KR101452033B1 - 소형 리포솜의 제조 방법 - Google Patents

소형 리포솜의 제조 방법 Download PDF

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Publication number
KR101452033B1
KR101452033B1 KR1020117015492A KR20117015492A KR101452033B1 KR 101452033 B1 KR101452033 B1 KR 101452033B1 KR 1020117015492 A KR1020117015492 A KR 1020117015492A KR 20117015492 A KR20117015492 A KR 20117015492A KR 101452033 B1 KR101452033 B1 KR 101452033B1
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South Korea
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composition
liposome
organic solvent
water
muc
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KR1020117015492A
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English (en)
Korean (ko)
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KR20110094114A (ko
Inventor
로버트 에이 뒤피
윌리엄 제이 레일리
Original Assignee
온코타이레온, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/10—Phosphatides, e.g. lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1735—Mucins, e.g. human intestinal mucin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Preparation (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
KR1020117015492A 2008-12-17 2009-12-17 소형 리포솜의 제조 방법 Expired - Fee Related KR101452033B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13835308P 2008-12-17 2008-12-17
US61/138,353 2008-12-17
PCT/US2009/068499 WO2010078045A2 (en) 2008-12-17 2009-12-17 Method of making small liposomes

Publications (2)

Publication Number Publication Date
KR20110094114A KR20110094114A (ko) 2011-08-19
KR101452033B1 true KR101452033B1 (ko) 2014-10-21

Family

ID=42310550

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117015492A Expired - Fee Related KR101452033B1 (ko) 2008-12-17 2009-12-17 소형 리포솜의 제조 방법

Country Status (12)

Country Link
US (3) US20120034294A1 (https=)
EP (1) EP2367532A4 (https=)
JP (2) JP2012512260A (https=)
KR (1) KR101452033B1 (https=)
CN (2) CN102256595A (https=)
AU (1) AU2009333177B2 (https=)
BR (1) BRPI0923001A2 (https=)
CA (1) CA2747182C (https=)
EA (1) EA020604B1 (https=)
MX (1) MX2011006562A (https=)
SG (1) SG172257A1 (https=)
WO (1) WO2010078045A2 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW201204410A (en) * 2004-04-01 2012-02-01 Oncothyreon Inc Mucinous glycoprotein (MUC-1) vaccine
JP5771366B2 (ja) * 2009-09-02 2015-08-26 株式会社バイオメッドコア リポソーム製造装置及び方法
KR20140023903A (ko) 2011-02-24 2014-02-27 온코타이레온, 인코포레이티드 항원보강제를 갖는 muc1 기초 당지질펩티드 백신
KR101387575B1 (ko) * 2012-08-10 2014-04-23 서울대학교산학협력단 인지질 및 아세틸렌기를 포함하는 리포좀 및 그의 용도
US9693958B2 (en) * 2013-03-15 2017-07-04 Cureport, Inc. Methods and devices for preparation of lipid nanoparticles
WO2015051122A2 (en) * 2013-10-02 2015-04-09 The Board Of Trustees Of The Leland Stanford Junior University Wnt compositions and methods for purification
CN107427791B (zh) * 2015-03-19 2021-05-14 康涅狄格大学 用于连续制造脂质体药物制剂的系统和方法
TWI774752B (zh) * 2017-04-13 2022-08-21 國立大學法人北海道大學 流路構造體及使用該流路構造體之脂質粒子至微胞的形成方法
EP3942050A4 (en) 2019-03-19 2023-02-22 Arcturus Therapeutics, Inc. PROCEDURE FOR THE PRODUCTION OF LIPID-COATED RNA NANOPARTICLES
EP3711749A1 (en) * 2019-03-19 2020-09-23 Polymun Scientific Immunbiologische Forschung GmbH Method of making lipid nanoparticles
KR20240052981A (ko) * 2021-09-14 2024-04-23 어드바팜 게엠베하 신규 지질펩티드 제형
WO2026011417A1 (en) * 2024-07-12 2026-01-15 The Hong Kong University Of Science And Technology Compositions and methods involving artificial poly (a) sequences

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007530663A (ja) * 2004-04-01 2007-11-01 バイオミラ インコーポレイティッド ムチン糖タンパク質（ｍｕｃ−１）ワクチン

Family Cites Families (14)

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Publication number Priority date Publication date Assignee Title
JPH11139961A (ja) * 1997-11-06 1999-05-25 Taisho Pharmaceut Co Ltd リポソームの製造方法
CA2318556A1 (en) * 1998-01-16 1999-07-22 Biomira, Inc. Lipomatrix preparation
CA2378430A1 (en) * 1999-07-15 2001-01-25 Inex Pharmaceuticals Corp. Methods and apparatus for preparation of lipid vesicles
ES2370262T3 (es) * 1999-11-15 2011-12-14 Oncothyreon Inc. Análogos del lípido a sintéticos y sus utilizaciones.
EP1343476B1 (en) * 2000-12-01 2008-05-28 Biomira Inc. Preparation of large liposomes by infusion into peg
US20030235610A1 (en) * 2002-06-21 2003-12-25 Piedmont Pharmaceuticals, Llc Liposomes containing biologically active compounds
WO2004071638A2 (en) * 2003-02-11 2004-08-26 Regents Of The University Of California, The Microfluidic devices and method for controlled viscous shearing and formation of amphiphilic vesicles
US9198645B2 (en) * 2003-11-26 2015-12-01 The United States of America, as represented by the Secretary of Commerce of The National Institute of Standards and Technology Controlled vesicle self-assembly in continuous two phase flow microfluidic channels
EP1855669A4 (en) * 2005-01-28 2010-07-07 Bc Cancer Agency LIPOSOMAL COMPOSITIONS FOR PARENTERAL SUPPLY OF AGENTS
PL1896051T3 (pl) * 2005-06-28 2015-04-30 Oncothyreon Inc Sposób leczenia pacjentów szczepionką glikoproteiny mucynowej (muc-1)
US9005654B2 (en) * 2005-07-27 2015-04-14 Protiva Biotherapeutics, Inc. Systems and methods for manufacturing liposomes
EP3354260B1 (en) * 2006-04-06 2020-12-09 Insmed Incorporated Methods for coacervation induced liposomal encapsulation and formulations thereof
US7811603B2 (en) * 2006-05-09 2010-10-12 The Regents Of The University Of California Microfluidic device for forming monodisperse lipoplexes
JP5126874B2 (ja) * 2007-05-21 2013-01-23 国立大学法人神戸大学 リポソーム製剤の製造方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007530663A (ja) * 2004-04-01 2007-11-01 バイオミラ インコーポレイティッド ムチン糖タンパク質（ｍｕｃ−１）ワクチン

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Jahn et al. Langmuir Vol 23, pp 6289-6293. *
Jahn et al. Langmuir Vol 23, pp 6289-6293.*

Also Published As

Publication number Publication date
EP2367532A4 (en) 2012-12-12
WO2010078045A2 (en) 2010-07-08
KR20110094114A (ko) 2011-08-19
US20120034294A1 (en) 2012-02-09
EA020604B1 (ru) 2014-12-30
JP2012512260A (ja) 2012-05-31
CN105935352A (zh) 2016-09-14
JP5895030B2 (ja) 2016-03-30
CA2747182A1 (en) 2010-07-08
CN102256595A (zh) 2011-11-23
EP2367532A2 (en) 2011-09-28
JP2014224127A (ja) 2014-12-04
AU2009333177A1 (en) 2011-07-07
US20150315217A1 (en) 2015-11-05
EA201100829A1 (ru) 2012-02-28
US20130330398A1 (en) 2013-12-12
SG172257A1 (en) 2011-07-28
MX2011006562A (es) 2011-09-27
BRPI0923001A2 (pt) 2018-09-18
AU2009333177B2 (en) 2013-09-19
CA2747182C (en) 2014-11-18
WO2010078045A3 (en) 2010-10-28

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