KR101157007B1 - 카르복시산 작용기화 중합체 제조 방법 - Google Patents

카르복시산 작용기화 중합체 제조 방법 Download PDF

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Publication number
KR101157007B1
KR101157007B1 KR1020067008804A KR20067008804A KR101157007B1 KR 101157007 B1 KR101157007 B1 KR 101157007B1 KR 1020067008804 A KR1020067008804 A KR 1020067008804A KR 20067008804 A KR20067008804 A KR 20067008804A KR 101157007 B1 KR101157007 B1 KR 101157007B1
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South Korea
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polymer
peg
acid
group
poly
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Korean (ko)
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KR20060117936A (ko
Inventor
밀턴 제이 해리스
안토니 코즈로브스키
리홍 궈
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넥타르 테라퓨틱스
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F251/00—Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F261/00—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00
    • C08F261/02—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols
    • C08F261/04—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols on to polymers of vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F265/00—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F271/00—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
    • C08F283/06—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polyethers, polyoxymethylenes or polyacetals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F289/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups C08F251/00 - C08F287/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F291/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
    • C08G65/3344—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur
    • C08G65/3346—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur having sulfur bound to carbon and oxygen

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020067008804A 2003-11-06 2004-11-05 카르복시산 작용기화 중합체 제조 방법 Expired - Lifetime KR101157007B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51779403P 2003-11-06 2003-11-06
US60/517,794 2003-11-06
PCT/US2004/036850 WO2005047366A1 (en) 2003-11-06 2004-11-05 Method of preparing carboxylic acid functionalized polymers

Publications (2)

Publication Number Publication Date
KR20060117936A KR20060117936A (ko) 2006-11-17
KR101157007B1 true KR101157007B1 (ko) 2012-06-21

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KR1020067008804A Expired - Lifetime KR101157007B1 (ko) 2003-11-06 2004-11-05 카르복시산 작용기화 중합체 제조 방법

Country Status (17)

Country Link
US (5) US20050214250A1 (https=)
EP (1) EP1692206B1 (https=)
JP (1) JP5101884B2 (https=)
KR (1) KR101157007B1 (https=)
CN (1) CN100580005C (https=)
AT (1) ATE465204T1 (https=)
AU (1) AU2004289992B2 (https=)
CA (1) CA2544697C (https=)
CY (1) CY1110303T1 (https=)
DE (1) DE602004026770D1 (https=)
DK (1) DK1692206T3 (https=)
ES (1) ES2342294T3 (https=)
IL (1) IL175406A (https=)
PL (1) PL1692206T3 (https=)
PT (1) PT1692206E (https=)
SI (1) SI1692206T1 (https=)
WO (1) WO2005047366A1 (https=)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050214250A1 (en) * 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
ES2720078T3 (es) * 2004-01-21 2019-07-17 Nektar Therapeutics Método para preparar polímeros terminados en ácido propiónico
CA2584510C (en) * 2004-10-25 2013-05-28 Intezyne Technologies, Incorporated Heterobifunctional poly(ethylene glycol) and uses thereof
US7989554B2 (en) * 2006-01-10 2011-08-02 Enzon Pharmaceuticals, Inc. Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid
US8133707B2 (en) 2006-01-17 2012-03-13 Enzon Pharmaceuticals, Inc. Methods of preparing activated polymers having alpha nitrogen groups
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US7560588B2 (en) * 2006-04-27 2009-07-14 Intezyne Technologies, Inc. Poly(ethylene glycol) containing chemically disparate endgroups
PL2054074T3 (pl) 2006-08-04 2015-03-31 Prolong Pharmaceuticals Llc Zmodyfikowana erytropoetyna
WO2008098178A2 (en) * 2007-02-09 2008-08-14 Enzon Pharmaceuticals, Inc. Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
JP2008308690A (ja) * 2007-06-13 2008-12-25 Bio-Cancer Treatment Internatl Ltd ポリ（エチレングリコール）機能性誘導体およびその製造方法
TW201010732A (en) * 2008-08-29 2010-03-16 Enzon Pharmaceuticals Inc Method of treating RAS associated cancer
WO2010037045A1 (en) 2008-09-28 2010-04-01 Nerites Corporation Multi-armed catechol compound blends
CA2738807A1 (en) * 2008-10-21 2010-04-29 Enzon Pharmaceuticals, Inc. Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
CA2751573C (en) * 2009-02-06 2014-05-13 Knc Ner Acquisition Sub, Inc. Multi-linked star-shaped polymers and synthetic methods therfor
WO2011140409A2 (en) * 2010-05-06 2011-11-10 Cornell University Tunable lcst polymers and methods of preparation
EP2606884A1 (en) 2011-12-21 2013-06-26 Ecole Polytechnique Fédérale de Lausanne (EPFL) Inhibitors of notch signaling pathway and use thereof in treatment of cancers
ES2774330T3 (es) 2013-04-09 2020-07-20 Massachusetts Inst Technology Polímero de suministro de fármaco y usos del mismo
US9447129B2 (en) 2014-02-07 2016-09-20 Massachusetts Institute Of Technology Suprametallogels and uses thereof
WO2016167759A1 (en) * 2015-04-15 2016-10-20 Multisorb Technologies, Inc. Surface modification of a resin
JP6777390B2 (ja) * 2015-10-30 2020-10-28 株式会社日本触媒 生体適合性医療用材料
EP3187254B1 (en) * 2015-12-30 2020-09-02 Italmatch SC, LLC Polymeric emulsifier and lubricity additives for aqueous metal removal, forming, rolling or other applications
WO2017214337A1 (en) 2016-06-07 2017-12-14 Massachusetts Institute Of Technology Drug delivery polymers and uses thereof
WO2018039577A1 (en) 2016-08-26 2018-03-01 Massachusetts Institute Of Technology Bottlebrush polymers and uses thereof
WO2018067702A1 (en) 2016-10-04 2018-04-12 Massachusetts Institute Of Technology Bottlebrush copolymers and uses thereof
JP6935059B2 (ja) * 2017-03-30 2021-09-15 日油株式会社 カルボキシル基を一つ有するポリエチレングリコールの精製方法
JP7158143B2 (ja) * 2017-04-13 2022-10-21 株式会社日本触媒 生体適合性医療用材料
WO2019006425A1 (en) 2017-06-30 2019-01-03 Massachusetts Institute Of Technology IMAGING AGENTS OF BRUSH ARRAY STAR POLYMERS AND USES THEREOF
US10973847B2 (en) 2017-06-30 2021-04-13 Massachusetts Institute Of Technology Core-to-surface polymerization for the synthesis of star polymers and uses thereof
JP7187048B2 (ja) 2017-06-30 2022-12-12 マサチューセッツ インスティテュート オブ テクノロジー 分枝多官能性マクロモノマーおよび関連ポリマーならびにそれらの使用
EP3774986A1 (en) 2018-04-13 2021-02-17 Massachusetts Institute of Technology Brush prodrugs and uses thereof
MA52954A (fr) 2018-06-21 2021-04-28 Cellestia Biotech Ag Procédé pour la fabrication d'aminoéthers de diaryle et sels de chlorhydrate d'aminoéthers de diaryle
EP3837266A1 (en) 2018-08-17 2021-06-23 Massachusetts Institute of Technology Degradable polymers of a cyclic silyl ether and uses thereof
US12018120B2 (en) * 2019-03-29 2024-06-25 Nof Corporation Method for producing terminal carboxyl group-containing polyethylene glycol and method for producing activated polyethylene glycol
CA3134791A1 (en) 2019-04-10 2020-10-15 Cellestia Biotech Ag Inhibitors of notch signalling pathway and use thereof in treatment of cancers
KR20220085791A (ko) 2019-10-16 2022-06-22 메사추세츠 인스티튜트 오브 테크놀로지 브러시 전구약물 및 그의 용도
WO2021141662A1 (en) 2020-01-10 2021-07-15 Massachusetts Institute Of Technology Proteolysis targeting chimeric molecules (protacs) with functional handles and uses thereof
EP4169113A2 (en) 2020-06-19 2023-04-26 Debreceni Egyetem Zn-air rechargeable battery
EP4008324A1 (en) 2020-12-07 2022-06-08 Cellestia Biotech AG Combinations comprising an inhibitor of an anti-apoptotic protein, such as bcl-2, bcl-xl, bclw or mcl-1, and a notch signaling pathway inhibitor for treating cancer
EP4255409A1 (en) 2020-12-07 2023-10-11 Cellestia Biotech AG Pharmaceutical combinations for treating cancer
US20240269120A1 (en) 2021-06-02 2024-08-15 Cellestia Biotech Ag Method for Treating an Autoimmune and Inflammatory Disease
WO2023079132A1 (en) 2021-11-08 2023-05-11 Cellestia Biotech Ag Pharmaceutical combinations for treating cancer
US12084415B2 (en) 2021-12-20 2024-09-10 Massachusetts Institute Of Technology Biomolecule-polymer-pharmaceutical agent conjugates for delivering the pharmaceutical agent
EP4223292A1 (en) 2022-02-07 2023-08-09 Cellestia Biotech AG Pharmaceutical combinations for treating cancer
CN115193363B (zh) * 2022-09-16 2023-02-24 世名(苏州)新材料研究院有限公司 高酸值低酯值氧化蜡、其制备工艺及由其制得的酯化蜡

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06135889A (ja) * 1992-10-26 1994-05-17 Tokuyama Soda Co Ltd 直鎖状脂肪族カルボン酸
JPH1087815A (ja) * 1996-08-22 1998-04-07 Enzon Inc ポリアルキレンオキシドカルボン酸の改良製造方法

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721579A (en) * 1980-08-15 1988-01-26 Basf Corporation Sodium carboxymethyl derivatives of polyoxyalkylene glycols, their production, and use in functional fluids
DE3032061C1 (de) * 1980-08-26 1982-06-09 Chem-y, Fabriek van Chemische Produkten B.V., Bodegraven Verfahren zur Herstellung eines verpumpbaren oberflaechenaktiven Produktes auf Basis von Polyaetheressigsaeuren
DE3120195C2 (de) * 1981-05-21 1986-09-04 Degussa Ag, 6000 Frankfurt Polymere Ammoniumverbindungen mit kieselsäureartigem Grundgerüst, Verfahren zu ihrer Herstellung und Verwendung
JPH04199152A (ja) * 1990-11-29 1992-07-20 Toshiba Corp 感光性組成物
US5483008A (en) * 1992-02-07 1996-01-09 Research Development Corporation Of Japan Polyether having heterofunctional groups at both ends, process for the preparation thereof and polymerization initiator therefor
US5278303A (en) 1992-06-12 1994-01-11 University Of Toronto Innovations Foundation Polymer-supported solution synthesis of oligosaccharides
US5919455A (en) * 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5605976A (en) * 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
US5693609A (en) 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
JP3855344B2 (ja) * 1997-02-19 2006-12-06 日本油脂株式会社 ポリオキシアルキレンカルボン酸の製造方法
US6448369B1 (en) * 1997-11-06 2002-09-10 Shearwater Corporation Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
DK1411075T3 (da) 1998-03-12 2008-10-27 Nektar Therapeutics Al Corp Fremgangsmåde til fremstilling af polymerkonjugater
DE19928128C1 (de) * 1999-06-19 2000-11-30 Clariant Gmbh Verfahren zur Herstellung von Ethercarbonsäuren mit niedrigem Restalkohol
CN1284603C (zh) * 1999-10-08 2006-11-15 内科塔治疗亚拉巴马公司 杂双官能聚乙二醇衍生物和它们的制备方法
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
DK1539857T3 (da) * 2002-07-24 2007-03-12 Hoffmann La Roche Polyethylenglycol-aldehydderivater
US20050214250A1 (en) 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH06135889A (ja) * 1992-10-26 1994-05-17 Tokuyama Soda Co Ltd 直鎖状脂肪族カルボン酸
JPH1087815A (ja) * 1996-08-22 1998-04-07 Enzon Inc ポリアルキレンオキシドカルボン酸の改良製造方法

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EP1692206A1 (en) 2006-08-23
IL175406A (en) 2012-01-31
US20110130539A1 (en) 2011-06-02
CY1110303T1 (el) 2015-01-14
US20050214250A1 (en) 2005-09-29
EP1692206B1 (en) 2010-04-21
DK1692206T3 (da) 2011-05-23
US20120041155A1 (en) 2012-02-16
CA2544697A1 (en) 2005-05-26
SI1692206T1 (sl) 2010-08-31
WO2005047366A1 (en) 2005-05-26
JP5101884B2 (ja) 2012-12-19
ES2342294T3 (es) 2010-07-05
US10011682B2 (en) 2018-07-03
ATE465204T1 (de) 2010-05-15
PL1692206T3 (pl) 2011-06-30
DE602004026770D1 (de) 2010-06-02
US8067505B2 (en) 2011-11-29
JP2007510800A (ja) 2007-04-26
CN100580005C (zh) 2010-01-13
CA2544697C (en) 2012-10-16
US20180282476A1 (en) 2018-10-04
US11111335B2 (en) 2021-09-07
IL175406A0 (en) 2006-09-05
CN1902257A (zh) 2007-01-24
US20130281634A1 (en) 2013-10-24
KR20060117936A (ko) 2006-11-17
PT1692206E (pt) 2010-07-19
AU2004289992A1 (en) 2005-05-26
AU2004289992B2 (en) 2010-05-20

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