BRPI0515518A - análogos de loxapina e métodos de usos dos mesmos - Google Patents

análogos de loxapina e métodos de usos dos mesmos

Info

Publication number
BRPI0515518A
BRPI0515518A BRPI0515518-5A BRPI0515518A BRPI0515518A BR PI0515518 A BRPI0515518 A BR PI0515518A BR PI0515518 A BRPI0515518 A BR PI0515518A BR PI0515518 A BRPI0515518 A BR PI0515518A
Authority
BR
Brazil
Prior art keywords
methods
loxapine
analogues
relates
novel compounds
Prior art date
Application number
BRPI0515518-5A
Other languages
English (en)
Inventor
Dale M Edgar
David G Hangauer
Kazumi Shiosaki
Michael Solomon
James F White
Original Assignee
Hypnion Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hypnion Inc filed Critical Hypnion Inc
Publication of BRPI0515518A publication Critical patent/BRPI0515518A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D267/16—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with two six-membered rings
    • C07D267/20—[b, f]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

"ANáLOGOS DE LOXAPINA E MéTODOS DE USO DOS MESMOS". A invenção relaciona-se aos novos compostos e métodos de utilizá-los para modular o sono.
BRPI0515518-5A 2004-09-21 2005-09-21 análogos de loxapina e métodos de usos dos mesmos BRPI0515518A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US61184904P 2004-09-21 2004-09-21
US67319805P 2005-04-19 2005-04-19
PCT/US2005/034015 WO2006034414A2 (en) 2004-09-21 2005-09-21 Loxapine analogs and methods of use thereof

Publications (1)

Publication Number Publication Date
BRPI0515518A true BRPI0515518A (pt) 2008-07-29

Family

ID=36090680

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0515518-5A BRPI0515518A (pt) 2004-09-21 2005-09-21 análogos de loxapina e métodos de usos dos mesmos

Country Status (19)

Country Link
US (3) US7592333B2 (pt)
EP (1) EP1804804B1 (pt)
JP (1) JP5049129B2 (pt)
KR (1) KR101264444B1 (pt)
AT (1) ATE542536T1 (pt)
AU (1) AU2005286713B2 (pt)
BR (1) BRPI0515518A (pt)
CA (1) CA2580250C (pt)
CY (1) CY1112590T1 (pt)
DK (1) DK1804804T3 (pt)
EA (1) EA012610B1 (pt)
ES (1) ES2378452T3 (pt)
MA (1) MA28985B1 (pt)
MX (1) MX2007003032A (pt)
NO (1) NO20071604L (pt)
NZ (1) NZ553900A (pt)
PL (1) PL1804804T3 (pt)
PT (1) PT1804804E (pt)
WO (1) WO2006034414A2 (pt)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
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US7355042B2 (en) * 2001-10-16 2008-04-08 Hypnion, Inc. Treatment of CNS disorders using CNS target modulators
CA2512043A1 (en) * 2003-01-23 2004-08-05 Acadia Pharmaceuticals Inc. Use of n-desmethylclozapine to treat human neuropsychiatric disease
US20050085463A1 (en) * 2003-01-23 2005-04-21 Weiner David M. Use of N-desmethylclozapine to treat human neuropsychiatric disease
US20050250767A1 (en) * 2003-01-23 2005-11-10 Weiner David M Use of N-desmethylclozapine to treat human neuropsychiatric disease
US7550454B2 (en) * 2003-12-22 2009-06-23 Acadia Pharmaceuticals, Inc. Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders
MXPA06011320A (es) * 2004-04-01 2007-03-21 Acadia Pharm Inc Metodo de sintesis y aislamiento de n-desmetilclozapina solida y sus formas cristalinas.
US7563785B2 (en) * 2004-10-29 2009-07-21 Hypnion, Inc. Quetiapine analogs and methods of use thereof
WO2007053618A1 (en) * 2005-10-31 2007-05-10 Acadia Pharmaceuticals Inc. Prodrugs of muscarinic agonists and methods of treatment of neuropsychiatric disorders
US7762006B2 (en) * 2006-06-14 2010-07-27 Siestamed, Technologies Medical equipment drying device
KR101312993B1 (ko) * 2006-10-28 2013-11-25 엔비보 파마슈티칼즈, 인코퍼레이티드 히스톤 데아세틸라아제의 억제제
EP2137180B1 (en) * 2007-03-15 2012-03-07 Aryx Therapeutics, Inc. Dibenzo [b,f][1,4] oxazapine compounds
US8622991B2 (en) 2007-03-19 2014-01-07 Insuline Medical Ltd. Method and device for drug delivery
CN104069567A (zh) 2007-03-19 2014-10-01 茵苏莱恩医药有限公司 药物输送设备
US9220837B2 (en) 2007-03-19 2015-12-29 Insuline Medical Ltd. Method and device for drug delivery
US8409133B2 (en) 2007-12-18 2013-04-02 Insuline Medical Ltd. Drug delivery device with sensor for closed-loop operation
EP2355758A2 (en) 2008-11-07 2011-08-17 Insuline Medical Ltd. Device and method for drug delivery
WO2014116684A1 (en) * 2013-01-22 2014-07-31 Edward Roberts Non-peptidic neuropeptide y receptor modulators
ES2926494T3 (es) 2015-03-26 2022-10-26 Sen Jam Pharmaceutical Llc Combinación de naproxeno y fexofenadina para inhibir los síntomas asociados con veisalgia
AU2020370063A1 (en) 2019-10-21 2022-06-02 Alairion, Inc. 3-(4-(llH-dibenzo[b,e][l,4]azepin-6- yl)piperazin-l-yl)- and 3- (4-(dibenzo[b,f][l,4]oxazepin/thiazepin/diazepin-11-yl)piperazin-1-yl)-propano ic acid derivatives as HI and 5- HT2A-receptor modulators for the treatment of sleep disorders

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US3928356A (en) * 1967-10-06 1975-12-23 Fujisawa Pharmaceutical Co 10-{8 4-({107 -Hydroxy alkyl)-1-piperazimyl{9 -dibenzo (h,f) oxofins and thiepins and acetyl esters thereof
NL7110453A (pt) 1970-08-06 1972-02-08 Wander Ag Dr A
US4072756A (en) * 1973-05-17 1978-02-07 Sandoz Ltd. Tricyclo piperidino ketones and soporific compositions thereof
US4642903A (en) 1985-03-26 1987-02-17 R. P. Scherer Corporation Freeze-dried foam dosage form
US4855326A (en) 1987-04-20 1989-08-08 Fuisz Pharmaceutical Ltd. Rapidly dissoluble medicinal dosage unit and method of manufacture
JPH04211071A (ja) * 1990-03-05 1992-08-03 Hokuriku Seiyaku Co Ltd 多環式化合物
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WO2003039255A1 (en) 2001-11-05 2003-05-15 Basf Aktiengesellschaft Use of substituted dibenzothiepine derivatives as insecticidal, acaricidal and nematicidal agents
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Also Published As

Publication number Publication date
CA2580250A1 (en) 2006-03-30
NO20071604L (no) 2007-06-20
CY1112590T1 (el) 2016-02-10
MA28985B1 (fr) 2007-11-01
US7592333B2 (en) 2009-09-22
US8101596B2 (en) 2012-01-24
AU2005286713B2 (en) 2010-10-28
NZ553900A (en) 2010-10-29
KR101264444B1 (ko) 2013-05-20
WO2006034414A2 (en) 2006-03-30
ES2378452T3 (es) 2012-04-12
PT1804804E (pt) 2012-03-30
MX2007003032A (es) 2007-05-21
EA200700702A1 (ru) 2007-10-26
EP1804804B1 (en) 2012-01-25
EA012610B1 (ru) 2009-10-30
JP5049129B2 (ja) 2012-10-17
PL1804804T3 (pl) 2012-08-31
EP1804804A2 (en) 2007-07-11
KR20070060126A (ko) 2007-06-12
AU2005286713A1 (en) 2006-03-30
DK1804804T3 (da) 2012-02-20
WO2006034414A3 (en) 2006-09-08
JP2008513510A (ja) 2008-05-01
EP1804804A4 (en) 2010-11-24
US20060063928A1 (en) 2006-03-23
CA2580250C (en) 2013-05-14
ATE542536T1 (de) 2012-02-15
US20060063755A1 (en) 2006-03-23
US20090186872A1 (en) 2009-07-23

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved

Owner name: HYPNION, INC. (US)

Free format text: SEDE ALTERADA CONFORME SOLICITADO NA PETICAO NO 020090112759/RJ DE 02/12/2009.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]