KR101309605B1 - （―）―할로페네이트 및 이의 중간체의 입체 선택적제조를 위한 방법 - Google Patents

（―）―할로페네이트 및 이의 중간체의 입체 선택적제조를 위한 방법 Download PDF

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Publication number
KR101309605B1
KR101309605B1 KR1020087009709A KR20087009709A KR101309605B1 KR 101309605 B1 KR101309605 B1 KR 101309605B1 KR 1020087009709 A KR1020087009709 A KR 1020087009709A KR 20087009709 A KR20087009709 A KR 20087009709A KR 101309605 B1 KR101309605 B1 KR 101309605B1
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formula
compound
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Korean (ko)
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KR20080050527A (ko
Inventor
얀 주
펭 쳉
씬 첸
징위안 마
주춘 조우
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메타볼렉스, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
KR1020087009709A 2005-09-23 2006-09-21 （―）―할로페네이트 및 이의 중간체의 입체 선택적제조를 위한 방법 Expired - Fee Related KR101309605B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US72030005P 2005-09-23 2005-09-23
US60/720,300 2005-09-23
US11/525,200 2006-09-20
US11/525,200 US7714131B2 (en) 2005-09-23 2006-09-20 Process for the stereoselective preparation of (−)-halofenate and derivatives thereof
PCT/US2006/036928 WO2007038243A1 (en) 2005-09-23 2006-09-21 Process for the stereoselective preparation of (-)-halofenate and intermediates thereof

Publications (2)

Publication Number Publication Date
KR20080050527A KR20080050527A (ko) 2008-06-05
KR101309605B1 true KR101309605B1 (ko) 2013-09-17

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Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020087009709A Expired - Fee Related KR101309605B1 (ko) 2005-09-23 2006-09-21 （―）―할로페네이트 및 이의 중간체의 입체 선택적제조를 위한 방법

Country Status (17)

Country Link
US (1) US7714131B2 (enExample)
EP (1) EP1940387B1 (enExample)
JP (1) JP2009515817A (enExample)
KR (1) KR101309605B1 (enExample)
AU (1) AU2006294950A1 (enExample)
BR (1) BRPI0616188A2 (enExample)
CA (1) CA2623350C (enExample)
DK (1) DK1940387T3 (enExample)
EA (1) EA015673B1 (enExample)
ES (1) ES2394973T3 (enExample)
HR (1) HRP20130001T1 (enExample)
IL (1) IL190325A (enExample)
PL (1) PL1940387T3 (enExample)
PT (1) PT1940387E (enExample)
RS (1) RS52608B (enExample)
SI (1) SI1940387T1 (enExample)
WO (1) WO2007038243A1 (enExample)

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WO2009121940A1 (en) * 2008-04-03 2009-10-08 Janssen Pharmaceutica Nv Process for the preparation of (-)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester
US8383833B2 (en) * 2008-06-03 2013-02-26 Kaneka Corporation Method for producing optically active amino acid derivative
US9023856B2 (en) 2011-11-04 2015-05-05 Cymabay Therapeutics, Inc. Methods for treating hyperuricemia in patients with gout using halofenate or halogenic acid and a second urate-lowering agent
US9060987B2 (en) 2011-11-04 2015-06-23 Cymabay Therapeutics, Inc. Methods for treating gout flares
US20210355065A1 (en) 2020-05-18 2021-11-18 Cymabay Therapeutics, Inc. CB-0406 tromethamine salt
WO2021236395A1 (en) 2020-05-18 2021-11-25 Cymabay Therapeutics, Inc. Cb-0406 choline salt

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Also Published As

Publication number Publication date
KR20080050527A (ko) 2008-06-05
US20070072858A1 (en) 2007-03-29
EA015673B1 (ru) 2011-10-31
PL1940387T3 (pl) 2013-02-28
ES2394973T3 (es) 2013-02-07
EP1940387A1 (en) 2008-07-09
WO2007038243A1 (en) 2007-04-05
EA200800884A1 (ru) 2008-12-30
AU2006294950A1 (en) 2007-04-05
SI1940387T1 (sl) 2013-04-30
HRP20130001T1 (hr) 2013-02-28
IL190325A (en) 2013-04-30
HK1119953A1 (en) 2009-03-20
CA2623350A1 (en) 2007-04-05
BRPI0616188A2 (pt) 2011-06-14
DK1940387T3 (da) 2013-01-02
RS52608B (sr) 2013-04-30
US7714131B2 (en) 2010-05-11
JP2009515817A (ja) 2009-04-16
EP1940387B1 (en) 2012-11-28
EP1940387A4 (en) 2010-11-03
IL190325A0 (en) 2009-09-22
PT1940387E (pt) 2012-12-17
CA2623350C (en) 2014-08-19

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