SI1692206T1 - Postopek za pripravo s karboksilno kislino funkcionaliziranih polimerov - Google Patents

Postopek za pripravo s karboksilno kislino funkcionaliziranih polimerov

Info

Publication number
SI1692206T1
SI1692206T1 SI200431461T SI200431461T SI1692206T1 SI 1692206 T1 SI1692206 T1 SI 1692206T1 SI 200431461 T SI200431461 T SI 200431461T SI 200431461 T SI200431461 T SI 200431461T SI 1692206 T1 SI1692206 T1 SI 1692206T1
Authority
SI
Slovenia
Prior art keywords
carboxylic acid
polymer
acid functionalized
carboxylate salt
treated
Prior art date
Application number
SI200431461T
Other languages
English (en)
Slovenian (sl)
Inventor
Milton J Harris
Antoni Kozlowski
Lihong Guo
Original Assignee
Nektar Therapeutics
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nektar Therapeutics filed Critical Nektar Therapeutics
Publication of SI1692206T1 publication Critical patent/SI1692206T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
    • C08G63/91—Polymers modified by chemical after-treatment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/765—Polymers containing oxygen
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F251/00—Macromolecular compounds obtained by polymerising monomers on to polysaccharides or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F261/00—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00
    • C08F261/02—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols
    • C08F261/04—Macromolecular compounds obtained by polymerising monomers on to polymers of oxygen-containing monomers as defined in group C08F16/00 on to polymers of unsaturated alcohols on to polymers of vinyl alcohol
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F265/00—Macromolecular compounds obtained by polymerising monomers on to polymers of unsaturated monocarboxylic acids or derivatives thereof as defined in group C08F20/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F271/00—Macromolecular compounds obtained by polymerising monomers on to polymers of nitrogen-containing monomers as defined in group C08F26/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F283/00—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G
    • C08F283/06—Macromolecular compounds obtained by polymerising monomers on to polymers provided for in subclass C08G on to polyethers, polyoxymethylenes or polyacetals
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F289/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds not provided for in groups C08F251/00 - C08F287/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F291/00—Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/30—Post-polymerisation treatment, e.g. recovery, purification, drying
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/331—Polymers modified by chemical after-treatment with organic compounds containing oxygen
    • C08G65/332—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof
    • C08G65/3322—Polymers modified by chemical after-treatment with organic compounds containing oxygen containing carboxyl groups, or halides, or esters thereof acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G65/00—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule
    • C08G65/02—Macromolecular compounds obtained by reactions forming an ether link in the main chain of the macromolecule from cyclic ethers by opening of the heterocyclic ring
    • C08G65/32—Polymers modified by chemical after-treatment
    • C08G65/329—Polymers modified by chemical after-treatment with organic compounds
    • C08G65/334—Polymers modified by chemical after-treatment with organic compounds containing sulfur
    • C08G65/3344—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur
    • C08G65/3346—Polymers modified by chemical after-treatment with organic compounds containing sulfur containing oxygen in addition to sulfur having sulfur bound to carbon and oxygen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Polyethers (AREA)
  • Other Resins Obtained By Reactions Not Involving Carbon-To-Carbon Unsaturated Bonds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Treatments Of Macromolecular Shaped Articles (AREA)
  • Peptides Or Proteins (AREA)
  • Polyamides (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SI200431461T 2003-11-06 2004-11-05 Postopek za pripravo s karboksilno kislino funkcionaliziranih polimerov SI1692206T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US51779403P 2003-11-06 2003-11-06
PCT/US2004/036850 WO2005047366A1 (en) 2003-11-06 2004-11-05 Method of preparing carboxylic acid functionalized polymers
EP04810369A EP1692206B1 (en) 2003-11-06 2004-11-05 Method of preparing carboxylic acid functionalized polymers

Publications (1)

Publication Number Publication Date
SI1692206T1 true SI1692206T1 (sl) 2010-08-31

Family

ID=34590189

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200431461T SI1692206T1 (sl) 2003-11-06 2004-11-05 Postopek za pripravo s karboksilno kislino funkcionaliziranih polimerov

Country Status (17)

Country Link
US (5) US20050214250A1 (https=)
EP (1) EP1692206B1 (https=)
JP (1) JP5101884B2 (https=)
KR (1) KR101157007B1 (https=)
CN (1) CN100580005C (https=)
AT (1) ATE465204T1 (https=)
AU (1) AU2004289992B2 (https=)
CA (1) CA2544697C (https=)
CY (1) CY1110303T1 (https=)
DE (1) DE602004026770D1 (https=)
DK (1) DK1692206T3 (https=)
ES (1) ES2342294T3 (https=)
IL (1) IL175406A (https=)
PL (1) PL1692206T3 (https=)
PT (1) PT1692206E (https=)
SI (1) SI1692206T1 (https=)
WO (1) WO2005047366A1 (https=)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050214250A1 (en) * 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers
ES2720078T3 (es) * 2004-01-21 2019-07-17 Nektar Therapeutics Método para preparar polímeros terminados en ácido propiónico
CA2584510C (en) * 2004-10-25 2013-05-28 Intezyne Technologies, Incorporated Heterobifunctional poly(ethylene glycol) and uses thereof
US7989554B2 (en) * 2006-01-10 2011-08-02 Enzon Pharmaceuticals, Inc. Reacting polyalkylene oxide with base, tertiary alkyl haloacetate, then acid to prepare polyalkylene oxide carboxylic acid
US8133707B2 (en) 2006-01-17 2012-03-13 Enzon Pharmaceuticals, Inc. Methods of preparing activated polymers having alpha nitrogen groups
US7671067B2 (en) * 2006-02-09 2010-03-02 Enzon Pharmaceuticals, Inc. Treatment of non-hodgkin's lymphomas with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamtothecin
US7462627B2 (en) * 2006-02-09 2008-12-09 Enzon Pharmaceuticals, Inc. Multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin for treatment of breast, colorectal, pancreatic, ovarian and lung cancers
US7560588B2 (en) * 2006-04-27 2009-07-14 Intezyne Technologies, Inc. Poly(ethylene glycol) containing chemically disparate endgroups
PL2054074T3 (pl) 2006-08-04 2015-03-31 Prolong Pharmaceuticals Llc Zmodyfikowana erytropoetyna
WO2008098178A2 (en) * 2007-02-09 2008-08-14 Enzon Pharmaceuticals, Inc. Treatment of resistant or refractory cancers with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
JP2008308690A (ja) * 2007-06-13 2008-12-25 Bio-Cancer Treatment Internatl Ltd ポリ（エチレングリコール）機能性誘導体およびその製造方法
TW201010732A (en) * 2008-08-29 2010-03-16 Enzon Pharmaceuticals Inc Method of treating RAS associated cancer
WO2010037045A1 (en) 2008-09-28 2010-04-01 Nerites Corporation Multi-armed catechol compound blends
CA2738807A1 (en) * 2008-10-21 2010-04-29 Enzon Pharmaceuticals, Inc. Treatment of neuroblastoma with multi-arm polymeric conjugates of 7-ethyl-10-hydroxycamptothecin
CA2751573C (en) * 2009-02-06 2014-05-13 Knc Ner Acquisition Sub, Inc. Multi-linked star-shaped polymers and synthetic methods therfor
WO2011140409A2 (en) * 2010-05-06 2011-11-10 Cornell University Tunable lcst polymers and methods of preparation
EP2606884A1 (en) 2011-12-21 2013-06-26 Ecole Polytechnique Fédérale de Lausanne (EPFL) Inhibitors of notch signaling pathway and use thereof in treatment of cancers
ES2774330T3 (es) 2013-04-09 2020-07-20 Massachusetts Inst Technology Polímero de suministro de fármaco y usos del mismo
US9447129B2 (en) 2014-02-07 2016-09-20 Massachusetts Institute Of Technology Suprametallogels and uses thereof
WO2016167759A1 (en) * 2015-04-15 2016-10-20 Multisorb Technologies, Inc. Surface modification of a resin
JP6777390B2 (ja) * 2015-10-30 2020-10-28 株式会社日本触媒 生体適合性医療用材料
EP3187254B1 (en) * 2015-12-30 2020-09-02 Italmatch SC, LLC Polymeric emulsifier and lubricity additives for aqueous metal removal, forming, rolling or other applications
WO2017214337A1 (en) 2016-06-07 2017-12-14 Massachusetts Institute Of Technology Drug delivery polymers and uses thereof
WO2018039577A1 (en) 2016-08-26 2018-03-01 Massachusetts Institute Of Technology Bottlebrush polymers and uses thereof
WO2018067702A1 (en) 2016-10-04 2018-04-12 Massachusetts Institute Of Technology Bottlebrush copolymers and uses thereof
JP6935059B2 (ja) * 2017-03-30 2021-09-15 日油株式会社 カルボキシル基を一つ有するポリエチレングリコールの精製方法
JP7158143B2 (ja) * 2017-04-13 2022-10-21 株式会社日本触媒 生体適合性医療用材料
WO2019006425A1 (en) 2017-06-30 2019-01-03 Massachusetts Institute Of Technology IMAGING AGENTS OF BRUSH ARRAY STAR POLYMERS AND USES THEREOF
US10973847B2 (en) 2017-06-30 2021-04-13 Massachusetts Institute Of Technology Core-to-surface polymerization for the synthesis of star polymers and uses thereof
JP7187048B2 (ja) 2017-06-30 2022-12-12 マサチューセッツ インスティテュート オブ テクノロジー 分枝多官能性マクロモノマーおよび関連ポリマーならびにそれらの使用
EP3774986A1 (en) 2018-04-13 2021-02-17 Massachusetts Institute of Technology Brush prodrugs and uses thereof
MA52954A (fr) 2018-06-21 2021-04-28 Cellestia Biotech Ag Procédé pour la fabrication d'aminoéthers de diaryle et sels de chlorhydrate d'aminoéthers de diaryle
EP3837266A1 (en) 2018-08-17 2021-06-23 Massachusetts Institute of Technology Degradable polymers of a cyclic silyl ether and uses thereof
US12018120B2 (en) * 2019-03-29 2024-06-25 Nof Corporation Method for producing terminal carboxyl group-containing polyethylene glycol and method for producing activated polyethylene glycol
CA3134791A1 (en) 2019-04-10 2020-10-15 Cellestia Biotech Ag Inhibitors of notch signalling pathway and use thereof in treatment of cancers
KR20220085791A (ko) 2019-10-16 2022-06-22 메사추세츠 인스티튜트 오브 테크놀로지 브러시 전구약물 및 그의 용도
WO2021141662A1 (en) 2020-01-10 2021-07-15 Massachusetts Institute Of Technology Proteolysis targeting chimeric molecules (protacs) with functional handles and uses thereof
EP4169113A2 (en) 2020-06-19 2023-04-26 Debreceni Egyetem Zn-air rechargeable battery
EP4008324A1 (en) 2020-12-07 2022-06-08 Cellestia Biotech AG Combinations comprising an inhibitor of an anti-apoptotic protein, such as bcl-2, bcl-xl, bclw or mcl-1, and a notch signaling pathway inhibitor for treating cancer
EP4255409A1 (en) 2020-12-07 2023-10-11 Cellestia Biotech AG Pharmaceutical combinations for treating cancer
US20240269120A1 (en) 2021-06-02 2024-08-15 Cellestia Biotech Ag Method for Treating an Autoimmune and Inflammatory Disease
WO2023079132A1 (en) 2021-11-08 2023-05-11 Cellestia Biotech Ag Pharmaceutical combinations for treating cancer
US12084415B2 (en) 2021-12-20 2024-09-10 Massachusetts Institute Of Technology Biomolecule-polymer-pharmaceutical agent conjugates for delivering the pharmaceutical agent
EP4223292A1 (en) 2022-02-07 2023-08-09 Cellestia Biotech AG Pharmaceutical combinations for treating cancer
CN115193363B (zh) * 2022-09-16 2023-02-24 世名(苏州)新材料研究院有限公司 高酸值低酯值氧化蜡、其制备工艺及由其制得的酯化蜡

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4721579A (en) * 1980-08-15 1988-01-26 Basf Corporation Sodium carboxymethyl derivatives of polyoxyalkylene glycols, their production, and use in functional fluids
DE3032061C1 (de) * 1980-08-26 1982-06-09 Chem-y, Fabriek van Chemische Produkten B.V., Bodegraven Verfahren zur Herstellung eines verpumpbaren oberflaechenaktiven Produktes auf Basis von Polyaetheressigsaeuren
DE3120195C2 (de) * 1981-05-21 1986-09-04 Degussa Ag, 6000 Frankfurt Polymere Ammoniumverbindungen mit kieselsäureartigem Grundgerüst, Verfahren zu ihrer Herstellung und Verwendung
JPH04199152A (ja) * 1990-11-29 1992-07-20 Toshiba Corp 感光性組成物
US5483008A (en) * 1992-02-07 1996-01-09 Research Development Corporation Of Japan Polyether having heterofunctional groups at both ends, process for the preparation thereof and polymerization initiator therefor
US5278303A (en) 1992-06-12 1994-01-11 University Of Toronto Innovations Foundation Polymer-supported solution synthesis of oligosaccharides
JP3236087B2 (ja) * 1992-10-26 2001-12-04 株式会社トクヤマ 重合性磁性流体製造用界面活性剤
US5919455A (en) * 1993-10-27 1999-07-06 Enzon, Inc. Non-antigenic branched polymer conjugates
US5605976A (en) * 1995-05-15 1997-02-25 Enzon, Inc. Method of preparing polyalkylene oxide carboxylic acids
US5693609A (en) 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US5932462A (en) 1995-01-10 1999-08-03 Shearwater Polymers, Inc. Multiarmed, monofunctional, polymer for coupling to molecules and surfaces
US5672662A (en) 1995-07-07 1997-09-30 Shearwater Polymers, Inc. Poly(ethylene glycol) and related polymers monosubstituted with propionic or butanoic acids and functional derivatives thereof for biotechnical applications
JPH1087815A (ja) 1996-08-22 1998-04-07 Enzon Inc ポリアルキレンオキシドカルボン酸の改良製造方法
JP3855344B2 (ja) * 1997-02-19 2006-12-06 日本油脂株式会社 ポリオキシアルキレンカルボン酸の製造方法
US6448369B1 (en) * 1997-11-06 2002-09-10 Shearwater Corporation Heterobifunctional poly(ethylene glycol) derivatives and methods for their preparation
DK1411075T3 (da) 1998-03-12 2008-10-27 Nektar Therapeutics Al Corp Fremgangsmåde til fremstilling af polymerkonjugater
DE19928128C1 (de) * 1999-06-19 2000-11-30 Clariant Gmbh Verfahren zur Herstellung von Ethercarbonsäuren mit niedrigem Restalkohol
CN1284603C (zh) * 1999-10-08 2006-11-15 内科塔治疗亚拉巴马公司 杂双官能聚乙二醇衍生物和它们的制备方法
TWI246524B (en) 2001-01-19 2006-01-01 Shearwater Corp Multi-arm block copolymers as drug delivery vehicles
DK1539857T3 (da) * 2002-07-24 2007-03-12 Hoffmann La Roche Polyethylenglycol-aldehydderivater
US20050214250A1 (en) 2003-11-06 2005-09-29 Harris J M Method of preparing carboxylic acid functionalized polymers

Also Published As

Publication number Publication date
EP1692206A1 (en) 2006-08-23
IL175406A (en) 2012-01-31
US20110130539A1 (en) 2011-06-02
CY1110303T1 (el) 2015-01-14
US20050214250A1 (en) 2005-09-29
EP1692206B1 (en) 2010-04-21
DK1692206T3 (da) 2011-05-23
US20120041155A1 (en) 2012-02-16
CA2544697A1 (en) 2005-05-26
KR101157007B1 (ko) 2012-06-21
WO2005047366A1 (en) 2005-05-26
JP5101884B2 (ja) 2012-12-19
ES2342294T3 (es) 2010-07-05
US10011682B2 (en) 2018-07-03
ATE465204T1 (de) 2010-05-15
PL1692206T3 (pl) 2011-06-30
DE602004026770D1 (de) 2010-06-02
US8067505B2 (en) 2011-11-29
JP2007510800A (ja) 2007-04-26
CN100580005C (zh) 2010-01-13
CA2544697C (en) 2012-10-16
US20180282476A1 (en) 2018-10-04
US11111335B2 (en) 2021-09-07
IL175406A0 (en) 2006-09-05
CN1902257A (zh) 2007-01-24
US20130281634A1 (en) 2013-10-24
KR20060117936A (ko) 2006-11-17
PT1692206E (pt) 2010-07-19
AU2004289992A1 (en) 2005-05-26
AU2004289992B2 (en) 2010-05-20

Similar Documents

Publication Publication Date Title
PL1692206T3 (pl) Sposób wytwarzania polimerów funkcjonalizowanych kwasem karboksylowym
NZ597960A (en) Biodegradable polyethylene glycol based water-insoluble hydrogels
DE602005025177D1 (de) Verfahren zur Herstellung einer wässrigen Dispersion enthaltend einen Komplex von Poly(3,4-dialkoxythiophen) und einem Polyanion
EP1686146A4 (en) PROCESS FOR PREPARING ALIPHATIC POLYESTER
WO2004022629A3 (en) Method for preparing water-soluble polymer derivatives bearing a terminal carboxylic acid
WO2009066879A3 (en) Organic-inorganic hybrid scaffolds with surface-immobilized nano-hydroxyapatite and preparation method thereof
WO2012083196A3 (en) Stable polyacrylic acids, their manufacture and their use
TW200736280A (en) Water-absorbing resin particle agglomerates and process for production thereof
ATE489125T1 (de) Oberflächenbehandlung zur biokompatibilitätsverbesserung
ATE384754T1 (de) Verfahren zur herstellung von hochverzweigten polyamiden
DE502004009729D1 (de) Pulverförmige, wasserlösliche kationische polymerzusammensetzung, verfahren zu ihrer herstellung und ihre verwendung
DK2287261T3 (en) Method of Preparing an Aqueous Oligomeric or Polymeric Compound
WO2005070973A3 (en) Method of preparing propionic acid-terminated polymers
WO2003040194A1 (en) (meth)acrylic acid (salt) polymer and process for production thereof
ATE264877T1 (de) Verfahren zur herstellung von wasserlöslichen polymerisaten, die polyalkylenglykolether- seitenketten enthalten
DE502005004152D1 (de) Verfahren zur herstellung wasserabsorbierender polymere
DE69813765D1 (de) Verfahren zur herstellung von wasserlöslichen polymer dispersionen
DE502006008732D1 (de) Verfahren zur herstellung von polyisobuten
CN106832243A (zh) 一种无金属催化制备聚己内酯的方法
DE50205051D1 (de) Verbessertes verfahren zur herstellung von polytetrahydrofuran
EP1123942A3 (en) Amino-group-containing polymer (salt) and production process therefor
ATE348118T1 (de) Verfahren zur herstellung von partikelförmigen polymerisaten
WO2009042825A3 (en) Process of preparing functionalized polymers via enzymatic catalysis
EP1857485A4 (en) CYCLE OPENING POLYMERIZATION METHOD AND CATALYST BASED ON ACTIVE CHARCOAL FOR CYCLE OPENING POLYMERIZATION
Wang et al. Facile graft copolymerization of chitosan powder with methyl acrylate using ceric ammonium nitrate