KR101482685B1 - 트리아진 유도체 및 인슐린 감작제의 조합물 - Google Patents

트리아진 유도체 및 인슐린 감작제의 조합물 Download PDF

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Publication number
KR101482685B1
KR101482685B1 KR20087019624A KR20087019624A KR101482685B1 KR 101482685 B1 KR101482685 B1 KR 101482685B1 KR 20087019624 A KR20087019624 A KR 20087019624A KR 20087019624 A KR20087019624 A KR 20087019624A KR 101482685 B1 KR101482685 B1 KR 101482685B1
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South Korea
Prior art keywords
dihydro
methyl
dimethylamino
triazine
amino
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Expired - Fee Related
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Korean (ko)
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KR20080088630A (ko
Inventor
제라르 모이네
다니엘 크라보
디디에 메상쥬
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메르크 파텐트 게엠베하
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
    • C07D251/40—Nitrogen atoms
    • C07D251/48—Two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50—Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR20087019624A 2006-01-13 2006-12-18 트리아진 유도체 및 인슐린 감작제의 조합물 Expired - Fee Related KR101482685B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR06/00344 2006-01-13
FR0600344A FR2896159B1 (fr) 2006-01-13 2006-01-13 Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline.
PCT/EP2006/012185 WO2007079917A2 (en) 2006-01-13 2006-12-18 Combination of triazine derivatives and insulin sensitisers

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020147002582A Division KR20140033498A (ko) 2006-01-13 2006-12-18 트리아진 유도체 및 인슐린 감작제의 조합물

Publications (2)

Publication Number Publication Date
KR20080088630A KR20080088630A (ko) 2008-10-02
KR101482685B1 true KR101482685B1 (ko) 2015-01-14

Family

ID=36654309

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020147002582A Ceased KR20140033498A (ko) 2006-01-13 2006-12-18 트리아진 유도체 및 인슐린 감작제의 조합물
KR20087019624A Expired - Fee Related KR101482685B1 (ko) 2006-01-13 2006-12-18 트리아진 유도체 및 인슐린 감작제의 조합물

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020147002582A Ceased KR20140033498A (ko) 2006-01-13 2006-12-18 트리아진 유도체 및 인슐린 감작제의 조합물

Country Status (22)

Country Link
US (2) US8791115B2 (enExample)
EP (1) EP1971330B1 (enExample)
JP (1) JP5249782B2 (enExample)
KR (2) KR20140033498A (enExample)
CN (1) CN101355933A (enExample)
AR (1) AR059032A1 (enExample)
AT (1) ATE476179T1 (enExample)
AU (1) AU2006334734B2 (enExample)
BR (1) BRPI0620985B8 (enExample)
CA (1) CA2640897C (enExample)
CY (1) CY1110789T1 (enExample)
DE (1) DE602006016014D1 (enExample)
DK (1) DK1971330T3 (enExample)
EA (1) EA015576B1 (enExample)
ES (1) ES2347177T3 (enExample)
FR (1) FR2896159B1 (enExample)
IL (1) IL192558A (enExample)
PL (1) PL1971330T3 (enExample)
PT (1) PT1971330E (enExample)
SI (1) SI1971330T1 (enExample)
WO (1) WO2007079917A2 (enExample)
ZA (1) ZA200806947B (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2896159B1 (fr) * 2006-01-13 2008-09-12 Merck Sante Soc Par Actions Si Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline.
CN102245581A (zh) 2008-12-12 2011-11-16 普克塞尔公司 用于治疗与ampk活性有关的疾病的四氢三嗪化合物
SI2355829T1 (sl) * 2008-12-12 2015-03-31 Poxel S.A.S. Kombinacija inzulina z derivati triazina in njegova uporaba za zdravljenje diabetesa
FR2948027A1 (fr) 2009-07-17 2011-01-21 Merck Sante Sas Derives amines de dihydro-1,3,5-triazine pour leur utilisation dans le traitement des maladies associees a une ischemie et/ou une reperfusion
FR2948026B1 (fr) * 2009-07-17 2011-12-02 Merck Sante Sas Derives amines de dihydro-1,3,5-triazine
TWI436768B (zh) * 2010-06-09 2014-05-11 Poxel 第２型糖尿病之治療
KR20120011667A (ko) * 2010-07-29 2012-02-08 광주과학기술원 당뇨병 치료제의 스크리닝 방법
KR101271218B1 (ko) * 2012-12-07 2013-06-07 광주과학기술원 당뇨병 치료제의 스크리닝 방법
BR112020006472A2 (pt) 2017-10-02 2020-10-06 Poxel método para tratamento ou prevenção de insuficiência cardíaca com fração de ejeção preservada (icfep)
BR112020024643A2 (pt) * 2018-06-06 2021-03-02 Metavant Sciences Gmbh método de tratamento de pré-diabetes ou diabetes mellitus tipo 1 ou tipo 2, método de melhoria do controle glicêmico em um sujeito tendo pré-diabetes ou diabetes tipo 1 ou tipo 2, imeglimina para uso em um método para tratamento de pré-diabetes ou diabetes mellitus tipo 1 ou tipo 2 de um sujeito, imeglimina para uso em um método para melhoria do controle glicêmico em um sujeito tendo pré-diabetes ou diabetes tipo 1 ou tipo 2, uso de imeglimina para a fabricação de um medicamento para o tratamento de um sujeito tendo pré-diabetes ou diabetes mellitus tipo 1 ou tipo 2 e uso de imeglimina para a fabricação de um medicamento para melhoria do controle glicêmico em um sujeito tendo pré-diabetes ou diabetes tipo 1 ou tipo 2
EP3806828A1 (en) 2018-06-14 2021-04-21 Poxel Film-coated tablet comprising a triazine derivative for use in the treatment of diabetes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055122A1 (fr) * 2000-01-26 2001-08-02 Lipha Derives amines de dihydro-1,3,5-triazine et leurs applications en therapeutique
WO2001082867A2 (en) * 2000-05-01 2001-11-08 Aeropharm Technology, Inc. A core formulation

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6288095B1 (en) * 1987-09-04 2001-09-11 Beecham Group P.L.C. Compounds
US5885980A (en) * 1996-06-25 1999-03-23 Enrique G. Gutierrez Composition and method for treating diabetes
US6011049A (en) 1997-02-19 2000-01-04 Warner-Lambert Company Combinations for diabetes
TW200514783A (en) 1999-09-22 2005-05-01 Bristol Myers Squibb Co Substituted acid derivatives useful as antiodiabetic and antiobesity agents and method
MY125516A (en) 1999-11-16 2006-08-30 Smithkline Beecham Plc Novel composition based on thiazolidinedione and metformin and use
FR2853650B1 (fr) * 2003-04-10 2006-07-07 Merck Sante Sas Procede de dedoublement d'amines utiles pour le traitement de desordres associes au syndrome d'insulino-resistance
WO2005012243A2 (en) * 2003-08-01 2005-02-10 Janssen Pharmaceutica N.V. Substituted indole-o-glucosides
FR2863484B1 (fr) * 2003-12-11 2007-04-13 Oreal Utilisation de composes capables d'agir sur la voie metabolique controlee par la dopachrome tautomerase trp-2 comme agent protecteur des melanocytes du follicule pileux et applications
US20050163842A1 (en) * 2003-12-31 2005-07-28 Garth Boehm Rosiglitazone and metformin formulations
FR2896159B1 (fr) * 2006-01-13 2008-09-12 Merck Sante Soc Par Actions Si Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline.

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001055122A1 (fr) * 2000-01-26 2001-08-02 Lipha Derives amines de dihydro-1,3,5-triazine et leurs applications en therapeutique
US20030109530A1 (en) * 2000-01-26 2003-06-12 Gerard Moinet Dihydro-1,3,5-triazine amine derivatives and their therapeutic uses
WO2001082867A2 (en) * 2000-05-01 2001-11-08 Aeropharm Technology, Inc. A core formulation

Also Published As

Publication number Publication date
EA015576B1 (ru) 2011-10-31
FR2896159A1 (fr) 2007-07-20
ZA200806947B (en) 2009-11-25
US20140050786A1 (en) 2014-02-20
SI1971330T1 (sl) 2010-11-30
ES2347177T3 (es) 2010-10-26
CY1110789T1 (el) 2015-06-10
KR20140033498A (ko) 2014-03-18
AU2006334734B2 (en) 2012-07-19
JP2009523142A (ja) 2009-06-18
IL192558A (en) 2013-04-30
KR20080088630A (ko) 2008-10-02
CA2640897A1 (en) 2007-07-19
WO2007079917A2 (en) 2007-07-19
FR2896159B1 (fr) 2008-09-12
DK1971330T3 (da) 2010-10-25
BRPI0620985B1 (pt) 2020-04-28
EA200801676A1 (ru) 2008-12-30
BRPI0620985B8 (pt) 2021-05-25
US8791115B2 (en) 2014-07-29
BRPI0620985A2 (pt) 2011-11-29
WO2007079917A3 (en) 2007-08-30
US20100285117A1 (en) 2010-11-11
ATE476179T1 (de) 2010-08-15
DE602006016014D1 (de) 2010-09-16
AR059032A1 (es) 2008-03-12
JP5249782B2 (ja) 2013-07-31
AU2006334734A1 (en) 2007-07-19
EP1971330A2 (en) 2008-09-24
PL1971330T3 (pl) 2011-01-31
EP1971330B1 (en) 2010-08-04
PT1971330E (pt) 2010-09-09
CA2640897C (en) 2015-10-20
CN101355933A (zh) 2009-01-28

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