KR101073742B1 - α-(페녹시)페닐아세트산 유도체의 분리 - Google Patents

α-(페녹시)페닐아세트산 유도체의 분리 Download PDF

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Publication number
KR101073742B1
KR101073742B1 KR1020057024492A KR20057024492A KR101073742B1 KR 101073742 B1 KR101073742 B1 KR 101073742B1 KR 1020057024492 A KR1020057024492 A KR 1020057024492A KR 20057024492 A KR20057024492 A KR 20057024492A KR 101073742 B1 KR101073742 B1 KR 101073742B1
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KR
South Korea
Prior art keywords
acid
cpta
enantiomer
phenoxy
phenylacetic acid
Prior art date
Application number
KR1020057024492A
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English (en)
Korean (ko)
Other versions
KR20060030048A (ko
Inventor
에드워드 디. 다우그스
Original Assignee
메타볼렉스, 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from US10/656,567 external-priority patent/US7199259B2/en
Application filed by 메타볼렉스, 인코포레이티드 filed Critical 메타볼렉스, 인코포레이티드
Publication of KR20060030048A publication Critical patent/KR20060030048A/ko
Application granted granted Critical
Publication of KR101073742B1 publication Critical patent/KR101073742B1/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/41—Preparation of salts of carboxylic acids
    • C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/43—Separation; Purification; Stabilisation; Use of additives by change of the physical state, e.g. crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
KR1020057024492A 2003-06-20 2005-12-20 α-(페녹시)페닐아세트산 유도체의 분리 KR101073742B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US60018903A 2003-06-20 2003-06-20
US10/600,189 2003-06-20
US10/656,567 2003-09-04
US10/656,567 US7199259B2 (en) 2003-06-20 2003-09-04 Resolution of α-(phenoxy)phenylacetic acid derivatives
PCT/US2004/019616 WO2004112774A1 (fr) 2003-06-20 2004-06-18 Resolution de derives d'acide ?lpha-(phenoxy)phenylacetique

Publications (2)

Publication Number Publication Date
KR20060030048A KR20060030048A (ko) 2006-04-07
KR101073742B1 true KR101073742B1 (ko) 2011-10-13

Family

ID=33544772

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057024492A KR101073742B1 (ko) 2003-06-20 2005-12-20 α-(페녹시)페닐아세트산 유도체의 분리

Country Status (7)

Country Link
EP (1) EP1635809A4 (fr)
KR (1) KR101073742B1 (fr)
CA (1) CA2529774C (fr)
IL (1) IL172663A0 (fr)
MX (1) MXPA05013981A (fr)
RS (1) RS20050937A (fr)
WO (1) WO2004112774A1 (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7576131B2 (en) 1999-06-04 2009-08-18 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia
US6262118B1 (en) 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia
US7199259B2 (en) 2003-06-20 2007-04-03 Metabolex, Inc. Resolution of α-(phenoxy)phenylacetic acid derivatives
US20080194646A1 (en) * 2005-03-21 2008-08-14 Sanders Martin E Methods For Avoiding Edema in the Treatment of Metabolic, Inflammatory, and Cardiovascular Disorders
KR100678287B1 (ko) * 2005-06-23 2007-02-02 한미약품 주식회사 클로피도그렐의 제조방법 및 이에 사용되는 중간체
US7714131B2 (en) * 2005-09-23 2010-05-11 Metabolex, Inc. Process for the stereoselective preparation of (−)-halofenate and derivatives thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262118B1 (en) 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6712585A (fr) * 1966-10-03 1968-04-04
US3517050A (en) * 1966-10-03 1970-06-23 Merck & Co Inc Ester and amide derivative of (3-trifluoromethylphenoxy) (4 - halophenyl)acetic acid
US6624194B1 (en) * 1999-06-04 2003-09-23 Metabolex, Inc. Use of (−) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes, hyperlipidemia and hyperuricemia

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6262118B1 (en) 1999-06-04 2001-07-17 Metabolex, Inc. Use of (-) (3-trihalomethylphenoxy) (4-halophenyl) acetic acid derivatives for treatment of insulin resistance, type 2 diabetes and hyperlipidemia

Also Published As

Publication number Publication date
MXPA05013981A (es) 2006-03-02
RS20050937A (en) 2008-04-04
CA2529774A1 (fr) 2004-12-29
EP1635809A4 (fr) 2006-09-27
WO2004112774A1 (fr) 2004-12-29
IL172663A0 (en) 2006-04-10
KR20060030048A (ko) 2006-04-07
EP1635809A1 (fr) 2006-03-22
CA2529774C (fr) 2014-05-27

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