KR101305976B1 - 연속희석을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템 - Google Patents

연속희석을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템 Download PDF

Info

Publication number
KR101305976B1
KR101305976B1 KR1020070014554A KR20070014554A KR101305976B1 KR 101305976 B1 KR101305976 B1 KR 101305976B1 KR 1020070014554 A KR1020070014554 A KR 1020070014554A KR 20070014554 A KR20070014554 A KR 20070014554A KR 101305976 B1 KR101305976 B1 KR 101305976B1
Authority
KR
South Korea
Prior art keywords
valve
mixing chamber
channel
microfluidic device
platform
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020070014554A
Other languages
English (en)
Korean (ko)
Other versions
KR20080075406A (ko
Inventor
조윤경
이정건
이범석
박종면
이영선
Original Assignee
삼성전자주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 삼성전자주식회사 filed Critical 삼성전자주식회사
Priority to KR1020070014554A priority Critical patent/KR101305976B1/ko
Priority to EP08151025.7A priority patent/EP1955770A3/en
Priority to JP2008026810A priority patent/JP5174481B2/ja
Priority to US12/029,480 priority patent/US7951332B2/en
Publication of KR20080075406A publication Critical patent/KR20080075406A/ko
Application granted granted Critical
Publication of KR101305976B1 publication Critical patent/KR101305976B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N37/00—Details not covered by any other group of this subclass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • B01L3/502792—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics for moving individual droplets on a plate, e.g. by locally altering surface tension
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0605—Metering of fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B01L2300/0806—Standardised forms, e.g. compact disc [CD] format
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/18—Means for temperature control
    • B01L2300/1861—Means for temperature control using radiation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
KR1020070014554A 2007-02-12 2007-02-12 연속희석을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템 Expired - Fee Related KR101305976B1 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
KR1020070014554A KR101305976B1 (ko) 2007-02-12 2007-02-12 연속희석을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템
EP08151025.7A EP1955770A3 (en) 2007-02-12 2008-02-04 Centrifugal force based microfluidic device for dilution and microfluidic system including the same
JP2008026810A JP5174481B2 (ja) 2007-02-12 2008-02-06 希釈のための遠心力基盤の微細流動装置及びそれを備える微細流動システム
US12/029,480 US7951332B2 (en) 2007-02-12 2008-02-12 Centrifugal force based microfluidic device for dilution and microfluidic system including the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020070014554A KR101305976B1 (ko) 2007-02-12 2007-02-12 연속희석을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템

Publications (2)

Publication Number Publication Date
KR20080075406A KR20080075406A (ko) 2008-08-18
KR101305976B1 true KR101305976B1 (ko) 2013-09-12

Family

ID=39477384

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020070014554A Expired - Fee Related KR101305976B1 (ko) 2007-02-12 2007-02-12 연속희석을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템

Country Status (4)

Country Link
US (1) US7951332B2 (enExample)
EP (1) EP1955770A3 (enExample)
JP (1) JP5174481B2 (enExample)
KR (1) KR101305976B1 (enExample)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101435942B1 (ko) * 2007-10-10 2014-09-02 삼성전자 주식회사 미세유동시스템을 위한 자동 검사 방법 및 장치
KR100915900B1 (ko) * 2008-03-07 2009-09-07 한국과학기술연구원 미세 채널을 이용한 선형 희석 장치 및 방법
KR100970480B1 (ko) * 2008-09-03 2010-07-16 삼성전자주식회사 마이크로파와 음이온을 이용한 액체 매질 가열방법, 음이온이 첨가된 생물학적 분석장치 및 액체 매질 가열용 용액
KR20100007809A (ko) * 2008-07-14 2010-01-22 삼성전자주식회사 미세유동장치, 이를 이용한 시료분석방법 및 희석비율측정방법
KR101130698B1 (ko) * 2009-11-03 2012-04-02 삼성전자주식회사 밸브 유닛과 이를 구비한 미세유동장치 및 밸브 유닛의 구동방법
KR101422573B1 (ko) * 2009-11-26 2014-07-25 삼성전자 주식회사 원심력기반의 미세유동장치 및 이를 이용한 면역혈청검사방법
KR20120091631A (ko) * 2011-02-09 2012-08-20 삼성전자주식회사 미세유동장치
KR20120093636A (ko) * 2011-02-15 2012-08-23 삼성전자주식회사 미세유동장치
SI3270141T1 (sl) 2011-03-08 2021-03-31 Universite Laval Fluidična centripetalna naprava
CN102688787B (zh) * 2011-03-23 2016-01-27 罗姆股份有限公司 圆盘式分析芯片
DE202011108189U1 (de) 2011-06-08 2011-12-13 Albert-Ludwigs-Universität Freiburg Vorrichtung und Fluidikmodul zum Erzeugen einer Verdünnungsreihe
PT105887B (pt) * 2011-09-14 2013-08-08 Inst Superior Tecnico Dispositivo para diluições sucessivas em microplacas
CN203519617U (zh) * 2011-10-10 2014-04-02 保生国际生医股份有限公司 离心式转盘
JP6257521B2 (ja) * 2011-12-08 2018-01-10 バイオサーフィット、 ソシエダッド アノニマ 逐次分注および沈降速度の指標の決定
WO2013096643A1 (en) * 2011-12-23 2013-06-27 Gigagen Methods and apparatuses for droplet mixing
KR101357808B1 (ko) * 2012-03-21 2014-02-04 국립대학법인 울산과학기술대학교 산학협력단 시약 보관용기, 미세 유동장치, 및 이들을 이용한 분석방법
TWI456196B (zh) 2012-04-24 2014-10-11 Ind Tech Res Inst 檢體免疫分析檢測裝置
DE102012213044B3 (de) * 2012-07-25 2014-01-23 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Vorrichtung und Verfahren zur Erzeugung von Kombinationen von Flüssigkeiten und Verfahren zur Herstellung einer Vorrichtung zur Erzeugung von Kombinationen von Flüssigkeiten
TWI475226B (zh) 2012-08-01 2015-03-01 Univ Feng Chia 利用分流結構進行生化檢測之裝置及其運作方法
JP5900269B2 (ja) * 2012-09-28 2016-04-06 ブラザー工業株式会社 検査チップ
EP3425401B1 (en) * 2012-10-08 2023-09-27 BL Technologies, Inc. Preloaded test substrates for testing lal-reactive substances, methods of use, and methods of making
TWI509066B (zh) * 2012-12-28 2015-11-21 中原大學 多通道微流體光盤檢測系統及其應用
KR102176587B1 (ko) * 2013-10-15 2020-11-10 삼성전자주식회사 시료분석장치, 시료분석방법, 및 밸브의 동적 작동 방법
US10596570B2 (en) 2014-05-16 2020-03-24 Qvella Corporation Apparatus, system and method for performing automated centrifugal separation
EP2952257A1 (en) 2014-06-06 2015-12-09 Roche Diagnostics GmbH Rotatable cartridge for processing and analyzing a biological sample
EP2952258A1 (en) * 2014-06-06 2015-12-09 Roche Diagnostics GmbH Rotatable cartridge for analyzing a biological sample
WO2015185763A1 (en) * 2014-06-06 2015-12-10 Roche Diagnostics Gmbh Rotatable cartridge with a metering chamber for analyzing a biological sample
EP2957890A1 (en) * 2014-06-16 2015-12-23 Roche Diagnostics GmbH Cartridge with a rotatable lid
US9993819B2 (en) 2014-12-30 2018-06-12 Stmicroelectronics S.R.L. Apparatus for actuating and reading a centrifugal microfluidic disk for biological and biochemical analyses, and use of the apparatus
KR101871042B1 (ko) * 2016-06-29 2018-06-26 강릉원주대학교산학협력단 정지액체상 랩온어칩을 이용한 핵산 시료의 제조 방법
GB2553100A (en) * 2016-08-19 2018-02-28 Univ Dublin City A microfluidic device
CN107739706B (zh) * 2017-09-26 2020-04-14 南京岚煜生物科技有限公司 主动控制流路的多通量微流控核酸检测芯片及其使用方法
CN108043481B (zh) * 2018-01-24 2020-10-27 北京博奥晶典生物技术有限公司 一种多指标检测微流控芯片及其使用方法
CN109283174A (zh) * 2018-09-29 2019-01-29 厦门大学 一种定量检测光盘和检测方法
CN110180610B (zh) * 2019-06-19 2021-09-03 深圳市刚竹医疗科技有限公司 试剂顺序加载方法、结构及微流控装置
CN110339880B (zh) * 2019-07-10 2022-06-10 深圳市刚竹医疗科技有限公司 基于相变阀的试剂顺序加载方法、装置及微流控系统
US20210079331A1 (en) * 2019-09-16 2021-03-18 Delta Electronics, Inc. Biological detection cartridge and method for performing the same
CN110732357B (zh) * 2019-11-25 2021-11-19 北京世纪沃德生物科技有限公司 一种微流控芯片的样本分流管路
CA3098079C (en) * 2019-12-13 2023-06-20 Autonomous Medical Devices Inc. Apparatus and method for point-of-care, rapid, field-deployable diagnostic testing of covid-19, viruses, antibodies and markers
CN111218395B (zh) * 2020-04-18 2020-08-07 博奥生物集团有限公司 一种全流程生物检测装置
CN114849797A (zh) * 2021-01-20 2022-08-05 南京岚煜生物科技有限公司 一种基于相变材料封闭试剂的微流控芯片
CN115555065A (zh) * 2022-09-22 2023-01-03 深圳市卓润生物科技有限公司 固液分离装置及方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063589A (en) * 1997-05-23 2000-05-16 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement on a microfluidics system
US6582662B1 (en) * 1999-06-18 2003-06-24 Tecan Trading Ag Devices and methods for the performance of miniaturized homogeneous assays
KR20040003004A (ko) * 2001-05-25 2004-01-07 가부시키가이샤 히타치세이사쿠쇼 핵산 정제 장치 및 핵산 정제 방법
KR20060034390A (ko) * 2004-10-19 2006-04-24 한국과학기술연구원 미소 유체 공급유로 설계방법 및 이를 이용한 생체물질 측정 장치

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010055812A1 (en) * 1995-12-05 2001-12-27 Alec Mian Devices and method for using centripetal acceleration to drive fluid movement in a microfluidics system with on-board informatics
US5836004A (en) 1997-01-07 1998-11-10 Industrial Technology Research Institute Differential mode time to digital converter
GB9804483D0 (en) * 1998-03-02 1998-04-29 Central Research Lab Ltd Apparatus for and method of controlling the rate of flow of fluid along a pathway
AU2001263162A1 (en) * 2000-05-15 2001-11-26 Tecan Trading Ag Microfluidics devices and methods for high throughput screening
JP2003533681A (ja) * 2000-05-15 2003-11-11 テカン・トレーディング・アクチェンゲゼルシャフト ミクロ流体装置および細胞ベースの分析を実行する方法
CA2422110A1 (en) 2000-09-18 2002-03-21 President And Fellows Of Harvard College Method and apparatus for gradient generation
US6919058B2 (en) * 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
US20030156991A1 (en) * 2001-10-23 2003-08-21 William Marsh Rice University Optomechanically-responsive materials for use as light-activated actuators and valves
EP1578533A2 (en) * 2002-12-24 2005-09-28 Tecan Trading AG Microfluidics devices and methods for diluting samples and reagents
WO2005036182A1 (ja) * 2003-10-15 2005-04-21 Matsushita Electric Industrial Co., Ltd. キャピラリチップにおける流体の流通方法
US20050249641A1 (en) * 2004-04-08 2005-11-10 Boehringer Ingelheim Microparts Gmbh Microstructured platform and method for manipulating a liquid
JP2005345160A (ja) * 2004-05-31 2005-12-15 Advance Co Ltd 生体情報分析ユニット
DE102005016509A1 (de) * 2005-04-09 2006-10-12 Boehringer Ingelheim Microparts Gmbh Vorrichtung und Verfahren zur Untersuchung einer Probenflüssigkeit
EP1899702A2 (de) * 2005-04-09 2008-03-19 Boehringer Ingelheim microParts GmbH Vorrichtung und verfahren zur untersuchung einer probenflüssigkeit
WO2006110093A1 (en) * 2005-04-14 2006-10-19 Gyros Patent Ab Liquid plugs
KR100851980B1 (ko) * 2006-09-05 2008-08-12 삼성전자주식회사 열 활성 유닛을 구비한 원심력 기반의 미세유동 장치, 이를포함하는 미세유동 시스템 및 상기 미세유동 시스템의구동방법
KR101343034B1 (ko) * 2006-09-05 2013-12-18 삼성전자 주식회사 원심력 기반의 단백질 검출용 미세유동 장치 및 이를포함하는 미세유동 시스템

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6063589A (en) * 1997-05-23 2000-05-16 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement on a microfluidics system
US6582662B1 (en) * 1999-06-18 2003-06-24 Tecan Trading Ag Devices and methods for the performance of miniaturized homogeneous assays
KR20040003004A (ko) * 2001-05-25 2004-01-07 가부시키가이샤 히타치세이사쿠쇼 핵산 정제 장치 및 핵산 정제 방법
KR20060034390A (ko) * 2004-10-19 2006-04-24 한국과학기술연구원 미소 유체 공급유로 설계방법 및 이를 이용한 생체물질 측정 장치

Also Published As

Publication number Publication date
EP1955770A2 (en) 2008-08-13
US7951332B2 (en) 2011-05-31
JP2008197097A (ja) 2008-08-28
KR20080075406A (ko) 2008-08-18
US20080193336A1 (en) 2008-08-14
EP1955770A3 (en) 2013-07-24
JP5174481B2 (ja) 2013-04-03

Similar Documents

Publication Publication Date Title
KR101305976B1 (ko) 연속희석을 위한 원심력 기반의 미세유동장치 및 이를포함하는 미세유동시스템
KR100858091B1 (ko) 시료 분배 구조를 갖는 원심력 기반의 미세유동장치 및이를 포함하는 미세유동시스템
KR100851980B1 (ko) 열 활성 유닛을 구비한 원심력 기반의 미세유동 장치, 이를포함하는 미세유동 시스템 및 상기 미세유동 시스템의구동방법
KR101228308B1 (ko) 미세유동 칩을 이용한 디스크형 미세유동장치 및 생체물질마이크로어레이 칩을 이용한 디스크형 미세유동장치
Park et al. Multifunctional microvalves control by optical illumination on nanoheaters and its application in centrifugal microfluidic devices
KR101335727B1 (ko) 원심력 기반의 혈액 검사용 디스크형 미세유동장치
KR101130698B1 (ko) 밸브 유닛과 이를 구비한 미세유동장치 및 밸브 유닛의 구동방법
EP2324924B1 (en) Microfluidic system
KR100883658B1 (ko) 원심력 기반의 미세유동장치 및 이를 포함하는미세유동시스템
EP1980322B1 (en) Centrifugal force-based microfluidic device and microfluidic system
US9101935B2 (en) Microfluidic apparatus and control method thereof
US9011795B2 (en) Valve unit, microfluidic device with the valve unit, and microfluidic substrate
EP2486979A2 (en) Microfluidic device
KR20080071786A (ko) 세포배양 및 세포기반 시험을 위한 원심력 기반의미세유동장치 및 이를 포함하는 미세유동시스템
KR100846516B1 (ko) 원심력 기반의 미세유동장치 및 이를 포함하는미세유동시스템
KR101391736B1 (ko) 미세유동 밸브, 상기 미세유동 밸브의 제조 방법 및 상기미세유동 밸브를 포함하는 미세유동 장치

Legal Events

Date Code Title Description
PA0109 Patent application

St.27 status event code: A-0-1-A10-A12-nap-PA0109

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

A201 Request for examination
PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U11-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20160904

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20160904