KR101264444B1 - 록사핀 유사체 및 이것의 사용 방법 - Google Patents

록사핀 유사체 및 이것의 사용 방법 Download PDF

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Publication number
KR101264444B1
KR101264444B1 KR1020077009122A KR20077009122A KR101264444B1 KR 101264444 B1 KR101264444 B1 KR 101264444B1 KR 1020077009122 A KR1020077009122 A KR 1020077009122A KR 20077009122 A KR20077009122 A KR 20077009122A KR 101264444 B1 KR101264444 B1 KR 101264444B1
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South Korea
Prior art keywords
sleep
hydrogen
compound
compounds
formula
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Expired - Fee Related
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KR1020077009122A
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English (en)
Korean (ko)
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KR20070060126A (ko
Inventor
데일 엠. 에드가
데이비드 지. 항고어
카즈미 시오사키
마이클 솔로몬
제임스 에프. 화이트
Original Assignee
히프니언 인크.
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
KR1020077009122A 2004-09-21 2005-09-21 록사핀 유사체 및 이것의 사용 방법 Expired - Fee Related KR101264444B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US61184904P 2004-09-21 2004-09-21
US60/611,849 2004-09-21
US67319805P 2005-04-19 2005-04-19
US60/673,198 2005-04-19

Publications (2)

Publication Number Publication Date
KR20070060126A KR20070060126A (ko) 2007-06-12
KR101264444B1 true KR101264444B1 (ko) 2013-05-20

Family

ID=36090680

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020077009122A Expired - Fee Related KR101264444B1 (ko) 2004-09-21 2005-09-21 록사핀 유사체 및 이것의 사용 방법

Country Status (19)

Country Link
US (3) US7592333B2 (https=)
EP (1) EP1804804B1 (https=)
JP (1) JP5049129B2 (https=)
KR (1) KR101264444B1 (https=)
AT (1) ATE542536T1 (https=)
AU (1) AU2005286713B2 (https=)
BR (1) BRPI0515518A (https=)
CA (1) CA2580250C (https=)
CY (1) CY1112590T1 (https=)
DK (1) DK1804804T3 (https=)
EA (1) EA012610B1 (https=)
ES (1) ES2378452T3 (https=)
MA (1) MA28985B1 (https=)
MX (1) MX2007003032A (https=)
NO (1) NO20071604L (https=)
NZ (1) NZ553900A (https=)
PL (1) PL1804804T3 (https=)
PT (1) PT1804804E (https=)
WO (1) WO2006034414A2 (https=)

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US7355042B2 (en) * 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
US20050250767A1 (en) * 2003-01-23 2005-11-10 Weiner David M Use of N-desmethylclozapine to treat human neuropsychiatric disease
JP2006515628A (ja) * 2003-01-23 2006-06-01 アカディア ファーマシューティカルズ，インコーポレーテッド ヒト神経精神疾患を処置するためのｎ−デスメチルクロザピンの使用
US20050085463A1 (en) * 2003-01-23 2005-04-21 Weiner David M. Use of N-desmethylclozapine to treat human neuropsychiatric disease
PT1696931E (pt) * 2003-12-22 2009-06-12 Acadia Pharm Inc Análogos diaril[a,d]ciclo-hepteno substituídos com amino utilizados como agonistas muscarínicos e métodos de tratamento de perturbações neuropsiquiátricas
BRPI0509524A (pt) * 2004-04-01 2007-09-18 Acadia Pharm Inc formas cristalinas de n-desmetilclozapina
US7563785B2 (en) * 2004-10-29 2009-07-21 Hypnion, Inc. Quetiapine analogs and methods of use thereof
WO2007053618A1 (en) * 2005-10-31 2007-05-10 Acadia Pharmaceuticals Inc. Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders
US7762006B2 (en) * 2006-06-14 2010-07-27 Siestamed, Technologies Medical equipment drying device
CN105481788A (zh) * 2006-10-28 2016-04-13 梅特希尔基因公司 组蛋白脱乙酰酶抑制剂
AU2008225014B2 (en) * 2007-03-15 2014-12-11 Protocell Therapeutics, Inc. Dibenzo(b,f)(1,4)oxazapine compounds
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
WO2009081262A1 (en) 2007-12-18 2009-07-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
CN104069567A (zh) 2007-03-19 2014-10-01 茵苏莱恩医药有限公司 药物输送设备
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
AU2009312474B2 (en) 2008-11-07 2014-12-04 Insuline Medical Ltd. Device and method for drug delivery
WO2014116684A1 (en) * 2013-01-22 2014-07-31 Edward Roberts Non-peptidic neuropeptide y receptor modulators
KR102597910B1 (ko) 2015-03-26 2023-11-02 재클린 엠. 이베르센 숙취상태와 연관된 증상들을 억제하기 위한 방법 및 조성물
JP7696354B2 (ja) * 2019-10-21 2025-06-20 アライリオン インコーポレイテッド 睡眠障害の治療のためのＨ１および５－ＨＴ２Ａ受容体調節物質としての３－（４－（１１Ｈ－ジベンゾ［ｂ，ｅ］［１，４］アゼピン－６－イル）ピペラジン－１－イル）－プロパン酸誘導体および３－（４－（ジベンゾ［ｂ，ｆ］［１，４］オキサゼピン／チアゼピン／ジアゼピン－１１－イル）ピペラジン－１－イル）－プロパン酸誘導体
WO2025076527A1 (en) * 2023-10-07 2025-04-10 Inspire Medical Systems, Inc. Pulmonary therapy for sleep disordered breathing care

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US20030187021A1 (en) 2001-10-16 2003-10-02 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators

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NL140242B (nl) * 1963-03-01 1973-11-15 Wander Ag Dr A Werkwijze voor het bereiden van op de 11-plaats door een basische groep gesubstitueerde dibenz (b.f.)(1.4) oxazepinen.
US3928356A (en) * 1967-10-06 1975-12-23 Fujisawa Pharmaceutical Co 10-{8 4-({107 -Hydroxy alkyl)-1-piperazimyl{9 -dibenzo (h,f) oxofins and thiepins and acetyl esters thereof
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Also Published As

Publication number Publication date
AU2005286713A1 (en) 2006-03-30
ATE542536T1 (de) 2012-02-15
US20090186872A1 (en) 2009-07-23
US20060063928A1 (en) 2006-03-23
KR20070060126A (ko) 2007-06-12
CA2580250C (en) 2013-05-14
PT1804804E (pt) 2012-03-30
EP1804804B1 (en) 2012-01-25
WO2006034414A3 (en) 2006-09-08
CY1112590T1 (el) 2016-02-10
DK1804804T3 (da) 2012-02-20
EA200700702A1 (ru) 2007-10-26
ES2378452T3 (es) 2012-04-12
BRPI0515518A (pt) 2008-07-29
AU2005286713B2 (en) 2010-10-28
EP1804804A2 (en) 2007-07-11
EP1804804A4 (en) 2010-11-24
MA28985B1 (fr) 2007-11-01
JP2008513510A (ja) 2008-05-01
MX2007003032A (es) 2007-05-21
WO2006034414A2 (en) 2006-03-30
JP5049129B2 (ja) 2012-10-17
CA2580250A1 (en) 2006-03-30
NZ553900A (en) 2010-10-29
US20060063755A1 (en) 2006-03-23
PL1804804T3 (pl) 2012-08-31
US7592333B2 (en) 2009-09-22
EA012610B1 (ru) 2009-10-30
NO20071604L (no) 2007-06-20
US8101596B2 (en) 2012-01-24

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