DK1567139T3 - Hidtil ukendt synergistisk kombination der omfatter roflumilast og formoterol - Google Patents
Hidtil ukendt synergistisk kombination der omfatter roflumilast og formoterolInfo
- Publication number
- DK1567139T3 DK1567139T3 DK03767663T DK03767663T DK1567139T3 DK 1567139 T3 DK1567139 T3 DK 1567139T3 DK 03767663 T DK03767663 T DK 03767663T DK 03767663 T DK03767663 T DK 03767663T DK 1567139 T3 DK1567139 T3 DK 1567139T3
- Authority
- DK
- Denmark
- Prior art keywords
- formoterol
- combination including
- synergistic combination
- hitherto unknown
- roflumilast
- Prior art date
Links
- BPZSYCZIITTYBL-UHFFFAOYSA-N formoterol Chemical compound C1=CC(OC)=CC=C1CC(C)NCC(O)C1=CC=C(O)C(NC=O)=C1 BPZSYCZIITTYBL-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002848 formoterol Drugs 0.000 title abstract 2
- MNDBXUUTURYVHR-UHFFFAOYSA-N roflumilast Chemical compound FC(F)OC1=CC=C(C(=O)NC=2C(=CN=CC=2Cl)Cl)C=C1OCC1CC1 MNDBXUUTURYVHR-UHFFFAOYSA-N 0.000 title abstract 2
- 229960002586 roflumilast Drugs 0.000 title abstract 2
- 239000011885 synergistic combination Substances 0.000 title 1
- 208000018569 Respiratory Tract disease Diseases 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02026505 | 2002-11-27 | ||
| PCT/EP2003/013275 WO2004047829A1 (en) | 2002-11-27 | 2003-11-26 | New synergistic combination comprising roflumilast and formoterol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1567139T3 true DK1567139T3 (da) | 2008-11-03 |
Family
ID=32338002
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK03767663T DK1567139T3 (da) | 2002-11-27 | 2003-11-26 | Hidtil ukendt synergistisk kombination der omfatter roflumilast og formoterol |
Country Status (31)
| Country | Link |
|---|---|
| US (1) | US20060142308A1 (enExample) |
| EP (1) | EP1567139B1 (enExample) |
| JP (1) | JP2006508994A (enExample) |
| KR (1) | KR101071798B1 (enExample) |
| CN (1) | CN100346777C (enExample) |
| AT (1) | ATE399543T1 (enExample) |
| AU (1) | AU2003292120B2 (enExample) |
| BR (1) | BR0316451A (enExample) |
| CA (1) | CA2506962C (enExample) |
| CO (1) | CO5690570A2 (enExample) |
| CY (1) | CY1110369T1 (enExample) |
| DE (1) | DE60321953D1 (enExample) |
| DK (1) | DK1567139T3 (enExample) |
| EA (1) | EA009935B1 (enExample) |
| ES (1) | ES2309357T3 (enExample) |
| HR (1) | HRP20050579B1 (enExample) |
| IL (1) | IL168308A (enExample) |
| IS (1) | IS2575B (enExample) |
| MA (1) | MA27539A1 (enExample) |
| ME (1) | ME00489B (enExample) |
| MX (1) | MXPA05005437A (enExample) |
| NO (1) | NO334247B1 (enExample) |
| NZ (1) | NZ540659A (enExample) |
| PL (1) | PL216752B1 (enExample) |
| PT (1) | PT1567139E (enExample) |
| RS (1) | RS51081B (enExample) |
| SI (1) | SI1567139T1 (enExample) |
| TN (1) | TNSN05131A1 (enExample) |
| UA (1) | UA83018C2 (enExample) |
| WO (1) | WO2004047829A1 (enExample) |
| ZA (1) | ZA200503308B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY140561A (en) * | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| PL1606261T3 (pl) | 2003-03-10 | 2010-04-30 | Astrazeneca Ab | Nowy sposób przygotowania roflumilastu |
| EP1861074B1 (en) * | 2005-03-16 | 2013-04-24 | Takeda GmbH | Taste masked dosage form containing roflumilast |
| DE102005030733A1 (de) * | 2005-07-01 | 2007-01-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff |
| EP2359826B1 (en) * | 2006-07-05 | 2013-10-30 | Takeda GmbH | Combination of HMG-COA reductase inhibitor rosuvastatin with a phosphodiesterase 4 inhibitor, such as roflumilast, roflumilast-N-oxide for the treatment of inflammatory pulmonary diseases |
| WO2013077830A1 (en) * | 2011-11-25 | 2013-05-30 | Mahmut Bilgic | Synergistilly active combinations of roflumilast and carmoterol |
| US20130172303A1 (en) * | 2012-01-03 | 2013-07-04 | Forest Laboratories Holdings Ltd. | Roflumilast compositions for the treatment of copd |
| WO2014115127A1 (en) | 2013-01-28 | 2014-07-31 | Incozen Therapeutics Pvt. Ltd. | Methods of treating autoimmune, respiratory and inflammatory disorders by inhalation of roflumilast n-oxide |
| CN104800214A (zh) * | 2014-01-27 | 2015-07-29 | 成都英诺新科技有限公司 | 一种罗氟司特吸入气雾剂复方及制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5795564A (en) * | 1991-04-05 | 1998-08-18 | Sepracor, Inc. | Methods and compositions for treating pulmonary disorders using optically pure (R,R)-formoterol |
| CZ290266B6 (cs) * | 1993-07-02 | 2002-06-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Substituované benzamidy, způsob jejich výroby a farmaceutické prostředky s jejich obsahem |
| BR9807399B1 (pt) * | 1997-02-17 | 2011-04-19 | composição para o tratamento de sìndrome da angústia respiratória infantil (irds) ou sìndrome da angústia respiratória aguda (ards) compreendendo 3-(ciclopropilmetóxi)-n-(3,5-dicloro-4-piridinil)-4-(difl uorometóxi) benzamida e tensoativo do pulmão, e seu uso. | |
| US6624181B1 (en) * | 1997-02-28 | 2003-09-23 | Altana Pharma Ag | Synergistic combination |
| US6333354B1 (en) * | 1997-02-28 | 2001-12-25 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Synergistic combination of PDE inhibitors and adenylate cyclase agonists or guanyl cyclyse agonists |
| NZ527232A (en) * | 1998-08-26 | 2005-03-24 | Smithkline Beecham Corp | A composition contaning a PDE 4 inhibitor and a beta adrenergic bronchodilator useful for treating pulmonary diseases |
| US6303145B2 (en) * | 1999-05-10 | 2001-10-16 | Sepracor Inc. | (S,R) formoterol methods and compositions |
| EP1671651B1 (en) * | 1999-08-21 | 2009-11-11 | Nycomed GmbH | Synergistic combination of pumafentrine and salmeterol |
| GB0103630D0 (en) * | 2001-02-14 | 2001-03-28 | Glaxo Group Ltd | Chemical compounds |
| JP4143413B2 (ja) * | 2001-03-22 | 2008-09-03 | グラクソ グループ リミテッド | β２−アドレナリン受容体アゴニストとしてのホルムアニリド誘導体 |
| ATE411334T1 (de) * | 2001-04-30 | 2008-10-15 | Glaxo Group Ltd | Antiphlogistische 7.beta.-carbothioate esterderivate von androstan mit einer 17.alpha.- zyklischen estergruppe |
-
2003
- 2003-11-26 MX MXPA05005437A patent/MXPA05005437A/es active IP Right Grant
- 2003-11-26 UA UAA200505966A patent/UA83018C2/uk unknown
- 2003-11-26 PL PL377732A patent/PL216752B1/pl unknown
- 2003-11-26 ME MEP-2008-782A patent/ME00489B/me unknown
- 2003-11-26 SI SI200331344T patent/SI1567139T1/sl unknown
- 2003-11-26 CA CA2506962A patent/CA2506962C/en not_active Expired - Fee Related
- 2003-11-26 AT AT03767663T patent/ATE399543T1/de active
- 2003-11-26 DE DE60321953T patent/DE60321953D1/de not_active Expired - Lifetime
- 2003-11-26 KR KR1020057009210A patent/KR101071798B1/ko not_active Expired - Fee Related
- 2003-11-26 ES ES03767663T patent/ES2309357T3/es not_active Expired - Lifetime
- 2003-11-26 CN CNB2003801037450A patent/CN100346777C/zh not_active Expired - Fee Related
- 2003-11-26 HR HRP20050579AA patent/HRP20050579B1/hr not_active IP Right Cessation
- 2003-11-26 US US10/535,816 patent/US20060142308A1/en not_active Abandoned
- 2003-11-26 EA EA200500774A patent/EA009935B1/ru not_active IP Right Cessation
- 2003-11-26 BR BR0316451-9A patent/BR0316451A/pt not_active IP Right Cessation
- 2003-11-26 PT PT03767663T patent/PT1567139E/pt unknown
- 2003-11-26 RS YUP-2005/0382A patent/RS51081B/sr unknown
- 2003-11-26 JP JP2004554480A patent/JP2006508994A/ja active Pending
- 2003-11-26 DK DK03767663T patent/DK1567139T3/da active
- 2003-11-26 EP EP03767663A patent/EP1567139B1/en not_active Expired - Lifetime
- 2003-11-26 AU AU2003292120A patent/AU2003292120B2/en not_active Ceased
- 2003-11-26 NZ NZ540659A patent/NZ540659A/en not_active IP Right Cessation
- 2003-11-26 WO PCT/EP2003/013275 patent/WO2004047829A1/en not_active Ceased
-
2005
- 2005-04-25 ZA ZA200503308A patent/ZA200503308B/en unknown
- 2005-05-01 IL IL168308A patent/IL168308A/en not_active IP Right Cessation
- 2005-05-10 TN TNP2005000131A patent/TNSN05131A1/en unknown
- 2005-06-16 MA MA28343A patent/MA27539A1/fr unknown
- 2005-06-17 NO NO20052999A patent/NO334247B1/no not_active IP Right Cessation
- 2005-06-20 IS IS7898A patent/IS2575B/is unknown
- 2005-06-27 CO CO05062787A patent/CO5690570A2/es not_active Application Discontinuation
-
2008
- 2008-09-17 CY CY20081101017T patent/CY1110369T1/el unknown
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