KR101476144B1 - 생약 유래 성분의 고감도 정량 방법 - Google Patents

생약 유래 성분의 고감도 정량 방법 Download PDF

Info

Publication number
KR101476144B1
KR101476144B1 KR1020137012465A KR20137012465A KR101476144B1 KR 101476144 B1 KR101476144 B1 KR 101476144B1 KR 1020137012465 A KR1020137012465 A KR 1020137012465A KR 20137012465 A KR20137012465 A KR 20137012465A KR 101476144 B1 KR101476144 B1 KR 101476144B1
Authority
KR
South Korea
Prior art keywords
alcohol
water
solid phase
plasma
alkali
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020137012465A
Other languages
English (en)
Korean (ko)
Other versions
KR20130076892A (ko
Inventor
가요코 스즈키
츠네하루 스즈키
미치코 츠카하라
유코 하루타
아키라 핫따
유지 하마다
히데오 이노우에
Original Assignee
미노파겐 파머수티컬 컴퍼니 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 미노파겐 파머수티컬 컴퍼니 리미티드 filed Critical 미노파겐 파머수티컬 컴퍼니 리미티드
Publication of KR20130076892A publication Critical patent/KR20130076892A/ko
Application granted granted Critical
Publication of KR101476144B1 publication Critical patent/KR101476144B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00Chemical aspects of mass spectrometric analysis of biological material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
KR1020137012465A 2010-11-16 2011-11-15 생약 유래 성분의 고감도 정량 방법 Active KR101476144B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JPJP-P-2010-256187 2010-11-16
JP2010256187A JP5193266B2 (ja) 2010-11-16 2010-11-16 生薬由来成分の高感度定量方法
PCT/JP2011/076248 WO2012067090A1 (ja) 2010-11-16 2011-11-15 生薬由来成分の高感度定量方法

Publications (2)

Publication Number Publication Date
KR20130076892A KR20130076892A (ko) 2013-07-08
KR101476144B1 true KR101476144B1 (ko) 2014-12-24

Family

ID=46084017

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137012465A Active KR101476144B1 (ko) 2010-11-16 2011-11-15 생약 유래 성분의 고감도 정량 방법

Country Status (5)

Country Link
JP (1) JP5193266B2 (enExample)
KR (1) KR101476144B1 (enExample)
CN (1) CN103210308B (enExample)
RU (1) RU2558042C2 (enExample)
WO (1) WO2012067090A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2603363C1 (ru) * 2015-09-23 2016-11-27 федеральное государственное бюджетное образовательное учреждение высшего образования "Новосибирский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО НГМУ Минздрава России) Вольтамперометрический способ количественного определения глицирризиновой кислоты в фармацевтических субстанциях
KR102617148B1 (ko) * 2016-08-15 2023-12-26 제넨테크, 인크. 비이온성 계면활성제 및 폴리펩티드를 포함하는 조성물에서 비이온성 계면활성제를 정량화하기 위한 크로마토그래피 방법
CN107064327A (zh) * 2016-12-23 2017-08-18 东北制药集团沈阳第制药有限公司 一种检测复方甘草片中吗啡和甘草酸含量的方法
JP7019372B2 (ja) * 2017-10-19 2022-02-15 株式会社あすか製薬メディカル ビタミンd代謝物の選択的測定法
RU2700831C1 (ru) * 2019-01-24 2019-09-23 Федеральное государственное бюджетное учреждение "Научный центр экспертизы средств медицинского применения" Министерства здравоохранения Российской Федерации (ФГБУ "НЦЭСМП" Минздрава России) Способ количественного определения глицина в биологических лекарственных препаратах методом гидрофильной высокоэффективной жидкостной хроматографии
JP7479633B2 (ja) 2020-12-03 2024-05-09 株式会社ツムラ アンバムの分析方法
CN113984916B (zh) * 2021-09-28 2024-04-19 天津中医药大学第一附属医院 一种正髓丸及正髓丸药材含量测定方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040099885A (ko) * 2003-05-20 2004-12-02 한국과학기술연구원 가미자도환의 주요성분 동시 분석방법
KR20090125764A (ko) * 2007-03-07 2009-12-07 사노피-아벤티스 유.에스. 엘엘씨 Spe―lc―ms―ms에 의한 소변 중의 리세드로네이트의 정량적 측정방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5325675B2 (enExample) * 1973-12-14 1978-07-28
JPS5251995A (en) * 1975-10-23 1977-04-26 Rooto Seiyaku Kk Method of analyzing clycyrrhizin
US20050148088A1 (en) * 2002-04-19 2005-07-07 Eng Shi Ong Pressurized hot water extraction
CN101216465B (zh) * 2007-12-28 2011-01-12 北京联合大学生物化学工程学院 甘草药材指纹图谱的建立方法及其标准指纹图谱
CN101532994B (zh) * 2009-04-18 2013-02-27 姚俊华 健脑补肾制剂的含量测定方法
CN101897680A (zh) * 2009-06-01 2010-12-01 天津药物研究院 液体胶囊制剂、其制备方法及用途

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040099885A (ko) * 2003-05-20 2004-12-02 한국과학기술연구원 가미자도환의 주요성분 동시 분석방법
KR20090125764A (ko) * 2007-03-07 2009-12-07 사노피-아벤티스 유.에스. 엘엘씨 Spe―lc―ms―ms에 의한 소변 중의 리세드로네이트의 정량적 측정방법

Also Published As

Publication number Publication date
KR20130076892A (ko) 2013-07-08
WO2012067090A1 (ja) 2012-05-24
JP2012107954A (ja) 2012-06-07
CN103210308A (zh) 2013-07-17
CN103210308B (zh) 2015-01-07
JP5193266B2 (ja) 2013-05-08
RU2013125221A (ru) 2014-12-10
RU2558042C2 (ru) 2015-07-27

Similar Documents

Publication Publication Date Title
KR101476144B1 (ko) 생약 유래 성분의 고감도 정량 방법
Busardò et al. Ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS) for determination of GHB, precursors and metabolites in different specimens: application to clinical and forensic cases
Cui et al. Gas chromatographic-mass spectrometric determination of 20 (S)-protopanaxadiol and 20 (S)-protopanaxatriol for study on human urinary excretion of ginsenosides after ingestion of ginseng preparations
Kubica et al. Modern approach for determination of lactulose, mannitol and sucrose in human urine using HPLC–MS/MS for the studies of intestinal and upper digestive tract permeability
Koželj et al. Simple validated LC–MS/MS method for the determination of atropine and scopolamine in plasma for clinical and forensic toxicological purposes
WO2018107975A1 (zh) 一种右丙亚胺的分析方法
Chang et al. Simultaneous determination of four phenolic acids and seven alkaloids in rat plasma after oral administration of traditional Chinese medicinal preparation Jinqi Jiangtang Tablet by LC-ESI–MS/MS
Ma et al. Determination of duloxetine in human plasma via LC/MS and subsequent application to a pharmacokinetic study in healthy Chinese volunteers
Klein et al. Simultaneous determination of lidocaine, prilocaine and the prilocaine metabolite o-toluidine in plasma by high-performance liquid chromatography
Jiang et al. Measurement of endogenous uracil and dihydrouracil in plasma and urine of normal subjects by liquid chromatography–tandem mass spectrometry
Santos-Fandila et al. Quantitative determination of β-hydroxymethylbutyrate and leucine in culture media and microdialysates from rat brain by UHPLC-tandem mass spectrometry
Wang et al. Simultaneous determination of eight β-adrenergic agonists in human urine by an isotope dilution-online clean-up system coupled with liquid chromatography-tandem mass spectrometry
Fan et al. Simultaneous separation and determination of vancomycin and its crystalline degradation products in human serum by ultra high performance liquid chromatography tandem mass spectrometry method and its application in therapeutic drug monitoring
Jeong et al. A sensitive UPLC–ESI–MS/MS method for the quantification of cinnamic acid in vivo and in vitro: Application to pharmacokinetic and protein binding study in human plasma
Yu et al. Simultaneous determination of eight flavonoids in plasma using LC–MS/MS and application to a pharmacokinetic study after oral administration of Pollen Typhae extract to rats
Sun et al. Quantification of the concentration and 13C tracer enrichment of long-chain fatty acyl-coenzyme A in muscle by liquid chromatography/mass spectrometry
Tettey-Amlalo et al. Rapid UPLC–MS/MS method for the determination of ketoprofen in human dermal microdialysis samples
Jiang et al. Rapid and sensitive liquid chromatography–tandem mass spectrometry method for the quantitation of colchicine in human plasma
Dai et al. Comparative pharmacokinetics of acteoside from total glycoside extracted from leaves of Rehmannia and Dihuangye total glycoside capsule in normal and diabetic nephropathy rats
JP7753359B2 (ja) ヒト血漿中のリゼルギン酸ジエチルアミド(lsd)及び2,3-ジヒドロ-3-ヒドロキシ-2-オキソリセルギド(o-h-lsd)を定量化するための方法
Rehman et al. An ultra-high-performance liquid chromatography-tandem mass spectrometric method for the determination of hederacoside C, a drug candidate for respiratory disorder, in rat plasma
Lamparczyk et al. RP‐HPLC method with electrochemical detection for the determination of metoclopramide in serum and its use in pharmacokinetic studies
Arafat et al. Determination of loperamide in human plasma and saliva by liquid chromatography–tandem mass spectrometry
Li et al. An improved LC–MS/MS method for determination of cinacalcet in human plasma and its application to the evaluation of food intake effect on the pharmacokinetics of cinacalcet in healthy volunteers
Zhang et al. Development of a novel HPLC‐MS/MS method for the determination of aconitine and its application to in vitro and rat microdialysis samples

Legal Events

Date Code Title Description
A201 Request for examination
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

FPAY Annual fee payment

Payment date: 20181023

Year of fee payment: 5

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 5

FPAY Annual fee payment

Payment date: 20191022

Year of fee payment: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 6

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 7

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 8

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 9

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 10

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 11

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 12

U11 Full renewal or maintenance fee paid

Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-OTH-PR1001 (AS PROVIDED BY THE NATIONAL OFFICE)

Year of fee payment: 12