KR101224468B1 - 신규한 형태의 이중표적항체 및 그 용도 - Google Patents

신규한 형태의 이중표적항체 및 그 용도 Download PDF

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Publication number
KR101224468B1
KR101224468B1 KR1020090044032A KR20090044032A KR101224468B1 KR 101224468 B1 KR101224468 B1 KR 101224468B1 KR 1020090044032 A KR1020090044032 A KR 1020090044032A KR 20090044032 A KR20090044032 A KR 20090044032A KR 101224468 B1 KR101224468 B1 KR 101224468B1
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South Korea
Prior art keywords
antibody
cancer
target antibody
antibodies
dna
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Expired - Fee Related
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KR1020090044032A
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English (en)
Korean (ko)
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KR20100125033A (ko
Inventor
유진산
이원섭
김성우
심상열
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주식회사 파멥신
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Priority to KR1020090044032A priority Critical patent/KR101224468B1/ko
Application filed by 주식회사 파멥신 filed Critical 주식회사 파멥신
Priority to US13/319,899 priority patent/US10125194B2/en
Priority to DK09844974.7T priority patent/DK2433968T3/en
Priority to CN200980159382.XA priority patent/CN102428104B/zh
Priority to CA2762555A priority patent/CA2762555C/en
Priority to JP2012511742A priority patent/JP5744012B2/ja
Priority to SG2011082542A priority patent/SG175971A1/en
Priority to ES09844974.7T priority patent/ES2605604T3/es
Priority to AU2009346447A priority patent/AU2009346447B2/en
Priority to EP09844974.7A priority patent/EP2433968B1/en
Priority to RU2011146088/10A priority patent/RU2520824C2/ru
Priority to BRPI0924535-9A priority patent/BRPI0924535B1/pt
Priority to PCT/KR2009/004084 priority patent/WO2010134666A1/ko
Publication of KR20100125033A publication Critical patent/KR20100125033A/ko
Application granted granted Critical
Publication of KR101224468B1 publication Critical patent/KR101224468B1/ko
Priority to JP2014263739A priority patent/JP2015119705A/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Zoology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Cell Biology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Physics & Mathematics (AREA)
  • Pain & Pain Management (AREA)
KR1020090044032A 2009-05-20 2009-05-20 신규한 형태의 이중표적항체 및 그 용도 Expired - Fee Related KR101224468B1 (ko)

Priority Applications (14)

Application Number Priority Date Filing Date Title
KR1020090044032A KR101224468B1 (ko) 2009-05-20 2009-05-20 신규한 형태의 이중표적항체 및 그 용도
RU2011146088/10A RU2520824C2 (ru) 2009-05-20 2009-07-22 Антитело двойной направленности в новой форме и его применение
CN200980159382.XA CN102428104B (zh) 2009-05-20 2009-07-22 双重靶定抗体及其用途
CA2762555A CA2762555C (en) 2009-05-20 2009-07-22 Dual targeting antibody of novel form, and use thereof
JP2012511742A JP5744012B2 (ja) 2009-05-20 2009-07-22 新規な形態の二重標的抗体およびその使用
SG2011082542A SG175971A1 (en) 2009-05-20 2009-07-22 Dual targeting antibody of novel form, and use thereof
ES09844974.7T ES2605604T3 (es) 2009-05-20 2009-07-22 Anticuerpo de dirección doble de forma nueva y uso del mismo
AU2009346447A AU2009346447B2 (en) 2009-05-20 2009-07-22 Dual targeting antibody of novel form, and use thereof
US13/319,899 US10125194B2 (en) 2009-05-20 2009-07-22 Dual targeting antibody of novel form, and use thereof
DK09844974.7T DK2433968T3 (en) 2009-05-20 2009-07-22 Dual targeting antibody of novel form and use thereof
BRPI0924535-9A BRPI0924535B1 (pt) 2009-05-20 2009-07-22 Anticorpo direcionado a dois alvos e seu método de produção, dna, vetor de expressão recombinante e composição farmacêutica
PCT/KR2009/004084 WO2010134666A1 (ko) 2009-05-20 2009-07-22 신규한 형태의 이중표적항체 및 그 용도
EP09844974.7A EP2433968B1 (en) 2009-05-20 2009-07-22 Dual targeting antibody of novel form, and use thereof
JP2014263739A JP2015119705A (ja) 2009-05-20 2014-12-26 新規な形態の二重標的抗体およびその使用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1020090044032A KR101224468B1 (ko) 2009-05-20 2009-05-20 신규한 형태의 이중표적항체 및 그 용도

Publications (2)

Publication Number Publication Date
KR20100125033A KR20100125033A (ko) 2010-11-30
KR101224468B1 true KR101224468B1 (ko) 2013-01-23

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KR1020090044032A Expired - Fee Related KR101224468B1 (ko) 2009-05-20 2009-05-20 신규한 형태의 이중표적항체 및 그 용도

Country Status (13)

Country Link
US (1) US10125194B2 (enExample)
EP (1) EP2433968B1 (enExample)
JP (2) JP5744012B2 (enExample)
KR (1) KR101224468B1 (enExample)
CN (1) CN102428104B (enExample)
AU (1) AU2009346447B2 (enExample)
BR (1) BRPI0924535B1 (enExample)
CA (1) CA2762555C (enExample)
DK (1) DK2433968T3 (enExample)
ES (1) ES2605604T3 (enExample)
RU (1) RU2520824C2 (enExample)
SG (1) SG175971A1 (enExample)
WO (1) WO2010134666A1 (enExample)

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CA2762555C (en) 2018-02-20
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EP2433968A1 (en) 2012-03-28
AU2009346447B2 (en) 2013-11-14
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EP2433968B1 (en) 2016-09-07
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US20120065380A1 (en) 2012-03-15
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JP2015119705A (ja) 2015-07-02
AU2009346447A1 (en) 2011-12-01
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JP2012527234A (ja) 2012-11-08
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