KR101088291B1 - 암의 치료를 위한 이미다졸리디노닐 아미노피리미딘 화합물 - Google Patents

암의 치료를 위한 이미다졸리디노닐 아미노피리미딘 화합물 Download PDF

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Publication number
KR101088291B1
KR101088291B1 KR1020097012835A KR20097012835A KR101088291B1 KR 101088291 B1 KR101088291 B1 KR 101088291B1 KR 1020097012835 A KR1020097012835 A KR 1020097012835A KR 20097012835 A KR20097012835 A KR 20097012835A KR 101088291 B1 KR101088291 B1 KR 101088291B1
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KR
South Korea
Prior art keywords
cancer
mmol
hydrogen
mixture
benzo
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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KR1020097012835A
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English (en)
Korean (ko)
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KR20090086114A (ko
Inventor
홍-유 리
해롤드 번스 브룩스
조이스 제트. 크리치
제임스 로버트 헨리
멜리사 케이트 슬레이터
얀 왕
Original Assignee
일라이 릴리 앤드 캄파니
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Publication of KR20090086114A publication Critical patent/KR20090086114A/ko
Application granted granted Critical
Publication of KR101088291B1 publication Critical patent/KR101088291B1/ko
Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020097012835A 2006-12-21 2007-12-11 암의 치료를 위한 이미다졸리디노닐 아미노피리미딘 화합물 Expired - Fee Related KR101088291B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87130206P 2006-12-21 2006-12-21
US60/871,302 2006-12-21
PCT/US2007/087044 WO2008076704A1 (en) 2006-12-21 2007-12-11 Imidazolidinonyl aminopyrimidine compounds for the treatment' of cancer

Publications (2)

Publication Number Publication Date
KR20090086114A KR20090086114A (ko) 2009-08-10
KR101088291B1 true KR101088291B1 (ko) 2011-11-30

Family

ID=39186811

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020097012835A Expired - Fee Related KR101088291B1 (ko) 2006-12-21 2007-12-11 암의 치료를 위한 이미다졸리디노닐 아미노피리미딘 화합물

Country Status (14)

Country Link
US (1) US8101628B2 (enExample)
EP (1) EP2125793B1 (enExample)
JP (1) JP5166441B2 (enExample)
KR (1) KR101088291B1 (enExample)
CN (1) CN101563342B (enExample)
AT (1) ATE479680T1 (enExample)
AU (1) AU2007334039B2 (enExample)
BR (1) BRPI0721045A2 (enExample)
CA (1) CA2671738A1 (enExample)
DE (1) DE602007008952D1 (enExample)
EA (1) EA016177B1 (enExample)
ES (1) ES2349169T3 (enExample)
MX (1) MX2009006634A (enExample)
WO (1) WO2008076704A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA016178B1 (ru) 2006-12-21 2012-02-28 Эли Лилли Энд Компани Соединения имидазолидинониламинопиримидина
EP2155735A2 (en) 2007-05-16 2010-02-24 Eli Lilly And Company Triazolyl aminopyrimidine compounds
TW200908981A (en) * 2007-05-16 2009-03-01 Lilly Co Eli Triazolyl aminopyrimidine compounds
CN108853111B (zh) * 2018-08-07 2020-06-05 浙江大学 一种组合物在制备治疗吉非替尼肝脏毒性药物中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004063192A1 (en) 2003-01-10 2004-07-29 Pharmacopeia Drug Discovery, Inc. Imidazolyl pyrimidine derivatives useful as il-8 receptor modulators
WO2006066172A1 (en) 2004-12-17 2006-06-22 Amgen, Inc. Aminopyrimidine compounds and methods of use

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929726A (en) 1988-02-09 1990-05-29 Georgia State University Foundation, Inc. Novel diazines and their method of preparation
US6939877B2 (en) * 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
WO2005012283A1 (en) * 2003-07-31 2005-02-10 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzothiophene compounds and uses thereof
TW200800201A (en) * 2005-11-18 2008-01-01 Lilly Co Eli Pyrimidinyl benzothiophene compounds
EP2001480A4 (en) * 2006-03-31 2011-06-15 Abbott Lab Indazole CONNECTIONS
EA016178B1 (ru) 2006-12-21 2012-02-28 Эли Лилли Энд Компани Соединения имидазолидинониламинопиримидина
EP2155735A2 (en) 2007-05-16 2010-02-24 Eli Lilly And Company Triazolyl aminopyrimidine compounds
TW200908981A (en) 2007-05-16 2009-03-01 Lilly Co Eli Triazolyl aminopyrimidine compounds

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004063192A1 (en) 2003-01-10 2004-07-29 Pharmacopeia Drug Discovery, Inc. Imidazolyl pyrimidine derivatives useful as il-8 receptor modulators
WO2006066172A1 (en) 2004-12-17 2006-06-22 Amgen, Inc. Aminopyrimidine compounds and methods of use

Also Published As

Publication number Publication date
CN101563342A (zh) 2009-10-21
CN101563342B (zh) 2012-09-05
US8101628B2 (en) 2012-01-24
US20100076001A1 (en) 2010-03-25
ATE479680T1 (de) 2010-09-15
ES2349169T3 (es) 2010-12-28
EA016177B1 (ru) 2012-02-28
EA200970615A1 (ru) 2009-10-30
JP5166441B2 (ja) 2013-03-21
AU2007334039A1 (en) 2008-06-26
WO2008076704A1 (en) 2008-06-26
AU2007334039B2 (en) 2012-02-16
DE602007008952D1 (de) 2010-10-14
BRPI0721045A2 (pt) 2014-07-29
JP2010513552A (ja) 2010-04-30
EP2125793B1 (en) 2010-09-01
MX2009006634A (es) 2009-06-30
EP2125793A1 (en) 2009-12-02
CA2671738A1 (en) 2008-06-26
KR20090086114A (ko) 2009-08-10

Similar Documents

Publication Publication Date Title
AU2008254319B2 (en) Triazolyl aminopyrimidine compounds
KR101088291B1 (ko) 암의 치료를 위한 이미다졸리디노닐 아미노피리미딘 화합물
KR101080594B1 (ko) 암의 치료를 위한 이미다졸리디노닐 아미노피리미딘 화합물
KR101131254B1 (ko) 트리아졸릴 아미노피리미딘 화합물

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