JP5193266B2 - 生薬由来成分の高感度定量方法 - Google Patents

生薬由来成分の高感度定量方法 Download PDF

Info

Publication number
JP5193266B2
JP5193266B2 JP2010256187A JP2010256187A JP5193266B2 JP 5193266 B2 JP5193266 B2 JP 5193266B2 JP 2010256187 A JP2010256187 A JP 2010256187A JP 2010256187 A JP2010256187 A JP 2010256187A JP 5193266 B2 JP5193266 B2 JP 5193266B2
Authority
JP
Japan
Prior art keywords
alcohol
water
plasma
alkali
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2010256187A
Other languages
English (en)
Japanese (ja)
Other versions
JP2012107954A (ja
JP2012107954A5 (enExample
Inventor
加代子 鈴木
恒陽 鈴木
路子 塚原
裕子 春田
明 八田
雄二 浜田
秀雄 井上
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Minophagen Pharmaceutical Co Ltd
Original Assignee
Minophagen Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Minophagen Pharmaceutical Co Ltd filed Critical Minophagen Pharmaceutical Co Ltd
Priority to JP2010256187A priority Critical patent/JP5193266B2/ja
Priority to KR1020137012465A priority patent/KR101476144B1/ko
Priority to CN201180054812.9A priority patent/CN103210308B/zh
Priority to PCT/JP2011/076248 priority patent/WO2012067090A1/ja
Priority to RU2013125221/15A priority patent/RU2558042C2/ru
Publication of JP2012107954A publication Critical patent/JP2012107954A/ja
Publication of JP2012107954A5 publication Critical patent/JP2012107954A5/ja
Application granted granted Critical
Publication of JP5193266B2 publication Critical patent/JP5193266B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Non-Biological Materials By The Use Of Chemical Means (AREA)
JP2010256187A 2010-11-16 2010-11-16 生薬由来成分の高感度定量方法 Active JP5193266B2 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
JP2010256187A JP5193266B2 (ja) 2010-11-16 2010-11-16 生薬由来成分の高感度定量方法
KR1020137012465A KR101476144B1 (ko) 2010-11-16 2011-11-15 생약 유래 성분의 고감도 정량 방법
CN201180054812.9A CN103210308B (zh) 2010-11-16 2011-11-15 源自生药的成分的定量方法
PCT/JP2011/076248 WO2012067090A1 (ja) 2010-11-16 2011-11-15 生薬由来成分の高感度定量方法
RU2013125221/15A RU2558042C2 (ru) 2010-11-16 2011-11-15 Высокочувствительный способ определения количества компонентов, полученных из лекарственных трав

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2010256187A JP5193266B2 (ja) 2010-11-16 2010-11-16 生薬由来成分の高感度定量方法

Publications (3)

Publication Number Publication Date
JP2012107954A JP2012107954A (ja) 2012-06-07
JP2012107954A5 JP2012107954A5 (enExample) 2012-09-20
JP5193266B2 true JP5193266B2 (ja) 2013-05-08

Family

ID=46084017

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010256187A Active JP5193266B2 (ja) 2010-11-16 2010-11-16 生薬由来成分の高感度定量方法

Country Status (5)

Country Link
JP (1) JP5193266B2 (enExample)
KR (1) KR101476144B1 (enExample)
CN (1) CN103210308B (enExample)
RU (1) RU2558042C2 (enExample)
WO (1) WO2012067090A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2603363C1 (ru) * 2015-09-23 2016-11-27 федеральное государственное бюджетное образовательное учреждение высшего образования "Новосибирский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО НГМУ Минздрава России) Вольтамперометрический способ количественного определения глицирризиновой кислоты в фармацевтических субстанциях
CN115598231B (zh) * 2016-08-15 2025-11-18 豪夫迈·罗氏有限公司 定量包含非离子表面活性剂和多肽的组合物中非离子表面活性剂的层析方法
CN107064327A (zh) * 2016-12-23 2017-08-18 东北制药集团沈阳第制药有限公司 一种检测复方甘草片中吗啡和甘草酸含量的方法
JP7019372B2 (ja) * 2017-10-19 2022-02-15 株式会社あすか製薬メディカル ビタミンd代謝物の選択的測定法
RU2700831C1 (ru) * 2019-01-24 2019-09-23 Федеральное государственное бюджетное учреждение "Научный центр экспертизы средств медицинского применения" Министерства здравоохранения Российской Федерации (ФГБУ "НЦЭСМП" Минздрава России) Способ количественного определения глицина в биологических лекарственных препаратах методом гидрофильной высокоэффективной жидкостной хроматографии
JP7479633B2 (ja) 2020-12-03 2024-05-09 株式会社ツムラ アンバムの分析方法
CN113984916B (zh) * 2021-09-28 2024-04-19 天津中医药大学第一附属医院 一种正髓丸及正髓丸药材含量测定方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5325675B2 (enExample) * 1973-12-14 1978-07-28
JPS5251995A (en) * 1975-10-23 1977-04-26 Rooto Seiyaku Kk Method of analyzing clycyrrhizin
US20050148088A1 (en) * 2002-04-19 2005-07-07 Eng Shi Ong Pressurized hot water extraction
KR20040099885A (ko) * 2003-05-20 2004-12-02 한국과학기술연구원 가미자도환의 주요성분 동시 분석방법
BRPI0808416A2 (pt) * 2007-03-07 2014-07-22 Sanofi Aventis Us Llc Determinação quantitativa de risedronato na urina por spe-lc-ms-ms
CN101216465B (zh) * 2007-12-28 2011-01-12 北京联合大学生物化学工程学院 甘草药材指纹图谱的建立方法及其标准指纹图谱
CN101532994B (zh) * 2009-04-18 2013-02-27 姚俊华 健脑补肾制剂的含量测定方法
CN101897680A (zh) * 2009-06-01 2010-12-01 天津药物研究院 液体胶囊制剂、其制备方法及用途

Also Published As

Publication number Publication date
WO2012067090A1 (ja) 2012-05-24
RU2013125221A (ru) 2014-12-10
KR20130076892A (ko) 2013-07-08
JP2012107954A (ja) 2012-06-07
KR101476144B1 (ko) 2014-12-24
CN103210308B (zh) 2015-01-07
RU2558042C2 (ru) 2015-07-27
CN103210308A (zh) 2013-07-17

Similar Documents

Publication Publication Date Title
Busardò et al. Ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC–MS/MS) for determination of GHB, precursors and metabolites in different specimens: application to clinical and forensic cases
Xie et al. High performance liquid chromatographic–mass spectrometric determination of ginsenoside Rg3 and its metabolites in rat plasma using solid-phase extraction for pharmacokinetic studies
WO2012067090A1 (ja) 生薬由来成分の高感度定量方法
Chang et al. Simultaneous determination and pharmacokinetic study of six flavonoids from Fructus Sophorae extract in rat plasma by LC–MS/MS
Fei et al. Sensitive analysis and pharmacokinetic study of the isomers paeoniflorin and albiflorin after oral administration of total glucosides of white paeony capsule in rats
Nugbienyo et al. Automated sugaring-out liquid-liquid extraction based on flow system coupled with HPLC-UV for the determination of procainamide in urine
Szultka-Mlynska et al. Application of solid phase microextraction followed by liquid chromatography-mass spectrometry in the determination of antibiotic drugs and their metabolites in human whole blood and tissue samples
Chang et al. Simultaneous determination of four phenolic acids and seven alkaloids in rat plasma after oral administration of traditional Chinese medicinal preparation Jinqi Jiangtang Tablet by LC-ESI–MS/MS
Wen et al. Simultaneous determination of calycosin-7-O-β-d-glucoside, ononin, astragaloside IV, astragaloside I and ferulic acid in rat plasma after oral administration of Danggui Buxue Tang extract for their pharmacokinetic studies by liquid chromatography–mass spectrometry
El Barkil et al. Relevance of a combined UV and single mass spectrometry detection for the determination of tenofovir in human plasma by HPLC in therapeutic drug monitoring
Wang et al. UHPLC-MS/MS analysis of cAMP and cGMP in rat plasma as potential biomarkers of Yin-Yang disharmony in traditional Chinese medicine
He et al. Simultaneous quantification of ginsenoside Rg1 and its metabolites by HPLC–MS/MS: Rg1 excretion in rat bile, urine and feces
Sun et al. Pharmacokinetic study of ginsenoside Rc and simultaneous determination of its metabolites in rats using RRLC-Q-TOF-MS
Jovanov et al. Hydrophilic interaction chromatography coupled to tandem mass spectrometry as a method for simultaneous determination of guanidinoacetate and creatine
Zuo et al. Simultaneous determination and pharmacokinetic study of twelve bioactive compounds in rat plasma after intravenous administration of Xuebijing injection by UHPLC-Q-Orbitrap HRMS
Yu et al. Simultaneous determination of eight flavonoids in plasma using LC–MS/MS and application to a pharmacokinetic study after oral administration of Pollen Typhae extract to rats
Jeong et al. A sensitive UPLC–ESI–MS/MS method for the quantification of cinnamic acid in vivo and in vitro: application to pharmacokinetic and protein binding study in human plasma: S. Jeong et al.
Huang et al. Simultaneous determination of human plasma protein binding of bioactive flavonoids in Polygonum orientale by equilibrium dialysis combined with UPLC–MS/MS
Zhang et al. Determination of 25-OH-PPD in rat plasma by high-performance liquid chromatography–mass spectrometry and its application in rat pharmacokinetic studies
Qiu et al. Quantitative bioanalytical assay for the human epidermal growth factor receptor (HER) inhibitor dacomitinib in rat plasma by UPLC-MS/MS
Liu et al. Determination of berberine, palmatine and jatrorrhizine in rabbit plasma by liquid chromatography–electrospray ionization-mass spectrometry
Cai et al. Metabolic profiling and pharmacokinetic studies of alkamides, a pair of cis-trans isomers N-isobutyl-2E, 4E, 8Z, 10E/Z-dodecatetraenamide, from Asari Radix et Rhizoma by UHPLC-Q/TOF-MS and UHPLC-MS/MS
Rehman et al. An ultra-high-performance liquid chromatography-tandem mass spectrometric method for the determination of hederacoside C, a drug candidate for respiratory disorder, in rat plasma
Jin et al. Simultaneous determination of multiple compounds of Da-Huang-Xiao-Shi decoction in rat plasma by LC-MS/MS and its application in a pharmacokinetic study
An et al. Gut microbiota-mediated deglycosylation of ginsenoside Rb1 in rats: in vitro and in vivo insights from quantitative ultra-performance liquid chromatography-mass spectrometry analysis

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120802

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20120802

A871 Explanation of circumstances concerning accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A871

Effective date: 20120802

A975 Report on accelerated examination

Free format text: JAPANESE INTERMEDIATE CODE: A971005

Effective date: 20120820

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120828

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120912

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20130108

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20130201

R150 Certificate of patent or registration of utility model

Ref document number: 5193266

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20160208

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250