DK1940387T3 - Fremgangsmåde til stereoselektiv fremstilling af (-)-halofenat og mellemprodukter deraf - Google Patents

Fremgangsmåde til stereoselektiv fremstilling af (-)-halofenat og mellemprodukter deraf

Info

Publication number
DK1940387T3
DK1940387T3 DK06815150.5T DK06815150T DK1940387T3 DK 1940387 T3 DK1940387 T3 DK 1940387T3 DK 06815150 T DK06815150 T DK 06815150T DK 1940387 T3 DK1940387 T3 DK 1940387T3
Authority
DK
Denmark
Prior art keywords
halophenate
intermediates
stereoselective production
stereoselective
production
Prior art date
Application number
DK06815150.5T
Other languages
Danish (da)
English (en)
Inventor
Peng Cheng
Yan Zhu
Xin Chen
Jingyuan Ma
Zuchun Zhao
Original Assignee
Metabolex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabolex Inc filed Critical Metabolex Inc
Application granted granted Critical
Publication of DK1940387T3 publication Critical patent/DK1940387T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
DK06815150.5T 2005-09-23 2006-09-21 Fremgangsmåde til stereoselektiv fremstilling af (-)-halofenat og mellemprodukter deraf DK1940387T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72030005P 2005-09-23 2005-09-23
US11/525,200 US7714131B2 (en) 2005-09-23 2006-09-20 Process for the stereoselective preparation of (−)-halofenate and derivatives thereof
PCT/US2006/036928 WO2007038243A1 (en) 2005-09-23 2006-09-21 Process for the stereoselective preparation of (-)-halofenate and intermediates thereof

Publications (1)

Publication Number Publication Date
DK1940387T3 true DK1940387T3 (da) 2013-01-02

Family

ID=37894903

Family Applications (1)

Application Number Title Priority Date Filing Date
DK06815150.5T DK1940387T3 (da) 2005-09-23 2006-09-21 Fremgangsmåde til stereoselektiv fremstilling af (-)-halofenat og mellemprodukter deraf

Country Status (17)

Country Link
US (1) US7714131B2 (enExample)
EP (1) EP1940387B1 (enExample)
JP (1) JP2009515817A (enExample)
KR (1) KR101309605B1 (enExample)
AU (1) AU2006294950A1 (enExample)
BR (1) BRPI0616188A2 (enExample)
CA (1) CA2623350C (enExample)
DK (1) DK1940387T3 (enExample)
EA (1) EA015673B1 (enExample)
ES (1) ES2394973T3 (enExample)
HR (1) HRP20130001T1 (enExample)
IL (1) IL190325A (enExample)
PL (1) PL1940387T3 (enExample)
PT (1) PT1940387E (enExample)
RS (1) RS52608B (enExample)
SI (1) SI1940387T1 (enExample)
WO (1) WO2007038243A1 (enExample)

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WO2009121940A1 (en) * 2008-04-03 2009-10-08 Janssen Pharmaceutica Nv Process for the preparation of (-)-(4-chloro-phenyl)-(3-trifluoromethyl-phenoxy)-acetic acid 2-acetylamino-ethyl ester
US8383833B2 (en) * 2008-06-03 2013-02-26 Kaneka Corporation Method for producing optically active amino acid derivative
US9023856B2 (en) 2011-11-04 2015-05-05 Cymabay Therapeutics, Inc. Methods for treating hyperuricemia in patients with gout using halofenate or halogenic acid and a second urate-lowering agent
US9060987B2 (en) 2011-11-04 2015-06-23 Cymabay Therapeutics, Inc. Methods for treating gout flares
US20210355065A1 (en) 2020-05-18 2021-11-18 Cymabay Therapeutics, Inc. CB-0406 tromethamine salt
WO2021236395A1 (en) 2020-05-18 2021-11-25 Cymabay Therapeutics, Inc. Cb-0406 choline salt

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Also Published As

Publication number Publication date
KR20080050527A (ko) 2008-06-05
US20070072858A1 (en) 2007-03-29
EA015673B1 (ru) 2011-10-31
PL1940387T3 (pl) 2013-02-28
ES2394973T3 (es) 2013-02-07
EP1940387A1 (en) 2008-07-09
WO2007038243A1 (en) 2007-04-05
EA200800884A1 (ru) 2008-12-30
AU2006294950A1 (en) 2007-04-05
SI1940387T1 (sl) 2013-04-30
KR101309605B1 (ko) 2013-09-17
HRP20130001T1 (hr) 2013-02-28
IL190325A (en) 2013-04-30
HK1119953A1 (en) 2009-03-20
CA2623350A1 (en) 2007-04-05
BRPI0616188A2 (pt) 2011-06-14
RS52608B (sr) 2013-04-30
US7714131B2 (en) 2010-05-11
JP2009515817A (ja) 2009-04-16
EP1940387B1 (en) 2012-11-28
EP1940387A4 (en) 2010-11-03
IL190325A0 (en) 2009-09-22
PT1940387E (pt) 2012-12-17
CA2623350C (en) 2014-08-19

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