CA2671738A1 - Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer - Google Patents

Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer Download PDF

Info

Publication number
CA2671738A1
CA2671738A1 CA002671738A CA2671738A CA2671738A1 CA 2671738 A1 CA2671738 A1 CA 2671738A1 CA 002671738 A CA002671738 A CA 002671738A CA 2671738 A CA2671738 A CA 2671738A CA 2671738 A1 CA2671738 A1 CA 2671738A1
Authority
CA
Canada
Prior art keywords
benzo
thiophen
ethyl
ylamino
imidazolidin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002671738A
Other languages
English (en)
French (fr)
Inventor
Hong-Yu Li
Harold Burns Brooks
Joyce Z. Crich
James Robert Henry
Melissa Kate Slater
Yan Wang
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2671738A1 publication Critical patent/CA2671738A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA002671738A 2006-12-21 2007-12-11 Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer Abandoned CA2671738A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US87130206P 2006-12-21 2006-12-21
US60/871,302 2006-12-21
PCT/US2007/087044 WO2008076704A1 (en) 2006-12-21 2007-12-11 Imidazolidinonyl aminopyrimidine compounds for the treatment' of cancer

Publications (1)

Publication Number Publication Date
CA2671738A1 true CA2671738A1 (en) 2008-06-26

Family

ID=39186811

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002671738A Abandoned CA2671738A1 (en) 2006-12-21 2007-12-11 Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer

Country Status (14)

Country Link
US (1) US8101628B2 (enExample)
EP (1) EP2125793B1 (enExample)
JP (1) JP5166441B2 (enExample)
KR (1) KR101088291B1 (enExample)
CN (1) CN101563342B (enExample)
AT (1) ATE479680T1 (enExample)
AU (1) AU2007334039B2 (enExample)
BR (1) BRPI0721045A2 (enExample)
CA (1) CA2671738A1 (enExample)
DE (1) DE602007008952D1 (enExample)
EA (1) EA016177B1 (enExample)
ES (1) ES2349169T3 (enExample)
MX (1) MX2009006634A (enExample)
WO (1) WO2008076704A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA016178B1 (ru) 2006-12-21 2012-02-28 Эли Лилли Энд Компани Соединения имидазолидинониламинопиримидина
EP2155735A2 (en) 2007-05-16 2010-02-24 Eli Lilly And Company Triazolyl aminopyrimidine compounds
TW200908981A (en) * 2007-05-16 2009-03-01 Lilly Co Eli Triazolyl aminopyrimidine compounds
CN108853111B (zh) * 2018-08-07 2020-06-05 浙江大学 一种组合物在制备治疗吉非替尼肝脏毒性药物中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929726A (en) 1988-02-09 1990-05-29 Georgia State University Foundation, Inc. Novel diazines and their method of preparation
US6939877B2 (en) * 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
WO2004063192A1 (en) * 2003-01-10 2004-07-29 Pharmacopeia Drug Discovery, Inc. Imidazolyl pyrimidine derivatives useful as il-8 receptor modulators
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
WO2005012283A1 (en) * 2003-07-31 2005-02-10 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzothiophene compounds and uses thereof
CN101115749B (zh) * 2004-12-17 2011-06-22 安姆根有限公司 氨基嘧啶化合物和使用方法
TW200800201A (en) * 2005-11-18 2008-01-01 Lilly Co Eli Pyrimidinyl benzothiophene compounds
EP2001480A4 (en) * 2006-03-31 2011-06-15 Abbott Lab Indazole CONNECTIONS
EA016178B1 (ru) 2006-12-21 2012-02-28 Эли Лилли Энд Компани Соединения имидазолидинониламинопиримидина
EP2155735A2 (en) 2007-05-16 2010-02-24 Eli Lilly And Company Triazolyl aminopyrimidine compounds
TW200908981A (en) 2007-05-16 2009-03-01 Lilly Co Eli Triazolyl aminopyrimidine compounds

Also Published As

Publication number Publication date
CN101563342A (zh) 2009-10-21
CN101563342B (zh) 2012-09-05
US8101628B2 (en) 2012-01-24
US20100076001A1 (en) 2010-03-25
ATE479680T1 (de) 2010-09-15
ES2349169T3 (es) 2010-12-28
EA016177B1 (ru) 2012-02-28
EA200970615A1 (ru) 2009-10-30
JP5166441B2 (ja) 2013-03-21
KR101088291B1 (ko) 2011-11-30
AU2007334039A1 (en) 2008-06-26
WO2008076704A1 (en) 2008-06-26
AU2007334039B2 (en) 2012-02-16
DE602007008952D1 (de) 2010-10-14
BRPI0721045A2 (pt) 2014-07-29
JP2010513552A (ja) 2010-04-30
EP2125793B1 (en) 2010-09-01
MX2009006634A (es) 2009-06-30
EP2125793A1 (en) 2009-12-02
KR20090086114A (ko) 2009-08-10

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AU2007334039B2 (en) Imidazolidinonyl aminopyrimidine compounds for the treatment' of cancer
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US8063212B2 (en) Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued

Effective date: 20131001