KR101380959B1 - 신규 ｃ-17-헤테로아릴 스테로이드성 ｃｙｐ17억제제／항안드로겐：합성, 시험관내 생물학적 활성,약물동태학 및 항종양 활성 - Google Patents

신규 ｃ-17-헤테로아릴 스테로이드성 ｃｙｐ17억제제／항안드로겐：합성, 시험관내 생물학적 활성,약물동태학 및 항종양 활성 Download PDF

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KR101380959B1
KR101380959B1 KR1020077022440A KR20077022440A KR101380959B1 KR 101380959 B1 KR101380959 B1 KR 101380959B1 KR 1020077022440 A KR1020077022440 A KR 1020077022440A KR 20077022440 A KR20077022440 A KR 20077022440A KR 101380959 B1 KR101380959 B1 KR 101380959B1
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KR20070120119A (ko
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안젤라 브로디
빈센트 자르
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유니버시티 오브 매릴랜드, 발티모어
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020077022440A 2005-03-02 2006-03-02 신규 ｃ-17-헤테로아릴 스테로이드성 ｃｙｐ17억제제／항안드로겐：합성, 시험관내 생물학적 활성,약물동태학 및 항종양 활성 Expired - Fee Related KR101380959B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65739005P 2005-03-02 2005-03-02
US60/657,390 2005-03-02
PCT/US2006/007143 WO2006093993A1 (en) 2005-03-02 2006-03-02 Novel c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity

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KR20070120119A KR20070120119A (ko) 2007-12-21
KR101380959B1 true KR101380959B1 (ko) 2014-04-04

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US20100047338A1 (en) * 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
WO2008154402A2 (en) 2007-06-06 2008-12-18 University Of Maryland, Baltimore Hdac inhibitors and hormone targeted drugs for the treatment of cancer
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US20110118219A1 (en) * 2008-03-25 2011-05-19 University Of Maryland, Baltimore Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
US8785423B2 (en) * 2008-04-14 2014-07-22 University Of Maryland, Baltimore Compositions and methods of inducing endoplasmic reticulum stress response for the treatment of cell proliferative diseases
WO2010024930A2 (en) 2008-08-28 2010-03-04 President And Fellows Of Harvard College Cortistatin analogues and syntheses therof
US20100105700A1 (en) * 2008-10-28 2010-04-29 Lead Therapeutics, Inc. Decahydro-1h-indenoquinolinone and decahydro-3h-cyclopentaphenanthridinone cyp17 inhibitors
GB2514957A (en) * 2009-02-05 2014-12-10 Tokai Pharmaceuticals Inc Combination of a 17 alpha-hydroxylase/c17, 20-lyase inhibitor with an additional therapeutic agent
US8791095B2 (en) 2009-02-05 2014-07-29 Tokai Pharmaceuticals, Inc. Steroidal CYP17 inhibitors/antiandrogens
AU2010210422A1 (en) * 2009-02-05 2011-08-18 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal CYP17 inhibitors/antiandrogens
UY32730A (es) 2009-06-26 2011-01-31 Novartis Ag Inhibidores de cyp17
AU2010279398A1 (en) * 2009-08-07 2012-03-08 Tokai Pharmaceuticals, Inc. Treatment of prostate cancer
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WO2012083112A2 (en) * 2010-12-16 2012-06-21 Biomarin Pharmaceutical Inc. Cyp11b, cyp17, and/or cyp21 inhibitors
MX359399B (es) 2011-04-28 2018-09-27 Novartis Ag Inhibidores de 17alfa-hidroxilasa/c17-20-liasa.
JP2014523445A (ja) * 2011-07-18 2014-09-11 トーカイ ファーマシューティカルズ，インク． 前立腺癌を処置するための新規な組成物及び方法
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EP2991644B1 (en) 2013-04-04 2020-03-25 University of Maryland, Baltimore Nonsteroidal and steroidal compounds with potent androgen receptor down-regulation and anti prostate cancer activity
WO2015023710A1 (en) 2013-08-12 2015-02-19 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
ES2709480T3 (es) 2013-12-24 2019-04-16 Harvard College Análogos de cortistatina y síntesis y usos de los mismos
CN103694299A (zh) * 2014-01-13 2014-04-02 中国药科大学 甾体类雄激素受体抑制剂、其制备方法及其医药用途
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EP3294298A4 (en) 2015-05-08 2018-10-17 President and Fellows of Harvard College Cortistatin analogues, syntheses, and uses thereof
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CA2599953A1 (en) 2006-09-08
IL185608A0 (en) 2008-01-06
JP2012255026A (ja) 2012-12-27
DE602006017175D1 (de) 2010-11-11
PL1853619T3 (pl) 2011-03-31
WO2006093993A1 (en) 2006-09-08
EP1853619B1 (en) 2010-09-29
IL210480A0 (en) 2011-03-31
JP5130453B2 (ja) 2013-01-30
IL185608A (en) 2016-06-30
EP1853619A1 (en) 2007-11-14
CN103349664A (zh) 2013-10-16
PL2206719T3 (pl) 2015-03-31
HK1115387A1 (en) 2008-11-28
NZ561571A (en) 2009-09-25
BRPI0607523A2 (pt) 2009-09-08
AU2006218711A2 (en) 2006-09-08
JP2008536807A (ja) 2008-09-11
US20080280864A1 (en) 2008-11-13
MX2007010593A (es) 2008-02-20
EP1853619A4 (en) 2009-08-26
CN101155823A (zh) 2008-04-02
DK2206719T3 (en) 2015-01-26
US7875599B2 (en) 2011-01-25
PT1853619E (pt) 2011-01-03
ES2528055T3 (es) 2015-02-03
AU2006218711A1 (en) 2006-09-08
ATE482969T1 (de) 2010-10-15
AU2006218711B2 (en) 2010-11-11
EP2206719B1 (en) 2014-10-22
IL210480A (en) 2015-06-30
EA200701872A1 (ru) 2008-06-30
IL210478A0 (en) 2011-03-31
EA019560B1 (ru) 2014-04-30
PT2206719E (pt) 2015-02-05
ZA200708106B (en) 2008-12-31
SI1853619T1 (sl) 2011-01-31
JP5613206B2 (ja) 2014-10-22
ES2353413T3 (es) 2011-03-01
EP2206719A3 (en) 2011-01-05
KR20070120119A (ko) 2007-12-21
EP2206719A2 (en) 2010-07-14
DK1853619T3 (da) 2011-01-10
CA2599953C (en) 2013-08-13
SI2206719T1 (sl) 2015-03-31

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