KR101169261B1 - 조혈 줄기세포 및 이를 포함하는 약제학적 조성물 - Google Patents

조혈 줄기세포 및 이를 포함하는 약제학적 조성물 Download PDF

Info

Publication number
KR101169261B1
KR101169261B1 KR1020057020854A KR20057020854A KR101169261B1 KR 101169261 B1 KR101169261 B1 KR 101169261B1 KR 1020057020854 A KR1020057020854 A KR 1020057020854A KR 20057020854 A KR20057020854 A KR 20057020854A KR 101169261 B1 KR101169261 B1 KR 101169261B1
Authority
KR
South Korea
Prior art keywords
lin
hsc
delete delete
cells
retinal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020057020854A
Other languages
English (en)
Korean (ko)
Other versions
KR20060008968A (ko
Inventor
마틴 프리들랜더
아쓰시 오타니
카렌 다실바
스테이시 하네캄프
Original Assignee
더 스크립스 리서치 인스티튜트
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/628,783 external-priority patent/US7153501B2/en
Application filed by 더 스크립스 리서치 인스티튜트 filed Critical 더 스크립스 리서치 인스티튜트
Publication of KR20060008968A publication Critical patent/KR20060008968A/ko
Application granted granted Critical
Publication of KR101169261B1 publication Critical patent/KR101169261B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/069—Vascular Endothelial cells
    • C12N5/0692—Stem cells; Progenitor cells; Precursor cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Wood Science & Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Neurology (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Surgery (AREA)
  • Neurosurgery (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020057020854A 2003-05-02 2004-04-28 조혈 줄기세포 및 이를 포함하는 약제학적 조성물 Expired - Fee Related KR101169261B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US46705103P 2003-05-02 2003-05-02
US60/467,051 2003-05-02
US10/628,783 US7153501B2 (en) 2002-07-25 2003-07-25 Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith
US10/628,783 2003-07-25
PCT/US2004/012989 WO2004098499A2 (en) 2002-07-25 2004-04-28 Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1020127006540A Division KR101224375B1 (ko) 2003-05-02 2004-04-28 조혈 줄기세포 및 이를 포함하는 약제학적 조성물
KR1020067009013A Division KR20060056420A (ko) 2003-05-02 2004-04-28 조혈 줄기세포 및 이를 사용한 신생혈관 안구 질환의치료방법

Publications (2)

Publication Number Publication Date
KR20060008968A KR20060008968A (ko) 2006-01-27
KR101169261B1 true KR101169261B1 (ko) 2012-08-03

Family

ID=36908146

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020057020854A Expired - Fee Related KR101169261B1 (ko) 2003-05-02 2004-04-28 조혈 줄기세포 및 이를 포함하는 약제학적 조성물
KR1020067009013A Ceased KR20060056420A (ko) 2003-05-02 2004-04-28 조혈 줄기세포 및 이를 사용한 신생혈관 안구 질환의치료방법
KR1020127006540A Expired - Fee Related KR101224375B1 (ko) 2003-05-02 2004-04-28 조혈 줄기세포 및 이를 포함하는 약제학적 조성물

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020067009013A Ceased KR20060056420A (ko) 2003-05-02 2004-04-28 조혈 줄기세포 및 이를 사용한 신생혈관 안구 질환의치료방법
KR1020127006540A Expired - Fee Related KR101224375B1 (ko) 2003-05-02 2004-04-28 조혈 줄기세포 및 이를 포함하는 약제학적 조성물

Country Status (10)

Country Link
EP (2) EP1624758A4 (enExample)
JP (2) JP4714682B2 (enExample)
KR (3) KR101169261B1 (enExample)
CN (2) CN1831119B (enExample)
AU (2) AU2004237749B2 (enExample)
BR (1) BRPI0409861A (enExample)
CA (2) CA2524063C (enExample)
MX (2) MXPA05011750A (enExample)
RU (2) RU2345780C2 (enExample)
ZA (2) ZA200509752B (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2554662A1 (en) * 2011-08-05 2013-02-06 M Maria Pia Cosma Methods of treatment of retinal degeneration diseases
CN110777124A (zh) 2011-10-27 2020-02-11 威尔斯达眼科制剂公司 编码视杆细胞来源的视锥细胞活力因子的载体
RU2495650C1 (ru) * 2012-02-29 2013-10-20 Федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения и социального развития Российской Федерации Трехкомпонентный комплекс для клеточной терапии в офтальмологии
RU2485922C1 (ru) * 2012-03-28 2013-06-27 Федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения и социального развития Российской Федерации Способ лечения "сухой" формы возрастной макулярной дегенерации
CN107043699B (zh) * 2017-04-25 2023-04-07 徐子雁 一种低能量激光诱导间充质干细胞血管化的试剂盒

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002033043A2 (en) * 2000-10-18 2002-04-25 Coriell Institute For Medical Research Method and marker for the isolation of human multipotent hematopoietic stem cells
CN1307300C (zh) * 2002-07-25 2007-03-28 斯克里普斯研究学院 造血干细胞和治疗新生血管性眼部疾病的方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Nature Medicine, 제8권, 제9호, 제1004-1010면 (2002.9.)

Also Published As

Publication number Publication date
EP1624758A2 (en) 2006-02-15
AU2005239702A1 (en) 2005-12-22
KR20060056420A (ko) 2006-05-24
JP2006166918A (ja) 2006-06-29
CN1816281A (zh) 2006-08-09
CA2524063A1 (en) 2004-11-18
CN100439493C (zh) 2008-12-03
EP1754783A1 (en) 2007-02-21
RU2389497C2 (ru) 2010-05-20
AU2005239702B2 (en) 2010-03-04
JP4714580B2 (ja) 2011-06-29
JP4714682B2 (ja) 2011-06-29
CA2524063C (en) 2015-02-17
CA2526670C (en) 2011-06-14
ZA200509756B (en) 2006-10-25
BRPI0409861A (pt) 2006-05-16
KR20120034251A (ko) 2012-04-10
ZA200509752B (en) 2006-11-29
MXPA05011752A (es) 2006-06-06
RU2005137569A (ru) 2006-06-10
CN1831119A (zh) 2006-09-13
CA2526670A1 (en) 2004-11-18
JP2006525806A (ja) 2006-11-16
EP1624758A4 (en) 2007-03-07
AU2004237749A1 (en) 2004-11-18
RU2006103574A (ru) 2007-08-20
KR101224375B1 (ko) 2013-01-21
RU2345780C2 (ru) 2009-02-10
MXPA05011750A (es) 2006-06-06
KR20060008968A (ko) 2006-01-27
AU2004237749B2 (en) 2011-09-15
CN1831119B (zh) 2010-05-26

Similar Documents

Publication Publication Date Title
KR101095287B1 (ko) 조혈 줄기세포 및 이를 분리하는 방법
KR100869914B1 (ko) 혈관 형성 조절에 유용한 트립토파닐-ｔＲＮＡ 신세타제기원 폴리펩타이드
CN101594781A (zh) 分离的髓样细胞群及其治疗方法
IL195854A (en) Aminoacyl polypeptides - trna human synthesis used to regulate angiogenesis
US20020182666A1 (en) Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis
PT1935976E (pt) Células do tipo mielóide transfectadas para o tratamento de retinopatia da prematuridade e doenças relacionadas
US20040152079A1 (en) Human aminoacyl-trna synthetase polypeptides useful for the regulation of angiogenesis
KR101224375B1 (ko) 조혈 줄기세포 및 이를 포함하는 약제학적 조성물
KR101309500B1 (ko) 분리된 계통 음성 조혈 줄기세포 및 이를 사용한 치료 방법
CN104328136B (zh) 鸡新城疫病毒毒株rClone30‑fliC的制备及其在鸡新城疫病防治中的应用
JP3012930B1 (ja) Ｓｐａｒｃ融合タンパク質含有医薬組成物
CN115232813A (zh) 用于构建vWF基因突变的血管性血友病模型猪核移植供体细胞的基因编辑系统及其应用
KR20080105373A (ko) 핵산 전달을 위한 재조합 ｈｍｇｂ1 펩티드

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A107 Divisional application of patent
AMND Amendment
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

A201 Request for examination
AMND Amendment
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

AMND Amendment
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E601 Decision to refuse application
PE0601 Decision on rejection of patent

St.27 status event code: N-2-6-B10-B15-exm-PE0601

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

AMND Amendment
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

J201 Request for trial against refusal decision
P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PJ0201 Trial against decision of rejection

St.27 status event code: A-3-3-V10-V11-apl-PJ0201

A107 Divisional application of patent
PA0104 Divisional application for international application

St.27 status event code: A-0-1-A10-A18-div-PA0104

St.27 status event code: A-0-1-A10-A16-div-PA0104

PB0901 Examination by re-examination before a trial

St.27 status event code: A-6-3-E10-E12-rex-PB0901

B701 Decision to grant
PB0701 Decision of registration after re-examination before a trial

St.27 status event code: A-3-4-F10-F13-rex-PB0701

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

FPAY Annual fee payment

Payment date: 20150619

Year of fee payment: 4

PR1001 Payment of annual fee

St.27 status event code: A-4-4-U10-U11-oth-PR1001

Fee payment year number: 4

P22-X000 Classification modified

St.27 status event code: A-4-4-P10-P22-nap-X000

LAPS Lapse due to unpaid annual fee
PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20160724

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20160724