KR101277352B1 - 비타민 ｂ1의 전구물질의 제조 방법 - Google Patents

비타민 ｂ1의 전구물질의 제조 방법 Download PDF

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Publication number
KR101277352B1
KR101277352B1 KR1020077017242A KR20077017242A KR101277352B1 KR 101277352 B1 KR101277352 B1 KR 101277352B1 KR 1020077017242 A KR1020077017242 A KR 1020077017242A KR 20077017242 A KR20077017242 A KR 20077017242A KR 101277352 B1 KR101277352 B1 KR 101277352B1
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KR
South Korea
Prior art keywords
gda
analyzed
nfgda
hydrolysis
sodium formate
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Expired - Lifetime
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KR1020077017242A
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English (en)
Korean (ko)
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KR20070098888A (ko
Inventor
베르너 본라스
조셀린 피스케서
리사 기라우디
라인하드 카르게
Original Assignee
디에스엠 아이피 어셋츠 비.브이.
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Publication of KR20070098888A publication Critical patent/KR20070098888A/ko
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Publication of KR101277352B1 publication Critical patent/KR101277352B1/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020077017242A 2005-01-28 2006-01-24 비타민 ｂ1의 전구물질의 제조 방법 Expired - Lifetime KR101277352B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP05001859.7 2005-01-28
EP05001859 2005-01-28
PCT/EP2006/000600 WO2006079504A2 (en) 2005-01-28 2006-01-24 Process for the manufacture of a precursor of vitamin b1

Publications (2)

Publication Number Publication Date
KR20070098888A KR20070098888A (ko) 2007-10-05
KR101277352B1 true KR101277352B1 (ko) 2013-06-20

Family

ID=36118080

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077017242A Expired - Lifetime KR101277352B1 (ko) 2005-01-28 2006-01-24 비타민 ｂ1의 전구물질의 제조 방법

Country Status (9)

Country Link
US (1) US9108925B2 (https=)
EP (1) EP1841745B1 (https=)
JP (1) JP5191237B2 (https=)
KR (1) KR101277352B1 (https=)
CN (1) CN101111484B (https=)
AT (1) ATE397593T1 (https=)
DE (1) DE602006001394D1 (https=)
ES (1) ES2308715T3 (https=)
WO (1) WO2006079504A2 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007104442A2 (en) * 2006-03-15 2007-09-20 Dsm Ip Assets B.V. Process for the manufacture of a precursor of vitamin b1
US8252927B2 (en) 2008-07-22 2012-08-28 Dsm Ip Assets B.V. Synthesis of substituted 4-amino-pyrimidines
CN103896935B (zh) * 2012-12-27 2016-08-10 江西天新药业有限公司 3-[(4-氨基-5-嘧啶基)甲基]-5-(2-羟乙基)-4-甲基噻唑硝酸盐的制备方法
CN104326989B (zh) * 2014-11-26 2016-04-27 江西天新药业有限公司 2-甲基-4-氨基-5-(氨基甲基)嘧啶的制备方法
US9682216B2 (en) 2014-12-05 2017-06-20 Anchor Endovascular, Inc. Anchor device for use with catheters
CN108546249B (zh) * 2018-02-28 2021-10-01 东北制药集团股份有限公司 一种制备双胺嘧啶的方法
CN109467553B (zh) * 2018-12-24 2021-02-12 江苏兄弟维生素有限公司 一种甲酰嘧啶的提纯方法以及维生素b1合成方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3511273A1 (de) * 1985-03-28 1986-10-09 Basf Ag, 6700 Ludwigshafen Verbessertes verfahren zur herstellung von 2-methyl-4-amino-5-aminomethyl-pyrimidin

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2775592A (en) * 1956-12-25 Z-methyl -
DE2860431D1 (en) * 1977-10-27 1981-02-26 Basf Ag Alpha-aminomethylene-beta-formylaminopropionitrile, process for its preparation and its use in the preparation of 2-methyl-4-amino-5-formylaminomethylpyrimidine
JPS5576084A (en) * 1978-12-01 1980-06-07 Takeda Chem Ind Ltd Method and apparatus for production of vitamin b1 and intermediate thereof
DE10015470A1 (de) * 2000-03-29 2001-10-11 Basf Ag Verfahren zur Herstellung von 2-Methyl-4-amino-5-aminomethyrimidin

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3511273A1 (de) * 1985-03-28 1986-10-09 Basf Ag, 6700 Ludwigshafen Verbessertes verfahren zur herstellung von 2-methyl-4-amino-5-aminomethyl-pyrimidin

Also Published As

Publication number Publication date
US9108925B2 (en) 2015-08-18
ES2308715T3 (es) 2008-12-01
EP1841745A2 (en) 2007-10-10
JP5191237B2 (ja) 2013-05-08
JP2008528529A (ja) 2008-07-31
WO2006079504A2 (en) 2006-08-03
CN101111484B (zh) 2013-07-24
CN101111484A (zh) 2008-01-23
ATE397593T1 (de) 2008-06-15
EP1841745B1 (en) 2008-06-04
WO2006079504A3 (en) 2007-02-15
DE602006001394D1 (de) 2008-07-17
KR20070098888A (ko) 2007-10-05
US20080242863A1 (en) 2008-10-02

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