KR101071798B1 - 로플루미래스트와 포르모테롤을 포함하는 신규한상승작용성 조합물 - Google Patents

로플루미래스트와 포르모테롤을 포함하는 신규한상승작용성 조합물 Download PDF

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Publication number
KR101071798B1
KR101071798B1 KR1020057009210A KR20057009210A KR101071798B1 KR 101071798 B1 KR101071798 B1 KR 101071798B1 KR 1020057009210 A KR1020057009210 A KR 1020057009210A KR 20057009210 A KR20057009210 A KR 20057009210A KR 101071798 B1 KR101071798 B1 KR 101071798B1
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South Korea
Prior art keywords
formoterol
roflumilast
pharmacologically acceptable
acceptable salt
combination
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KR1020057009210A
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English (en)
Korean (ko)
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KR20050085104A (ko
Inventor
롤프 보이메
다니엘라 분트슈
노르베르트 콜라사
데겐하르트 마르크스
크리스티안 바이마르
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니코메드 게엠베하
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
KR1020057009210A 2002-11-27 2003-11-26 로플루미래스트와 포르모테롤을 포함하는 신규한상승작용성 조합물 Expired - Fee Related KR101071798B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02026505 2002-11-27
EP02026505.4 2002-11-27

Publications (2)

Publication Number Publication Date
KR20050085104A KR20050085104A (ko) 2005-08-29
KR101071798B1 true KR101071798B1 (ko) 2011-10-11

Family

ID=32338002

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057009210A Expired - Fee Related KR101071798B1 (ko) 2002-11-27 2003-11-26 로플루미래스트와 포르모테롤을 포함하는 신규한상승작용성 조합물

Country Status (31)

Country Link
US (1) US20060142308A1 (enExample)
EP (1) EP1567139B1 (enExample)
JP (1) JP2006508994A (enExample)
KR (1) KR101071798B1 (enExample)
CN (1) CN100346777C (enExample)
AT (1) ATE399543T1 (enExample)
AU (1) AU2003292120B2 (enExample)
BR (1) BR0316451A (enExample)
CA (1) CA2506962C (enExample)
CO (1) CO5690570A2 (enExample)
CY (1) CY1110369T1 (enExample)
DE (1) DE60321953D1 (enExample)
DK (1) DK1567139T3 (enExample)
EA (1) EA009935B1 (enExample)
ES (1) ES2309357T3 (enExample)
HR (1) HRP20050579B1 (enExample)
IL (1) IL168308A (enExample)
IS (1) IS2575B (enExample)
MA (1) MA27539A1 (enExample)
ME (1) ME00489B (enExample)
MX (1) MXPA05005437A (enExample)
NO (1) NO334247B1 (enExample)
NZ (1) NZ540659A (enExample)
PL (1) PL216752B1 (enExample)
PT (1) PT1567139E (enExample)
RS (1) RS51081B (enExample)
SI (1) SI1567139T1 (enExample)
TN (1) TNSN05131A1 (enExample)
UA (1) UA83018C2 (enExample)
WO (1) WO2004047829A1 (enExample)
ZA (1) ZA200503308B (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY140561A (en) 2002-02-20 2009-12-31 Nycomed Gmbh Dosage form containing pde 4 inhibitor as active ingredient
RS52908B (sr) 2003-03-10 2014-02-28 Takeda Gmbh Novi postupak za dobijanje roflumilasta
CA2601250C (en) * 2005-03-16 2014-10-28 Nycomed Gmbh Taste masked dosage form containing roflumilast
DE102005030733A1 (de) * 2005-07-01 2007-01-04 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
ATE535244T1 (de) * 2006-07-05 2011-12-15 Nycomed Gmbh Kombination aus atorvastatin mit einem phosphodiesterase-4-hemmer zur behandlung von entzündlichen lungenerkrankungen
WO2013077830A1 (en) * 2011-11-25 2013-05-30 Mahmut Bilgic Synergistilly active combinations of roflumilast and carmoterol
US20130172303A1 (en) * 2012-01-03 2013-07-04 Forest Laboratories Holdings Ltd. Roflumilast compositions for the treatment of copd
PL2948148T3 (pl) * 2013-01-28 2021-01-25 Incozen Therapeutics Pvt. Ltd. Sposoby leczenia zaburzeń autoimmunologicznych, oddechowych i zapalnych przez wziewne podawanie n-tlenku roflumilastu
CN104800214A (zh) * 2014-01-27 2015-07-29 成都英诺新科技有限公司 一种罗氟司特吸入气雾剂复方及制备方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001013953A2 (en) * 1999-08-21 2001-03-01 Byk Gulden Lomberg Chemische Fabrik Gmbh Synergistic combination of pde inhibitors and beta 2 adrenoceptor agonist

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5795564A (en) * 1991-04-05 1998-08-18 Sepracor, Inc. Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol
SI0706513T1 (en) * 1993-07-02 2002-10-31 Altana Pharma Ag Fluoroalkoxy-substituted benzamides and their use as cyclic nucleotide phosphodiesterase inhibitors
EA001758B1 (ru) * 1997-02-17 2001-08-27 Бык Гульден Ломберг Хемише Фабрик Гмбх Композиции для лечения респираторного дистресс-синдрома взрослых или респираторного дистресс-синдрома новорожденных, содержащие 3-(циклопропилметокси)-n-(3,5-дихлор-4-пиридинил)-4-(дифторметокси)бензамид и легочное поверхностно-активное вещество
US6624181B1 (en) * 1997-02-28 2003-09-23 Altana Pharma Ag Synergistic combination
JP2001513097A (ja) * 1997-02-28 2001-08-28 ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング Ｐｄｅ−抑制物質とアデニル酸シクラーゼ・アゴニストもしくはグアニル酸シクラーゼ・アゴニストとからなる相乗的組み合わせ組成物
CZ293735B6 (cs) * 1998-08-26 2004-07-14 Smithkline Beecham Corporation Farmaceutický prostředek pro léčbu plicní nemoci
US6303145B2 (en) * 1999-05-10 2001-10-16 Sepracor Inc. (S,R) formoterol methods and compositions
GB0103630D0 (en) * 2001-02-14 2001-03-28 Glaxo Group Ltd Chemical compounds
ES2296923T3 (es) * 2001-03-22 2008-05-01 Glaxo Group Limited Derivados formanilidas como agonistas del adrenorreceptor beta2.
ES2314052T3 (es) * 2001-04-30 2009-03-16 Glaxo Group Limited Derivados de ester de 17beta-carbotioato de androstano con un grupo ester ciclico en la posicion 17alfa.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001013953A2 (en) * 1999-08-21 2001-03-01 Byk Gulden Lomberg Chemische Fabrik Gmbh Synergistic combination of pde inhibitors and beta 2 adrenoceptor agonist

Also Published As

Publication number Publication date
DK1567139T3 (da) 2008-11-03
MA27539A1 (fr) 2005-09-01
RS51081B (sr) 2010-10-31
IS2575B (is) 2010-02-15
PL216752B1 (pl) 2014-05-30
JP2006508994A (ja) 2006-03-16
ZA200503308B (en) 2006-11-29
ES2309357T3 (es) 2008-12-16
EP1567139B1 (en) 2008-07-02
CO5690570A2 (es) 2006-10-31
CY1110369T1 (el) 2015-04-29
AU2003292120B2 (en) 2010-01-21
CA2506962C (en) 2012-01-03
CA2506962A1 (en) 2004-06-10
CN100346777C (zh) 2007-11-07
IS7898A (is) 2005-06-20
NO20052999L (no) 2005-06-17
AU2003292120A1 (en) 2004-06-18
EA009935B1 (ru) 2008-04-28
ATE399543T1 (de) 2008-07-15
MXPA05005437A (es) 2005-08-03
TNSN05131A1 (en) 2007-05-14
SI1567139T1 (sl) 2008-12-31
DE60321953D1 (de) 2008-08-14
NZ540659A (en) 2007-05-31
EP1567139A1 (en) 2005-08-31
HRP20050579B1 (hr) 2014-01-31
PL377732A1 (pl) 2006-02-06
RS20050382A (sr) 2007-08-03
WO2004047829A8 (en) 2005-06-30
WO2004047829A1 (en) 2004-06-10
HRP20050579A2 (hr) 2006-04-30
US20060142308A1 (en) 2006-06-29
NO334247B1 (no) 2014-01-20
KR20050085104A (ko) 2005-08-29
ME00489B (me) 2011-10-10
PT1567139E (pt) 2008-10-01
IL168308A (en) 2010-12-30
UA83018C2 (uk) 2008-06-10
EA200500774A1 (ru) 2005-12-29
BR0316451A (pt) 2005-10-11
CN1713903A (zh) 2005-12-28
HK1081861A1 (en) 2006-05-26

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