KR101490836B1 - 외상 치료법 - Google Patents

외상 치료법 Download PDF

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Publication number
KR101490836B1
KR101490836B1 KR1020097003827A KR20097003827A KR101490836B1 KR 101490836 B1 KR101490836 B1 KR 101490836B1 KR 1020097003827 A KR1020097003827 A KR 1020097003827A KR 20097003827 A KR20097003827 A KR 20097003827A KR 101490836 B1 KR101490836 B1 KR 101490836B1
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KR
South Korea
Prior art keywords
composition
adenosine
heart
lignocaine
blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020097003827A
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English (en)
Korean (ko)
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KR20090047489A (ko
Inventor
제프리 필립 돕슨
Original Assignee
하이버네이션 테라퓨틱스, 어 케이에프 엘엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Priority claimed from AU2006904007A external-priority patent/AU2006904007A0/en
Application filed by 하이버네이션 테라퓨틱스, 어 케이에프 엘엘씨 filed Critical 하이버네이션 테라퓨틱스, 어 케이에프 엘엘씨
Publication of KR20090047489A publication Critical patent/KR20090047489A/ko
Application granted granted Critical
Publication of KR101490836B1 publication Critical patent/KR101490836B1/ko
Expired - Fee Related legal-status Critical Current
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A61P23/02—Local anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Pain & Pain Management (AREA)
  • Inorganic Chemistry (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Anesthesiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Medicinal Preparation (AREA)
KR1020097003827A 2006-07-25 2007-07-25 외상 치료법 Expired - Fee Related KR101490836B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
AU2006904007A AU2006904007A0 (en) 2006-07-25 Trauma Therapy
AU2006904007 2006-07-25
AU2007900283A AU2007900283A0 (en) 2007-01-19 Trauma therapy (II)
AU2007900283 2007-01-19
PCT/AU2007/001029 WO2008011670A1 (en) 2006-07-25 2007-07-25 Trauma therapy

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR20147023077A Division KR20140108346A (ko) 2006-07-25 2007-07-25 외상 치료법

Publications (2)

Publication Number Publication Date
KR20090047489A KR20090047489A (ko) 2009-05-12
KR101490836B1 true KR101490836B1 (ko) 2015-02-09

Family

ID=38981058

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020097003827A Expired - Fee Related KR101490836B1 (ko) 2006-07-25 2007-07-25 외상 치료법
KR20147023077A Ceased KR20140108346A (ko) 2006-07-25 2007-07-25 외상 치료법

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR20147023077A Ceased KR20140108346A (ko) 2006-07-25 2007-07-25 외상 치료법

Country Status (12)

Country Link
US (3) US20090324748A1 (https=)
EP (1) EP2139316B1 (https=)
JP (2) JP2009544628A (https=)
KR (2) KR101490836B1 (https=)
CN (2) CN101516185A (https=)
AU (1) AU2007278754B2 (https=)
CA (1) CA2692256C (https=)
ES (1) ES2539762T3 (https=)
IL (1) IL196702A0 (https=)
SG (1) SG173404A1 (https=)
WO (1) WO2008011670A1 (https=)
ZA (1) ZA200901376B (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ514515A (en) 1999-03-23 2003-11-28 Global Cardiac Solutions Pty L Organ arrest, protection and preservation using a potassium channel operator and/or adenosine receptor and a local anaesthetic
AU2006345361B2 (en) 2006-05-29 2014-04-10 Hibernation Therapeutics, A Kf Llc Improved tissue maintenance
CA2692256C (en) 2006-07-25 2017-01-10 Hibernation Therapeutics Limited Trauma therapy
WO2008070741A1 (en) * 2006-12-06 2008-06-12 Ikaria, Inc. Compositions and methods for enhancing survival and reducing injury under ischemic or hypoxic conditions
US7717855B2 (en) 2006-12-06 2010-05-18 The Hospital For Sick Children System for performing remote ischemic preconditioning
EP2173353B1 (en) 2007-03-02 2015-05-06 Hibernation Therapeutics, a KF LLC Composition including Adenosine and Lignocaine
US7754247B2 (en) 2007-05-29 2010-07-13 University Of South Carolina Resuscitation fluid
SG185322A1 (en) * 2007-07-25 2012-11-29 Hibernation Therapeutics Ltd Improved organ protection, preservation and recovery
US20110318431A1 (en) * 2008-12-30 2011-12-29 Endogenx Pharmaceutical Compositions and Methods of Treating Neurological Insults
AU2010248156B2 (en) * 2009-05-13 2015-01-22 CellAegis Devices Inc. Performance enhancement
TW201201764A (en) * 2010-02-01 2012-01-16 Hospital For Sick Children Remote ischemic conditioning for treatment and prevention of restenosis
KR20130040851A (ko) 2010-03-31 2013-04-24 더 호스피탈 포 식 칠드런 심근 경색 후 결과를 개선시키기 위한 원격 허혈 처치의 사용
KR20130040878A (ko) 2010-04-08 2013-04-24 더 호스피탈 포 식 칠드런 외상성 손상을 위한 원격 허혈 처치의 사용
US8764789B2 (en) 2011-04-15 2014-07-01 CellAegis Devices Inc. System for performing remote ischemic conditioning
USD708338S1 (en) 2012-08-15 2014-07-01 CellAegis Devices Inc. Cuff for remote ischemic conditioning
CA2904504A1 (en) 2013-03-15 2014-09-18 The Hospital For Sick Children Treatment of erectile dysfunction using remote ischemic conditioning
JP2016512709A (ja) 2013-03-15 2016-05-09 ザ・ホスピタル・フォー・シック・チルドレンＴｈｅ Ｈｏｓｐｉｔａｌ Ｆｏｒ Ｓｉｃｋ Ｃｈｉｌｄｒｅｎ 遠隔虚血コンディショニングを用いてオートファジをモジュレートする方法
AU2013203746B2 (en) 2013-03-15 2015-05-07 Cellaegis Devices, Inc. Gas Powered System for Performing Remote Ischemic Conditioning
WO2014199239A2 (en) 2013-03-15 2014-12-18 The Hospital For Sick Children Methods relating to the use of remote ischemic conditioning
BR112016000809A2 (pt) * 2013-07-17 2017-08-22 Hibernation Therapeuitics A Kf Llc Método para tratar infecção, sepsia e lesão
US10517892B2 (en) * 2013-10-22 2019-12-31 Medtronic Minimed, Inc. Methods and systems for inhibiting foreign-body responses in diabetic patients
US20150148739A1 (en) * 2013-11-27 2015-05-28 April Marie Radicella Simplified Microplegia Delivery System
US11974568B2 (en) 2020-03-20 2024-05-07 The Cleveland Clinic Foundation Portable, ex vivo, normothermic limb perfusion machine
US12419850B1 (en) 2024-03-21 2025-09-23 GanD, Inc. Bioactive fluid compositions

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020001797A (ko) * 1999-03-23 2002-01-09 제임스 쿡 유니버시티 신체 기관의 정지, 보호 및 보존

Family Cites Families (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU878297A1 (ru) 1978-05-03 1981-11-07 Научно-Исследовательский Институт Трансплантологии И Искусственных Органов Состав дл сохранени жизнеспособности оперируемого сердца
US4798824A (en) * 1985-10-03 1989-01-17 Wisconsin Alumni Research Foundation Perfusate for the preservation of organs
US5006512A (en) 1987-10-02 1991-04-09 Tsuyoshi Ohnishi Therapeutic usages of inhibitors for a potassium efflux channel
US5256770A (en) * 1990-04-09 1993-10-26 Schering Ag Oxidation resistant thrombomodulin analogs
DE3926287A1 (de) 1989-08-09 1991-02-21 Bernhard Clasbrummel Medizinische anwendung von omega-conotoxin gvia oder omega-conotoxin gvia-analoga zur sympathikolyse
US5145771A (en) * 1990-04-12 1992-09-08 The University Of North Carolina At Chapel Hill Rinse solution for organs and tissues
US5206222A (en) * 1991-05-22 1993-04-27 Vanderbilt University Methods for the reduction of myocardial reperfusion injury
CN1057192A (zh) 1991-06-30 1991-12-25 汪庆富 风油精聚胺酯海绵的制备工艺
US5407793A (en) * 1991-10-18 1995-04-18 University Of Pittsburgh Of The Commonwealth System Of Higher Education An aqueous heart preservation and cardioplegia solution
RU2025973C1 (ru) * 1992-02-10 1995-01-09 Научно-производственное предприятие "Биофарм" Раствор для консервации живых органов
US5370989A (en) * 1992-04-03 1994-12-06 The Trustees Of Columbia University In The City Of New York Solution for prolonged organ preservation
US5405742A (en) * 1993-07-16 1995-04-11 Cyromedical Sciences, Inc. Solutions for tissue preservation and bloodless surgery and methods using same
US5679706A (en) * 1994-09-30 1997-10-21 Bristol-Myers Squibb Company Combination of a potassium channel activator and an antiarrhythmic agent
US5554497A (en) * 1994-12-12 1996-09-10 Charlotte-Mecklenburg Hospital Authority Cardioplegic solution for arresting an organ
US5656420A (en) * 1995-02-24 1997-08-12 University Of Kentucky Research Foundation Method for employing the delta opioid dadle to extend tissue survival time during ischemia
JP3875295B2 (ja) 1995-11-30 2007-01-31 功 竹内 心筋保護液
EP1006798A4 (en) * 1996-09-05 2003-03-05 Massachusetts Inst Technology COMPOSITIONS AND METHODS FOR TREATING NEUROLOGICAL DISORDERS AND NEURODEGENERATIVE DISEASES
IT1297886B1 (it) 1997-02-28 1999-12-20 Carmine Antropoli Nifedipina per uso topico
EP1014995A4 (en) * 1997-06-18 2005-02-16 Aderis Pharmaceuticals Inc COMPOSITIONS AND METHODS FOR PREVENTING RESTENOSES CONSECUTIVE TO REVASCULARIZATION INTERVENTIONS
CN1057192C (zh) 1997-09-10 2000-10-11 上海长征医院 一种配制多器官保存液的方法
US6011017A (en) * 1998-04-15 2000-01-04 Cypros Pharmaceutical Corp. Method of reducing pulmonary hypertension and atrial fibrillation after surgery using cardiopulmonary bypass
KR100762018B1 (ko) 1998-07-16 2007-10-04 메모리얼 슬로안-케터링 캔서 센터 오피오이드 진통제 및 엔엠디에이 길항제를 함유하는 국소조성물
KR100269540B1 (ko) * 1998-08-28 2000-10-16 윤종용 웨이퍼 상태에서의 칩 스케일 패키지 제조 방법
KR100683603B1 (ko) * 1998-10-23 2007-02-20 폴리힐 엘티디. 창상 치유용 미소구 조성물
US6358208B1 (en) * 1998-11-21 2002-03-19 Philipp Lang Assessment of cardiovascular performance using ultrasound methods and devices that interrogate interstitial fluid
US6586413B2 (en) * 1999-11-05 2003-07-01 The United States Of America As Represented By The Department Of Health And Human Services Methods and compositions for reducing ischemic injury of the heart by administering adenosine receptor agonists and antagonists
WO2001054679A2 (en) 2000-01-27 2001-08-02 Children's Hospital Research Foundation Transdermal composition containing an anesthetic and a vasodilator agent
JP2001261575A (ja) 2000-03-13 2001-09-26 General Hospital Corp 血管収縮を調節する方法とその組成物
US6569615B1 (en) * 2000-04-10 2003-05-27 The United States Of America As Represented By The Department Of Veteran's Affairs Composition and methods for tissue preservation
KR20030060771A (ko) 2000-04-28 2003-07-16 메모리얼 슬로안-케터링 캔서 센터 국소용 마취제/아편양약물 제제 및 이들의 용도
WO2002026140A1 (en) 2000-09-26 2002-04-04 Medtronic, Inc. Medical method and system for directing blood flow
JP2005532260A (ja) 2002-01-29 2005-10-27 コグネティックス・インコーポレイテッド 器官保護剤としてのカッパ−ｐｖｉｉａ−関連コノトキシン
ATE418991T1 (de) 2002-04-18 2009-01-15 Cv Therapeutics Inc Methode zur behandlung von herzrhythmusstörungen mit einem a1 adenosin agonist zusammen mit einem beta blocker
AUPS312602A0 (en) * 2002-06-21 2002-07-18 James Cook University Organ arrest, protection, preservation and recovery
US20040229780A1 (en) * 2002-09-20 2004-11-18 Olivera Baldomero M. KappaM-conopeptides as organ protectants
US6921633B2 (en) 2002-11-18 2005-07-26 Biolife Solutions Incorporated Methods and compositions for the preservation of cells, tissues or organs in the vitreous state
US20040167226A1 (en) * 2002-12-16 2004-08-26 Serafini Tito A. Methods for the treatment of pain and traumatic injury using benzamides and compositions containing the same
GB2436255B (en) 2002-12-23 2007-11-28 Global Cardiac Solutions Pty L Organ preconditioning, arrest, protection, preservation and recovery
CA2551169A1 (en) * 2002-12-23 2004-07-08 Global Cardiac Solutions Pty Ltd Organ preconditioning, arrest, protection, preservation and recovery
US6992075B2 (en) * 2003-04-04 2006-01-31 Barr Laboratories, Inc. C(14) estrogenic compounds
EP1628649A4 (en) 2003-06-02 2010-06-02 Samaritan Pharmaceuticals Inc NEUROPROTECTIVE BENZOATE AND BENZAMIDE COMPOUNDS
US7049309B2 (en) * 2003-10-14 2006-05-23 Bristol-Myers Squibb Company 3-Thia-4-arylquinolin-2-one potassium channel modulators
JP2008525468A (ja) 2004-12-22 2008-07-17 エモリー・ユニバーシティ ポストコンディショニング臓器保護作用を増強する治療補助薬
WO2007030198A2 (en) 2005-07-11 2007-03-15 Human Biosystems Improved methods and solutions for storing donor organs
AU2006345361B2 (en) 2006-05-29 2014-04-10 Hibernation Therapeutics, A Kf Llc Improved tissue maintenance
CA2692256C (en) 2006-07-25 2017-01-10 Hibernation Therapeutics Limited Trauma therapy
EP2173353B1 (en) 2007-03-02 2015-05-06 Hibernation Therapeutics, a KF LLC Composition including Adenosine and Lignocaine
CN100423638C (zh) 2007-03-22 2008-10-08 南京吉脉生物技术有限公司 一种器官保存液及其制备方法
SG185322A1 (en) 2007-07-25 2012-11-29 Hibernation Therapeutics Ltd Improved organ protection, preservation and recovery

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20020001797A (ko) * 1999-03-23 2002-01-09 제임스 쿡 유니버시티 신체 기관의 정지, 보호 및 보존

Also Published As

Publication number Publication date
AU2007278754B2 (en) 2014-11-13
JP2009544628A (ja) 2009-12-17
WO2008011670A1 (en) 2008-01-31
CA2692256A1 (en) 2008-01-31
EP2139316A1 (en) 2010-01-06
EP2139316A4 (en) 2012-04-25
US9125929B2 (en) 2015-09-08
CN103495173A (zh) 2014-01-08
KR20140108346A (ko) 2014-09-05
IL196702A0 (en) 2009-11-18
AU2007278754A1 (en) 2008-01-31
ES2539762T3 (es) 2015-07-03
ZA200901376B (en) 2015-12-23
CN103495173B (zh) 2016-11-23
EP2139316B1 (en) 2015-03-18
US20130190264A1 (en) 2013-07-25
JP5833618B2 (ja) 2015-12-16
SG173404A1 (en) 2011-08-29
CN101516185A (zh) 2009-08-26
US20090324748A1 (en) 2009-12-31
JP2014065724A (ja) 2014-04-17
US20160051572A1 (en) 2016-02-25
KR20090047489A (ko) 2009-05-12
CA2692256C (en) 2017-01-10

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