MX2009006634A - Compuestos de imidazolidinonil aminopirimidina para el tratamiento de cancer. - Google Patents

Compuestos de imidazolidinonil aminopirimidina para el tratamiento de cancer.

Info

Publication number
MX2009006634A
MX2009006634A MX2009006634A MX2009006634A MX2009006634A MX 2009006634 A MX2009006634 A MX 2009006634A MX 2009006634 A MX2009006634 A MX 2009006634A MX 2009006634 A MX2009006634 A MX 2009006634A MX 2009006634 A MX2009006634 A MX 2009006634A
Authority
MX
Mexico
Prior art keywords
sup
hydrogen
halo
cancer
treatment
Prior art date
Application number
MX2009006634A
Other languages
English (en)
Inventor
James Robert Henry
Yang Wang
Hong-Yu Li
Harold Burns Brooks
Joyce Z Crich
Melissa Kate Slater
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of MX2009006634A publication Critical patent/MX2009006634A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se refiere a nuevos compuestos de imidazolidinonil aminopirimidina, que se cree tienen uso clínico para el tratamiento de cáncer a través de la inhibición de Plk1, en donde: R1 es hidrógeno, hidroxi, halo, metilo, C1-C2 alcoxi, amino o metilamino; R2 es hidrógeno, halo o ciano; R3 es hidrógeno o halo; R4 es hidrógeno, halo o metilo; siempre que al menos dos de R1, R2, R3 y R4 son hidrógeno; R5 es hidrógeno, halo o metilo; o una sal farmacéuticamente aceptable de los mismos.
MX2009006634A 2006-12-21 2007-12-11 Compuestos de imidazolidinonil aminopirimidina para el tratamiento de cancer. MX2009006634A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US87130206P 2006-12-21 2006-12-21
PCT/US2007/087044 WO2008076704A1 (en) 2006-12-21 2007-12-11 Imidazolidinonyl aminopyrimidine compounds for the treatment' of cancer

Publications (1)

Publication Number Publication Date
MX2009006634A true MX2009006634A (es) 2009-06-30

Family

ID=39186811

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006634A MX2009006634A (es) 2006-12-21 2007-12-11 Compuestos de imidazolidinonil aminopirimidina para el tratamiento de cancer.

Country Status (14)

Country Link
US (1) US8101628B2 (es)
EP (1) EP2125793B1 (es)
JP (1) JP5166441B2 (es)
KR (1) KR101088291B1 (es)
CN (1) CN101563342B (es)
AT (1) ATE479680T1 (es)
AU (1) AU2007334039B2 (es)
BR (1) BRPI0721045A2 (es)
CA (1) CA2671738A1 (es)
DE (1) DE602007008952D1 (es)
EA (1) EA016177B1 (es)
ES (1) ES2349169T3 (es)
MX (1) MX2009006634A (es)
WO (1) WO2008076704A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2673564A1 (en) 2006-12-21 2008-06-26 Eli Lilly And Company Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer
JP5204838B2 (ja) 2007-05-16 2013-06-05 イーライ リリー アンド カンパニー トリアゾリルアミノピリミジン化合物
TW200908981A (en) 2007-05-16 2009-03-01 Lilly Co Eli Triazolyl aminopyrimidine compounds
CN108853111B (zh) * 2018-08-07 2020-06-05 浙江大学 一种组合物在制备治疗吉非替尼肝脏毒性药物中的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4929726A (en) 1988-02-09 1990-05-29 Georgia State University Foundation, Inc. Novel diazines and their method of preparation
US6939877B2 (en) * 2002-09-12 2005-09-06 Wyeth Antidepressant piperidine derivatives of heterocycle-fused benzodioxans
WO2004063192A1 (en) 2003-01-10 2004-07-29 Pharmacopeia Drug Discovery, Inc. Imidazolyl pyrimidine derivatives useful as il-8 receptor modulators
GB0308466D0 (en) 2003-04-11 2003-05-21 Novartis Ag Organic compounds
WO2005012283A1 (en) * 2003-07-31 2005-02-10 Boehringer Ingelheim Pharmaceuticals, Inc. Substituted benzothiophene compounds and uses thereof
EP1831207B1 (en) * 2004-12-17 2012-11-14 Amgen Inc. Aminopyrimidine compounds as plk inhibitors
TW200800201A (en) * 2005-11-18 2008-01-01 Lilly Co Eli Pyrimidinyl benzothiophene compounds
CN101437519A (zh) * 2006-03-31 2009-05-20 艾博特公司 吲唑化合物
CA2673564A1 (en) 2006-12-21 2008-06-26 Eli Lilly And Company Imidazolidinonyl aminopyrimidine compounds for the treatment of cancer
JP5204838B2 (ja) 2007-05-16 2013-06-05 イーライ リリー アンド カンパニー トリアゾリルアミノピリミジン化合物
TW200908981A (en) 2007-05-16 2009-03-01 Lilly Co Eli Triazolyl aminopyrimidine compounds

Also Published As

Publication number Publication date
EA016177B1 (ru) 2012-02-28
CN101563342A (zh) 2009-10-21
EP2125793B1 (en) 2010-09-01
US20100076001A1 (en) 2010-03-25
JP5166441B2 (ja) 2013-03-21
JP2010513552A (ja) 2010-04-30
WO2008076704A1 (en) 2008-06-26
EP2125793A1 (en) 2009-12-02
AU2007334039B2 (en) 2012-02-16
US8101628B2 (en) 2012-01-24
CA2671738A1 (en) 2008-06-26
BRPI0721045A2 (pt) 2014-07-29
AU2007334039A1 (en) 2008-06-26
DE602007008952D1 (de) 2010-10-14
ATE479680T1 (de) 2010-09-15
EA200970615A1 (ru) 2009-10-30
KR101088291B1 (ko) 2011-11-30
CN101563342B (zh) 2012-09-05
ES2349169T3 (es) 2010-12-28
KR20090086114A (ko) 2009-08-10

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