SI1567139T1 - Nova sinergistična kombinacija, ki obsega roflumilast in formoterol - Google Patents
Nova sinergistična kombinacija, ki obsega roflumilast in formoterolInfo
- Publication number
- SI1567139T1 SI1567139T1 SI200331344T SI200331344T SI1567139T1 SI 1567139 T1 SI1567139 T1 SI 1567139T1 SI 200331344 T SI200331344 T SI 200331344T SI 200331344 T SI200331344 T SI 200331344T SI 1567139 T1 SI1567139 T1 SI 1567139T1
- Authority
- SI
- Slovenia
- Prior art keywords
- roflumilast
- formoterol
- synergistic combination
- new synergistic
- new
- Prior art date
Links
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002848 formoterol Drugs 0.000 title abstract 2
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002586 roflumilast Drugs 0.000 title abstract 2
- 239000011885 synergistic combination Substances 0.000 title 1
- 208000018569 Respiratory Tract disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02026505 | 2002-11-27 | ||
| EP03767663A EP1567139B1 (en) | 2002-11-27 | 2003-11-26 | New synergistic combination comprising roflumilast and formoterol |
| PCT/EP2003/013275 WO2004047829A1 (en) | 2002-11-27 | 2003-11-26 | New synergistic combination comprising roflumilast and formoterol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI1567139T1 true SI1567139T1 (sl) | 2008-12-31 |
Family
ID=32338002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200331344T SI1567139T1 (sl) | 2002-11-27 | 2003-11-26 | Nova sinergistična kombinacija, ki obsega roflumilast in formoterol |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20060142308A1 (enExample) |
| EP (1) | EP1567139B1 (enExample) |
| JP (1) | JP2006508994A (enExample) |
| KR (1) | KR101071798B1 (enExample) |
| CN (1) | CN100346777C (enExample) |
| AT (1) | ATE399543T1 (enExample) |
| AU (1) | AU2003292120B2 (enExample) |
| BR (1) | BR0316451A (enExample) |
| CA (1) | CA2506962C (enExample) |
| CO (1) | CO5690570A2 (enExample) |
| CY (1) | CY1110369T1 (enExample) |
| DE (1) | DE60321953D1 (enExample) |
| DK (1) | DK1567139T3 (enExample) |
| EA (1) | EA009935B1 (enExample) |
| ES (1) | ES2309357T3 (enExample) |
| HR (1) | HRP20050579B1 (enExample) |
| IL (1) | IL168308A (enExample) |
| IS (1) | IS2575B (enExample) |
| MA (1) | MA27539A1 (enExample) |
| ME (1) | ME00489B (enExample) |
| MX (1) | MXPA05005437A (enExample) |
| NO (1) | NO334247B1 (enExample) |
| NZ (1) | NZ540659A (enExample) |
| PL (1) | PL216752B1 (enExample) |
| PT (1) | PT1567139E (enExample) |
| RS (1) | RS51081B (enExample) |
| SI (1) | SI1567139T1 (enExample) |
| TN (1) | TNSN05131A1 (enExample) |
| UA (1) | UA83018C2 (enExample) |
| WO (1) | WO2004047829A1 (enExample) |
| ZA (1) | ZA200503308B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| ES2335498T3 (es) | 2003-03-10 | 2010-03-29 | Nycomed Gmbh | Nuevo proceso para la preparacion de reflumilast. |
| EP2258350B1 (en) * | 2005-03-16 | 2014-12-24 | Takeda GmbH | Taste masked dosage form containing roflumilast |
| DE102005030733A1 (de) * | 2005-07-01 | 2007-01-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff |
| RS53084B (sr) * | 2006-07-05 | 2014-06-30 | Takeda Gmbh | Kombinacija inhibitora hmg-coa reduktaze rosuvastatina sa inhibitorom fosfodiesteraze 4, kao što je roflumilast, roflumilast-n-oksid za lečenje inflamatornih plućnih obolenja |
| WO2013077830A1 (en) * | 2011-11-25 | 2013-05-30 | Mahmut Bilgic | Synergistilly active combinations of roflumilast and carmoterol |
| US20130172303A1 (en) * | 2012-01-03 | 2013-07-04 | Forest Laboratories Holdings Ltd. | Roflumilast compositions for the treatment of copd |
| EP2948148B1 (en) * | 2013-01-28 | 2020-07-29 | Incozen Therapeutics Pvt. Ltd. | Methods of treating autoimmune, respiratory and inflammatory disorders by inhalation of roflumilast n-oxide |
| CN104800214A (zh) * | 2014-01-27 | 2015-07-29 | 成都英诺新科技有限公司 | 一种罗氟司特吸入气雾剂复方及制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795564A (en) * | 1991-04-05 | 1998-08-18 | Sepracor, Inc. | Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol |
| KR100331255B1 (ko) * | 1993-07-02 | 2002-10-25 | 빅굴덴 롬베르그 케미쉐 화부리크 게엠베하 | 플루오로알콕시-치환된벤즈아미드및시클릭뉴클레오티드포스포디에스테라아제억제제로서의그의용도 |
| TR199901772T2 (enExample) * | 1997-02-17 | 1999-09-21 | Byk Gulden Lomberg Chemische Fabrik Gmbh | |
| US6624181B1 (en) * | 1997-02-28 | 2003-09-23 | Altana Pharma Ag | Synergistic combination |
| JP2001513097A (ja) * | 1997-02-28 | 2001-08-28 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | Ｐｄｅ−抑制物質とアデニル酸シクラーゼ・アゴニストもしくはグアニル酸シクラーゼ・アゴニストとからなる相乗的組み合わせ組成物 |
| KR20010072931A (ko) * | 1998-08-26 | 2001-07-31 | 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 | 폐 질환 치료 요법 |
| US6303145B2 (en) * | 1999-05-10 | 2001-10-16 | Sepracor Inc. | (S,R) formoterol methods and compositions |
| CZ302882B6 (cs) * | 1999-08-21 | 2012-01-04 | Nycomed Gmbh | Farmaceutický prostredek |
| GB0103630D0 (en) * | 2001-02-14 | 2001-03-28 | Glaxo Group Ltd | Chemical compounds |
| US7045658B2 (en) * | 2001-03-22 | 2006-05-16 | Glaxo Group Limited | Formailide derivatives as beta2-adrenoreceptor agonists |
| CA2445839A1 (en) * | 2001-04-30 | 2002-11-07 | Glaxo Group Limited | Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha |
-
2003
- 2003-11-26 WO PCT/EP2003/013275 patent/WO2004047829A1/en not_active Ceased
- 2003-11-26 US US10/535,816 patent/US20060142308A1/en not_active Abandoned
- 2003-11-26 NZ NZ540659A patent/NZ540659A/en not_active IP Right Cessation
- 2003-11-26 HR HRP20050579AA patent/HRP20050579B1/hr not_active IP Right Cessation
- 2003-11-26 UA UAA200505966A patent/UA83018C2/uk unknown
- 2003-11-26 DE DE60321953T patent/DE60321953D1/de not_active Expired - Lifetime
- 2003-11-26 PT PT03767663T patent/PT1567139E/pt unknown
- 2003-11-26 CN CNB2003801037450A patent/CN100346777C/zh not_active Expired - Fee Related
- 2003-11-26 SI SI200331344T patent/SI1567139T1/sl unknown
- 2003-11-26 JP JP2004554480A patent/JP2006508994A/ja active Pending
- 2003-11-26 RS YUP-2005/0382A patent/RS51081B/sr unknown
- 2003-11-26 DK DK03767663T patent/DK1567139T3/da active
- 2003-11-26 EP EP03767663A patent/EP1567139B1/en not_active Expired - Lifetime
- 2003-11-26 BR BR0316451-9A patent/BR0316451A/pt not_active IP Right Cessation
- 2003-11-26 PL PL377732A patent/PL216752B1/pl unknown
- 2003-11-26 AT AT03767663T patent/ATE399543T1/de active
- 2003-11-26 ME MEP-2008-782A patent/ME00489B/me unknown
- 2003-11-26 AU AU2003292120A patent/AU2003292120B2/en not_active Ceased
- 2003-11-26 MX MXPA05005437A patent/MXPA05005437A/es active IP Right Grant
- 2003-11-26 EA EA200500774A patent/EA009935B1/ru not_active IP Right Cessation
- 2003-11-26 ES ES03767663T patent/ES2309357T3/es not_active Expired - Lifetime
- 2003-11-26 CA CA2506962A patent/CA2506962C/en not_active Expired - Fee Related
- 2003-11-26 KR KR1020057009210A patent/KR101071798B1/ko not_active Expired - Fee Related
-
2005
- 2005-04-25 ZA ZA200503308A patent/ZA200503308B/en unknown
- 2005-05-01 IL IL168308A patent/IL168308A/en not_active IP Right Cessation
- 2005-05-10 TN TNP2005000131A patent/TNSN05131A1/en unknown
- 2005-06-16 MA MA28343A patent/MA27539A1/fr unknown
- 2005-06-17 NO NO20052999A patent/NO334247B1/no not_active IP Right Cessation
- 2005-06-20 IS IS7898A patent/IS2575B/is unknown
- 2005-06-27 CO CO05062787A patent/CO5690570A2/es not_active Application Discontinuation
-
2008
- 2008-09-17 CY CY20081101017T patent/CY1110369T1/el unknown
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