KR101023035B1 - 세펨 화합물 - Google Patents

세펨 화합물 Download PDF

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Publication number
KR101023035B1
KR101023035B1 KR1020057007538A KR20057007538A KR101023035B1 KR 101023035 B1 KR101023035 B1 KR 101023035B1 KR 1020057007538 A KR1020057007538 A KR 1020057007538A KR 20057007538 A KR20057007538 A KR 20057007538A KR 101023035 B1 KR101023035 B1 KR 101023035B1
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KR
South Korea
Prior art keywords
amino
alkyl
methyl
tert
added
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
KR1020057007538A
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English (en)
Korean (ko)
Other versions
KR20050084897A (ko
Inventor
히데노리 오키
신야 오쿠다
도시오 야마나카
마사루 오가키
아야코 토다
고지 가와바타
사토시 이노우에
케이지 미스미
겐지 이토
겐지 사토
Original Assignee
와쿠나가 세이야쿠 가부시키 가이샤
아스텔라스세이야쿠 가부시키가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2002952355A external-priority patent/AU2002952355A0/en
Priority claimed from AU2003904813A external-priority patent/AU2003904813A0/en
Application filed by 와쿠나가 세이야쿠 가부시키 가이샤, 아스텔라스세이야쿠 가부시키가이샤 filed Critical 와쿠나가 세이야쿠 가부시키 가이샤
Publication of KR20050084897A publication Critical patent/KR20050084897A/ko
Application granted granted Critical
Publication of KR101023035B1 publication Critical patent/KR101023035B1/ko
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
KR1020057007538A 2002-10-30 2003-10-27 세펨 화합물 Expired - Lifetime KR101023035B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
AU2002952355 2002-10-30
AU2002952355A AU2002952355A0 (en) 2002-10-30 2002-10-30 Cephem compounds
AU2003904813 2003-09-04
AU2003904813A AU2003904813A0 (en) 2003-09-04 Cephem Compounds

Publications (2)

Publication Number Publication Date
KR20050084897A KR20050084897A (ko) 2005-08-29
KR101023035B1 true KR101023035B1 (ko) 2011-03-24

Family

ID=32231625

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020057007538A Expired - Lifetime KR101023035B1 (ko) 2002-10-30 2003-10-27 세펨 화합물

Country Status (19)

Country Link
US (2) US7129232B2 (enExample)
EP (1) EP1556389B9 (enExample)
JP (1) JP4448821B2 (enExample)
KR (1) KR101023035B1 (enExample)
AR (1) AR041729A1 (enExample)
AT (1) ATE368042T1 (enExample)
BE (1) BE2016C002I2 (enExample)
BR (1) BRPI0315188B8 (enExample)
CA (1) CA2504730C (enExample)
DE (1) DE60315178T3 (enExample)
DK (1) DK1556389T6 (enExample)
ES (1) ES2290498T7 (enExample)
FR (1) FR16C0004I2 (enExample)
HU (1) HUS1600008I1 (enExample)
LU (1) LU92943I2 (enExample)
NL (1) NL300793I1 (enExample)
PT (1) PT1556389E (enExample)
TW (1) TWI319403B (enExample)
WO (1) WO2004039814A1 (enExample)

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CA2446099A1 (en) * 2001-05-01 2002-11-14 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
ATE368042T1 (de) * 2002-10-30 2007-08-15 Astellas Pharma Inc Cephemverbindungen
AU2003902380A0 (en) * 2003-05-16 2003-06-05 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
ATE463248T1 (de) 2003-09-18 2010-04-15 Astellas Pharma Inc Cephem-verbindungen
WO2005063704A1 (ja) * 2003-12-25 2005-07-14 Ono Pharmaceutical Co., Ltd. アゼチジン環化合物およびその医薬
WO2007119511A1 (en) * 2006-03-16 2007-10-25 Astellas Pharma Inc. Cephem compounds and use as antimicrobial agents
ITFE20060029A1 (it) * 2006-10-17 2008-04-18 Gruppo Kemon Spa Intermedi eterociclici primari per la colorazione ossidativa dei capelli a struttura pirazolica
CA2702257C (en) 2007-10-09 2016-07-12 Sopharmia, Inc. Broad spectrum beta-lactamase inhibitors
NZ618795A (en) * 2011-05-13 2015-07-31 Array Biopharma Inc Pyrrolidinyl urea, pyrrolidinyl thiourea and pyrrolidinyl guanidine compounds as trka kinase inhibitors
WO2013036783A2 (en) 2011-09-09 2013-03-14 Cubist Pharmaceuticals, Inc. Methods for treating intrapulmonary infections
EP2628730B1 (en) * 2012-02-16 2017-12-06 Noxell Corporation Telescoping synthesis of 5-amino-4-nitroso-1-alkyl-1h-pyrazole salts
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
US20150306076A1 (en) 2012-09-27 2015-10-29 Cubist Pharmaceuticals, Inc. Tazobactam arginine antibiotic compositions
US20140274999A1 (en) 2013-03-14 2014-09-18 Cubist Pharmaceuticals, Inc. Cephalosporin compositions and methods of manufacture
KR102329764B1 (ko) * 2013-03-15 2021-11-23 머크 샤프 앤드 돔 코포레이션 세프톨로잔 항균성 조성물
US20140275000A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane pharmaceutical compositions
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US10376496B2 (en) 2013-09-09 2019-08-13 Merck, Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) * 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane
US20160228448A1 (en) * 2013-09-27 2016-08-11 Merck Sharp & Dohme Corp. Solid Forms of Ceftolozane
US9120796B2 (en) 2013-10-02 2015-09-01 Cubist Pharmaceuticals, Inc. B-lactamase inhibitor picoline salt
CN106459013B (zh) 2014-05-15 2019-10-25 阵列生物制药公司 作为trka激酶抑制剂的化合物及其用途
CN106795175A (zh) 2014-08-15 2017-05-31 默沙东公司 头孢菌素化合物的合成
WO2016025813A1 (en) 2014-08-15 2016-02-18 Merck Sharp & Dohme Corp. Intermediates in the synthesis of cephalosporin compounds
WO2016028670A1 (en) * 2014-08-18 2016-02-25 Merck Sharp & Dohme Corp. Salt forms of ceftolozane
WO2016095860A1 (en) * 2014-12-18 2016-06-23 Merck Sharp & Dohme Corp. Pyrazolyl carboxylic acid and pyrazolyl urea derivative compounds
WO2016100897A1 (en) * 2014-12-18 2016-06-23 Merck Sharp & Dohme Corp. Thiadiazolyl-oximinoacetic acid derivative compounds
US20160176897A1 (en) 2014-12-23 2016-06-23 Merck Sharp & Dohme Corp. 7-aminocephem derivative compounds
WO2016109259A2 (en) * 2014-12-30 2016-07-07 Merck Sharp & Dohme Corp. Synthesis of cephalosporin compounds
EP3313821B1 (en) 2015-06-29 2019-04-10 Sandoz AG Process for the preparation of carbamoylamino pyrazole derivatives
CA2991521A1 (en) 2015-09-08 2017-03-16 Sandoz Ag Process for preparing ceftolozane from 7-aminocephalosporanic acid (7-aca)
US9751894B2 (en) 2015-12-10 2017-09-05 Naeja-Rgm Pharmaceuticals Inc. Cephem compounds, their production and use
WO2017213944A1 (en) 2016-06-06 2017-12-14 Merck Sharp & Dohme Corp. Solid forms of ceftolozane and processes for preparing
CN107586305A (zh) * 2017-06-23 2018-01-16 浙江惠迪森药业有限公司 一种β‑内酰胺类化合物羧基及羟基保护基脱除方法
WO2019145784A2 (en) * 2018-01-26 2019-08-01 Legochem Biosciences, Inc. Combination therapies for multi-drug resistant pathogens
CN109369535A (zh) * 2018-11-07 2019-02-22 浙江东邦药业有限公司 一种氨基甲酰氨基吡唑衍生化合物的制备方法

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US5173485A (en) * 1988-03-09 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Cephem compounds
GB8905301D0 (en) * 1989-03-08 1989-04-19 Fujisawa Pharmaceutical Co New cephem compound and a process for preparation thereof
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GB9023479D0 (en) * 1990-10-29 1990-12-12 Fujisawa Pharmaceutical Co New cephem compounds and processes for preparation thereof
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CA2446099A1 (en) * 2001-05-01 2002-11-14 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
ATE368042T1 (de) * 2002-10-30 2007-08-15 Astellas Pharma Inc Cephemverbindungen
AU2003902380A0 (en) * 2003-05-16 2003-06-05 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
ATE463248T1 (de) * 2003-09-18 2010-04-15 Astellas Pharma Inc Cephem-verbindungen

Also Published As

Publication number Publication date
HUS1600008I1 (hu) 2016-03-29
KR20050084897A (ko) 2005-08-29
AR041729A1 (es) 2005-05-26
US20070037786A1 (en) 2007-02-15
EP1556389B1 (en) 2007-07-25
CA2504730A1 (en) 2004-05-13
DK1556389T6 (da) 2015-05-11
DE60315178T2 (de) 2008-04-30
FR16C0004I2 (fr) 2017-01-06
ES2290498T3 (es) 2008-02-16
WO2004039814A1 (en) 2004-05-13
BRPI0315188B1 (pt) 2017-04-25
US20040132994A1 (en) 2004-07-08
PT1556389E (pt) 2007-11-08
CA2504730C (en) 2011-04-12
EP1556389A1 (en) 2005-07-27
JP2006506459A (ja) 2006-02-23
NL300793I2 (enExample) 2016-03-15
HK1086566A1 (zh) 2006-09-22
JP4448821B2 (ja) 2010-04-14
ATE368042T1 (de) 2007-08-15
ES2290498T7 (es) 2015-07-10
NL300793I1 (enExample) 2016-03-15
BE2016C002I2 (enExample) 2023-03-07
BR0315188A (pt) 2005-09-06
DE60315178D1 (de) 2007-09-06
US7129232B2 (en) 2006-10-31
EP1556389B3 (en) 2015-04-01
DE60315178T3 (de) 2015-06-18
BRPI0315188B8 (pt) 2021-05-25
DK1556389T3 (da) 2007-11-26
LU92943I2 (fr) 2016-03-14
TW200410977A (en) 2004-07-01
EP1556389B9 (en) 2015-09-09
TWI319403B (en) 2010-01-11
FR16C0004I1 (fr) 2016-03-25

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