KR101455081B1 - 톨―유사 수용체 기초 면역 반응을 조절하기 위한 면역조절 올리고누클레오티드 (iro) - Google Patents
톨―유사 수용체 기초 면역 반응을 조절하기 위한 면역조절 올리고누클레오티드 (iro) Download PDFInfo
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- KR101455081B1 KR101455081B1 KR1020087011265A KR20087011265A KR101455081B1 KR 101455081 B1 KR101455081 B1 KR 101455081B1 KR 1020087011265 A KR1020087011265 A KR 1020087011265A KR 20087011265 A KR20087011265 A KR 20087011265A KR 101455081 B1 KR101455081 B1 KR 101455081B1
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- iro
- ome
- artificial sequence
- tlr
- dna
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/17—Immunomodulatory nucleic acids
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- C12N2310/314—Phosphoramidates
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- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
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- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
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- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Pulmonology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Dermatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72603405P | 2005-10-12 | 2005-10-12 | |
| US60/726,034 | 2005-10-12 | ||
| US78424306P | 2006-03-21 | 2006-03-21 | |
| US60/784,243 | 2006-03-21 | ||
| US82544006P | 2006-09-13 | 2006-09-13 | |
| US60/825,440 | 2006-09-13 | ||
| PCT/US2006/039954 WO2007047396A2 (en) | 2005-10-12 | 2006-10-12 | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20080065653A KR20080065653A (ko) | 2008-07-14 |
| KR101455081B1 true KR101455081B1 (ko) | 2014-10-27 |
Family
ID=37963095
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020087011265A Expired - Fee Related KR101455081B1 (ko) | 2005-10-12 | 2006-10-12 | 톨―유사 수용체 기초 면역 반응을 조절하기 위한 면역조절 올리고누클레오티드 (iro) |
Country Status (9)
| Country | Link |
|---|---|
| US (4) | US8357665B2 (https=) |
| EP (4) | EP1934239B8 (https=) |
| JP (1) | JP6406793B2 (https=) |
| KR (1) | KR101455081B1 (https=) |
| CN (2) | CN104278037B (https=) |
| AU (1) | AU2006304205C1 (https=) |
| CA (1) | CA2624755C (https=) |
| ES (2) | ES2544877T3 (https=) |
| WO (1) | WO2007047396A2 (https=) |
Families Citing this family (63)
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| MXPA05013658A (es) * | 2003-06-11 | 2006-03-02 | Hybridon Inc | Oligonucleotidos inmunomoduladores estabilizados. |
| ES2544877T3 (es) | 2005-10-12 | 2015-09-04 | Idera Pharmaceuticals | Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll |
| AU2007322033B2 (en) | 2006-11-20 | 2013-07-11 | President And Fellows Of Harvard College | Methods, compositions, and kits for treating pain and pruritis |
| KR20100053598A (ko) * | 2007-08-01 | 2010-05-20 | 이데라 파마슈티칼즈, 인코포레이티드 | Tlr9의 신규한 합성 효능제 |
| MX2010001785A (es) * | 2007-08-15 | 2010-03-10 | Idera Pharmaceuticals Inc | Moduladores de receptores tipo larga distancia. |
| EP2238155A4 (en) * | 2007-12-26 | 2011-07-06 | Centocor Ortho Biotech Inc | CYNOMOLGUS TYPE TOLL 3 RECEIVER |
| WO2009154610A1 (en) * | 2008-06-17 | 2009-12-23 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
| CN101643496B (zh) * | 2008-08-07 | 2015-09-09 | 长春华普生物技术有限公司 | 一种具有免疫抑制功能的寡核苷酸 |
| WO2010039615A2 (en) * | 2008-10-03 | 2010-04-08 | Centocor Ortho Biotech Inc. | Papio cynocephalus toll-like receptor 3 |
| AU2009302468A1 (en) * | 2008-10-06 | 2010-04-15 | Idera Pharmaceuticals, Inc. | Use of inhibitors of toll-like receptors in the prevention and treatment of hypercholesterolemia and hyperlipidemia and diseases related thereto |
| KR20110081338A (ko) | 2008-11-04 | 2011-07-13 | 이데라 파마슈티칼즈, 인코포레이티드 | 안티센스 올리고누클레오티드에 의한 toll―유사 수용체 5 발현의 조절 |
| RU2572826C2 (ru) | 2008-12-02 | 2016-01-20 | Чиралджен, Лтд. | Способ синтеза модифицированных по атому фосфора нуклеиновых кислот |
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| ES2534947T3 (es) | 2009-03-25 | 2015-04-30 | The Board Of Regents Of The University Of Texas System | Composiciones para la estimulación de resistencia inmunitaria innata de mamíferos a patógenos |
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| JP6205133B2 (ja) | 2009-07-10 | 2017-09-27 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 抗炎症剤としての恒久的に荷電したナトリウムおよびカルシウムチャンネルブロッカー |
| DE102009034779A1 (de) | 2009-07-25 | 2011-02-03 | Emc Microcollections Gmbh | Synthetische Analoga bakterieller Lipopeptide und ihre Anwendung zur Therapie und Prophylaxe allergischer Erkrankungen |
| DK2470656T3 (da) * | 2009-08-27 | 2015-06-22 | Idera Pharmaceuticals Inc | Sammensætning til hæmning af genekspression og anvendelser heraf |
| EP2483406A2 (en) | 2009-09-30 | 2012-08-08 | President and Fellows of Harvard College | Methods for modulation of autophagy through the modulation of autophagy-inhibiting gene products |
| CN103153346A (zh) | 2010-06-16 | 2013-06-12 | 戴纳瓦克斯技术公司 | 使用tlr7和/或tlr9抑制剂的治疗方法 |
| JP5868324B2 (ja) | 2010-09-24 | 2016-02-24 | 株式会社Wave Life Sciences Japan | 不斉補助基 |
| KR101985382B1 (ko) * | 2010-11-19 | 2019-06-03 | 이데라 파마슈티칼즈, 인코포레이티드 | 톨-유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고뉴클레오타이드(iro) 화합물 |
| GB201021867D0 (en) | 2010-12-23 | 2011-02-02 | Mologen Ag | Non-coding immunomodulatory DNA construct |
| AU2012284265B2 (en) | 2011-07-19 | 2017-08-17 | Wave Life Sciences Ltd. | Methods for the synthesis of functionalized nucleic acids |
| CN104684923B (zh) * | 2012-07-13 | 2018-09-28 | 株式会社新日本科学 | 手性核酸佐剂 |
| JP6453212B2 (ja) | 2012-07-13 | 2019-01-16 | ウェイブ ライフ サイエンシズ リミテッドWave Life Sciences Ltd. | キラル制御 |
| SG11201500239VA (en) | 2012-07-13 | 2015-03-30 | Wave Life Sciences Japan | Asymmetric auxiliary group |
| US10130632B2 (en) | 2012-11-27 | 2018-11-20 | Beth Israel Deaconess Medical Center, Inc. | Methods for treating renal disease |
| KR101898177B1 (ko) * | 2013-01-08 | 2018-09-12 | 이데라 파마슈티칼즈, 인코포레이티드 | 톨-유사 수용체 기반 면역 반응을 조절하기 위한 면역 조절 올리고누클레오티드 (iro) 화합물 |
| AR095882A1 (es) | 2013-04-22 | 2015-11-18 | Hoffmann La Roche | Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9 |
| WO2015108047A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤 |
| JPWO2015108046A1 (ja) | 2014-01-15 | 2017-03-23 | 株式会社新日本科学 | 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤 |
| WO2015108048A1 (ja) | 2014-01-15 | 2015-07-23 | 株式会社新日本科学 | 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤 |
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| EP1934239B1 (en) | 2015-07-15 |
| CN104278037A (zh) | 2015-01-14 |
| US20130267583A1 (en) | 2013-10-10 |
| EP1934239A2 (en) | 2008-06-25 |
| EP2343307B1 (en) | 2015-08-05 |
| ES2542989T3 (es) | 2015-08-13 |
| CN101287742B (zh) | 2016-01-06 |
| AU2006304205C1 (en) | 2012-11-15 |
| US20090060898A1 (en) | 2009-03-05 |
| KR20080065653A (ko) | 2008-07-14 |
| JP2009515823A (ja) | 2009-04-16 |
| CA2624755C (en) | 2017-03-28 |
| EP2341059A1 (en) | 2011-07-06 |
| EP1934239A4 (en) | 2009-01-14 |
| CA2624755A1 (en) | 2007-04-26 |
| EP1934239B8 (en) | 2015-11-04 |
| WO2007047396A3 (en) | 2007-12-21 |
| US8357665B2 (en) | 2013-01-22 |
| AU2006304205A1 (en) | 2007-04-26 |
| US9206430B2 (en) | 2015-12-08 |
| AU2006304205B2 (en) | 2011-09-08 |
| ES2544877T3 (es) | 2015-09-04 |
| CN104278037B (zh) | 2020-09-15 |
| WO2007047396A2 (en) | 2007-04-26 |
| US20170145417A1 (en) | 2017-05-25 |
| CN101287742A (zh) | 2008-10-15 |
| US20160138022A1 (en) | 2016-05-19 |
| EP2343307A1 (en) | 2011-07-13 |
| US9453228B2 (en) | 2016-09-27 |
| JP6406793B2 (ja) | 2018-10-17 |
| EP2982679A1 (en) | 2016-02-10 |
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