HK1126759A1 (en) 2009-09-11
RU2008151726A (ru) 2010-07-20
CN102167678A (zh) 2011-08-31
PE20080851A1 (es) 2008-08-18
DK2032533T3 (da) 2013-07-01
ES2416286T3 (es) 2013-07-31
IL195211A0 (en) 2009-08-03

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